{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T23:44:28Z","timestamp":1786146268510,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinical-breast-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Breast Cancer"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.clbc.2026.06.016","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T15:54:44Z","timestamp":1783007684000},"page":"121-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heterozygous BRCA1 SNPs in the Central Functional Region are Associated With Increased Sensitivity to PARP Inhibition in Breast Cancer Cells"],"prefix":"10.1016","volume":"26","author":[{"given":"Ming-Hsin","family":"Yeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ying","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Chi","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Di","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clbc.2026.06.016_bib0001","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.breast.2022.08.010","article-title":"Current and future burden of breast cancer: global statistics for 2020 and 2040","volume":"66","author":"Arnold","year":"2022","journal-title":"Breast"},{"key":"10.1016\/j.clbc.2026.06.016_bib0002","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.3390\/cancers13174287","article-title":"Breast cancer\u2014epidemiology, risk factors, classification, prognostic markers, and current treatment strategies\u2014an updated review","volume":"13","author":"\u0141ukasiewicz","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.clbc.2026.06.016_bib0003","first-page":"31","article-title":"Breast cancer statistics, 2015: convergence of incidence rates between black and white women","volume":"66","author":"DeSantis","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.clbc.2026.06.016_bib0004","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3390\/cancers16030579","article-title":"Gender-specific genetic predisposition to breast cancer: BRCA genes and beyond","volume":"16","author":"Valentini","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.clbc.2026.06.016_bib0005","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s12282-020-01148-2","article-title":"Hereditary breast and ovarian cancer (HBOC): review of its molecular characteristics, screening, treatment, and prognosis","volume":"28","author":"Yoshida","year":"2021","journal-title":"Breast Cancer"},{"key":"10.1016\/j.clbc.2026.06.016_bib0006","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10120524","article-title":"BRCA mutations and breast cancer prevention","volume":"10","author":"Kotsopoulos","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.clbc.2026.06.016_bib0007","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12943-020-01227-0","article-title":"PARP inhibitor resistance: the underlying mechanisms and clinical implications","volume":"19","author":"Li","year":"2020","journal-title":"Mol Cancer"},{"key":"10.1016\/j.clbc.2026.06.016_bib0008","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.4161\/cc.10.8.15273","article-title":"Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations","volume":"10","author":"Dedes","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.clbc.2026.06.016_bib0009","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1001\/jamasurg.2017.0552","article-title":"The role of genetic testing in patients with breast cancer: a review","volume":"152","author":"Valencia","year":"2017","journal-title":"JAMA Surg"},{"key":"10.1016\/j.clbc.2026.06.016_bib0010","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/747318","article-title":"Hereditary breast cancer: the era of new susceptibility genes","volume":"2013","author":"Apostolou","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.clbc.2026.06.016_bib0011","doi-asserted-by":"crossref","first-page":"110635","DOI":"10.18632\/oncotarget.22372","article-title":"Single nucleotide polymorphisms and cancer susceptibility","volume":"8","author":"Deng","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.clbc.2026.06.016_bib0012","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1158\/0008-5472.CAN-09-3541","article-title":"Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility","volume":"70","author":"Nicoloso","year":"2010","journal-title":"Cancer Res"},{"issue":"Suppl 1","key":"10.1016\/j.clbc.2026.06.016_bib0013","article-title":"The UPS: a promising target for breast cancer treatment","volume":"9","author":"Sato","year":"2008","journal-title":"BMC Biochem"},{"key":"10.1016\/j.clbc.2026.06.016_bib0014","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1109\/TCBB.2020.2973148","article-title":"FUNMarker: fusion network-based method to identify prognostic and heterogeneous breast cancer biomarkers","volume":"18","author":"Li","year":"2021","journal-title":"IEEE\/ACM Trans Comput Biol Bioinform"},{"key":"10.1016\/j.clbc.2026.06.016_bib0015","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrc3181","article-title":"BRCA1 and BRCA2: different roles in a common pathway of genome protection","volume":"12","author":"Roy","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.clbc.2026.06.016_bib0016","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.7150\/jca.30410","article-title":"BRCA genes: the role in genome stability, cancer stemness and therapy resistance","volume":"10","author":"Gorodetska","year":"2019","journal-title":"J. Cancer"},{"key":"10.1016\/j.clbc.2026.06.016_bib0017","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1158\/0008-5472.CAN-13-2611","article-title":"BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability","volume":"74","author":"Savage","year":"2014","journal-title":"Cancer Res"},{"key":"10.1016\/j.clbc.2026.06.016_bib0018","doi-asserted-by":"crossref","first-page":"17773","DOI":"10.1073\/pnas.1110969108","article-title":"Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells","volume":"108","author":"Konishi","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.clbc.2026.06.016_bib0019","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1038\/ncomms8505","article-title":"Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence","volume":"6","author":"Sedic","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.clbc.2026.06.016_bib0020","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1038\/ncomms6496","article-title":"BRCA1 haploinsufficiency for replication stress suppression in primary cells","volume":"5","author":"Pathania","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.clbc.2026.06.016_bib0021","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.18632\/oncotarget.24064","article-title":"The association between BRCA1 gene polymorphism and cancer risk: a meta-analysis","volume":"9","author":"Xu","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.clbc.2026.06.016_bib0022","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1093\/hmg\/ddr388","article-title":"Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers","volume":"20","author":"Cox","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.clbc.2026.06.016_bib0023","doi-asserted-by":"crossref","first-page":"R171","DOI":"10.1186\/bcr973","article-title":"Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer","volume":"7","author":"Cox","year":"2005","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.clbc.2026.06.016_bib0024","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/hmg\/ddm050","article-title":"Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility","volume":"16","author":"Johnson","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.clbc.2026.06.016_bib0025","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/hmg\/5.6.835","article-title":"Comparison of BRCA1 polymorphisms, rare sequence variants and\/or missense mutations in unaffected and breast\/ovarian cancer populations","volume":"5","author":"Durocher","year":"1996","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.clbc.2026.06.016_bib0026","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.ccr.2011.11.014","article-title":"BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance","volume":"20","author":"Drost","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.clbc.2026.06.016_bib0027","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41467-017-00388-9","article-title":"BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers","volume":"8","author":"Maxwell","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.clbc.2026.06.016_bib0028","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.4161\/cc.6.19.4754","article-title":"DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency","volume":"6","author":"Bartek","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.clbc.2026.06.016_bib0029","article-title":"Olaparib shows promise in multiple tumor types","volume":"3","year":"2013","journal-title":"Cancer Discov"},{"key":"10.1016\/j.clbc.2026.06.016_bib0030","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.3390\/cancers14061420","article-title":"PARP inhibitors resistance: mechanisms and perspectives","volume":"14","author":"Giudice","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.clbc.2026.06.016_bib0031","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrc.2015.21","article-title":"BRCAness revisited","volume":"16","author":"Lord","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.clbc.2026.06.016_bib0032","doi-asserted-by":"crossref","first-page":"515","DOI":"10.18632\/aging.100325","article-title":"Mutations in the BRCT binding site of BRCA1 result in hyper-recombination","volume":"3","author":"Dever","year":"2011","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.clbc.2026.06.016_bib0033","doi-asserted-by":"crossref","first-page":"D587","DOI":"10.1093\/nar\/gkac963","article-title":"KEGG for taxonomy-based analysis of pathways and genomes","volume":"51","author":"Kanehisa","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"7873","key":"10.1016\/j.clbc.2026.06.016_bib0034","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.clbc.2026.06.016_bib0035","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1073\/pnas.97.3.1020","article-title":"CBP\/p300 interact with and function as transcriptional coactivators of BRCA1","volume":"97","author":"Pao","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.clbc.2026.06.016_bib0036","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1007\/s12035-018-1431-z","article-title":"Conditional haploinsufficiency of \u03b2-catenin aggravates neuronal damage in a paraquat-based mouse model of Parkinson disease","volume":"56","author":"Zhao","year":"2019","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.clbc.2026.06.016_bib0037","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.imlet.2004.09.015","article-title":"Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection","volume":"97","author":"Mitchison","year":"2005","journal-title":"Immunol Lett"},{"key":"10.1016\/j.clbc.2026.06.016_bib0038","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/jmg.2005.033878","article-title":"Comprehensive statistical study of 452 BRCA1 missense substitutions with classification of eight recurrent substitutions as neutral","volume":"43","author":"Tavtigian","year":"2006","journal-title":"J Med Genet"},{"key":"10.1016\/j.clbc.2026.06.016_bib0039","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1158\/0008-5472.CAN-09-4563","article-title":"Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays","volume":"70","author":"Lee","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.clbc.2026.06.016_bib0040","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41586-018-0461-z","article-title":"Accurate classification of BRCA1 variants with saturation genome editing","volume":"562","author":"Findlay","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.clbc.2026.06.016_bib0041","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1158\/1541-7786.MCR-17-0357","article-title":"Combining homologous recombination and phosphopeptide-binding data to predict the impact of BRCA1 BRCT variants on cancer risk","volume":"17","author":"Petitalot","year":"2019","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.clbc.2026.06.016_bib0042","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1056\/NEJM200102223440801","article-title":"Gene-expression profiles in hereditary breast cancer","volume":"344","author":"Hedenfalk","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clbc.2026.06.016_bib0043","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s10549-009-0653-1","article-title":"Subtypes of familial breast tumours revealed by expression and copy number profiling","volume":"123","author":"Waddell","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.clbc.2026.06.016_bib0044","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064268","article-title":"Classifications within molecular subtypes enables identification of BRCA1\/BRCA2 mutation carriers by RNA tumor profiling","volume":"8","author":"Larsen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clbc.2026.06.016_bib0045","doi-asserted-by":"crossref","first-page":"5854","DOI":"10.1038\/sj.onc.1209872","article-title":"The role of BRCA1 in transcriptional regulation and cell cycle control","volume":"25","author":"Mullan","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.clbc.2026.06.016_bib0046","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11912-009-0076-5","article-title":"CYP2D6 polymorphisms and tamoxifen metabolism: clinical relevance","volume":"12","author":"Higgins","year":"2010","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.clbc.2026.06.016_bib0047","doi-asserted-by":"crossref","first-page":"88","DOI":"10.14744\/ejmo.2024.61033","article-title":"Expression patterns and relevance of FN3K, Nrf2, and NQO1 in breast cancers","volume":"8","author":"Beeraka","year":"2024","journal-title":"Eurasian J Med Oncol"},{"key":"10.1016\/j.clbc.2026.06.016_bib0048","doi-asserted-by":"crossref","first-page":"322","DOI":"10.14744\/ejmo.2024.97120","article-title":"Unlocking the potential of 3D spheroid cultures in breast cancer stem cell enrichment and isolation","volume":"8","author":"Ishtiah","year":"2024","journal-title":"Eurasian J Med Oncol"},{"key":"10.1016\/j.clbc.2026.06.016_bib0049","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1111\/febs.16768","article-title":"MAEL facilitates metabolic reprogramming and breast cancer progression by promoting the degradation of citrate synthase and fumarate hydratase via chaperone-mediated autophagy","volume":"290","author":"Zhou","year":"2023","journal-title":"FEBS J"}],"container-title":["Clinical Breast Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152682092600100X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152682092600100X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T23:30:39Z","timestamp":1786145439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152682092600100X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S152682092600100X"],"URL":"https:\/\/doi.org\/10.1016\/j.clbc.2026.06.016","relation":{},"ISSN":["1526-8209"],"issn-type":[{"value":"1526-8209","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heterozygous BRCA1 SNPs in the Central Functional Region are Associated With Increased Sensitivity to PARP Inhibition in Breast Cancer Cells","name":"articletitle","label":"Article Title"},{"value":"Clinical Breast Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clbc.2026.06.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}