{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:06:51Z","timestamp":1788952011266,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013200","name":"Alberta Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009192","name":"Alberta Innovates","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009192","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinical-breast-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Breast Cancer"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.clbc.2026.07.029","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:51:56Z","timestamp":1785073916000},"page":"171-178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost-effectiveness of Biennial Breast Screening in Women With Dense Breasts: Exploratory Analysis of Pathways Incorporating an Emerging Blood RNA Test"],"prefix":"10.1016","volume":"26","author":[{"given":"Jacie T.","family":"Cooper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Hollingsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy D.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Croft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8827-8693","authenticated-orcid":false,"given":"Kristina D.","family":"Rinker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldon","family":"Spackman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.clbc.2026.07.029_bib0001","doi-asserted-by":"crossref","first-page":"W292","DOI":"10.2214\/AJR.10.6049","article-title":"The relationship of mammographic density and age: implications for breast cancer screening","volume":"198","author":"Checka","year":"2012","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.clbc.2026.07.029_bib0002","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1398196","article-title":"Status of breast cancer detection in young women and potential of liquid biopsy","volume":"14","author":"Stibbards-Lyle","year":"2024","journal-title":"Front Oncol"},{"issue":"8","key":"10.1016\/j.clbc.2026.07.029_bib0003","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1001\/jama.2020.0572","article-title":"Comparison of abbreviated breast MRI vs digital breast tomosynthesis for breast cancer detection among women with dense breasts undergoing screening","volume":"323","author":"Comstock","year":"2020","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.clbc.2026.07.029_bib0004","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.3390\/curroncol29050291","article-title":"The impact of dense breasts on the stage of breast cancer at diagnosis: a review and options for supplemental screening","volume":"29","author":"Gordon","year":"2022","journal-title":"Curr Oncol"},{"key":"10.1016\/j.clbc.2026.07.029_bib0005","unstructured":"Johnson, C., Update to the Health Resources and Services Administration-Supported Women\u2019s Preventive Services Guidelines (Federal Register). 2024."},{"issue":"17","key":"10.1016\/j.clbc.2026.07.029_bib0006","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1056\/NEJMoa052911","article-title":"Diagnostic performance of digital versus film mammography for breast-cancer screening","volume":"353","author":"Pisano","year":"2005","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.clbc.2026.07.029_bib0007","first-page":"75","article-title":"American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography","volume":"57","author":"Saslow","year":"2007","journal-title":"CA"},{"issue":"1","key":"10.1016\/j.clbc.2026.07.029_bib0008","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1148\/radiol.2017161103","article-title":"Evaluation of the utility of screening mammography for high-risk women undergoing screening breast MR imaging","volume":"285","author":"Lo","year":"2017","journal-title":"Radiology"},{"issue":"5","key":"10.1016\/j.clbc.2026.07.029_bib0009","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1001\/jamaoncol.2018.7078","article-title":"Association of digital breast tomosynthesis vs digital mammography with cancer detection and recall rates by age and breast density","volume":"5","author":"Conant","year":"2019","journal-title":"JAMA Oncol"},{"issue":"4","key":"10.1016\/j.clbc.2026.07.029_bib0010","doi-asserted-by":"crossref","first-page":"894","DOI":"10.2214\/AJR.19.22429","article-title":"The ``sweet spot'' revisited: optimal recall rates for cancer detection with 2D and 3D digital screening mammography in the Metro Chicago breast cancer registry","volume":"216","author":"Rauscher","year":"2021","journal-title":"AJR Am J Roentgenol"},{"issue":"9","key":"10.1016\/j.clbc.2026.07.029_bib0011","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.annonc.2021.05.806","article-title":"Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set","volume":"32","author":"Klein","year":"2021","journal-title":"Ann Oncol"},{"issue":"10409","key":"10.1016\/j.clbc.2026.07.029_bib0012","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0140-6736(23)01700-2","article-title":"Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study","volume":"402","author":"Schrag","year":"2023","journal-title":"Lancet"},{"issue":"4_Supplement","key":"10.1016\/j.clbc.2026.07.029_bib0013","doi-asserted-by":"crossref","DOI":"10.1158\/1538-7445.SABCS21-P2-01-02","article-title":"Abstract P2-01-02: a whole blood assay to identify breast cancer: interim analysis of the international identify breast cancer (IDBC) study evidence supporting the Syantra DX breast cancer test","volume":"82","author":"Bundred","year":"2022","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.clbc.2026.07.029_bib0014","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1200\/JCO.19.01525","article-title":"Systematic review of the cost effectiveness of breast cancer prevention, screening, and treatment interventions","volume":"38","author":"Jayasekera","year":"2020","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.clbc.2026.07.029_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-148-1-200801010-00002","article-title":"Cost-effectiveness of digital mammography breast cancer screening","volume":"148","author":"Tosteson","year":"2008","journal-title":"Ann Intern Med"},{"issue":"6","key":"10.1016\/j.clbc.2026.07.029_bib0016","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/jnci\/djz184","article-title":"Long-term outcomes and cost-effectiveness of breast cancer screening with digital breast tomosynthesis in the United States","volume":"112","author":"Lowry","year":"2019","journal-title":"JNCI"},{"issue":"3","key":"10.1016\/j.clbc.2026.07.029_bib0017","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1148\/radiol.14141237","article-title":"Comparative effectiveness of combined digital mammography and tomosynthesis screening for women with dense breasts","volume":"274","author":"Lee","year":"2015","journal-title":"Radiology"},{"issue":"11","key":"10.1016\/j.clbc.2026.07.029_bib0018","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1093\/jnci\/djab119","article-title":"Cost-effectiveness of magnetic resonance imaging screening for women with extremely dense breast tissue","volume":"113","author":"Geuzinge","year":"2021","journal-title":"J Natl Cancer Inst"},{"issue":"32","key":"10.1016\/j.clbc.2026.07.029_bib0019","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1200\/JCO.24.00285","article-title":"Breast cancer screening interval: effect on rate of late-stage disease at diagnosis and overall survival","volume":"42","author":"Zuley","year":"2024","journal-title":"J Clin Oncol"},{"issue":"Suppl 2","key":"10.1016\/j.clbc.2026.07.029_bib0020","doi-asserted-by":"crossref","first-page":"S154","DOI":"10.1016\/j.acra.2023.01.007","article-title":"Interval breast cancers versus screen detected breast cancers: a retrospective cohort study","volume":"30","author":"Ambinder","year":"2023","journal-title":"Acad Radiol"},{"issue":"9","key":"10.1016\/j.clbc.2026.07.029_bib0021","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.18179","article-title":"Incidence, characteristics, and outcomes of interval breast cancers compared with screening-detected breast cancers","volume":"3","author":"Niraula","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"1","key":"10.1016\/j.clbc.2026.07.029_bib0022","first-page":"1","article-title":"United States life tables, 2020","volume":"71","author":"Arias","year":"2022","journal-title":"Natl Vital Stat Rep"},{"issue":"2","key":"10.1016\/j.clbc.2026.07.029_bib0023","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/jnci\/djaa096","article-title":"All-cause and cardiovascular disease mortality among breast cancer survivors in CLUE II, a long-standing community-based cohort","volume":"113","author":"Ramin","year":"2021","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"10.1016\/j.clbc.2026.07.029_bib0024","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13244-024-01653-4","article-title":"The paradox of MRI for breast cancer screening: high-risk and dense breasts\u2014available evidence and current practice","volume":"15","author":"Sardanelli","year":"2024","journal-title":"Insights Imaging"},{"issue":"3","key":"10.1016\/j.clbc.2026.07.029_bib0025","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/jbi\/wbad096","article-title":"Prevalent vs incident screen: why does it matter?","volume":"6","author":"Hayward","year":"2024","journal-title":"J Breast Imaging"},{"key":"10.1016\/j.clbc.2026.07.029_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/S0959-8049(22)01365-X","article-title":"Breast cancer whole blood screening: analytical and clinical performance from early analysis of the international identify Breast cancer (IDBC) study","volume":"175","author":"Bundred","year":"2022","journal-title":"Eur J Cancer"},{"issue":"8","key":"10.1016\/j.clbc.2026.07.029_bib0027","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1080\/03007995.2022.2047536","article-title":"Cost of cancer management by stage at diagnosis among Medicare beneficiaries","volume":"38","author":"Reddy","year":"2022","journal-title":"Curr Med Res Opin"},{"issue":"24","key":"10.1016\/j.clbc.2026.07.029_bib0028","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17249412","article-title":"A meta-regression analysis of utility weights for breast cancer: the power of patients' experience","volume":"17","author":"Gong","year":"2020","journal-title":"Int J Environ Res Public Health"},{"issue":"3","key":"10.1016\/j.clbc.2026.07.029_bib0029","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/jnci\/djab202","article-title":"The incidence of breast cancer recurrence 10-32 years after primary diagnosis","volume":"114","author":"Pedersen","year":"2022","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.clbc.2026.07.029_bib0032","unstructured":"BC Cancer Breast Screening Provincial Health Services Authority. BC Cancer Breast Screening 2018 Program Results. 2019:1\u201364."},{"issue":"11","key":"10.1016\/j.clbc.2026.07.029_bib0033","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1001\/jama.289.11.1414","article-title":"Screening men for prostate and colorectal cancer in the United States: does practice reflect the evidence?","volume":"289","author":"Sirovich","year":"2003","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.clbc.2026.07.029_bib0038","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.amepre.2015.09.026","article-title":"Breast cancer in young women: health state utility impacts by race\/ethnicity","volume":"50","author":"Trogdon","year":"2016","journal-title":"Am J Prev Med"},{"issue":"22","key":"10.1016\/j.clbc.2026.07.029_bib0030","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1001\/jama.2024.5534","article-title":"Screening for breast cancer: US Preventive Services Task Force Recommendation statement","volume":"331","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.clbc.2026.07.029_bib0031","unstructured":"NCCN. Breast Cancer NCCN Guidelines. National Comprehensive Cancer Network; Plymouth Meeting, PA. 2025."},{"issue":"10","key":"10.1016\/j.clbc.2026.07.029_bib0034","first-page":"376","article-title":"The influence of breast density on breast cancer diagnosis: a study of participants in the BC Cancer Breast Screening Program","volume":"61","author":"Mar","year":"2019","journal-title":"BC Med J"},{"issue":"2","key":"10.1016\/j.clbc.2026.07.029_bib0035","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jnci\/djaa103","article-title":"Comparing the cost-effectiveness of innovative colorectal cancer screening tests","volume":"113","author":"Peterse","year":"2021","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"10.1016\/j.clbc.2026.07.029_bib0039","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1001\/jama.2015.18603","article-title":"Comparison of site of death, health care utilization, and hospital expenditures for patients dying with cancer in 7 developed countries","volume":"315","author":"Bekelman","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.clbc.2026.07.029_bib0040","unstructured":"Healthcare Inc. Context4 Reference-based Pricing UCR Fee Viewer, Naperville, IL: Context4 Healthcare, Inc; https:\/\/www.feeinfo.com\/DecisionPointUCR\/welcome.html?acctkey=C4Hs6lDkAvalon_HealthhkASk9MkXhjd."},{"issue":"9","key":"10.1016\/j.clbc.2026.07.029_bib0041","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1097\/MLR.0b013e3181e57918","article-title":"Cost of breast-related care in the year following false positive screening mammograms","volume":"48","author":"Chubak","year":"2010","journal-title":"Med Care"},{"issue":"1","key":"10.1016\/j.clbc.2026.07.029_bib0036","doi-asserted-by":"crossref","first-page":"25","DOI":"10.7326\/M20-1392","article-title":"Health opportunity cost threshold for cost-effectiveness analysis in the United States","volume":"174","author":"Vanness","year":"2021","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clbc.2026.07.029_bib0037","unstructured":"Weist, Michael. New Survey: Patients and Physicians Overwhelmingly Agree Blood Tests Could Help Close the Colorectal Cancer Screening Gap. Guardant; 2024."}],"container-title":["Clinical Breast Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526820926001308?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526820926001308?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:08:11Z","timestamp":1788948491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526820926001308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1526820926001308"],"URL":"https:\/\/doi.org\/10.1016\/j.clbc.2026.07.029","relation":{},"ISSN":["1526-8209"],"issn-type":[{"value":"1526-8209","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cost-effectiveness of Biennial Breast Screening in Women With Dense Breasts: Exploratory Analysis of Pathways Incorporating an Emerging Blood RNA Test","name":"articletitle","label":"Article Title"},{"value":"Clinical Breast Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clbc.2026.07.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}