{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:22:33Z","timestamp":1791051753913,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinical-breast-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Breast Cancer"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.clbc.2012.12.002","type":"journal-article","created":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T22:04:33Z","timestamp":1359497073000},"page":"188-195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Favorable Changes in Serum Estrogens and Other Biologic Factors After Weight Loss in Breast Cancer Survivors Who are Overweight or Obese"],"prefix":"10.1016","volume":"13","author":[{"given":"Cheryl L.","family":"Rock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetna","family":"Pande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley W.","family":"Flatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilge","family":"Pakiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne A.","family":"Bardwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis D.","family":"Heath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne F.","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clbc.2012.12.002_bib2","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1200\/JCO.2002.20.4.1128","article-title":"Weight loss in breast cancer patient management","volume":"20","author":"Chlebowski","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clbc.2012.12.002_bib3","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1200\/JCO.2005.01.079","article-title":"Weight, weight gain, and survival after breast cancer diagnosis","volume":"23","author":"Kroenke","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clbc.2012.12.002_bib4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10549-007-9785-3","article-title":"Is obesity an independent prognosis factor in woman breast cancer?","volume":"111","author":"Majed","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.clbc.2012.12.002_bib5","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s10549-010-0990-0","article-title":"Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis","volume":"123","author":"Protani","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.clbc.2012.12.002_bib6","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0140-6736(08)60269-X","article-title":"Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies","volume":"371","author":"Renehan","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.clbc.2012.12.002_bib7","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1017\/S1368980008002358","article-title":"Food, nutrition, physical activity and cancer prevention","volume":"11","author":"McMichael","year":"2008","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.clbc.2012.12.002_bib8","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1200\/JCO.2002.03.008","article-title":"Nutrition and survival after the diagnosis of breast cancer: a review of the evidence","volume":"20","author":"Rock","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clbc.2012.12.002_bib9","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1467-789X.2010.00805.x","article-title":"Weight gain in breast cancer survivors: prevalence, pattern and health consequences","volume":"12","author":"Vance","year":"2011","journal-title":"Obes Rev"},{"key":"10.1016\/j.clbc.2012.12.002_bib10","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1158\/1055-9965.EPI-08-1094","article-title":"Body mass index before and after breast cancer diagnosis: associations with all-cause, breast cancer, and cardiovascular disease mortality","volume":"18","author":"Nichols","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.clbc.2012.12.002_bib11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.maturitas.2010.01.004","article-title":"Physical activity, diet, adiposity and female breast cancer prognosis: a review of the epidemiologic literature","volume":"66","author":"Patterson","year":"2010","journal-title":"Maturitas"},{"key":"10.1016\/j.clbc.2012.12.002_bib12","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1677\/erc.1.01038","article-title":"Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition","volume":"12","author":"Kaaks","year":"2005","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.clbc.2012.12.002_bib13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10911-008-9100-x","article-title":"The role of endocrine insulin-like growth factor-I and insulin in breast cancer","volume":"13","author":"Lann","year":"2008","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"10.1016\/j.clbc.2012.12.002_bib14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s12038-012-9191-9","article-title":"Adipokine leptin in obesity-related pathology of breast cancer","volume":"37","author":"Ray","year":"2012","journal-title":"J Biosci"},{"key":"10.1016\/j.clbc.2012.12.002_bib15","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1093\/jnci\/djg022","article-title":"Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women","volume":"95","author":"Key","year":"2003","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.clbc.2012.12.002_bib16","first-page":"994","article-title":"Obesity and breast cancer","volume":"25","author":"Ligibel","year":"2011","journal-title":"Oncology (Williston Park)"},{"key":"10.1016\/j.clbc.2012.12.002_bib17","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1753-4887.2008.00083.x","article-title":"Impact of diet and adiposity on circulating levels of sex hormone-binding globulin and androgens","volume":"66","author":"Morisset","year":"2008","journal-title":"Nutr Rev"},{"key":"10.1016\/j.clbc.2012.12.002_bib18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1200\/JCO.2010.32.1752","article-title":"Obesity and breast cancer prognosis: weight of the evidence","volume":"29","author":"Sinicrope","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clbc.2012.12.002_bib19","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1158\/1055-9965.EPI-07-0761","article-title":"Reproductive steroid hormones and recurrence-free survival in women with a history of breast cancer","volume":"17","author":"Rock","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.clbc.2012.12.002_bib21","first-page":"3","article-title":"1983 metropolitan height and weight tables","volume":"64","year":"1983","journal-title":"Stat Bull Metrop Life Found"},{"key":"10.1016\/j.clbc.2012.12.002_bib22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0039-128X(76)90108-2","article-title":"A simple method for the assay of eight steroids in small volumes of plasma","volume":"28","author":"Anderson","year":"1976","journal-title":"Steroids"},{"key":"10.1016\/j.clbc.2012.12.002_bib23","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0010-7824(74)90099-7","article-title":"Plasma concentrations of free and non-TeBG bound testosterone in women on oral contraceptives","volume":"10","author":"Tremblay","year":"1974","journal-title":"Contraception"},{"key":"10.1016\/j.clbc.2012.12.002_bib24","first-page":"2083","article-title":"Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial","volume":"289","author":"Appel","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.clbc.2012.12.002_bib25","first-page":"1566","article-title":"Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial","volume":"170","author":"Wing","year":"2010","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.clbc.2012.12.002_bib26","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/S0140-6736(09)61457-4","article-title":"10-Year follow-up of diabetes incidence and weight loss in the diabetes prevention program outcomes study","volume":"374","author":"Knowler","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.clbc.2012.12.002_bib27","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1200\/JCO.2011.37.9792","article-title":"Reduced-calorie dietary weight loss, exercise, and sex hormones in postmenopausal women: randomized controlled trial","volume":"30","author":"Campbell","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clbc.2012.12.002_bib28","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/jnci\/94.8.606","article-title":"Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies","volume":"94","author":"Key","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.clbc.2012.12.002_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1207\/S15327914NC4501_1","article-title":"Breast cancer and obesity: an update","volume":"45","author":"Stephenson","year":"2003","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.clbc.2012.12.002_bib30","first-page":"211","article-title":"Hormonal and environmental factors affecting cell proliferation and neoplasia in the mammary gland","volume":"394","author":"Snedeker","year":"1996","journal-title":"Prog Clin Biol Res"},{"key":"10.1016\/j.clbc.2012.12.002_bib31","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1001\/jama.296.2.193","article-title":"Adult weight change and risk of postmenopausal breast cancer","volume":"296","author":"Eliassen","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.clbc.2012.12.002_bib32","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/ijc.21812","article-title":"Metabolic syndrome as a prognostic factor for breast cancer recurrences","volume":"119","author":"Pasanisi","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.clbc.2012.12.002_bib33","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1200\/JCO.2002.20.1.42","article-title":"Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study","volume":"20","author":"Goodwin","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clbc.2012.12.002_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1079\/PNS200070","article-title":"Energy balance and cancer: the role of insulin and insulin-like growth factor-I","volume":"60","author":"Kaaks","year":"2001","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.clbc.2012.12.002_bib35","doi-asserted-by":"crossref","first-page":"789174","DOI":"10.1155\/2012\/789174","article-title":"Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms","volume":"2012","author":"Arcidiacono","year":"2012","journal-title":"Exp Diabetes RES"},{"key":"10.1016\/j.clbc.2012.12.002_bib36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1677\/ERC-06-0068","article-title":"Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression","volume":"14","author":"Vona-Davis","year":"2007","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.clbc.2012.12.002_bib37","first-page":"207","article-title":"Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells","volume":"1825","author":"Guo","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.clbc.2012.12.002_bib38","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00109-010-0611-8","article-title":"Correlation of body mass index and leptin with tumor size and stage of disease in hormone-dependent postmenopausal breast cancer: preliminary results and therapeutic implications","volume":"88","author":"Macci\u00f2","year":"2010","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.clbc.2012.12.002_bib39","first-page":"905","article-title":"Leptin and leptin receptor involvement in cancer development: a study on human primary breast carcinoma","volume":"19","author":"Jard\u00e9","year":"2008","journal-title":"Oncol Rep"},{"key":"10.1016\/j.clbc.2012.12.002_bib40","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1158\/1078-0432.CCR-03-0749","article-title":"Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer","volume":"10","author":"Ishikawa","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.clbc.2012.12.002_bib41","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jss.2003.09.004","article-title":"Leptin is a growth factor in cancer","volume":"116","author":"Somasundar","year":"2004","journal-title":"J Surg Res"},{"key":"10.1016\/j.clbc.2012.12.002_bib42","doi-asserted-by":"crossref","first-page":"233","DOI":"10.33549\/physiolres.930848","article-title":"Adipocytokines and cancer","volume":"55","author":"Housa","year":"2006","journal-title":"Physiol Res"},{"key":"10.1016\/j.clbc.2012.12.002_bib43","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/hc0502.103331","article-title":"Weight loss reduces C-reactive protein levels in obese postmenopausal women","volume":"105","author":"Tchernof","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.clbc.2012.12.002_bib44","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1080\/01635581.2010.513803","article-title":"Changes in body weight and metabolic indexes in overweight breast cancer survivors enrolled in a randomized trial of low-fat vs. reduced carbohydrate diets","volume":"62","author":"Thomson","year":"2010","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.clbc.2012.12.002_bib45","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/oby.2004.38","article-title":"Improvement of metabolism among obese breast cancer survivors in differing weight loss regimens","volume":"12","author":"Jen","year":"2004","journal-title":"Obes Res"},{"key":"10.1016\/j.clbc.2012.12.002_bib46","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199602013340503","article-title":"Serum immunoreactive-leptin concentrations in normal-weight and obese humans","volume":"334","author":"Considine","year":"1996","journal-title":"N Engl J Med"}],"container-title":["Clinical Breast Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526820912002959?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526820912002959?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:12:31Z","timestamp":1761513151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526820912002959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S1526820912002959"],"URL":"https:\/\/doi.org\/10.1016\/j.clbc.2012.12.002","relation":{},"ISSN":["1526-8209"],"issn-type":[{"value":"1526-8209","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Favorable Changes in Serum Estrogens and Other Biologic Factors After Weight Loss in Breast Cancer Survivors Who are Overweight or Obese","name":"articletitle","label":"Article Title"},{"value":"Clinical Breast Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clbc.2012.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}