{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:38:53Z","timestamp":1792633133726,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","contactlensjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contact Lens and Anterior Eye"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.clae.2020.01.004","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T01:06:03Z","timestamp":1579050363000},"page":"315-321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["On the in vivo assessment of goblet cells of the human bulbar conjunctiva by confocal microscopy \u2013 A review"],"prefix":"10.1016","volume":"43","author":[{"given":"Michael J.","family":"Doughty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clae.2020.01.004_bib0005","series-title":"Ocular surface","first-page":"32","article-title":"Comparative anatomy and physiology of the cornea and conjunctiva","author":"Doughty","year":"2012"},{"key":"10.1016\/j.clae.2020.01.004_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000131066","article-title":"The normal tear film","volume":"41","author":"Tiffany","year":"2008","journal-title":"Dev Ophthalmol"},{"key":"10.1016\/j.clae.2020.01.004_bib0015","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.tice.2014.05.004","article-title":"Functional morphology of mucosal goblet cells based on spatial separation of orifice openings to the surface - application to the rabbit bulbar conjunctiva","volume":"46","author":"Doughty","year":"2014","journal-title":"Tissue Cell"},{"key":"10.1016\/j.clae.2020.01.004_bib0020","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.clae.2011.04.004","article-title":"Contact lens wear and the goblet cells of the human conjunctiva-A review","volume":"34","author":"Doughty","year":"2011","journal-title":"Cont Lens Anterior Eye"},{"key":"10.1016\/j.clae.2020.01.004_bib0025","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/cxo.12373","article-title":"Effect of three months of soft contact lens wear on conjunctival cytology","volume":"99","author":"Sapkota","year":"2016","journal-title":"Clin Exp Optom"},{"key":"10.1016\/j.clae.2020.01.004_bib0030","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jtos.2012.05.001","article-title":"Goblet cells of the normal human conjunctiva and their assessment by impression cytology sampling","volume":"10","author":"Doughty","year":"2012","journal-title":"Ocular Surf."},{"key":"10.1016\/j.clae.2020.01.004_bib0035","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1097\/01.ico.0000160976.88824.2b","article-title":"In vivo findings of the bulbar\/palpebral conjunctiva and presumed Meibomian glands by laser scanning confocal microscopy","volume":"24","author":"Kobayashi","year":"2005","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2020.01.004_bib0040","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/bjo.87.2.225","article-title":"In vivo confocal microscopy of the human cornea","volume":"87","author":"Jalbert","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.clae.2020.01.004_bib0045","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.clae.2016.01.006","article-title":"Assessment of conjunctival goblet cell density using laser scanning confocal microscopy versus impression cytology","volume":"39","author":"Colorado","year":"2016","journal-title":"Contact Lens Anterior Eye"},{"key":"10.1016\/j.clae.2020.01.004_bib0050","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000315021","article-title":"Laser scanning confocal microscopy for conjunctival epithelium imaging","volume":"45","author":"J\u00fcrgens","year":"2010","journal-title":"Dev Ophthalmol"},{"key":"10.1016\/j.clae.2020.01.004_bib0055","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/01.ico.0000224648.74095.90","article-title":"In vivo confocal microscopy of normal conjunctiva and conjunctivitis","volume":"25","author":"Messmer","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2020.01.004_bib0060","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1167\/iovs.10-6215","article-title":"In vivo confocal microscopy of conjunctival roundish bright objects: young, older, and Sj\u00f6gren subjects","volume":"52","author":"Villani","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2020.01.004_bib0065","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1442-9071.2009.02065.x","article-title":"In vivo confocal microscopy of the bulbar conjunctiva","volume":"37","author":"Efron","year":"2009","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.clae.2020.01.004_bib0070","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1167\/iovs.16-19298","article-title":"Time course of changes in goblet cell density in symptomatic and asymptomatic contact lens wearers","volume":"57","author":"Colorado","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2020.01.004_bib0075","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.jfma.2013.10.003","article-title":"In vivo confocal microscopy of bulbar conjunctiva in patients with Graves\u2019 ophthalmopathy","volume":"114","author":"Wei","year":"2015","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.clae.2020.01.004_bib0080","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/112067210801800314","article-title":"An in vivo confocal microscopy and impression cytology analysis of preserved and unpreserved levobunolol-induced conjunctival changes","volume":"18","author":"Ciancaglini","year":"2008","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.clae.2020.01.004_bib0085","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1167\/iovs.16-19257","article-title":"In vivo goblet cell density as a potential indicator of glaucoma filtration surgery outcome","volume":"57","author":"Agnifili","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2020.01.004_bib0090","doi-asserted-by":"crossref","first-page":"BIO114","DOI":"10.1167\/iovs.17-21795","article-title":"In vivo confocal imaging of the conjunctiva as a predictive tool for the glaucoma filtration surgery outcome","volume":"58","author":"Mastropasqua","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2020.01.004_bib0095","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/IJG.0000000000000899","article-title":"Meibomian gland features and conjunctival goblet cell density in glaucomatous patients controlled with prostaglandin\/ timolol fixed combinations: a case control, cross-sectional study","volume":"27","author":"Agnifili","year":"2018","journal-title":"J Glaucoma"},{"key":"10.1016\/j.clae.2020.01.004_bib0100","doi-asserted-by":"crossref","first-page":"e397","DOI":"10.1111\/aos.12131","article-title":"Conjunctival goblet cells density and preservative-free tafluprost therapy for glaucoma: an in vivo confocal microscopy and impression cytology study","volume":"91","author":"Mastropasqua","year":"2013","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.clae.2020.01.004_bib0105","first-page":"437","article-title":"In vivo scanning laser confocal microscopy of conjunctival goblet cells in medically-controlled glaucoma","volume":"32","author":"Di Staso","year":"2018","journal-title":"In Vivo (Brooklyn)"},{"issue":"2","key":"10.1016\/j.clae.2020.01.004_bib0110","doi-asserted-by":"crossref","first-page":"e133","DOI":"10.1111\/aos.12261","article-title":"In vivo confocal microscopy of conjunctiva in preservative-free timolol 0.1% gel formulation therapy for glaucoma","volume":"92","author":"Frezzotti","year":"2014","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.clae.2020.01.004_bib0115","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/ICO.0b013e3181acf82a","article-title":"Confocal microscopy of the bulbar conjunctiva in contact lens wear","volume":"29","author":"Efron","year":"2010","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2020.01.004_bib0120","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1136\/bjo.2008.155820","article-title":"Age-related changes of human conjunctiva on in vivo confocal microscopy","volume":"94","author":"Zhu","year":"2010","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.clae.2020.01.004_bib0125","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/IJG.0000000000000316","article-title":"Vitamin A palmitate and carbomer gel protects the conjunctiva of patients with long-term prostaglandin analogs application","volume":"25","author":"Cui","year":"2016","journal-title":"J Glaucoma"},{"key":"10.1016\/j.clae.2020.01.004_bib0130","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1159\/000357100","article-title":"Changes in the morphological and functional patterns of the ocular surface in patients treated with prostaglandin analogues after the use of TSP 0.5%\u00ae preservative-free eyedrops: a prospective, multicenter study","volume":"51","author":"Iester","year":"2014","journal-title":"Ophthalmic Res"},{"key":"10.1016\/j.clae.2020.01.004_bib0135","doi-asserted-by":"crossref","first-page":"11299","DOI":"10.1038\/s41598-019-47823-z","article-title":"The ocular surface after successful glaucoma filtration surgery: a clinical, in vivo confocal microscopy, and immune-cytology study","volume":"9","author":"Agnifili","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.clae.2020.01.004_bib0140","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1136\/bjo.2009.161059","article-title":"In vivo confocal microscopy of conjunctival goblet cells in patients with Sjogren\u2019s syndrome dry eye","volume":"94","author":"Hong","year":"2010","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.clae.2020.01.004_bib0145","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1167\/iovs.09-3886","article-title":"An in vivo confocal microscopy and impression cytology analysis of goblet cells in patients with chemical burns","volume":"51","author":"Le QH","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2020.01.004_bib0150","series-title":"Biostatistical analysis","author":"Zar","year":"1984"}],"container-title":["Contact Lens and Anterior Eye"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367048420300047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367048420300047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T01:16:50Z","timestamp":1761268610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1367048420300047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S1367048420300047"],"URL":"https:\/\/doi.org\/10.1016\/j.clae.2020.01.004","relation":{},"ISSN":["1367-0484"],"issn-type":[{"value":"1367-0484","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"On the in vivo assessment of goblet cells of the human bulbar conjunctiva by confocal microscopy \u2013 A review","name":"articletitle","label":"Article Title"},{"value":"Contact Lens and Anterior Eye","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clae.2020.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2020 Published by Elsevier Ltd on behalf of British Contact Lens Association. All rights reserved.","name":"copyright","label":"Copyright"}]}}