{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:12:21Z","timestamp":1773681141980,"version":"3.50.1"},"reference-count":60,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Lens and Anterior Eye"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.clae.2004.09.004","type":"journal-article","created":{"date-parts":[[2004,11,8]],"date-time":"2004-11-08T17:01:02Z","timestamp":1099933262000},"page":"21-28","source":"Crossref","is-referenced-by-count":10,"title":["Effect of multipurpose solutions for contact lens care on the in vitro drug-induced spoliation of poly(2-hydroxyethyl methacrylate) in simulated aqueous humour"],"prefix":"10.1016","volume":"28","author":[{"given":"Traian V.","family":"Chirila","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoya","family":"Gridneva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Meyrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia R.","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clae.2004.09.004_bib1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/bjo.59.3.141","article-title":"Calcium deposition as a cause of spoilation of hydrophilic soft contact lenses","volume":"59","author":"Ruben","year":"1975","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.clae.2004.09.004_bib2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00006324-197602000-00001","article-title":"Deposition of substances within hydrophilic lenses","volume":"53","author":"Hilbert","year":"1976","journal-title":"J Optom Physiol Optics"},{"key":"10.1016\/j.clae.2004.09.004_bib3","unstructured":"Lowther GE. The relationship between the chemistry of the tear film and hydrophilic lens deposits. In: Soft contact lenses. Proceedings of the Second National Research Symposium, Chicago, 1975. Amsterdam: Excerpta Medica, 1977. p. 42\u201350."},{"key":"10.1016\/j.clae.2004.09.004_bib4","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/j.1755-3768.1979.tb01852.x","article-title":"Morphological, histochemical and X-ray microanalytical examination of deposits on soft contact lenses in extended wearing","volume":"57","author":"Dreyer","year":"1979","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.clae.2004.09.004_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0014-4835(85)90113-7","article-title":"Adsorption of tear proteins on soft contact lenses","volume":"40","author":"Gachon","year":"1985","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.clae.2004.09.004_bib6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-4835(86)80083-5","article-title":"Deposits on soft contact lenses. Electrophoresis and scanning electron microscopic examinations","volume":"43","author":"Bilbaut","year":"1986","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.clae.2004.09.004_bib7","first-page":"842","article-title":"Specificity and biological activity of the protein deposited on the hydrogel surface","volume":"28","author":"Sack","year":"1987","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2004.09.004_bib8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0142-9612(87)90094-9","article-title":"Studies of the ocular compatibility of hydrogels. A review of the clinical manifestations of spoilation","volume":"8","author":"Bowers","year":"1987","journal-title":"Biomaterials"},{"key":"10.1016\/j.clae.2004.09.004_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0142-9612(87)90095-0","article-title":"Studies of the ocular compatibility of hydrogels. White spot deposits\u2014incidence of occurrence, location and gross morphology","volume":"8","author":"Bowers","year":"1987","journal-title":"Biomaterials"},{"key":"10.1016\/j.clae.2004.09.004_bib10","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0142-9612(87)90059-7","article-title":"Studies of the ocular compatibility of hydrogels. White spot deposits\u2014chemical composition and geological arrangement of components","volume":"8","author":"Bowers","year":"1987","journal-title":"Biomaterials"},{"key":"10.1016\/j.clae.2004.09.004_bib11","first-page":"362","article-title":"Adsorption of proteins from artificial tear solutions to contact lens materials","volume":"29","author":"Bohnert","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2004.09.004_bib12","first-page":"185","article-title":"Protein deposits on individual hydrophilic contact lenses: effects of water and ionicity","volume":"15","author":"Minarik","year":"1989","journal-title":"CLAO J"},{"key":"10.1016\/j.clae.2004.09.004_bib13","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1097\/00006324-199110000-00003","article-title":"Quantity of protein deposited on hydrogel contact lenses and its relation to visible protein deposits","volume":"68","author":"Myers","year":"1991","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.clae.2004.09.004_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0141-7037(91)80058-T","article-title":"Studies in the ocular compatibility of hydrogels (IV): observations on the role of calcium in deposit formation","volume":"14","author":"Abbott","year":"1991","journal-title":"J Br Contact Lens Assoc"},{"key":"10.1016\/j.clae.2004.09.004_bib15","series-title":"The eye in contact lens wear","article-title":"Lens deposition and spoilation","author":"Tighe","year":"1997"},{"key":"10.1016\/j.clae.2004.09.004_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/(SICI)1097-4636(199707)36:1<119::AID-JBM14>3.0.CO;2-D","article-title":"Radiochemical studies on contact lens soilation. I. Lens uptake of 14C-lysozyme from simple and complex artificial tear solutions","volume":"36","author":"Prager","year":"1997","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.clae.2004.09.004_bib17","series-title":"Contact Lenses","first-page":"93","article-title":"Drugs and solutions in contact lens practice and related microbiology","author":"Stapleton","year":"1997"},{"key":"10.1016\/j.clae.2004.09.004_bib18","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1001\/archopht.1995.01100110091031","article-title":"Dystrophic calcification of an implanted hydroxyethylmethacrylate intraocular lens","volume":"113","author":"Bucher","year":"1995","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.clae.2004.09.004_bib19","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0886-3350(01)00841-0","article-title":"Dense opacification of the optical component of a hydrophilic acrylic intraocular lens. A clinicopathological analysis of 9 explanted lenses","volume":"27","author":"Werner","year":"2001","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.clae.2004.09.004_bib20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0886-3350(03)00461-9","article-title":"Late postoperative opacification of MemoryLens hydrophilic acrylic intraocular lenses","volume":"30","author":"Tehrani","year":"2004","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.clae.2004.09.004_bib21","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1016\/S0161-6420(00)00416-4","article-title":"Post-operative deposition of calcium on the surfaces of a hydrogel intraocular lens","volume":"107","author":"Werner","year":"2000","journal-title":"Ophthalmology"},{"key":"10.1016\/j.clae.2004.09.004_bib22","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1046\/j.1442-9071.2000.00331.x","article-title":"Visually significant calcification of hydrogel intraocular lenses necessitating explantation","volume":"28","author":"Fernando","year":"2000","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.clae.2004.09.004_bib23","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1001\/archopht.119.4.611","article-title":"Hydroxyapatite formation on implanted hydrogel lenses","volume":"119","author":"Yu","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.clae.2004.09.004_bib24","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/S0886-3350(01)01038-0","article-title":"Clinical features of 46 eyes with calcified hydrogel intraocular lenses","volume":"27","author":"Yu","year":"2001","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.clae.2004.09.004_bib25","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0886-3350(02)01357-3","article-title":"Complications and clinical outcomes of intraocular lens exchange in patients with calcified hydrogel lenses","volume":"28","author":"Yu","year":"2002","journal-title":"J. Cataract Refract Surg"},{"key":"10.1016\/j.clae.2004.09.004_bib26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/sj.eye.6700069","article-title":"Late surface opacification of Hydroview\u00ae intraocular lenses","volume":"16","author":"Habib","year":"2002","journal-title":"Eye"},{"key":"10.1016\/j.clae.2004.09.004_bib27","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1001\/archopht.120.3.391","article-title":"Calcium precipitation on the optical surfaces of a foldable intraocular lens: a clinicopathological correlation","volume":"120","author":"Pandey","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.clae.2004.09.004_bib28","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0002-9394(02)02154-2","article-title":"Proposed pathogenesis for the delayed post-operative opacification of the hydroview hydrogel intraocular lens","volume":"135","author":"Dorey","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.clae.2004.09.004_bib29","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/sj.eye.6700341","article-title":"Calcification of modern foldable hydrogel intraocular lens designs","volume":"17","author":"Izak","year":"2003","journal-title":"Eye"},{"key":"10.1016\/j.clae.2004.09.004_bib30","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/jbm.820280612","article-title":"Interpenetrating polymer network (IPN) as a permanent joint between the elements of a new type of artificial cornea","volume":"28","author":"Chirila","year":"1994","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.clae.2004.09.004_bib31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/bjo.82.1.18","article-title":"Clinical results of implantation of the Chirila keratoprosthesis in rabbits","volume":"82","author":"Hicks","year":"1998","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.clae.2004.09.004_bib32","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1016\/S0142-9612(01)00168-5","article-title":"An overview of the development of artificial corneas with porous skirts and the use of PHEMA for such an application","volume":"22","author":"Chirila","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.clae.2004.09.004_bib33","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0161-6420(02)00958-2","article-title":"The Chirila keratoprosthesis: phase I human clinical trial","volume":"109","author":"Crawford","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.clae.2004.09.004_bib34","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/sj.eye.6700333","article-title":"Corneal replacement using a synthetic hydrogel cornea, AlphaCor\u2122: device, preliminary outcomes and complications","volume":"17","author":"Hicks","year":"2003","journal-title":"Eye"},{"key":"10.1016\/j.clae.2004.09.004_bib35","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/00003226-200310000-00001","article-title":"AlphaCor\u2122 cases: comparative outcomes","volume":"22","author":"Hicks","year":"2003","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2004.09.004_bib36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1442-9071.2004.00781.x","article-title":"Deposits in artificial corneas: risk factors and prevention","volume":"32","author":"Hicks","year":"2004","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.clae.2004.09.004_bib37","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1023\/B:JMSC.0000016204.30023.69","article-title":"Spontaneous calcification of acrylic hydrogels in abiotic calcifying media and the relevance of ionic solute effects","volume":"39","author":"Chirila","year":"2004","journal-title":"J Mater Sci"},{"key":"10.1016\/j.clae.2004.09.004_bib38","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/01.ico.0000121703.74077.ea","article-title":"In vitro drug-induced spoliation of a keratoprosthetic hydrogel","volume":"23","author":"Chirila","year":"2004","journal-title":"Cornea"},{"issue":"5500","key":"10.1016\/j.clae.2004.09.004_bib39","first-page":"25","article-title":"Disclosure\u2014the true story of multi-purpose solutions","volume":"209","author":"Franklin","year":"1995","journal-title":"Optician"},{"issue":"5717","key":"10.1016\/j.clae.2004.09.004_bib40","first-page":"20","volume":"218","author":"Christie","year":"1999","journal-title":"Solutions: same or different?"},{"key":"10.1016\/j.clae.2004.09.004_bib41","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/1521-3781(200112)35:6<348::AID-CIUZ348>3.0.CO;2-F","article-title":"Damit der Durchblick erhalten bleibt: Proteinentfernung von Kontaktlinsen","volume":"35","author":"Janiak","year":"2001","journal-title":"Chem uns Zeit"},{"key":"10.1016\/j.clae.2004.09.004_bib42","first-page":"238","article-title":"Contact lens daily cleaner efficacy: multipurpose versus single-purpose products","volume":"18","author":"House","year":"1991","journal-title":"ICLC"},{"key":"10.1016\/j.clae.2004.09.004_bib43","first-page":"47","article-title":"The efficacy of hydrophilic contact lens cleaning systems in removing protein deposits","volume":"19","author":"Jung","year":"1993","journal-title":"CLAO J"},{"key":"10.1016\/j.clae.2004.09.004_bib44","first-page":"33","article-title":"Passive protein removal by two multipurpose lens solutions: comparison of effects on in vitro deposited and patient-worn hydrogel contact lenses","volume":"26","author":"Simmons","year":"1999","journal-title":"ICLC"},{"key":"10.1016\/j.clae.2004.09.004_bib45","first-page":"308","article-title":"A masked quantitative cytologic study of the safety of a multipurpose contact lens solution applied to the in vivo rabbit eye","volume":"64","author":"Bergmanson","year":"1993","journal-title":"J Am Optom Assoc"},{"key":"10.1016\/j.clae.2004.09.004_bib46","first-page":"52","article-title":"The effects of soft contact lens disinfection solutions on rabbit corneal epithelium","volume":"20","author":"Begley","year":"1994","journal-title":"CLAO J"},{"key":"10.1016\/j.clae.2004.09.004_bib47","first-page":"28","article-title":"Cytotoxicity evaluation of multipurpose contact lens solutions using an in vitro test battery","volume":"25","author":"Pham","year":"1999","journal-title":"CLAO J"},{"key":"10.1016\/j.clae.2004.09.004_bib48","first-page":"151","article-title":"Comparison of contact lens multipurpose solutions by in vitro sodium fluorescein permeability assay","volume":"28","author":"Tchao","year":"2002","journal-title":"CLAO J"},{"key":"10.1016\/j.clae.2004.09.004_bib49","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jbm.b.10510","article-title":"Effects of multipurpose solutions (MPS) for hydrogel contact lenses on gap-junctional intercellular communication (GJIC) in rabbit corneal keratocytes","volume":"64 B","author":"Sumide","year":"2003","journal-title":"J Biomed Mater Res B: Appl Biomater"},{"key":"10.1016\/j.clae.2004.09.004_bib50","first-page":"297","article-title":"The comfort factor: assessing patient satisfaction with Opti-Free\u00ae vs. other contact cleaning products","volume":"11","author":"Yeaton","year":"1994","journal-title":"Adv Therapy"},{"key":"10.1016\/j.clae.2004.09.004_bib51","first-page":"192","article-title":"Conditioning of hydrogel lenses by a multipurpose solution containing an ocular lubricant","volume":"27","author":"Simmons","year":"2001","journal-title":"CLAO J"},{"key":"10.1016\/j.clae.2004.09.004_bib52","first-page":"186","article-title":"Clinical acceptance of two multipurpose solutions: MPS containing HPMC versus citrate-based MPS without rubbing","volume":"28","author":"Guillon","year":"2002","journal-title":"CLAO J"},{"key":"10.1016\/j.clae.2004.09.004_bib53","first-page":"190","article-title":"An analysis of contact lens enzyme cleaners","volume":"61","author":"Begley","year":"1990","journal-title":"J Am Optom Assoc"},{"key":"10.1016\/j.clae.2004.09.004_bib54","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0014-4835(70)80016-1","article-title":"Intraocular fluid dynamics. I. Steady-state concentration gradients of magnesium, potassium and calcium in relation to the sites and mechanisms of ocular cation transport process","volume":"10","author":"Bito","year":"1970","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.clae.2004.09.004_bib55","first-page":"1139","article-title":"Rhesus monkey aqueous humor composition and a primate ocular perfusate","volume":"18","author":"Gaasterland","year":"1979","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2004.09.004_bib56","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0039-6257(81)90145-4","article-title":"Clinical biochemistry of tears","volume":"26","author":"van Haeringen","year":"1982","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.clae.2004.09.004_bib57","series-title":"Adler's physiology of the eye","article-title":"The ciliary epithelia and aqueous humor","author":"Caprioli","year":"1992"},{"key":"10.1016\/j.clae.2004.09.004_bib58","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/00003226-200308000-00001","article-title":"Melting after keratoprosthesis implantation: the effects of medroxyprogesterone","volume":"22","author":"Hicks","year":"2003","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2004.09.004_bib59","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/0275-5408(95)00107-O","article-title":"Clinical assessment of ocular response to a multipurpose contact lens care solution","volume":"15","author":"Bergmanson","year":"1995","journal-title":"Ophthal Physiol Opt"},{"key":"10.1016\/j.clae.2004.09.004_bib60","unstructured":"Hu Z, Ellis EJ, Denick Jr J, Method and composition for rewetting and preventing deposits on contact lens. U.S. Pat. 6,037,328; March 14, 2000."}],"container-title":["Contact Lens and Anterior Eye"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367048404000724?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367048404000724?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T01:54:30Z","timestamp":1549072470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1367048404000724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S1367048404000724"],"URL":"https:\/\/doi.org\/10.1016\/j.clae.2004.09.004","relation":{},"ISSN":["1367-0484"],"issn-type":[{"value":"1367-0484","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}