{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:55:10Z","timestamp":1789430110989,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Lens and Anterior Eye"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.clae.2007.12.001","type":"journal-article","created":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T00:17:59Z","timestamp":1204849079000},"page":"141-146","source":"Crossref","is-referenced-by-count":67,"title":["Oral omega-6 essential fatty acid treatment in contact lens associated dry eye"],"prefix":"10.1016","volume":"31","author":[{"given":"Karolien H.","family":"Kokke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Lawrenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clae.2007.12.001_bib1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1097\/00006324-198912000-00006","article-title":"Symptomology of HEMA contact lens wear","volume":"66","author":"Brennan","year":"1989","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.clae.2007.12.001_bib2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/00006324-200001000-00012","article-title":"Responses of contact lens wearers to a dry eye survey","volume":"77","author":"Begley","year":"2000","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.clae.2007.12.001_bib3","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1046\/j.1475-1313.2002.00066.x","article-title":"A multi-centre study of lapsed contact lens wearers","volume":"22","author":"Young","year":"2002","journal-title":"Ophth Physiol Opt"},{"key":"10.1016\/j.clae.2007.12.001_bib4","first-page":"234","article-title":"The dry eye: its mechanisms and therapy, with evidence that contact lens is a cause","volume":"12","author":"Farris","year":"1986","journal-title":"CLAO J"},{"key":"10.1016\/j.clae.2007.12.001_bib5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0892-8967(93)90118-B","article-title":"Comparison of hydrogel contact lens patients with and without the symptom of dryness","volume":"20","author":"Lowther","year":"1993","journal-title":"Int Contact Lens Clin"},{"key":"10.1016\/j.clae.2007.12.001_bib6","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/00006324-200403000-00012","article-title":"Effect of contact lens materials on tear physiology","volume":"81","author":"Thai","year":"2004","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.clae.2007.12.001_bib7","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1167\/iovs.03-1185","article-title":"Effect of environmental conditions on tear dynamics in soft contact lens wearers","volume":"45","author":"Maruyama","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2007.12.001_bib8","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1167\/iovs.05-0094","article-title":"Thinning rate of the precorneal and prelens tear films","volume":"46","author":"Nichols","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2007.12.001_bib9","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1097\/01.ico.0000157904.52305.29","article-title":"The impact of contact lens care solutions on the thickness of the tear film and contact lens","volume":"24","author":"Nichols","year":"2005","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2007.12.001_bib10","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1167\/iovs.03-0685","article-title":"Differences in clinical parameters and tear film of tolerant and intolerant contact lens wearers","volume":"44","author":"Glasson","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2007.12.001_bib11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00140068-200301000-00010","article-title":"Preservative-free ocular hydrating agents in symptomatic contact lens wearers: saline versus PVP solution","volume":"29","author":"Malet","year":"2003","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.clae.2007.12.001_bib12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/01.ICL.0000101489.13687.9A","article-title":"Effect of povidone 2% preservative-free eyedrops on contact lens wearers with computer visual syndrome: pilot study","volume":"30","author":"Guillon","year":"2004","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.clae.2007.12.001_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.clae.2004.09.002","article-title":"The impact of lens choice in the relief of contact lens related symptoms and ocular surface findings","volume":"28","author":"Riley","year":"2005","journal-title":"Contact Lens Ant Eye"},{"key":"10.1016\/j.clae.2007.12.001_bib14","first-page":"481","article-title":"Inferior punctal occlusion with removable silicone punctal plugs in the treatment of dry-eye related contact lens discomfort","volume":"63","author":"Giovagnoli","year":"1992","journal-title":"J Am Optom Assoc"},{"key":"10.1016\/j.clae.2007.12.001_bib15","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/eye.1996.169","article-title":"Lacrimal plugs as a therapy for contact lens intolerance","volume":"10","author":"Virtenal","year":"1996","journal-title":"Eye"},{"key":"10.1016\/j.clae.2007.12.001_bib16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.exer.2003.09.003","article-title":"The role of the lacrimal functional unit in the pathophysiology of dry eye","volume":"78","author":"Stern","year":"2004","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.clae.2007.12.001_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ico.0000141486.56931.9b","article-title":"The tear film complex: pathogenesis and emerging therapies for dry eyes","volume":"24","author":"Smith","year":"2005","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2007.12.001_bib18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ajo.2003.10.036","article-title":"Antiinflammatory therapy for dry eye","volume":"137","author":"Pflugfelder","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.clae.2007.12.001_bib19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/01.icl.0000175651.30487.58","article-title":"Use of cyclosporine 0.05% ophthalmic emulsion for contact lens intolerant patients","volume":"32","author":"Hom","year":"2006","journal-title":"Eye Contact Lens"},{"issue":"suppl.","key":"10.1016\/j.clae.2007.12.001_bib20","doi-asserted-by":"crossref","first-page":"S343","DOI":"10.1093\/ajcn\/71.1.343s","article-title":"Dietary polyunsaturated fatty acids and inflammatory mediator production","volume":"71","author":"James","year":"2000","journal-title":"Am J Clin Nutr"},{"issue":"suppl.","key":"10.1016\/j.clae.2007.12.001_bib21","doi-asserted-by":"crossref","first-page":"S352","DOI":"10.1093\/ajcn\/71.1.352s","article-title":"Evening primrose oil and borage oil n rheumatic conditions","volume":"71","author":"Belch","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clae.2007.12.001_bib22","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1002\/art.1780391106","article-title":"Gammalinolenic acid treatment of rheumatoid arthritis. A randomized, placebo controlled trial","volume":"39","author":"Zurier","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clae.2007.12.001_bib23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00003226-200303000-00002","article-title":"Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component","volume":"22","author":"Barabino","year":"2003","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2007.12.001_bib24","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.1167\/iovs.04-1394","article-title":"Systemic omega-6 essential fatty acid treatment and PGE1 tear content in Sjogren's syndrome patients","volume":"46","author":"Aragona","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2007.12.001_bib25","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/00006324-199303000-00011","article-title":"CCLRU standards for success of daily and extended wear contact lenses","volume":"70","author":"Terry","year":"1993","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.clae.2007.12.001_bib26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1001\/archopht.1969.00990020012003","article-title":"Diagnostic tests in the Sicca syndrome","volume":"82","author":"van Bijsterveld","year":"1969","journal-title":"Arch Ophth"},{"key":"10.1016\/j.clae.2007.12.001_bib27","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00006324-199701000-00014","article-title":"The importance of the lipid layer in human tear film stability and evaporation","volume":"74","author":"Craig","year":"1997","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.clae.2007.12.001_bib28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/sim.2231","article-title":"Multiple imputation techniques in small sample clinical trials","volume":"25","author":"Barnes","year":"2006","journal-title":"Stat Med"},{"key":"10.1016\/j.clae.2007.12.001_bib29","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/exer.1999.0767","article-title":"Contact lens wear alters the production of certain inflammatory mediators in tears","volume":"70","author":"Thakur","year":"2000","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.clae.2007.12.001_bib30","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1097\/00003226-200111000-00009","article-title":"Ocular surface changes induced by contact lens wear","volume":"20","author":"Pisella","year":"2001","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2007.12.001_bib31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000027387","article-title":"Conjunctival epithelium expression of HLA-DR in dry eye patients","volume":"213","author":"Tsubota","year":"1999","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.clae.2007.12.001_bib32","first-page":"1356","article-title":"Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes","volume":"41","author":"Brignole","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2007.12.001_bib33","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1097\/01.ico.0000157421.93522.00","article-title":"Distribution of conjunctival HLA-DR expression and the pathogenesis of damage in early dry eyes","volume":"24","author":"Rolando","year":"2005","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2007.12.001_bib34","first-page":"35","article-title":"Conjunctival histologic findings of dry eye and non-dry eye contact lens wearing subjects","volume":"27","author":"Albietz","year":"2001","journal-title":"CLAO J"},{"key":"10.1016\/j.clae.2007.12.001_bib35","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00417-003-0685-x","article-title":"Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy","volume":"241","author":"Macri","year":"2003","journal-title":"Greafes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.clae.2007.12.001_bib36","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1006\/clin.1997.4343","article-title":"Gammalinolenic acid and dihomogammalinolenic acid suppress the CD3-mediated signal transduction pathway in human T cells","volume":"83","author":"Vassilopoulos","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.clae.2007.12.001_bib37","first-page":"217","article-title":"Topical prostaglandins inhibit trauma induced inflammation in the rabbit eye","volume":"27","author":"Hoyng","year":"1986","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2007.12.001_bib38","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0161-4630(79)90102-2","article-title":"Secretory effect of prostaglandins on the rabbit lacrimal gland in vivo","volume":"3","author":"Pholpramool","year":"1979","journal-title":"Prostaglandins Med"},{"key":"10.1016\/j.clae.2007.12.001_bib39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3109\/03009748609102073","article-title":"Patients with primary Sj\u00f6grens syndrome treated for two months with evening primrose oil","volume":"15","author":"Oxholm","year":"1996","journal-title":"Scand J Reumatol"},{"key":"10.1016\/j.clae.2007.12.001_bib40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/437045a","article-title":"Phytochemistry: ibuprofen-like activity in extra-virgin olive oil","volume":"437","author":"Beauchamp","year":"2005","journal-title":"Nature"},{"issue":"suppl.","key":"10.1016\/j.clae.2007.12.001_bib41","doi-asserted-by":"crossref","first-page":"S560","DOI":"10.1093\/ajcn\/70.3.560s","article-title":"Essential fatty acids in health and chronic disease","volume":"70","author":"Simopoulos","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clae.2007.12.001_bib42","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/ajcn\/82.4.887","article-title":"Relation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in women","volume":"82","author":"Miljanovic","year":"2005","journal-title":"Am J Clin Nutr"}],"container-title":["Contact Lens and Anterior Eye"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367048408000039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367048408000039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T19:20:23Z","timestamp":1557343223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1367048408000039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S1367048408000039"],"URL":"https:\/\/doi.org\/10.1016\/j.clae.2007.12.001","relation":{},"ISSN":["1367-0484"],"issn-type":[{"value":"1367-0484","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}