{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:13:37Z","timestamp":1790511217735,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"publisher","award":["81202809"],"award-info":[{"award-number":["81202809"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"publisher","award":["81373856"],"award-info":[{"award-number":["81373856"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinical-breast-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Breast Cancer"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.clbc.2017.01.004","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T01:48:49Z","timestamp":1484704129000},"page":"239-244","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Magnetic Resonance Spectroscopy-Detected Change in Marrow Adiposity Is Strongly Correlated to Postmenopausal Breast Cancer Risk"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0840-9022","authenticated-orcid":false,"given":"Guanwu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingmi","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Polat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clbc.2017.01.004_bib1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.clbc.2016.05.010","article-title":"Association of quality and quantity of bone metastases and computed tomography volumetric bone mineral density with prevalence of vertebral fractures in breast cancer patients","volume":"16","author":"Neuhaus","year":"2016","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.clbc.2017.01.004_bib2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S2213-8587(14)70007-5","article-title":"The bone\u2013fat interface: basic and clinical implications of marrow adiposity","volume":"3","author":"Devlin","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.clbc.2017.01.004_bib3","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1002\/jbmr.2512","article-title":"Adverse fat depots and marrow adiposity are associated with skeletal deficits and insulin resistance in long-term survivors of pediatric hematopoietic stem cell transplantation","volume":"30","author":"Mostoufi-Moab","year":"2015","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.clbc.2017.01.004_bib4","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1194\/jlr.M700131-JLR200","article-title":"Direct evidence of lipid translocation between adipocytes and prostate cancer cells with imaging FTIR microspectroscopy","volume":"48","author":"Gazi","year":"2007","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.clbc.2017.01.004_bib5","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/sj.bjc.6605481","article-title":"Influence of omega-6 PUFA arachidonic acid and bone marrow adipocytes on metastatic spread from prostate cancer","volume":"102","author":"Brown","year":"2010","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clbc.2017.01.004_bib6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s10585-015-9714-5","article-title":"Marrow adipocyte-derived CXCL1 and CXCL2 contribute to osteolysis in metastatic prostate cancer","volume":"32","author":"Hardaway","year":"2015","journal-title":"Clin Exp Metastasis"},{"key":"10.1016\/j.clbc.2017.01.004_bib7","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.18632\/oncotarget.1482","article-title":"Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms","volume":"4","author":"Herroon","year":"2013","journal-title":"Oncotarget"},{"key":"10.1016\/j.clbc.2017.01.004_bib8","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.neo.2015.11.005","article-title":"Breast cancer cell colonization of the human bone marrow adipose tissue niche","volume":"17","author":"Templeton","year":"2015","journal-title":"Neoplasia"},{"key":"10.1016\/j.clbc.2017.01.004_bib9","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.cmet.2014.06.003","article-title":"Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction","volume":"20","author":"Cawthorn","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.clbc.2017.01.004_bib10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1515\/hmbci-2014-0037","article-title":"Adipose tissue, obesity and adipokines: role in cancer promotion","volume":"21","author":"Booth","year":"2015","journal-title":"Horm Mol Biol Clin Investig"},{"key":"10.1016\/j.clbc.2017.01.004_bib11","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.3892\/ol.2015.3094","article-title":"Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer","volume":"9","author":"Bilir","year":"2015","journal-title":"Oncol Lett"},{"key":"10.1016\/j.clbc.2017.01.004_bib12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10549-015-3318-2","article-title":"Cancer-mediated adipose reversion promotes cancer cell migration via IL-6 and MCP-1","volume":"150","author":"Fujisaki","year":"2015","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.clbc.2017.01.004_bib13","doi-asserted-by":"crossref","first-page":"253519","DOI":"10.1155\/2015\/253519","article-title":"Resistin, visfatin, adiponectin, and leptin: risk of breast cancer in pre- and postmenopausal Saudi females and their possible diagnostic and predictive implications as novel biomarkers","volume":"2015","author":"Assiri","year":"2015","journal-title":"Dis Markers"},{"key":"10.1016\/j.clbc.2017.01.004_bib14","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1158\/1055-9965.EPI-12-1444","article-title":"Adipocytokines, inflammation, and breast cancer risk in postmenopausal women: a prospective study","volume":"22","author":"Gross","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.clbc.2017.01.004_bib15","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/jcb.22799","article-title":"Osteoblasts are a major source of inflammatory cytokines in the tumor microenvironment of bone metastatic breast cancer","volume":"111","author":"Bussard","year":"2010","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.clbc.2017.01.004_bib16","doi-asserted-by":"crossref","first-page":"djv169","DOI":"10.1093\/jnci\/djv169","article-title":"Circulating adipokines and inflammatory markers and postmenopausal breast cancer risk","volume":"107","author":"Gunter","year":"2015","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.clbc.2017.01.004_bib17","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10549-008-9958-8","article-title":"The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study","volume":"113","author":"Cust","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.clbc.2017.01.004_bib18","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1096\/fasebj.12.9.747","article-title":"High expression of leptin by human bone marrow adipocytes in primary culture","volume":"12","author":"Laharrague","year":"1998","journal-title":"FASEB J"},{"key":"10.1016\/j.clbc.2017.01.004_bib19","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1158\/1940-6207.CAPR-11-0090","article-title":"Postmenopausal serum sex steroids and risk of hormone receptor-positive and -negative breast cancer: a nested case-control study","volume":"4","author":"James","year":"2011","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.clbc.2017.01.004_bib20","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0959-8049(95)95915-S","article-title":"666 Have histological grade nuclear components (MSBR) of scarff bloom richardson (SBR) a prognostic value for lobular invasive breast carcinoma?","volume":"31","author":"Le Doussal","year":"1995","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.clbc.2017.01.004_bib21","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","article-title":"International physical activity questionnaire: 12-country reliability and validity","volume":"35","author":"Craig","year":"2003","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.clbc.2017.01.004_bib22","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/jmri.25351","article-title":"Comparison of chemical shift-encoded water-fat MRI and MR spectroscopy in quantification of marrow fat in postmenopausal females","volume":"45","author":"Li","year":"2017","journal-title":"J\u00a0Magn Reson Imaging"},{"key":"10.1016\/j.clbc.2017.01.004_bib23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00256-015-2292-4","article-title":"Short- and long-term reproducibility of marrow adipose tissue quantification by 1H-MR spectroscopy","volume":"45","author":"Singhal","year":"2016","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.clbc.2017.01.004_bib24","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1002\/ijc.21543","article-title":"High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels","volume":"118","author":"Miyoshi","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.clbc.2017.01.004_bib25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/jnci\/djn415","article-title":"Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women","volume":"101","author":"Gunter","year":"2009","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.clbc.2017.01.004_bib26","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1097\/GME.0000000000000721","article-title":"Longitudinal assessment of marrow fat content using\u00a0three-point Dixon technique in osteoporotic rabbits","volume":"23","author":"Li","year":"2016","journal-title":"Menopause"},{"key":"10.1016\/j.clbc.2017.01.004_bib27","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1210\/en.2015-1477","article-title":"Expansion of bone marrow adipose tissue during caloric restriction is associated with increased circulating glucocorticoids and not with hypoleptinemia","volume":"157","author":"Cawthorn","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.clbc.2017.01.004_bib28","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1002\/jcp.24954","article-title":"A\u00a0high fat diet increases bone marrow adipose tissue (MAT) but does not alter trabecular or cortical bone mass in C57BL\/6J mice","volume":"230","author":"Doucette","year":"2015","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.clbc.2017.01.004_bib29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4331\/wjbc.v6.i2.39","article-title":"Adipocyte activation of cancer stem cell signaling in breast cancer","volume":"6","author":"Wolfson","year":"2015","journal-title":"World J Biol Chem"},{"key":"10.1016\/j.clbc.2017.01.004_bib30","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13058-015-0622-z","article-title":"Leptin produced by obese adipose stromal\/stem cells enhances proliferation and metastasis of estrogen receptor positive breast cancers","volume":"17","author":"Strong","year":"2015","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.clbc.2017.01.004_bib31","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/carcin\/bgq267","article-title":"Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3","volume":"32","author":"Kim","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.clbc.2017.01.004_bib32","first-page":"1","article-title":"Leptin regulation of aromatase activity in adipose stromal cells from regularly cycling women","volume":"70","author":"Magoffin","year":"1999","journal-title":"Ginekol Pol"},{"key":"10.1016\/j.clbc.2017.01.004_bib33","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/bcr2321","article-title":"Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer","volume":"11","author":"Rene Gonzalez","year":"2009","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.clbc.2017.01.004_bib34","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/(SICI)1097-0215(19990209)80:4<523::AID-IJC7>3.0.CO;2-C","article-title":"Leptin in relation to carcinoma in situ of the breast: a study of pre-menopausal cases and controls","volume":"80","author":"Mantzoros","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1016\/j.clbc.2017.01.004_bib35","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00011-016-1000-8","article-title":"Breast cancer cells and bone marrow mesenchymal stromal cells: a regulated modulation of the breast tumor in the context of immune response","volume":"66","author":"Najar","year":"2017","journal-title":"Inflamm Res"},{"key":"10.1016\/j.clbc.2017.01.004_bib36","first-page":"121","article-title":"The role of bone marrow adipocytes in bone metastasis","volume":"5","author":"Morris","year":"2016","journal-title":"J\u00a0Bone Oncol"},{"key":"10.1016\/j.clbc.2017.01.004_bib37","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s10555-013-9484-y","article-title":"Bone marrow fat: linking adipocyte-induced inflammation with skeletal metastases","volume":"33","author":"Hardaway","year":"2014","journal-title":"Cancer Metastasis Rev"}],"container-title":["Clinical Breast Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526820917300113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526820917300113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:15:23Z","timestamp":1761513323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526820917300113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S1526820917300113"],"URL":"https:\/\/doi.org\/10.1016\/j.clbc.2017.01.004","relation":{},"ISSN":["1526-8209"],"issn-type":[{"value":"1526-8209","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Magnetic Resonance Spectroscopy-Detected Change in Marrow Adiposity Is Strongly Correlated to Postmenopausal Breast Cancer Risk","name":"articletitle","label":"Article Title"},{"value":"Clinical Breast Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clbc.2017.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}