{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:15:11Z","timestamp":1789780511099,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1C11009345"],"award-info":[{"award-number":["2020R1C11009345"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinical-colorectal-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Colorectal Cancer"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.clcc.2022.10.005","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T10:17:22Z","timestamp":1668161842000},"page":"129-135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pathologic Implications of Magnetic Resonance Imaging-detected Extramural Venous Invasion of Rectal Cancer"],"prefix":"10.1016","volume":"22","author":[{"given":"Hyun Gu","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2382-0939","authenticated-orcid":false,"given":"Chan Wook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Keon","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Ho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Il","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Lyul","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Sik","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Ja","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Byung","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Sik","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Cheon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clcc.2022.10.005_bib0001","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.clcc.2022.10.005_bib0002","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3393\/ac.2021.00927.0132","article-title":"Surgical treatment of low-lying rectal cancer: updates","volume":"37","author":"Cristopher Varela","year":"2021","journal-title":"Ann Coloproctol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0003","doi-asserted-by":"crossref","first-page":"iv22","DOI":"10.1093\/annonc\/mdx224","article-title":"Rectal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"28","author":"Glynne-Jones","year":"2017","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0004","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.3748\/wjg.v19.i20.3052","article-title":"Neoadjuvant-intensified treatment for rectal cancer: time to change?","volume":"19","author":"Musio","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0005","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2018.0071","article-title":"Adoption of total neoadjuvant therapy for locally advanced rectal cancer","volume":"4","author":"Cercek","year":"2018","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0006","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3393\/ac.2018.07.19","article-title":"Early and late functional outcomes of anal sphincter-sparing procedures with total mesorectal excision for anorectal adenocarcinoma","volume":"36","author":"Eldamshety","year":"2020","journal-title":"Ann Coloproctol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0007","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/BF02052215","article-title":"The role of venous and neural invasion on survival in rectal adenocarcinoma","volume":"33","author":"Horn","year":"1990","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.clcc.2022.10.005_bib0008","first-page":"320","article-title":"Analysis of Clinicopathological Factors Affecting Local Recurrence of Colorectal Cancer after Curative Resection","volume":"21","author":"Ho","year":"2005","journal-title":"J Korean Soc Coloproctol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0009","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/annonc\/mdu029","article-title":"EMVI-positive stage II rectal cancer has similar clinical outcomes as stage III disease following pre-operative chemoradiotherapy","volume":"25","author":"Chand","year":"2014","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0010","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/bjs.1800670619","article-title":"The clinical significance of invasion of veins by rectal cancer","volume":"67","author":"Talbot","year":"1980","journal-title":"Br J Surg"},{"key":"10.1016\/j.clcc.2022.10.005_bib0011","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF02055674","article-title":"Factors affecting survival after excision of the rectum for cancer: a multivariate analysis","volume":"40","author":"Bokey","year":"1997","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.clcc.2022.10.005_bib0012","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/cncr.26310","article-title":"Intramural and extramural vascular invasion in colorectal cancer: prognostic significance and quality of pathology reporting","volume":"118","author":"Betge","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.clcc.2022.10.005_bib0013","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s11547-018-0978-0","article-title":"Dynamic contrast-enhanced magnetic resonance imaging in locally advanced rectal cancer: role of perfusion parameters in the assessment of response to treatment","volume":"124","author":"Ciolina","year":"2019","journal-title":"Radiol Med"},{"key":"10.1016\/j.clcc.2022.10.005_bib0014","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.ejso.2017.03.010","article-title":"Diffusion-weighted magnetic resonance imaging in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy","volume":"43","author":"De Felice","year":"2017","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0015","doi-asserted-by":"crossref","DOI":"10.1007\/s00330-022-09086-7","article-title":"Predictive role of diffusion-weighted MRI in the assessment of response to total neoadjuvant therapy in locally advanced rectal cancer","author":"Iafrate","year":"2022","journal-title":"Eur Radiol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0016","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/bjs.4034","article-title":"Preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging","volume":"90","author":"Brown","year":"2003","journal-title":"Br J Surg"},{"key":"10.1016\/j.clcc.2022.10.005_bib0017","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/bjs.5917","article-title":"Prognostic significance of magnetic resonance imaging-detected extramural vascular invasion in rectal cancer","volume":"95","author":"Smith","year":"2008","journal-title":"Br J Surg"},{"key":"10.1016\/j.clcc.2022.10.005_bib0018","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2214\/AJR.19.21112","article-title":"The diagnostic performance of MRI for detection of extramural venous invasion in colorectal cancer: a systematic review and meta-analysis of the literature","volume":"213","author":"Kim","year":"2019","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0019","first-page":"93","article-title":"The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \"personalized\" approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.clcc.2022.10.005_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4132\/jptm.2019.09.28","article-title":"Standardized pathology report for colorectal cancer, 2nd Edition","volume":"54","author":"Kim","year":"2020","journal-title":"J Pathol Transl Med"},{"key":"10.1016\/j.clcc.2022.10.005_bib0021","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s00330-017-5026-2","article-title":"Magnetic resonance imaging for clinical management of rectal cancer: updated recommendations from the 2016 European society of gastrointestinal and abdominal radiology (ESGAR) consensus meeting","volume":"28","author":"Beets-Tan","year":"2018","journal-title":"Eur Radiol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0022","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1148\/rg.2019180114","article-title":"MRI of rectal cancer: tumor staging, imaging techniques, and management","volume":"39","author":"Horvat","year":"2019","journal-title":"RadioGraphics"},{"key":"10.1016\/j.clcc.2022.10.005_bib0023","first-page":"149","article-title":"Pathologic prognostic factors in the recurrence of rectal cancer","volume":"2","author":"Compton","year":"2002","journal-title":"Clin Colorectal Cancer"},{"key":"10.1016\/j.clcc.2022.10.005_bib0024","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/bjc.2017.99","article-title":"A meta-analysis comparing the risk of metastases in patients with rectal cancer and MRI-detected extramural vascular invasion (mrEMVI) vs mrEMVI-negative cases","volume":"116","author":"Siddiqui","year":"2017","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clcc.2022.10.005_bib0025","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2021.1919377","article-title":"Tumor spread or siege immunity: dissemination to distant metastasis or not","volume":"10","author":"Bindea","year":"2021","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.clcc.2022.10.005_bib0026","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1245\/s10434-011-2210-5","article-title":"Diagnostic accuracy of MRI for assessment of T category, lymph node metastases, and circumferential resection margin involvement in patients with rectal cancer: a systematic review and meta-analysis","volume":"19","author":"Al-Sukhni","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0027","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.709070","article-title":"Magnetic resonance imaging evaluation of the accuracy of various lymph node staging criteria in rectal cancer: a systematic review and meta-analysis","volume":"11","author":"Zhuang","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0028","first-page":"267","article-title":"The relationship between MR demonstration of extramural venous invasion and nodal disease in rectal cancer","volume":"2","author":"Koh","year":"2008","journal-title":"Clin Med Oncol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0029","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.clinimag.2016.01.007","article-title":"Correlation of MRI-detected extramural vascular invasion with regional lymph node metastasis in rectal cancer","volume":"40","author":"Liu","year":"2016","journal-title":"Clin Imaging"},{"key":"10.1016\/j.clcc.2022.10.005_bib0030","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3393\/jksc.2012.28.4.179","article-title":"An update on preoperative radiotherapy for locally advanced rectal cancer","volume":"28","author":"Yeo","year":"2012","journal-title":"J Korean Soc Coloproctol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0031","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1200\/JCO.2011.34.9068","article-title":"Magnetic resonance imaging-detected tumor response for locally advanced rectal cancer predicts survival outcomes: MERCURY experience","volume":"29","author":"Patel","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clcc.2022.10.005_bib0032","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/bjc.2013.603","article-title":"Extramural venous invasion is a potential imaging predictive biomarker of neoadjuvant treatment in rectal cancer","volume":"110","author":"Chand","year":"2014","journal-title":"Br J Cancer"}],"container-title":["Clinical Colorectal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1533002822001190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1533002822001190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:09:15Z","timestamp":1761520155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1533002822001190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S1533002822001190"],"URL":"https:\/\/doi.org\/10.1016\/j.clcc.2022.10.005","relation":{},"ISSN":["1533-0028"],"issn-type":[{"value":"1533-0028","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathologic Implications of Magnetic Resonance Imaging-detected Extramural Venous Invasion of Rectal Cancer","name":"articletitle","label":"Article Title"},{"value":"Clinical Colorectal Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clcc.2022.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}