{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:07:55Z","timestamp":1788350875743,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100005341","name":"American Optometric Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","contactlensjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contact Lens and Anterior Eye"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.clae.2021.101442","type":"journal-article","created":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T19:53:30Z","timestamp":1617479610000},"page":"101442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Inflammatory proteins associated with contact lens-related dry eye"],"prefix":"10.1016","volume":"45","author":[{"given":"Padmapriya","family":"Ramamoorthy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3755-8046","authenticated-orcid":false,"given":"Safal","family":"Khanal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1519-7734","authenticated-orcid":false,"given":"Jason","family":"J. Nichols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clae.2021.101442_bib0005","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.clae.2021.101442_bib0010","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jtos.2017.08.003","article-title":"TFOS DEWS II report executive summary","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.clae.2021.101442_bib0015","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.clae.2021.101442_bib0020","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.ajo.2013.12.023","article-title":"Dry eye in the beaver dam offspring study: prevalence, risk factors, and health-related quality of life","volume":"157","author":"Paulsen","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.clae.2021.101442_bib0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/cxo.12210","article-title":"Prevalence of and risk factors for symptomatic dry eye disease in Singapore","volume":"98","author":"Tan","year":"2015","journal-title":"Clin Exp Optom"},{"key":"10.1016\/j.clae.2021.101442_bib0030","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1097\/OPX.0000000000000541","article-title":"Risk factors for dry eye syndrome: a retrospective case-control study","volume":"92","author":"Yang","year":"2015","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.clae.2021.101442_bib0035","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.ophtha.2008.06.022","article-title":"Prevalence of dry eye disease among Japanese visual display terminal users","volume":"115","author":"Uchino","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.clae.2021.101442_bib0040","first-page":"54","article-title":"The TFOS international workshop on contact Lens discomfort: executive summary","author":"Nichols","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2021.101442_bib0045","first-page":"54","article-title":"The TFOS International Workshop on Contact Lens discomfort: report of the contact lens interactions with the tear film subcommittee","author":"Craig","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2021.101442_bib0050","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1167\/iovs.05-1392","article-title":"Tear film, contact lens, and patient-related factors associated with contact lens-related dry eye","volume":"47","author":"Nichols","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2021.101442_bib0055","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0892-8967(01)00040-2","article-title":"Discontinuation of contact lens wear: a survey","volume":"26","author":"Pritchard","year":"1999","journal-title":"Int Contact Lens Clin"},{"key":"10.1016\/j.clae.2021.101442_bib0060","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/01.ico.0000248382.32143.86","article-title":"Frequency of and factors associated with contact lens dissatisfaction and discontinuation","volume":"26","author":"Richdale","year":"2007","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2021.101442_bib0065","first-page":"83","article-title":"Why one million contact lens wearers dropped out","volume":"27","author":"Young","year":"2004","journal-title":"Cont Lens Anterior Eye"},{"key":"10.1016\/j.clae.2021.101442_bib0070","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1167\/iovs.04-1294","article-title":"Self-reported dry eye disease across refractive modalities","volume":"46","author":"Nichols","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2021.101442_bib0075","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1016\/S0142-9612(01)00159-4","article-title":"Bacterial adhesion to surface hydrophilic and hydrophobic contact lenses","volume":"22","author":"Bruinsma","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.clae.2021.101442_bib0080","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/00006324-198812000-00003","article-title":"Visual decrement with deposit accumulation of HEMA contact lenses","volume":"65","author":"Gellatly","year":"1988","journal-title":"Am J Optom Physiol Opt"},{"key":"10.1016\/j.clae.2021.101442_bib0085","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jtos.2017.03.006","article-title":"TFOS DEWS II tear film report","volume":"15","author":"Willcox","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.clae.2021.101442_bib0090","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/ICO.0b013e3181a16578","article-title":"Analysis of inflammatory cytokines in the tears of dry eye patients","volume":"28","author":"Massingale","year":"2009","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2021.101442_bib0095","first-page":"127","article-title":"Inflammatory cytokines analysis in the tears in sjogeren and non-sjogren dry eye patients","author":"Na","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clae.2021.101442_bib0100","first-page":"797","article-title":"Cytokines in tear fluid of patients with ocular graft-versus-host disease after allogeneic stem cell transplantation","volume":"18","author":"Riemens","year":"2012","journal-title":"Mol Vis"},{"key":"10.1016\/j.clae.2021.101442_bib0105","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/ICO.0b013e31803dcda2","article-title":"Interleukin-6 and tumor necrosis factor-alpha levels in tears of patients with dry eye syndrome","volume":"26","author":"Yoon","year":"2007","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2021.101442_bib0110","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1097\/00003226-200111000-00009","article-title":"Ocular surface changes induced by contact lens wear","volume":"20","author":"Pisella","year":"2001","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2021.101442_bib0115","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/exer.1999.0767","article-title":"Contact lens wear alters the production of certain inflammatory mediators in tears","volume":"70","author":"Thakur","year":"2000","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.clae.2021.101442_bib0120","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1089\/107999000312441","article-title":"Interleukin-6 levels in tears of contact lens wearers","volume":"20","author":"Schultz","year":"2000","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.clae.2021.101442_bib0125","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1136\/bjophthalmol-2012-301527","article-title":"Tear film inflammatory mediators during continuous wear of contact lenses and corneal refractive therapy","volume":"96","author":"Gonz\u00e1lez-P\u00e9rez","year":"2012","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.clae.2021.101442_bib0130","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/cxo.12918","article-title":"Tear film, contact lenses and tear biomarkers","volume":"102","author":"Willcox","year":"2019","journal-title":"Clin Exp Optom"},{"key":"10.1016\/j.clae.2021.101442_bib0135","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/cxo.12487","article-title":"Contact lens wear is intrinsically inflammatory","volume":"100","author":"Efron","year":"2017","journal-title":"Clin Exp Optom"},{"key":"10.1016\/j.clae.2021.101442_bib0140","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/ICL.0000000000000343","article-title":"Is there a role for inflammation in contact lens discomfort?","volume":"43","author":"Willcox","year":"2017","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.clae.2021.101442_bib0145","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2147\/OPTO.S111130","article-title":"Contact lens wear and dry eyes: challenges and solutions","volume":"9","author":"Markoulli","year":"2017","journal-title":"Clin Optom (Auckl)"},{"key":"10.1016\/j.clae.2021.101442_bib0150","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1097\/OPX.0000000000000784","article-title":"Corneal sensitivity and inflammatory biomarkers in contact lens discomfort","volume":"93","author":"L\u00f3pez-de la Rosa","year":"2016","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.clae.2021.101442_bib0155","first-page":"293","article-title":"Cytokine changes in tears and relationship to contact lens discomfort","volume":"21","author":"Willcox","year":"2015","journal-title":"Mol Vis"},{"key":"10.1016\/j.clae.2021.101442_bib0160","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/OPX.0000000000000888","article-title":"Contact lens-induced discomfort and protein changes in tears","volume":"93","author":"Masoudi","year":"2016","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.clae.2021.101442_bib0165","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/ICL.0000000000000237","article-title":"Contact lens-induced discomfort and inflammatory mediator changes in tears","volume":"43","author":"Masoudi","year":"2017","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.clae.2021.101442_bib0170","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1097\/OPX.0000000000001110","article-title":"Differences in tear film biochemistry of symptomatic and asymptomatic lens wearers","volume":"94","author":"Masoudi","year":"2017","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.clae.2021.101442_bib0175","first-page":"35","article-title":"Conjunctival histologic findings of dry eye and non-dry eye contact lens wearing subjects","volume":"27","author":"Albietz","year":"2001","journal-title":"CLAO J"},{"key":"10.1016\/j.clae.2021.101442_bib0180","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/ICL.0b013e3181b3e87f","article-title":"Elevated nerve growth factor in dry eye associated with established contact lens wear","volume":"35","author":"Liu","year":"2009","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.clae.2021.101442_bib0185","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00003226-200207000-00007","article-title":"The performance of the contact lens dry eye questionnaire as a screening survey for contact lens-related dry eye","volume":"21","author":"Nichols","year":"2002","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2021.101442_bib0190","first-page":"52","article-title":"Optimization Of Quantitative Antibody Array Analyses For Tears From Normal And Dry Eye Subjects (abstract)","author":"Thangavelu","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2021.101442_bib0195","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jtos.2017.05.001","article-title":"TFOS DEWS II diagnostic methodology report","volume":"15","author":"Wolffsohn","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.clae.2021.101442_bib0200","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/ICL.0000000000000009","article-title":"Compliance factors associated with contact lens-related dry eye","volume":"40","author":"Ramamoorthy","year":"2014","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.clae.2021.101442_bib0205","first-page":"177","article-title":"Analysis of tear inflammatory mediators: A comparison between the microarray and Luminex methods","volume":"22","author":"Dionne","year":"2016","journal-title":"Mol Vis"},{"key":"10.1016\/j.clae.2021.101442_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ico.0000167877.11687.7e","article-title":"Assessment of stromal keratocytes and tear film inflammatory mediators during extended wear of contact lenses","volume":"25","author":"Kallinikos","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2021.101442_bib0215","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/OPX.0b013e31828d7d3b","article-title":"Effect of contact lens wear on the diurnal profile of matrix metalloproteinase 9 in tears","volume":"90","author":"Markoulli","year":"2013","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.clae.2021.101442_bib0220","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jtos.2018.10.004","article-title":"Tear film inflammatory cytokine upregulation in contact lens discomfort","volume":"17","author":"Gad","year":"2019","journal-title":"Ocul Surf"},{"key":"10.1016\/j.clae.2021.101442_bib0225","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1097\/ICO.0b013e3181a2ad81","article-title":"Mass spectrometry-based proteomic analyses in contact lens-related dry eye","volume":"28","author":"Nichols","year":"2009","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2021.101442_bib0230","first-page":"862","article-title":"Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye disease","volume":"16","author":"Enr\u00edquez-de-Salamanca","year":"2010","journal-title":"Mol Vis"},{"key":"10.1016\/j.clae.2021.101442_bib0235","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ajo.2008.08.032","article-title":"Tear cytokine profiles in dysfunctional tear syndrome","volume":"147","author":"Lam","year":"2009","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.clae.2021.101442_bib0240","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1159\/000150445","article-title":"Inflammatory markers in the tears of patients with ocular surface disease","volume":"40","author":"Acera","year":"2008","journal-title":"Ophthalmic Res"},{"key":"10.1016\/j.clae.2021.101442_bib0245","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/ICO.0b013e318033a729","article-title":"Strain-related cytokine profiles on the murine ocular surface in response to desiccating stress","volume":"26","author":"Corrales","year":"2007","journal-title":"Cornea"},{"key":"10.1016\/j.clae.2021.101442_bib0250","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1006\/exer.1998.0528","article-title":"The role of conjunctival epithelial cells in chronic ocular allergic disease","volume":"67","author":"Hingorani","year":"1998","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.clae.2021.101442_bib0255","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1365-2222.2006.02499.x","article-title":"Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures","volume":"36","author":"Leonardi","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.clae.2021.101442_bib0260","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/exer.1998.0480","article-title":"Cytokine and lipid inflammatory mediator profile of human tears during contact lens associated inflammatory diseases","volume":"67","author":"Thakur","year":"1998","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.clae.2021.101442_bib0265","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1167\/iovs.11-9417","article-title":"Correlations between tear cytokines, chemokines, and soluble receptors and clinical severity of dry eye disease","volume":"53","author":"Na","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clae.2021.101442_bib0270","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/08830185.2012.748052","article-title":"Dry eye as a mucosal autoimmune disease","volume":"32","author":"Stern","year":"2013","journal-title":"Int Rev Immunol"}],"container-title":["Contact Lens and Anterior Eye"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367048421000539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367048421000539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T01:19:02Z","timestamp":1761268742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1367048421000539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S1367048421000539"],"URL":"https:\/\/doi.org\/10.1016\/j.clae.2021.101442","relation":{},"ISSN":["1367-0484"],"issn-type":[{"value":"1367-0484","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammatory proteins associated with contact lens-related dry eye","name":"articletitle","label":"Article Title"},{"value":"Contact Lens and Anterior Eye","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clae.2021.101442","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101442"}}