{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:57:49Z","timestamp":1789750669486,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","contactlensjournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contact Lens and Anterior Eye"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.clae.2016.06.009","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T18:27:23Z","timestamp":1468607243000},"page":"431-434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects of topical acne treatment on the ocular surface in patients with acne vulgaris"],"prefix":"10.1016","volume":"39","author":[{"given":"Seray","family":"Aslan Bayhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Ali","family":"Bayhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"\u00c7\u00f6lge\u00e7en","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"G\u00fcrdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clae.2016.06.009_bib0005","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1610-0387.2007.06274.x","article-title":"Pathophysiology of acne","volume":"5","author":"Degitz","year":"2007","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"10.1016\/j.clae.2016.06.009_bib0010","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(11)60321-8","article-title":"Acne vulgaris","volume":"379","author":"Williams","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.clae.2016.06.009_bib0015","first-page":"s2","article-title":"Emerging topical antimicrobial options for mild-to-moderate acne: a review of the clinical evidence","volume":"7","author":"Del Rosso","year":"2008","journal-title":"J. Drugs Dermatol."},{"key":"10.1016\/j.clae.2016.06.009_bib0020","first-page":"s109","article-title":"The sequence of inflammation, relevant biomarkers, and the pathogenesis of acne vulgaris: what does recent research show and what does it mean to the clinician?","volume":"12","author":"Del Rosso","year":"2013","journal-title":"J. Drugs Dermatol."},{"key":"10.1016\/j.clae.2016.06.009_bib0025","first-page":"734","article-title":"Diagnosis and treatment of acne","volume":"86","author":"Titus","year":"2012","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.clae.2016.06.009_bib0030","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/dth.12084","article-title":"Isotretinoin updates","volume":"26","author":"On","year":"2013","journal-title":"Dermatol. Ther."},{"key":"10.1016\/j.clae.2016.06.009_bib0035","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/tera.1057","article-title":"Continued occurrence of Accutane-exposed pregnancies","volume":"64","author":"Honein","year":"2001","journal-title":"Teratology"},{"key":"10.1016\/j.clae.2016.06.009_bib0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1517\/14740338.3.2.119","article-title":"Safety and side effects of the acne drug, oral isotretinoin","volume":"3","author":"Charakida","year":"2004","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.clae.2016.06.009_bib0045","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0002-9394(01)01024-8","article-title":"Ocular side effects possibly associated with isotretinoin usage","volume":"132","author":"Fraunfelder","year":"2001","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.clae.2016.06.009_bib0050","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/ICO.0b013e318183a396","article-title":"Conjunctival impression cytology, ocular surface, and tear film changes in patients treated with systemic isotretinoin","volume":"28","author":"Karalezli","year":"2009","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2016.06.009_bib0055","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1365-2230.1991.tb01232.x","article-title":"The finger-tip unit\u2014a new practical measure","volume":"16","author":"Long","year":"1991","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.clae.2016.06.009_bib0060","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaad.2009.01.019","article-title":"New insights into management of acne: an update from the global alliance to improve outcomes in acne group","volume":"60","author":"Thiboutot","year":"2009","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.clae.2016.06.009_bib0065","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/0002-9394(85)90676-2","article-title":"Adverse ocular reactions associated with isotretinoin","volume":"100","author":"Fraunfelder","year":"1985","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.clae.2016.06.009_bib0070","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000267402","article-title":"Toxic effects of systemic retinoids on mebomian glands","volume":"26","author":"Kremer","year":"1994","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.clae.2016.06.009_bib0075","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ophtha.2012.06.064","article-title":"Improving awareness, identification, and management of meibomian gland dysfunction","volume":"119","author":"Foulks","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.clae.2016.06.009_bib0080","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1001\/archopht.1987.01060030136044","article-title":"Isotretinoin in lacrimal gland fluid and tears","volume":"105","author":"Rismondo","year":"1987","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.clae.2016.06.009_bib0085","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0022-2275(20)43203-1","article-title":"13-cis-retinoic acid is an endogenous compound in human serum","volume":"31","author":"Tang","year":"1990","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.clae.2016.06.009_bib0090","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0190-9622(91)70065-A","article-title":"The negligible systemic availability of retinoids with multiple and excessive topical application of isotretinoin 0.05% gel (Isotrex) in patients with acne vulgaris","volume":"24","author":"Jensen","year":"1991","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.clae.2016.06.009_bib0095","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1016\/S0190-9622(97)70059-8","article-title":"The percutaneous absorption of topically applied tretinoin and its effect on endogenous concentrations of tretinoin and its metabolites after single doses or long-term use","volume":"36","author":"Latriano","year":"1997","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.clae.2016.06.009_bib0100","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/000155501750208119","article-title":"A double-blind investigation of the potential systemic absorption of isotretinoin, when combined with chemical sunscreens, following topical application to patients with widespread acne of the face and trunk","volume":"81","author":"Cunliffe","year":"2001","journal-title":"Acta Derm. Venereaol."},{"key":"10.1016\/j.clae.2016.06.009_bib0105","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1177\/112067210901900204","article-title":"Comparison of dose-related ocular side effects during systemic isotretinoin administration","volume":"19","author":"Cumurcu","year":"2009","journal-title":"Eur. J. Ophthalmol."},{"issue":"8856","key":"10.1016\/j.clae.2016.06.009_bib0110","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/0140-6736(93)90868-H","article-title":"Multiple congenital defects associated with maternal use of topical tretinoin","volume":"341","author":"Lipson","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.clae.2016.06.009_bib0115","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0387-7604(00)00104-2","article-title":"Otocerebral anomalies associated with topical tretinoin use","volume":"22","author":"Selcen","year":"2000","journal-title":"Brain Dev."},{"key":"10.1016\/j.clae.2016.06.009_bib0120","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1046\/j.1523-1747.1999.00481.x","article-title":"Inter- and intra-individual differences in human stratum corneum lipid content related to physical parameters of skin barrier function in vivo","volume":"112","author":"Norlen","year":"1999","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.clae.2016.06.009_bib0125","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jdermsci.2010.06.003","article-title":"Structural and functional differences in barrier properties of African American, Caucasian and East Asian skin","volume":"59","author":"Muizzuddin","year":"2010","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.clae.2016.06.009_bib0130","first-page":"WC04","article-title":"A study on the prescribing pattern of drugs for acne in a tertiary care teaching hospital in odisha","volume":"9","author":"Patro","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.clae.2016.06.009_bib0135","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1097\/ICO.0b013e318207fc42","article-title":"Oral azithromycin for treatment of posterior blepharitis","volume":"30","author":"Igami","year":"2011","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2016.06.009_bib0140","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/exd.12358","article-title":"Do tetracyclines and erythromycin exert anti-acne effects by inhibition of P450-mediated degradation of retinoic acid?","volume":"23","author":"Hellmann-Regen","year":"2014","journal-title":"Exp. Dermatol."},{"issue":"4","key":"10.1016\/j.clae.2016.06.009_bib0145","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1365-2133.1982.tb00395.x","article-title":"Ophthalmological effects of 13-cis-retinoic acid therapy for acne vulgaris","volume":"107","author":"Milson","year":"1982","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.clae.2016.06.009_bib0150","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1346-8138.2005.tb00740.x","article-title":"Ocular surface disorders and tear function changes in nodulo-cystic acne","volume":"32","author":"Ozdemir","year":"2005","journal-title":"J. Dermatol."},{"key":"10.1016\/j.clae.2016.06.009_bib0155","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/09273940701486803","article-title":"Ocular surface disease index for the diagnosis of dry eye syndrome","volume":"15","author":"\u00d6zcura","year":"2007","journal-title":"Ocul. Immunol. Inflamm."},{"key":"10.1016\/j.clae.2016.06.009_bib0160","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00003226-199107000-00002","article-title":"Meibomian gland morphology and tear osmolarity: changes with Accutane therapy","volume":"10","author":"Mathers","year":"1991","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2016.06.009_bib0165","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3109\/02713683.2010.484557","article-title":"Performance of tear osmolarity compared to previous diagnostic tests for dry eye diseases","volume":"35","author":"Versura","year":"2010","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.clae.2016.06.009_bib0170","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.ajo.2010.10.032","article-title":"Tear osmolarity in the diagnosis and management of dry eye disease","volume":"151","author":"Lemp","year":"2011","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.clae.2016.06.009_bib0175","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1177\/112067210201200316","article-title":"Lacrimal function and ocular complications in patients treated with systemic isotretinoin","volume":"12","author":"Bozkurt","year":"2002","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.clae.2016.06.009_bib0180","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1600-0420.1995.tb00043.x","article-title":"Ocular side effects associated with 13-cis-retinoic acid therapy for acne vulgaris: clinical features, alterations of tearfilm and conjunctival flora","volume":"73","author":"Egger","year":"1995","journal-title":"Acta Ophthalmol. Scand."}],"container-title":["Contact Lens and Anterior Eye"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367048416300698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367048416300698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T00:32:30Z","timestamp":1656808350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1367048416300698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1367048416300698"],"URL":"https:\/\/doi.org\/10.1016\/j.clae.2016.06.009","relation":{},"ISSN":["1367-0484"],"issn-type":[{"value":"1367-0484","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of topical acne treatment on the ocular surface in patients with acne vulgaris","name":"articletitle","label":"Article Title"},{"value":"Contact Lens and Anterior Eye","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clae.2016.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}