{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:48:11Z","timestamp":1792259291952,"version":"4.4.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinical-breast-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Breast Cancer"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.clbc.2026.01.005","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:13:17Z","timestamp":1768263197000},"page":"119-127.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predicting Skeletal-Related Events in Bone Metastasis from Advanced Breast Cancer Using Machine Learning"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0433-9779","authenticated-orcid":false,"given":"Hirotaka","family":"Miyashita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Aoshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.clbc.2026.01.005_bib0001","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.clbc.2026.01.005_bib0002","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-3-030-20301-6_7","article-title":"Bone Metastasis of breast cancer","volume":"1152","author":"Tahara","year":"2019","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"10.1016\/j.clbc.2026.01.005_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.soncn.2022.151276","article-title":"Pharmacological prevention and management of skeletal-related events and bone loss in individuals with cancer","volume":"38","author":"Park","year":"2022","journal-title":"Semin Oncol Nurs"},{"issue":"2","key":"10.1016\/j.clbc.2026.01.005_bib0004","first-page":"106","article-title":"Impact of skeletal-related events on survival in patients with metastatic prostate cancer prescribed androgen deprivation therapy","volume":"22","author":"Wong","year":"2016","journal-title":"Hong Kong Med J = Xianggang yi xue za zhi"},{"issue":"1","key":"10.1016\/j.clbc.2026.01.005_bib0005","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10549-011-1721-x","article-title":"Mortality following bone metastasis and skeletal-related events among women with breast cancer: a population-based analysis of U.S. Medicare beneficiaries, 1999-2006","volume":"131","author":"Sathiakumar","year":"2012","journal-title":"Breast Cancer Res Treat"},{"issue":"35","key":"10.1016\/j.clbc.2026.01.005_bib0006","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.1200\/JCO.2010.29.7101","article-title":"Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study","volume":"28","author":"Stopeck","year":"2010","journal-title":"J Clin Oncol"},{"issue":"16","key":"10.1016\/j.clbc.2026.01.005_bib0007","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1200\/JCO.2003.04.105","article-title":"Zoledronic acid versus placebo in the treatment of skeletal metastases in patients with lung cancer and other solid tumors: a phase III, double-blind, randomized trial\u2013the zoledronic acid lung cancer and other solid tumors study group","volume":"21","author":"Rosen","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clbc.2026.01.005_bib0008","article-title":"Long-term use of denosumab and its association with skeletal-related events and osteonecrosis of the jaw","volume":"13","author":"Fu","year":"2023"},{"issue":"1","key":"10.1016\/j.clbc.2026.01.005_bib0009","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1200\/JCO.23.00753","article-title":"Prophylactic radiation therapy versus standard of care for patients with high-risk asymptomatic bone metastases: a multicenter, randomized phase II clinical trial","volume":"42","author":"Gillespie","year":"2024","journal-title":"J Clin Oncol"},{"issue":"7","key":"10.1016\/j.clbc.2026.01.005_bib0010","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1001\/jamaoncol.2016.6316","article-title":"Continued treatment effect of zoledronic acid dosing every 12 vs 4 weeks in women with breast cancer metastatic to bone: the OPTIMIZE-2 randomized clinical trial","volume":"3","author":"Hortobagyi","year":"2017","journal-title":"JAMA Oncol"},{"issue":"2","key":"10.1016\/j.clbc.2026.01.005_bib0011","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10549-020-05712-4","article-title":"Risk factors for skeletal-related events in patients with bone metastasis from breast cancer undergoing treatment with zoledronate","volume":"182","author":"Miyashita","year":"2020","journal-title":"Breast Cancer Res Treat"},{"issue":"11","key":"10.1016\/j.clbc.2026.01.005_bib0012","doi-asserted-by":"crossref","first-page":"12612","DOI":"10.18632\/oncotarget.7278","article-title":"Exploiting machine learning for predicting skeletal-related events in cancer patients with bone metastases","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.clbc.2026.01.005_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbo.2022.100423","article-title":"Risk factors associated with skeletal-related events following discontinuation of denosumab treatment among patients with bone metastases from solid tumors: a real-world machine learning approach","volume":"34","author":"Jacobson","year":"2022","journal-title":"J bone Oncol"},{"issue":"11","key":"10.1016\/j.clbc.2026.01.005_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i11","article-title":"Feature selection with the Boruta package","volume":"36","author":"Kursa","year":"2010","journal-title":"J Stat Softw"},{"key":"10.1016\/j.clbc.2026.01.005_bib0015","article-title":"On averaging ROC curves","author":"Hogan","year":"2023","journal-title":"Trans Mach Learn Res"},{"key":"10.1016\/j.clbc.2026.01.005_bib0016","series-title":"NIPS\u201917: Proceedings of the 31st International Conference on Neural Information Processing Systems","first-page":"4768","article-title":"A unified approach to interpreting model predictions","author":"Lundberg","year":"2017"},{"issue":"12","key":"10.1016\/j.clbc.2026.01.005_bib0017","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.prp.2016.09.007","article-title":"Clinicopathologic factors associated with de novo metastatic breast cancer","volume":"212","author":"Shen","year":"2016","journal-title":"Pathol Res Pract"}],"container-title":["Clinical Breast Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526820926000042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526820926000042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:15:38Z","timestamp":1776467738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526820926000042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1526820926000042"],"URL":"https:\/\/doi.org\/10.1016\/j.clbc.2026.01.005","relation":{},"ISSN":["1526-8209"],"issn-type":[{"value":"1526-8209","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predicting Skeletal-Related Events in Bone Metastasis from Advanced Breast Cancer Using Machine Learning","name":"articletitle","label":"Article Title"},{"value":"Clinical Breast Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clbc.2026.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}