{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:46:23Z","timestamp":1792035983874,"version":"4.4.0"},"reference-count":94,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M692576"],"award-info":[{"award-number":["2021M692576"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC0114705"],"award-info":[{"award-number":["2018YFC0114705"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2017LH072"],"award-info":[{"award-number":["ZR2017LH072"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MH115"],"award-info":[{"award-number":["ZR2023MH115"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902702"],"award-info":[{"award-number":["81902702"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinical-breast-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Breast Cancer"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.clbc.2026.08.008","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T23:26:18Z","timestamp":1786577178000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Paradox of Breast Invasive Micropapillary Carcinoma"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1995-3016","authenticated-orcid":false,"given":"Yongzhi","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengbin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongming","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clbc.2026.08.008_bib0001","doi-asserted-by":"crossref","first-page":"799","DOI":"10.5858\/arpa.2016-0040-RA","article-title":"Invasive micropapillary carcinoma of the breast: an update","volume":"140","author":"Yang","year":"2016","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.clbc.2026.08.008_bib0002","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/ajcp\/73.3.313","article-title":"Pathologic findings from the national surgical adjuvant breast project (protocol no. 4): VI. Invasive papillary cancer","volume":"73","author":"Fisher","year":"1980","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0003","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/dc.20427","article-title":"Intracytoplasmic lumina in invasive micropapillary carcinoma of the lung","volume":"34","author":"Kuroda","year":"2006","journal-title":"Diagn Cytopathol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0004","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/pin.12450","article-title":"Pure invasive micropapillary carcinoma of the esophagogastric junction with lymph nodes and liver metastasis","volume":"66","author":"Hattori","year":"2016","journal-title":"Pathol Int"},{"key":"10.1016\/j.clbc.2026.08.008_bib0005","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1440-1827.2008.02265.x","article-title":"Primary invasive micropapillary carcinoma of the stomach","volume":"58","author":"Shimoda","year":"2008","journal-title":"Pathol Int"},{"key":"10.1016\/j.clbc.2026.08.008_bib0006","article-title":"Cytological, histological, and molecular characteristics of pure invasive micropapillary carcinoma of pancreas: a case report","volume":"99","author":"Lee","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.clbc.2026.08.008_bib0007","doi-asserted-by":"crossref","DOI":"10.1002\/deo2.70184","article-title":"A case of human epidermal growth factor receptor 2-positive colon cancer with invasive micropapillary carcinoma component","volume":"6","author":"Kono","year":"2026","journal-title":"DEN Open"},{"key":"10.1016\/j.clbc.2026.08.008_bib0008","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-025-14487-0","article-title":"Comparison of somatic mutations and clinicopathologic features of micropapillary and non-micropapillary colorectal carcinomas","volume":"25","author":"Sagnak Yilmaz","year":"2025","journal-title":"BMC Cancer"},{"key":"10.1016\/j.clbc.2026.08.008_bib0009","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.21037\/gs-21-506","article-title":"Invasive micropapillary carcinoma of mixed breast cancer metastasizing to the cervical region and thyroid: report of a rare case","volume":"10","author":"Yu","year":"2021","journal-title":"Gland Surg"},{"key":"10.1016\/j.clbc.2026.08.008_bib0010","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1097\/00000478-199412000-00005","article-title":"Micropapillary variant of transitional cell carcinoma of the urinary bladder histologic pattern resembling ovarian papillary serous carcinoma","volume":"18","author":"Amin","year":"1994","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.149192","article-title":"Lower expression of MMP2, FLNA, and CFL1 is correlated with favorable prognosis in invasive micropapillary breast cancer","volume":"940","author":"Wang","year":"2025","journal-title":"Gene"},{"key":"10.1016\/j.clbc.2026.08.008_bib0012","first-page":"327","article-title":"Xp11.2 translocation\/TFE3 gene fusion renal cell carcinoma with a micropapillary pattern: cases report and literature review","volume":"11","author":"Xu","year":"2019","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.clbc.2026.08.008_bib0013","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/PAI.0000000000001123","article-title":"Molecular pathology of micropapillary carcinomas: is characteristic morphology related to molecular mechanisms?","volume":"31","author":"Sagnak Yilmaz","year":"2023","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.anndiagpath.2022.152047","article-title":"The presence of retraction clefts correlates with lymphovascular invasion and lymph node metastasis and predicts poor outcome: analysis of 2497 breast cancer patients","volume":"61","author":"Li","year":"2022","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0015","article-title":"Clinico-pathological features and prognosis of invasive micropapillary carcinoma compared to invasive ductal carcinoma: a population-based study from China","volume":"9","author":"Shi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.clbc.2026.08.008_bib0016","doi-asserted-by":"crossref","first-page":"42455","DOI":"10.18632\/oncotarget.16405","article-title":"Clinicopathologic study of invasive micropapillary carcinoma of the breast","volume":"8","author":"Tang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.clbc.2026.08.008_bib0017","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/PAS.0b013e318185e171","article-title":"The presence of micropapillary features and retraction artifact in core needle biopsy material predicts lymph node metastasis in breast carcinoma","volume":"33","author":"Acs","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0018","article-title":"Identifying micropapillary patterns with fine-needle aspiration biopsy at metastatic sites to enhance breast cancer diagnosis: a case series","volume":"17","author":"Gupta","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.clbc.2026.08.008_bib0019","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S0344-0338(11)80745-4","article-title":"Invasive micropapillary carcinoma of the breast","volume":"190","author":"Luna-Mor\u00e9","year":"1994","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.clbc.2026.08.008_bib0020","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2325\/jbcs.13.58","article-title":"The reversed apical pattern of MUC1 expression is characteristics of invasive micropapillary carcinoma of the breast","volume":"13","author":"Li","year":"2006","journal-title":"Breast Cancer"},{"key":"10.1016\/j.clbc.2026.08.008_bib0021","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1097\/PAS.0b013e3181f5539c","article-title":"Invasive ductal carcinomas of the breast showing partial reversed cell polarity are associated with lymphatic tumor spread and may represent part of a spectrum of invasive micropapillary carcinoma","volume":"34","author":"Acs","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0022","doi-asserted-by":"crossref","first-page":"477","DOI":"10.20892\/j.issn.2095-3941.2020.0422","article-title":"sLex expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1\/EMA as a supplementary diagnostic indicator","volume":"18","author":"Song","year":"2021","journal-title":"Cancer Biol Med"},{"key":"10.1016\/j.clbc.2026.08.008_bib0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/9242305","article-title":"Involvement of annexin A2 expression and apoptosis in reverse polarization of invasive micropapillary carcinoma of the breast","volume":"2020","author":"Arai","year":"2020","journal-title":"Case Rep Pathol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0024","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/his.13121","article-title":"\u2018Inside-out\u2019 p120 immunostaining pattern in invasive micropapillary carcinoma of the breast; additional unequivocal evidence of reversed polarity","volume":"70","author":"Lepe","year":"2017","journal-title":"Histopathology"},{"key":"10.1016\/j.clbc.2026.08.008_bib0025","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2022.1011773","article-title":"Invasive micropapillary breast carcinoma: a retrospective study on the clinical imaging features and pathologic findings","volume":"9","author":"Nangong","year":"2022","journal-title":"Front Surg"},{"key":"10.1016\/j.clbc.2026.08.008_bib0026","doi-asserted-by":"crossref","first-page":"979","DOI":"10.5858\/arpa.2020-0288-OA","article-title":"HER2 immunohistochemistry in invasive micropapillary breast carcinoma: complete assessment of an incomplete pattern","volume":"145","author":"Perron","year":"2021","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.clbc.2026.08.008_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.crad.2023.09.010","article-title":"Radiological characteristics of invasive micropapillary carcinoma of the breast","volume":"79","author":"Fakhry","year":"2024","journal-title":"Clin Radiol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0028","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.3892\/ol.2020.11848","article-title":"MRI and the pathology of breast invasive micropapillary carcinoma","volume":"20","author":"Han","year":"2020","journal-title":"Oncol Lett"},{"key":"10.1016\/j.clbc.2026.08.008_bib0029","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.202200224","article-title":"Label-free detection of invasive micropapillary carcinoma of the breast using multiphoton microscopy","volume":"16","author":"He","year":"2023","journal-title":"J Biophotonics"},{"key":"10.1016\/j.clbc.2026.08.008_bib0030","doi-asserted-by":"crossref","first-page":"428","DOI":"10.5114\/aoms\/173213","article-title":"Clinicopathological characteristics and prognostic factors in invasive micropapillary carcinoma of the breast","volume":"20","author":"Liu","year":"2024","journal-title":"Arch Med Sci"},{"key":"10.1016\/j.clbc.2026.08.008_bib0031","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.breast.2020.01.041","article-title":"Prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in breast: a meta-analysis of PSM studies","volume":"51","author":"Ye","year":"2020","journal-title":"Breast"},{"key":"10.1016\/j.clbc.2026.08.008_bib0032","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.clbc.2015.01.008","article-title":"Differences in prognostic factors and failure patterns between invasive micropapillary carcinoma and carcinoma with micropapillary component versus invasive ductal carcinoma of the breast: retrospective multicenter case\u2013control study (KROG 13-06)","volume":"15","author":"Yu","year":"2015","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.clbc.2026.08.008_bib0033","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1186\/s12885-017-3855-7","article-title":"The prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in the breast: a meta-analysis","volume":"17","author":"Wu","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.clbc.2026.08.008_bib0034","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.breast.2010.01.020","article-title":"Differences in prognostic factors and patterns of failure between invasive micropapillary carcinoma and invasive ductal carcinoma of the breast: matched case\u2013control study","volume":"19","author":"Yu","year":"2010","journal-title":"Breast"},{"key":"10.1016\/j.clbc.2026.08.008_bib0035","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1177\/0284185119834689","article-title":"Comparison of invasive micropapillary and invasive ductal carcinoma of the breast: a matched cohort study","volume":"60","author":"Yoon","year":"2019","journal-title":"Acta Radiol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0036","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/bjc.2014.301","article-title":"Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast","volume":"111","author":"Chen","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clbc.2026.08.008_bib0037","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1002\/cam4.1227","article-title":"Invasive micropapillary carcinoma of the breast has a better long-term survival than invasive ductal carcinoma of the breast in spite of its aggressive clinical presentations: a comparison based on large population database and case\u2013control analysis","volume":"6","author":"Chen","year":"2017","journal-title":"Cancer Med"},{"key":"10.1016\/j.clbc.2026.08.008_bib0038","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4274\/ejbh.galenos.2022.2022-7-4","article-title":"The clinicopathologic features of 22 cases with primary invasive papillary carcinoma of the breast identified in 1153 cases with invasive breast carcinoma: single-center experience","volume":"18","author":"Kelten Talu","year":"2022","journal-title":"Eur J Breast Health"},{"key":"10.1016\/j.clbc.2026.08.008_bib0039","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/s41379-018-0024-8","article-title":"Precise pathologic diagnosis and individualized treatment improve the outcomes of invasive micropapillary carcinoma of the breast: a 12-year prospective clinical study","volume":"31","author":"Li","year":"2018","journal-title":"Mod Pathol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0040","article-title":"MRI response pattern of breast invasive micropapillary carcinoma after neoadjuvant chemotherapy: a matched cohort study with invasive breast cancer of no special type","volume":"25","author":"Gao","year":"2024","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.clbc.2026.08.008_bib0041","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s12957-025-03807-0","article-title":"Preoperative lymph node metastasis risk assessment in invasive micropapillary carcinoma of the breast: development of a machine learning-based predictive model with a web-based calculator","volume":"23","author":"Zhang","year":"2025","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0042","doi-asserted-by":"crossref","first-page":"625","DOI":"10.21614\/chirurgia.3221","article-title":"Management of HER2-positive invasive micropapillary breast cancer: focus on chemotherapy toxicities and surgical implications of typhlitis","volume":"120","author":"Chipuc","year":"2025","journal-title":"Chirurgia (Bucur.)"},{"key":"10.1016\/j.clbc.2026.08.008_bib0043","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.29271\/jcpsp.2022.09.1196","article-title":"Clinicopathological features and prognosis of invasive micropapillary carcinoma compared to invasive ductal carcinoma-NOS: worse or better?","volume":"32","year":"2022","journal-title":"J Coll Physicians Surg Pak"},{"key":"10.1016\/j.clbc.2026.08.008_bib0044","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40880-019-0406-4","article-title":"Prognosis of lymphotropic invasive micropapillary breast carcinoma analyzed by using data from the National Cancer Database","volume":"39","author":"Lewis","year":"2019","journal-title":"Cancer Commun"},{"key":"10.1016\/j.clbc.2026.08.008_bib0045","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s12282-023-01523-9","article-title":"Association of molecular subtypes and treatment with survival in invasive micropapillary breast cancer: an analysis of the surveillance, epidemiology, and end results database","volume":"31","author":"Tang","year":"2024","journal-title":"Breast Cancer"},{"key":"10.1016\/j.clbc.2026.08.008_bib0046","doi-asserted-by":"crossref","DOI":"10.3389\/pore.2024.1611987","article-title":"Invasive micropapillary carcinoma of the breast and invasive breast carcinoma of no special type: a comparison of claudin proteins\u2019 expression and its impact on survival","volume":"30","author":"Kramer","year":"2024","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.clbc.2026.08.008_bib0047","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10549-024-07384-w","article-title":"The differences between pure and mixed invasive micropapillary breast cancer: the epithelial\u2013mesenchymal transition molecules and prognosis","volume":"208","author":"Oz","year":"2024","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.clbc.2026.08.008_bib0048","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/08941939.2018.1474302","article-title":"The impact of micropapillary component ratio on the prognosis of patients with invasive micropapillary breast carcinoma","volume":"33","author":"Kaya","year":"2020","journal-title":"J Invest Surg"},{"key":"10.1016\/j.clbc.2026.08.008_bib0049","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-024-12673-0","article-title":"Micropapillary breast carcinoma in comparison with invasive duct carcinoma. Does it have an aggressive clinical presentation and an unfavorable prognosis?","volume":"24","author":"Elzohery","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.clbc.2026.08.008_bib0050","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10549-024-07422-7","article-title":"Long-term outcome of invasive pure micropapillary breast cancer compared with invasive mixed micropapillary and invasive ductal breast cancer: a matched retrospective study","volume":"208","author":"Magnoni","year":"2024","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.clbc.2026.08.008_bib0051","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1158\/0008-5472.CAN-19-1362","article-title":"Wnt signaling in cancer: not a binary ON:OFF switch","volume":"79","author":"Flanagan","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.clbc.2026.08.008_bib0052","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/PAI.0000000000001052","article-title":"Increased expression of LEF1 and \u03b2-catenin in invasive micropapillary carcinoma of the breast is associated with lymphovascular invasion and lymph node metastasis","volume":"30","author":"Dolezal","year":"2022","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0053","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.7150\/jca.31411","article-title":"High expression of plakoglobin promotes metastasis in invasive micropapillary carcinoma of the breast via tumor cluster formation","volume":"10","author":"Huang","year":"2019","journal-title":"J Cancer"},{"key":"10.1016\/j.clbc.2026.08.008_bib0054","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.4161\/cbt.6.10.4904","article-title":"Aberrant activation of \u03b3-catenin promotes genomic instability and oncogenic effects during tumor progression","volume":"6","author":"Pan","year":"2007","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.clbc.2026.08.008_bib0055","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.18632\/oncotarget.22774","article-title":"Overexpression of \u03b21 integrin contributes to polarity reversal and a poor prognosis of breast invasive micropapillary carcinoma","volume":"9","author":"Liu","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.clbc.2026.08.008_bib0056","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13058-016-0680-x","article-title":"LIN7A is a major determinant of cell-polarity defects in breast carcinomas","volume":"18","author":"Gruel","year":"2016","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.clbc.2026.08.008_bib0057","article-title":"Jagged1 modulated tumor-associated macrophage differentiation predicts poor prognosis in patients with invasive micropapillary carcinoma of the breast","volume":"96","author":"Liu","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.clbc.2026.08.008_bib0058","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4274\/ejbh.galenos.2021.2021-2-8","article-title":"The expression of galectin-3 in tumor and cancer-associated fibroblasts in invasive micropapillary breast carcinomas: relationship with clinicopathologic parameters","volume":"17","author":"\u00c7ak\u0131r","year":"2021","journal-title":"Eur J Breast Health"},{"key":"10.1016\/j.clbc.2026.08.008_bib0059","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12885-018-5221-9","article-title":"CD1d- and PJA2-related immune microenvironment differs between invasive breast carcinomas with and without a micropapillary feature","volume":"19","author":"Kanomata","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.clbc.2026.08.008_bib0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020702","article-title":"CD1d-expressing breast cancer cells modulate NKT cell-mediated antitumor immunity in a murine model of breast cancer metastasis","volume":"6","author":"Hix","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.clbc.2026.08.008_bib0061","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.278.5343.1626","article-title":"CD1d-restricted and TCR-mediated activation of v\u03b1 14 NKT cells by glycosylceramides","volume":"278","author":"Kawano","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.clbc.2026.08.008_bib0062","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/ncb2209","article-title":"Control of PKA stability and signalling by the RING ligase praja2","volume":"13","author":"Lignitto","year":"2011","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0063","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.102","article-title":"Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways","volume":"8","author":"Zhong","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.clbc.2026.08.008_bib0064","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1365-2559.2009.03289.x","article-title":"Increased expression of SDF-1\/CXCR4 is associated with lymph node metastasis of invasive micropapillary carcinoma of the breast","volume":"54","author":"Liu","year":"2009","journal-title":"Histopathology"},{"key":"10.1016\/j.clbc.2026.08.008_bib0065","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s12253-015-9923-x","article-title":"Loss of leucine zipper putative tumor suppressor 1 (LZTS1) expression contributes to lymph node metastasis of breast invasive micropapillary carcinoma","volume":"21","author":"Wang","year":"2015","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.clbc.2026.08.008_bib0066","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/tbj.12823","article-title":"Loss of ARID1A expression is associated with poor prognosis in invasive micropapillary carcinomas of the breast: a clinicopathologic and immunohistochemical study with long-term survival analysis","volume":"23","author":"Onder","year":"2017","journal-title":"Breast J"},{"key":"10.1016\/j.clbc.2026.08.008_bib0067","article-title":"MiR-30c suppresses the proliferation, metastasis and polarity reversal of tumor cell clusters by targeting MTDH in invasive micropapillary carcinoma of the breast","volume":"10","author":"Han","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.clbc.2026.08.008_bib0068","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.prp.2010.09.008","article-title":"The clinicopathological significance of CD44+\/CD24-\/low and CD24+ tumor cells in invasive micropapillary carcinoma of the breast","volume":"206","author":"Li","year":"2010","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.clbc.2026.08.008_bib0069","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/2350073","article-title":"Comprehensive immunohistochemical analysis of epithelial\u2013mesenchymal transition biomarkers in the invasive micropapillary cancer of the breast","volume":"2024","author":"Oz","year":"2024","journal-title":"Int J Breast Cancer"},{"key":"10.1016\/j.clbc.2026.08.008_bib0070","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s10549-017-4407-1","article-title":"Amplification and overexpression of PSCA at 8q24 in invasive micropapillary carcinoma of breast","volume":"166","author":"Meng","year":"2017","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.clbc.2026.08.008_bib0071","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/path.2368","article-title":"Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast","volume":"215","author":"Marchi\u00f2","year":"2008","journal-title":"J Pathol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0072","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41467-021-27794-4","article-title":"Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast","volume":"13","author":"Shi","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.clbc.2026.08.008_bib0073","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-04380-6","article-title":"Spatial transcriptomics reveals gene expression characteristics in invasive micropapillary carcinoma of the breast","volume":"12","author":"Lv","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.clbc.2026.08.008_bib0074","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-97347-8","article-title":"Cell polarity and cell adhesion associated gene expression differences between invasive micropapillary and no special type breast carcinomas and their prognostic significance","volume":"11","author":"Kramer","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.clbc.2026.08.008_bib0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111178","article-title":"Deciphering the composition and key driver genes of breast invasive micropapillary carcinoma by multi-omics analysis","volume":"27","author":"Xie","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.clbc.2026.08.008_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2022.104511","article-title":"Integrative proteomic and phosphoproteomic profiling of invasive micropapillary breast carcinoma","volume":"257","author":"Chen","year":"2022","journal-title":"J Proteomics"},{"key":"10.1016\/j.clbc.2026.08.008_bib0077","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.ajpath.2023.05.010","article-title":"Metabolome sequencing reveals that protein arginine-N-methyltransferase 1 promotes the progression of invasive micropapillary carcinoma of the breast and predicts a poor prognosis","volume":"193","author":"Wu","year":"2023","journal-title":"Am J Pathol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0078","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1111\/cas.15724","article-title":"PRMT3 regulates the progression of invasive micropapillary carcinoma of the breast","volume":"114","author":"Zhi","year":"2023","journal-title":"Cancer Sci"},{"key":"10.1016\/j.clbc.2026.08.008_bib0079","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-072632","article-title":"Nomogram predicting overall prognosis for invasive micropapillary carcinoma of the breast: a SEER-based population study","volume":"13","author":"Liu","year":"2023","journal-title":"BMJ Open"},{"key":"10.1016\/j.clbc.2026.08.008_bib0080","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1016\/j.asjsur.2023.02.090","article-title":"Nomograms for predicting overall survival and cancer-specific survival in patients with invasive micropapillary carcinoma: based on the SEER database","volume":"46","author":"Zhang","year":"2023","journal-title":"Asian J Surg"},{"key":"10.1016\/j.clbc.2026.08.008_bib0081","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12874-024-02218-1","article-title":"Log odds of positive lymph nodes (LODDS)-based novel nomogram for survival estimation in patients with invasive micropapillary carcinoma of the breast","volume":"24","author":"Meng","year":"2024","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0082","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1231302","article-title":"Construction and validation of a nomogram for predicting the prognosis of patients with lymph node-positive invasive micropapillary carcinoma of the breast: based on SEER database and external validation cohort","volume":"13","author":"Li","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0083","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3390\/curroncol32100559","article-title":"Oncotype DX recurrence score predicts survival in invasive micropapillary breast carcinoma: a national cancer database analysis","volume":"32","author":"Haider","year":"2025","journal-title":"Curr Oncol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0084","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12911-024-02669-y","article-title":"Predictive model of prognosis index for invasive micropapillary carcinoma of the breast based on machine learning: a SEER population-based study","volume":"24","author":"Jiang","year":"2024","journal-title":"BMC Med Inform Decis Mak"},{"key":"10.1016\/j.clbc.2026.08.008_bib0085","article-title":"Prediction of lymph node metastasis in patients with breast invasive micropapillary carcinoma based on machine learning and SHapley additive exPlanations framework","volume":"12","author":"Jiang","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0086","article-title":"Survival outcomes after breast-conserving therapy compared with mastectomy for patients with early-stage invasive micropapillary carcinoma of the breast: a SEER population-based study","volume":"11","author":"Wang","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0087","doi-asserted-by":"crossref","DOI":"10.1016\/j.clbc.2020.12.003","article-title":"Nomogram predicting the risk of locoregional recurrence after mastectomy for invasive micropapillary carcinoma of the breast","volume":"21","author":"Meng","year":"2021","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.clbc.2026.08.008_bib0088","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1007\/s13304-023-01530-7","article-title":"A web-based novel model for predicting prognostic value in patients with invasive micropapillary carcinoma in breast cancer: a real-world data retrospective cohort study","volume":"75","author":"Chen","year":"2023","journal-title":"Updates Surg"},{"key":"10.1016\/j.clbc.2026.08.008_bib0089","doi-asserted-by":"crossref","first-page":"8050","DOI":"10.1002\/cam4.5595","article-title":"A prognostic nomogram based on risk assessment for invasive micropapillary carcinoma of the breast after surgery","volume":"12","author":"Chen","year":"2023","journal-title":"Cancer Med"},{"key":"10.1016\/j.clbc.2026.08.008_bib0090","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-065312","article-title":"Development and validation of nomograms to predict survival in patients with invasive micropapillary carcinoma of the breast","volume":"13","author":"Cheng","year":"2023","journal-title":"BMJ Open"},{"key":"10.1016\/j.clbc.2026.08.008_bib0091","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2022.1009149","article-title":"Nomogram for predicting overall survival in patients with invasive micropapillary carcinoma after breast-conserving surgery: a population-based analysis","volume":"9","author":"Zhao","year":"2022","journal-title":"Front Surg"},{"key":"10.1016\/j.clbc.2026.08.008_bib0092","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1177\/10668969241291878","article-title":"Endocervical adenocarcinoma with micropapillary component, a distinct histological subtype associated with aggressive behavior and poor prognosis: a clinicopathologic study of 10 patients","volume":"33","author":"Wang","year":"2025","journal-title":"Int J Surg Pathol"},{"key":"10.1016\/j.clbc.2026.08.008_bib0093","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2147\/CMAR.S141338","article-title":"Postoperative radiotherapy for invasive micropapillary carcinoma of the breast: an analysis of surveillance, epidemiology, and end results database","volume":"9","author":"Wu","year":"2017","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.clbc.2026.08.008_bib0094","article-title":"HER2-positive breast cancer with invasive micropapillary carcinoma component shows immunosuppressive microenvironment and resistance to neoadjuvant therapy","volume":"16","author":"Zhang","year":"2025","journal-title":"Front Immunol"}],"container-title":["Clinical Breast Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152682092600145X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152682092600145X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:04:54Z","timestamp":1792033494000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152682092600145X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":94,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S152682092600145X"],"URL":"https:\/\/doi.org\/10.1016\/j.clbc.2026.08.008","relation":{},"ISSN":["1526-8209"],"issn-type":[{"value":"1526-8209","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic Paradox of Breast Invasive Micropapillary Carcinoma","name":"articletitle","label":"Article Title"},{"value":"Clinical Breast Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clbc.2026.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}