{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:57:21Z","timestamp":1791435441592,"version":"4.3.3"},"reference-count":15,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 CA149196"],"award-info":[{"award-number":["U54 CA149196"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 CA210181"],"award-info":[{"award-number":["U54 CA210181"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006988","name":"John S. Dunn Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006988","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinical-breast-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Breast Cancer"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.clbc.2020.09.015","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T12:32:49Z","timestamp":1601901169000},"page":"199-204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["A Phase II Study of the Efficacy and Safety of Chloroquine in Combination With Taxanes in the Treatment of Patients With Advanced or Metastatic Anthracycline-refractory Breast Cancer"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4480-1443","authenticated-orcid":false,"given":"Kartik","family":"Anand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly","family":"Niravath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejal","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Ensor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0735-3039","authenticated-orcid":false,"given":"Angel","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toniva","family":"Boone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9188-6502","authenticated-orcid":false,"given":"Stephen T.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny C.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clbc.2020.09.015_bib1","doi-asserted-by":"crossref","first-page":"13820","DOI":"10.1073\/pnas.0905718106","article-title":"Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features","volume":"106","author":"Creighton","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.clbc.2020.09.015_bib2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1158\/0008-5472.CAN-11-2333","article-title":"A\u00a0novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy","volume":"72","author":"Jin","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.clbc.2020.09.015_bib3","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1002\/stem.1746","article-title":"Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1","volume":"32","author":"Choi","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.clbc.2020.09.015_bib4","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.4161\/cc.10.22.17976","article-title":"Autophagy positively regulates the CD44+ CD24-\/low breast cancer stem-like phenotype","volume":"10","author":"Cuf\u00ed","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.clbc.2020.09.015_bib5","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.3171\/foc.2003.14.2.4","article-title":"Therapy of glioblastoma multiforme improved by the antimutagenic chloroquine","volume":"14","author":"Brice\u00f1o","year":"2003","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.clbc.2020.09.015_bib6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ophtha.2010.11.017","article-title":"Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy","volume":"118","author":"Marmor","year":"2011","journal-title":"Ophthalmol"},{"key":"10.1016\/j.clbc.2020.09.015_bib7","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1200\/JCO.1999.17.5.1413","article-title":"Prospective randomized trial of docetaxel versus mitomycin plus vinblastine in patients with metastatic breast cancer progressing despite previous anthracycline-containing chemotherapy","volume":"17","author":"Nabholtz","year":"1999","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clbc.2020.09.015_bib8","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1200\/JCO.2005.02.027","article-title":"Randomized phase III study of docetaxel compared with paclitaxel in metastatic breast cancer","volume":"23","author":"Jones","year":"2005","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clbc.2020.09.015_bib9","first-page":"1429","article-title":"BMS247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy","volume":"7","author":"Lee","year":"2001","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.clbc.2020.09.015_bib10","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1200\/JCO.2006.09.7535","article-title":"Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy","volume":"25","author":"Roch\u00e9","year":"2007","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clbc.2020.09.015_bib11","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1158\/1078-0432.CCR-13-3227","article-title":"Hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in ER+ breast cancer","volume":"20","author":"Cook","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.clbc.2020.09.015_bib12","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.canlet.2016.04.002","article-title":"The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair","volume":"376","author":"Liang","year":"2016","journal-title":"Cancer Lett"},{"key":"10.1016\/j.clbc.2020.09.015_bib13","first-page":"5761","article-title":"Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance","volume":"60","author":"Allen","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.clbc.2020.09.015_bib14","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1158\/1078-0432.CCR-19-4042","article-title":"A\u00a0randomized phase II preoperative study of autophagy inhibition with high-dose hydroxychloroquine and gemcitabine\/nab-paclitaxel in pancreatic cancer patients","volume":"26","author":"Zeh","year":"2020","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.clbc.2020.09.015_bib15","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.3892\/ijo.2013.1884","article-title":"Cytoprotective role of autophagy during paclitaxel-induced apoptosis in Saos-2 osteosarcoma cells","volume":"42","author":"Kim","year":"2013","journal-title":"Int J Oncol"}],"container-title":["Clinical Breast Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526820920302597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526820920302597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:20:26Z","timestamp":1761513626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526820920302597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S1526820920302597"],"URL":"https:\/\/doi.org\/10.1016\/j.clbc.2020.09.015","relation":{},"ISSN":["1526-8209"],"issn-type":[{"value":"1526-8209","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Phase II Study of the Efficacy and Safety of Chloroquine in Combination With Taxanes in the Treatment of Patients With Advanced or Metastatic Anthracycline-refractory Breast Cancer","name":"articletitle","label":"Article Title"},{"value":"Clinical Breast Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clbc.2020.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}