{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:43:54Z","timestamp":1787244234356,"version":"build-2736575974"},"reference-count":115,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinical-breast-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Breast Cancer"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.clbc.2018.06.015","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T14:04:23Z","timestamp":1530713063000},"page":"e825-e840","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"title":["Radiation-induced Skin Toxicity in Breast Cancer Patients: A Systematic Review of Randomized Trials"],"prefix":"10.1016","volume":"18","author":[{"given":"Caitlin","family":"Yee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashi","family":"Asthana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Drost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Vesprini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7109-4620","authenticated-orcid":false,"given":"Carlo","family":"DeAngelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clbc.2018.06.015_bib1","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/S0140-6736(11)61629-2","article-title":"Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10 801 women in 17 randomised trials","volume":"378","author":"Darby","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.clbc.2018.06.015_bib2","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/S0140-6736(14)60488-8","article-title":"Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials","volume":"383","author":"McGale","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.clbc.2018.06.015_bib3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2147\/BCTT.S109763","article-title":"Acute radiation dermatitis in breast cancer patients: challenges and solutions","volume":"9","author":"Kole","year":"2017","journal-title":"Breast Cancer Targets Ther"},{"key":"10.1016\/j.clbc.2018.06.015_bib4","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s11136-017-1526-4","article-title":"Patient-reported symptoms of radiation dermatitis during breast cancer radiotherapy: a pilot study","volume":"26","author":"Lee","year":"2017","journal-title":"Qual Life Res"},{"key":"10.1016\/j.clbc.2018.06.015_bib5","doi-asserted-by":"crossref","first-page":"e357","DOI":"10.1016\/j.ijrobp.2012.05.009","article-title":"Re-examining the evidence in radiation dermatitis management literature: an overview and a critical appraisal of systematic reviews","volume":"84","author":"Chan","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib6","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)","volume":"31","author":"Cox","year":"1995","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib8","doi-asserted-by":"crossref","first-page":"E40","DOI":"10.1016\/j.ijrobp.2017.06.688","article-title":"Risk factors for the development of acute radiation dermatitis in breast cancer patients","volume":"99","author":"Parker","year":"2017","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib9","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.breast.2013.07.047","article-title":"Smoking as an independent risk factor for severe skin reactions due to adjuvant radiotherapy for breast cancer","volume":"22","author":"Sharp","year":"2013","journal-title":"Breast"},{"issue":"suppl","key":"10.1016\/j.clbc.2018.06.015_bib10","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1016\/j.ijrobp.2013.06.298","article-title":"Factors affecting breast cancer patient quality of life in association with radiation","volume":"87","author":"Sura","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib11","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.ijrobp.2014.07.001","article-title":"Topical agents for radiation dermatitis in breast cancer: 50 shades of red or same old, same old?","volume":"90","author":"Freedman","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1471-2407-14-53","article-title":"Prevention and treatment of acute radiation-induced skin reactions: a systematic\u00a0review and meta-analysis of randomized controlled trials","volume":"14","author":"Chan","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.clbc.2018.06.015_bib13","first-page":"409","article-title":"Quality of life (QOL) and symptom burden (SB) in patients with breast cancer","volume":"25","author":"Hamer","year":"2017","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.clbc.2018.06.015_bib14","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.12659\/MSM.893585","article-title":"Similar outcomes of standard radiotherapy and hypofractionated radiotherapy following breast-conserving surgery","volume":"21","author":"Hou","year":"2015","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.clbc.2018.06.015_bib15","first-page":"3","article-title":"Acute and late adverse effects of breast cancer radiation: two hypo-fractionation protocols","volume":"7","author":"Aboziada","year":"2016","journal-title":"J\u00a0Solid Tumors"},{"key":"10.1016\/j.clbc.2018.06.015_bib16","first-page":"282","article-title":"Post mastectomy adjuvant radiotherapy in breast cancer: a comparison of three hypofractionated protocols","volume":"59","author":"Shahid","year":"2009","journal-title":"J\u00a0Pak Med Assoc"},{"key":"10.1016\/j.clbc.2018.06.015_bib17","first-page":"4705","article-title":"Analysis of radiotherapy optimization regimens after modified radical mastectomy","volume":"20","author":"Zhao","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.clbc.2018.06.015_bib18","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa0906260","article-title":"Long-term results of hypofractionated radiation therapy for breast cancer","volume":"362","author":"Whelan","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clbc.2018.06.015_bib19","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/S1470-2045(13)70386-3","article-title":"The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials","volume":"14","author":"Haviland","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.radonc.2005.01.005","article-title":"Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: long-term results of a randomised trial","volume":"75","author":"Yarnold","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib21","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.ijrobp.2007.02.044","article-title":"Intensity-modulated radiotherapy results in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapy","volume":"68","author":"Harsolia","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib22","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1200\/JCO.2013.49.7842","article-title":"Randomized controlled trial of intensity-modulated radiotherapy for early breast cancer: 5-year results confirm superior overall cosmesis","volume":"31","author":"Mukesh","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib23","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.breast.2015.08.002","article-title":"Intensity modulated radiotherapy with simultaneous integrated boost vs. conventional radiotherapy with sequential boost for breast cancer\u2014a preliminary result","volume":"24","author":"Lee","year":"2015","journal-title":"Breast"},{"key":"10.1016\/j.clbc.2018.06.015_bib24","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.ijrobp.2013.08.046","article-title":"Five-year outcomes, cosmesis, and toxicity with 3-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation","volume":"87","author":"Rodr\u00edguez","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ejca.2014.12.013","article-title":"Accelerated partial breast irradiation using intensity-modulated radiotherapy versus whole breast irradiation: 5-year survival analysis of a phase 3 randomised controlled trial","volume":"51","author":"Livi","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.clbc.2018.06.015_bib26","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10549-015-3565-2","article-title":"Accelerated partial breast irradiation using intensity-modulated radiotherapy technique compared to whole breast irradiation for patients aged 70 years or older: subgroup analysis from a randomized phase 3 trial","volume":"153","author":"Meattini","year":"2015","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.clbc.2018.06.015_bib27","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1200\/JCO.2013.50.5511","article-title":"Interim cosmetic and toxicity results from RAPID: a randomized trial of accelerated partial breast irradiation using three-dimensional conformal external beam radiation therapy","volume":"31","author":"Olivotto","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.radonc.2013.08.040","article-title":"Hypofractionated whole breast irradiation for patients with large breasts: a randomized trial comparing prone and supine positions","volume":"108","author":"Mulliez","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib29","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0167-8140(95)01607-I","article-title":"Tangential breast irradiation with or without internal mammary chain irradiation: results of a randomized trial","volume":"36","author":"Kaija","year":"1995","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib30","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.radonc.2016.12.023","article-title":"Does an integrated boost increase acute toxicity in prone hypofractionated breast irradiation? A randomized controlled trial","volume":"122","author":"Paelinck","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijrobp.2005.06.040","article-title":"A\u00a0phase III randomized study on the sequencing of radiotherapy and chemotherapy in the conservative management of early-stage breast cancer","volume":"64","author":"Arcangeli","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib32","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1200\/JCO.2008.17.9549","article-title":"Radiotherapy and adjuvant trastuzumab in operable breast cancer: tolerability and adverse event data from the NCCTG phase III trial N9831","volume":"27","author":"Halyard","year":"2009","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib33","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/annonc\/mdv602","article-title":"Concurrent or sequential letrozole with adjuvant breast radiotherapy: final results of the CO-HO-RT phase II randomized trial","volume":"27","author":"Bourgier","year":"2016","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib34","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1748-717X-7-80","article-title":"Short course radiotherapy with simultaneous integrated boost for stage I-II breast cancer, early toxicities of a randomized clinical trial","volume":"7","author":"Van Parijs","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib35","first-page":"278","article-title":"Comparison of two radiation dose schedules in post mastectomy carcinoma of the breast","volume":"54","author":"Goel","year":"2000","journal-title":"Indian J Med Sci"},{"key":"10.1016\/j.clbc.2018.06.015_bib36","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1001\/jamaoncol.2015.2666","article-title":"Acute and short-term toxic effects of conventionally fractionated vs hypofractionated whole-breast irradiation","volume":"1","author":"Shaitelman","year":"2015","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib37","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.radonc.2016.02.027","article-title":"Acute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3-week regimen delivered in the UK FAST-Forward trial","volume":"120","author":"Brunt","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib38","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1200\/JCO.2007.15.2488","article-title":"A\u00a0multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis","volume":"26","author":"Pignol","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib39","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ijrobp.2008.10.045","article-title":"Individual positioning: a comparative study of adjuvant breast radiotherapy in the prone versus supine position","volume":"75","author":"Varga","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib40","first-page":"290","article-title":"Effect of an essential oil mixture on skin reactions\u00a0in woman undergoing radiotherapy for breast cancer","volume":"32","author":"Halm","year":"2014","journal-title":"J\u00a0Holist Nurs"},{"key":"10.1016\/j.clbc.2018.06.015_bib41","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00066-004-1174-9","article-title":"Th\u00eata-Cream\u00ae versus Bepanthol\u00ae lotion in breast cancer patients under radiotherapy: a new prophylactic agent in skin care?","volume":"180","author":"R\u00f6per","year":"2004","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.clbc.2018.06.015_bib42","first-page":"1146","article-title":"Randomized, prospective assessment of moisturizer efficacy for the treatment of radiation dermatitis following radiotherapy after breast-conserving surgery","volume":"45","author":"Sekiguchi","year":"2015","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib43","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1211\/jpp.62.06.0015","article-title":"Evaluation of the effect of topical agents on radiation-induced skin disease by reflectance spectrophotometry","volume":"62","author":"Rizza","year":"2010","journal-title":"J\u00a0Pharm Pharmacol"},{"key":"10.1016\/j.clbc.2018.06.015_bib44","doi-asserted-by":"crossref","first-page":"4859","DOI":"10.7314\/APJCP.2013.14.8.4859","article-title":"Topical use of recombinant human epidermal growth factor (EGF)-based cream to prevent radiation dermatitis in breast cancer patients: a single-blind randomized preliminary study","volume":"14","author":"Kong","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.clbc.2018.06.015_bib45","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3109\/02841869409098406","article-title":"Skin protection by sucralfate cream during electron beam therapy","volume":"33","author":"Maiche","year":"1994","journal-title":"Acta Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib46","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1200\/JCO.2004.07.063","article-title":"Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer","volume":"22","author":"Pommier","year":"2004","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib47","first-page":"193","article-title":"Clinical effects of Lianbai liquid in prevention and treatment of dermal injury caused by radiotherapy","volume":"27","author":"Hongbing","year":"2007","journal-title":"J\u00a0Tradit Chin Med"},{"key":"10.1016\/j.clbc.2018.06.015_bib48","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.amjsurg.2005.02.001","article-title":"Combination glutathione and anthocyanins as an alternative for skin care during external-beam radiation","volume":"189","author":"Enomoto","year":"2005","journal-title":"Am J Surg"},{"key":"10.1016\/j.clbc.2018.06.015_bib49","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s00066-011-2224-8","article-title":"Treatment of acute radiodermatitis with an oil-in-water emulsion following radiation therapy for breast cancer","volume":"187","author":"Jensen","year":"2011","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.clbc.2018.06.015_bib50","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1188\/15.CJON.451-455","article-title":"Optimal topical agent for radiation dermatitis during breast radiotherapy: a pilot study","volume":"19","author":"Fenton-Kerimian","year":"2015","journal-title":"Clin J Oncol Nurs"},{"key":"10.1016\/j.clbc.2018.06.015_bib51","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.ijrobp.2014.06.033","article-title":"Mometasone furoate cream reduces acute radiation dermatitis in patients receiving breast radiation therapy: results of a randomized trial","volume":"90","author":"Hindley","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib52","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1586\/17512433.2016.1126506","article-title":"A\u00a0randomized, double-blind trial on the use of 1% hydrocortisone cream for the prevention of acute radiation dermatitis","volume":"9","author":"Meghrajani","year":"2016","journal-title":"Expert Rev Clin Pharmacol"},{"key":"10.1016\/j.clbc.2018.06.015_bib53","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.ijrobp.2010.01.031","article-title":"Mometasone furoate effect on acute skin toxicity in breast cancer patients receiving radiotherapy: a phase III double-blind, randomized trial from the North Central Cancer Treatment Group N06C4","volume":"79","author":"Miller","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib54","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0009-9260(79)80217-2","article-title":"Effectiveness of topical steroids in the control of radiation dermatitis: a randomised trial using 1% hydrocortisone cream and 0.05% clobetasone butyrate (Eumovate)","volume":"30","author":"Glees","year":"1979","journal-title":"Clin Radiol"},{"key":"10.1016\/j.clbc.2018.06.015_bib55","first-page":"188","article-title":"Melatonin for prevention of breast radiation dermatitis: a phase II, prospective, double-blind randomized trial","volume":"18","author":"Ben-David","year":"2016","journal-title":"Isr Med Assoc J"},{"key":"10.1016\/j.clbc.2018.06.015_bib56","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0167-8140(01)00327-9","article-title":"Potent corticosteroid cream (mometasone furoate) significant reduces acute radiation dermatitis: results from a double-blind, randomized study","volume":"59","author":"Bostrom","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib57","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.radonc.2013.05.033","article-title":"A\u00a0potent steroid cream is superior to emollients in reducing acute radiation dermatitis in breast cancer patients treated with adjuvant radiotherapy: a randomised study of betamethasone versus two moisturizing creams","volume":"108","author":"Ulff","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib58","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.radonc.2016.11.013","article-title":"Prophylactic treatment with a potent corticosteroid cream ameliorates radiodermatitis, independent of radiation schedule: a randomized double blinded study","volume":"122","author":"Ulff","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib59","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1046\/j.1365-2133.2002.04751.x","article-title":"Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study","volume":"146","author":"Schmuth","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clbc.2018.06.015_bib60","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4103\/0378-6323.32755","article-title":"Topical betamethasone for prevention of radiation dermatitis","volume":"73","author":"Omidvari","year":"2007","journal-title":"Indian J Dermatol Venereal Leprol"},{"key":"10.1016\/j.clbc.2018.06.015_bib61","first-page":"293","article-title":"Efficacy of topical alpha ointment (containing natural henna) compared to topical hydrocortisone (1%) in the healing of radiation-induced dermatitis in patients with breast cancer: a randomized controlled clinical trial","volume":"38","author":"Ansari","year":"2013","journal-title":"Iran J Med Sci"},{"key":"10.1016\/j.clbc.2018.06.015_bib62","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/NCC.0000000000000161","article-title":"Effectiveness and acceptability of a moisturizing cream and a barrier cream during radiation therapy for breast cancer in the tropics","volume":"38","author":"Laffin","year":"2015","journal-title":"Cancer Nurs"},{"key":"10.1016\/j.clbc.2018.06.015_bib63","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jfma.2013.04.003","article-title":"3M Cavilon No-Sting Barrier Film or topical corticosteroid (mometasone furoate) for protection against radiation dermatitis: a clinical trial","volume":"114","author":"Shaw","year":"2015","journal-title":"J\u00a0Formos Med Assoc"},{"key":"10.1016\/j.clbc.2018.06.015_bib64","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jmir.2010.08.005","article-title":"Phase III study of silver leaf nylon dressing vs standard care for reduction of inframammary moist desquamation in patients undergoing adjuvant whole breast radiation therapy","volume":"41","author":"Aquino-Parsons","year":"2010","journal-title":"J\u00a0Med Imaging Radiat Sci"},{"key":"10.1016\/j.clbc.2018.06.015_bib65","first-page":"347","article-title":"Randomized intra-patient controlled trial of Mepilex Lite dressings versus aqueous cream in managing radiation-induced skin reactions post-mastectomy","volume":"4","author":"Paterson","year":"2012","journal-title":"J\u00a0Cancer Sci Ther"},{"key":"10.1016\/j.clbc.2018.06.015_bib66","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/02841860600781799","article-title":"The effect of honey compared to conventional treatment on healing of radiotherapy-induced skin toxicity in breast cancer patients","volume":"45","author":"Moolenaar","year":"2006","journal-title":"Acta Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib67","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.radonc.2014.01.005","article-title":"Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients","volume":"110","author":"Herst","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib68","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0360-3016(03)01431-7","article-title":"Randomized, paired comparison of No-Sting Barrier Film versus sorbolene cream (10% glycerine) skin care during postmastectomy irradiation","volume":"58","author":"Graham","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib69","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.radonc.2015.08.028","article-title":"Hydrosorb(R) versus control (water based spray) in the management of radio-induced skin toxicity: results of multicentre controlled randomized trial","volume":"117","author":"Bazire","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib70","first-page":"317","article-title":"A\u00a0double-blind, randomised, vehicle-controlled clinical study to evaluate the efficacy of MAS065D in limiting the effects of radiation on the skin: interim analysis","volume":"18","author":"Leonardi","year":"2008","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.clbc.2018.06.015_bib71","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0360-3016(96)00320-3","article-title":"Phase II double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity","volume":"36","author":"Williams","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib72","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/00002820-200212000-00007","article-title":"A\u00a0phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue","volume":"25","author":"Heggie","year":"2002","journal-title":"Cancer Nurs"},{"key":"10.1016\/j.clbc.2018.06.015_bib73","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/S0360-3016(00)00782-3","article-title":"Randomized phase III study comparing best supportive care to biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97-13","volume":"48","author":"Fisher","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib74","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.clbc.2014.12.006","article-title":"Three-arm randomized phase III trial: quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy","volume":"15","author":"Hoopfer","year":"2015","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.clbc.2018.06.015_bib75","first-page":"1613","article-title":"Topical silver sulfadiazine for the prevention of acute dermatitis during irradiation for breast cancer","volume":"20","author":"Hemati","year":"2012","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.clbc.2018.06.015_bib76","first-page":"193","article-title":"Clinical effects of Lianbai liquid in prevention and treatment of dermal injury caused by radiotherapy","volume":"27","author":"Ma","year":"2007","journal-title":"J\u00a0Tradit Chin Med"},{"key":"10.1016\/j.clbc.2018.06.015_bib77","first-page":"395","article-title":"Effect of chamomile cream and almond ointment on acute radiation skin reaction","volume":"30","author":"Maiche","year":"1991","journal-title":"Acta Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib78","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ejon.2012.11.003","article-title":"No differences between calendula cream and aqueous cream in the prevention of acute radiation skin reactions\u2014results from a randomised blinded trial","volume":"17","author":"Sharp","year":"2013","journal-title":"Eur J Oncol Nurs"},{"key":"10.1016\/j.clbc.2018.06.015_bib79","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.ijrobp.2015.02.028","article-title":"Double-blind, placebo-controlled pilot study of processed ultra emu oil versus placebo in the prevention of radiation dermatitis","volume":"92","author":"Rollmann","year":"2015","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib80","doi-asserted-by":"crossref","first-page":"E468","DOI":"10.1016\/j.ijrobp.2015.07.1743","article-title":"Prospective randomized pilot study of standard skin care versus medihoney in the prophylactic and acute management of radiation dermatitis in patients receiving adjuvant radiation therapy for breast cancer","volume":"93","author":"Kwok","year":"2015","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib81","first-page":"305","article-title":"Topical biafine and lipiderm for the prevention of radiation dermatitis: a randomized prospective trial","volume":"8","author":"Fenig","year":"2001","journal-title":"Oncol Rep"},{"key":"10.1016\/j.clbc.2018.06.015_bib82","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/08941939.2016.1232449","article-title":"Effects of boron-based gel on radiation-induced dermatitis in breast cancer: a double-blind, placebo-controlled trial","volume":"30","author":"Aysan","year":"2017","journal-title":"J\u00a0Invest Surg"},{"key":"10.1016\/j.clbc.2018.06.015_bib83","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1748-717X-8-57","article-title":"Preventing the acute skin side effects in patients treated with radiotherapy for breast cancer: the use of corneometry in order to evaluate the protective effect of moisturizing creams","volume":"8","author":"Di Franco","year":"2013","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib84","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1188\/10.ONF.619-626","article-title":"A\u00a0prospective randomized, placebo-controlled skin care study in women diagnosed with breast cancer undergoing radiation therapy","volume":"37","author":"Gosselin","year":"2010","journal-title":"Oncol Nurs Forum"},{"key":"10.1016\/j.clbc.2018.06.015_bib85","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1259\/bjr\/62011713","article-title":"Mepilex Lite dressings for the management of radiation-induced erythema: a systematic inpatient controlled clinical trial","volume":"83","author":"Diggelmann","year":"2010","journal-title":"Br J Radiol"},{"key":"10.1016\/j.clbc.2018.06.015_bib86","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.radonc.2011.05.014","article-title":"Can we decrease the skin reaction in breast cancer patients using hyaluronic acid during radiation therapy? Results of phase III randomised trial","volume":"100","author":"Kirova","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib87","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.ijrobp.2011.09.021","article-title":"Topical hyaluronic acid vs. standard of care for the prevention of radiation dermatitis after adjuvant radiotherapy for breast cancer: single-blind randomized phase III clinical trial","volume":"83","author":"Pinnix","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib88","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4103\/0019-509X.29424","article-title":"Prophylactic beclomethasone spray to the skin during postoperative radiotherapy of carcinoma breast: a prospective randomized study","volume":"43","author":"Shukla","year":"2006","journal-title":"Indian J Cancer"},{"key":"10.1016\/j.clbc.2018.06.015_bib89","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/15569520600860009","article-title":"A\u00a0double-blind, vehicle-controlled clinical study to evaluate the efficacy of MAS065D (Xclair\u2122), a hyaluronic acid-based formulation, in the management of radiation-induced dermatitis","volume":"25","author":"Primavera","year":"2006","journal-title":"Cutan Ocul Toxicol"},{"key":"10.1016\/j.clbc.2018.06.015_bib90","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/tbj.12348","article-title":"Hydration during breast radiotherapy may lower skin toxicity","volume":"20","author":"Kunos","year":"2014","journal-title":"Breast J"},{"key":"10.1016\/j.clbc.2018.06.015_bib91","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3109\/02841856709138590","article-title":"Effect of complamin on radiation-induced erythema","volume":"6","author":"Notter","year":"1967","journal-title":"Acta Radiol"},{"key":"10.1016\/j.clbc.2018.06.015_bib92","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.clnu.2015.03.009","article-title":"The effects of enteral glutamine on radiotherapy induced dermatitis in breast cancer","volume":"35","author":"Eda","year":"2016","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clbc.2018.06.015_bib93","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1054\/homp.1999.0328","article-title":"Efficacy of homeopathic treatment of skin reactions during radiotherapy for breast cancer: a randomised, double-blind clinical trial","volume":"89","author":"Balzarini","year":"2000","journal-title":"Br Homeopath J"},{"key":"10.1016\/j.clbc.2018.06.015_bib94","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1748-717X-7-12","article-title":"Skin toxicity from external beam radiation therapy in breast cancer patients: protective effects of resveratrol, lycopene, vitamin C and anthocianin (Ixor\u00ae)","volume":"7","author":"Di Franco","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib95","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1017\/S146039690800647X","article-title":"An investigation into the use of a non-metallic deodorant during radiotherapy treatment: a randomised controlled trial","volume":"8","author":"Bennett","year":"2009","journal-title":"J\u00a0Radiother Pract"},{"key":"10.1016\/j.clbc.2018.06.015_bib96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-8140(96)91825-3","article-title":"Effect of acetylsalicylic acid on radiation and cosmetic results after conservative surgery for early breast cancer: a randomized trial","volume":"41","author":"Olivotto","year":"1996","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib97","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1667\/RR3255.1","article-title":"Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients","volume":"180","author":"Ryan","year":"2013","journal-title":"Radiat Res"},{"key":"10.1016\/j.clbc.2018.06.015_bib98","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1016\/j.ijrobp.2011.12.006","article-title":"Randomized control trial: evaluating aluminum-based antiperspirant use, axilla skin toxicity, and reported quality of life in women receiving external beam radiotherapy for treatment of stage 0, I, and II breast cancer","volume":"83","author":"Watson","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib99","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ijrobp.2014.06.054","article-title":"Evaluating the effects of aluminum-containing and non-aluminum containing deodorants on axillary skin toxicity during radiation therapy for breast cancer: a 3-armed randomized controlled trial","volume":"90","author":"Lewis","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib100","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0167-8140(00)00322-4","article-title":"The impact of skin washing with water and soap during breast irradiation: a randomized study","volume":"58","author":"Roy","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib101","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1017\/S1460396999000321","article-title":"A\u00a0randomised controlled trial to test a non-metallic deodorant used during a course of radiotherapy","volume":"1","author":"Gee","year":"2000","journal-title":"J\u00a0Radiother Pract"},{"key":"10.1016\/j.clbc.2018.06.015_bib102","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0936-6555(05)80971-9","article-title":"Can patients wash during radiotherapy to the breast or chest wall? A randomzied controlled trial","volume":"4","author":"Campbell","year":"1992","journal-title":"Clin Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib103","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1111\/j.1524-4725.2010.01801.x","article-title":"A\u00a0randomized, controlled, double-blind study of light emitting diode photomodulation for the prevention of radiation dermatitis in patients with breast cancer","volume":"36","author":"Fife","year":"2010","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.clbc.2018.06.015_bib104","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00066-017-1117-x","article-title":"Photobiomodulation therapy for the management of radiation-induced dermatitis","volume":"193","author":"Strouthos","year":"2017","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.clbc.2018.06.015_bib105","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/j.1365-2133.2009.09104.x","article-title":"Intense pulsed light vs. long-pulsed dye laser treatment of telangiectasia after radiotherapy for breast cancer: a randomized split-lesion trial of two different treatments","volume":"160","author":"Nymann","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clbc.2018.06.015_bib106","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0140-6736(15)00518-8","article-title":"Accelerated partial breast irradiation: the new standard?","volume":"387","author":"Coles","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.clbc.2018.06.015_bib107","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1600-0846.2007.00263.x","article-title":"A\u00a0randomized, prospective study using the LPG\u00ae technique in treating radiation-induced skin fibrosis: clinical and profilometric analysis","volume":"14","author":"Bourgeois","year":"2008","journal-title":"Ski Res Technol"},{"key":"10.1016\/j.clbc.2018.06.015_bib108","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.ijrobp.2008.12.046","article-title":"Use of axillary deodorant and effect on acute skin toxicity during radiotherapy for breast cancer: a prospective randomized noninferiority trial","volume":"75","author":"Th\u00e9berge","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib109","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1118\/1.2799579","article-title":"Dosimetric comparison of partial and whole breast external beam irradiation in the treatment of early stage breast cancer","volume":"34","author":"Kim","year":"2007","journal-title":"Med Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib110","doi-asserted-by":"crossref","first-page":"9481413","DOI":"10.1155\/2016\/9481413","article-title":"The efficacy and safety of Jaungo, a traditional medicinal ointment, in preventing radiation dermatitis in patients with breast cancer: a prospective, single-blinded, randomized pilot study","volume":"2016","author":"Kong","year":"2016","journal-title":"J\u00a0Evid Based Complement Altern Med"},{"key":"10.1016\/j.clbc.2018.06.015_bib111","doi-asserted-by":"crossref","first-page":"312072","DOI":"10.1155\/2015\/312072","article-title":"Prophylactic treatment with adlay bran extract reduces the risk of severe acute radiation dermatitis: a prospective, randomized, double-blind study","volume":"2015","author":"Huang","year":"2015","journal-title":"Evid Based Complement Altern Med eCAM"},{"key":"10.1016\/j.clbc.2018.06.015_bib112","first-page":"536","article-title":"Hypofractionation for breast cancer: lessons learned from our neighbors to the north and across the pond","volume":"28","author":"Eblan","year":"2014","journal-title":"Oncology (Williston Park)"},{"key":"10.1016\/j.clbc.2018.06.015_bib113","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.1016\/j.ijrobp.2014.05.669","article-title":"Randomized controlled trial of the use of tissue-equivalent bolus in postmastectomy radiation therapy in breast cancer: toxicity and economic impact evaluation","volume":"90","author":"Sapienza","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib114","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ijrobp.2011.01.002","article-title":"The effect of adjuvant postmastectomy radiotherapy bolus technique on local recurrence","volume":"81","author":"Tieu","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clbc.2018.06.015_bib115","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.clon.2012.05.003","article-title":"Intensity-modulated radiotherapy in the treatment of breast cancer","volume":"24","author":"Dayes","year":"2012","journal-title":"Clin Oncol"},{"key":"10.1016\/j.clbc.2018.06.015_bib116","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/jso.21785","article-title":"Accelerated partial breast irradiation","volume":"103","author":"Beitsch","year":"2011","journal-title":"J\u00a0Surg Oncol"}],"container-title":["Clinical Breast Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526820918301149?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526820918301149?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:19:27Z","timestamp":1761513567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526820918301149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":115,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S1526820918301149"],"URL":"https:\/\/doi.org\/10.1016\/j.clbc.2018.06.015","relation":{},"ISSN":["1526-8209"],"issn-type":[{"value":"1526-8209","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radiation-induced Skin Toxicity in Breast Cancer Patients: A Systematic Review of Randomized Trials","name":"articletitle","label":"Article Title"},{"value":"Clinical Breast Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clbc.2018.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}