{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:42:59Z","timestamp":1768534979343,"version":"3.49.0"},"reference-count":13,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinical-colorectal-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Colorectal Cancer"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.clcc.2017.10.017","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T22:16:10Z","timestamp":1509574570000},"page":"80-83","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer"],"prefix":"10.1016","volume":"17","author":[{"given":"Giovanni","family":"Germano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Mauri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7132-6484","authenticated-orcid":false,"given":"Giulia","family":"Siravegna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Dive","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackie","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9618-2010","authenticated-orcid":false,"given":"Federica","family":"Di Nicolantonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"D'Incalci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Bardelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Siena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Sartore-Bianchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clcc.2017.10.017_bib1","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1200\/JCO.2007.15.8923","article-title":"Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer","volume":"26","author":"Cohen","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clcc.2017.10.017_bib2","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1158\/0008-5472.CAN-12-4140","article-title":"Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing","volume":"73","author":"Heitzer","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.clcc.2017.10.017_bib3","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/nm.3600","article-title":"Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer","volume":"20","author":"Hodgkinson","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.clcc.2017.10.017_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15252\/emmm.201303698","article-title":"Biology, detection, and clinical implications of circulating tumor cells","volume":"7","author":"Joosse","year":"2014","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.clcc.2017.10.017_bib5","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1373\/clinchem.2012.188557","article-title":"Heterogeneity of epidermal growth factor receptor status and mutations of KRAS\/PIK3CA in circulating tumor cells of patients with colorectal cancer","volume":"59","author":"Gasch","year":"2013","journal-title":"Clin Chem"},{"key":"10.1016\/j.clcc.2017.10.017_bib6","doi-asserted-by":"crossref","first-page":"224ra24","DOI":"10.1126\/scitranslmed.3007094","article-title":"Detection of circulating tumor DNA in early- and late-stage human malignancies","volume":"6","author":"Bettegowda","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.clcc.2017.10.017_bib7","doi-asserted-by":"crossref","first-page":"346ra92","DOI":"10.1126\/scitranslmed.aaf6219","article-title":"Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer","volume":"8","author":"Tie","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.clcc.2017.10.017_bib8","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nm0715-827b","article-title":"Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients","volume":"21","author":"Siravegna","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.clcc.2017.10.017_bib9","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nm.3511","article-title":"Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA","volume":"20","author":"Thierry","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.clcc.2017.10.017_bib10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1158\/2159-8290.CD-15-1283","article-title":"Tumor heterogeneity and lesion-specific response to targeted therapy in colorectal cancer","volume":"6","author":"Russo","year":"2016","journal-title":"Cancer Discov"},{"key":"10.1016\/j.clcc.2017.10.017_bib11","first-page":"1","article-title":"Dynamic molecular analysis and clinical correlates of tumor evolution within a phase 2 trial of panitumumab-based therapy in metastatic colorectal cancer","author":"Siena","year":"2017","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clcc.2017.10.017_bib12","first-page":"1","article-title":"Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer","author":"Barault","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.clcc.2017.10.017_bib13","doi-asserted-by":"crossref","first-page":"85349","DOI":"10.18632\/oncotarget.13350","article-title":"Enumeration and targeted analysis of KRAS, BRAF, and PIK3CA mutations in CTCs captured by a label-free platform: comparison to ctDNA and tissue in metastatic colorectal cancer","volume":"7","author":"Kidess-Sigal","year":"2016","journal-title":"Oncotarget"}],"container-title":["Clinical Colorectal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1533002817303080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1533002817303080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:04:15Z","timestamp":1761519855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1533002817303080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S1533002817303080"],"URL":"https:\/\/doi.org\/10.1016\/j.clcc.2017.10.017","relation":{},"ISSN":["1533-0028"],"issn-type":[{"value":"1533-0028","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer","name":"articletitle","label":"Article Title"},{"value":"Clinical Colorectal Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clcc.2017.10.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}