{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:55:48Z","timestamp":1781657748762,"version":"3.54.5"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinical-colorectal-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Colorectal Cancer"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.clcc.2023.07.007","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T02:07:17Z","timestamp":1695089237000},"page":"485-495.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Secondary Primary Cancer Risk After Radiation Therapy in Rectal Cancer: A Population-Based Cohort Study With Propensity Score Matching"],"prefix":"10.1016","volume":"22","author":[{"given":"Anne","family":"Schlesinger-Raab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Schubert-Fritschle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Belka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Agha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Friess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Combs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"H\u00e4ussler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Halfter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clcc.2023.07.007_bib0001","unstructured":"Munich Cancer Registry. Cancer Statistics - Cancer specific analyses: Matrix - C19, C20 rectal cancer survival Munich, Germany. 2021. Available from: https:\/\/www.tumorregister-muenchen.de\/en\/facts\/specific_analysis.php. Accessed 13 July 2022."},{"key":"10.1016\/j.clcc.2023.07.007_bib0002","unstructured":"German Guideline Program in Oncology. S3-Guideline for Colorectal Cancer, Long Version 2.1. Berlin: AWMF online: das Portal der wissenschaftlichen Medizin; 2019. Available from: https:\/\/www.awmf.org\/leitlinien\/detail\/ll\/021-007OL.html. Accessed 13 July 2022."},{"key":"10.1016\/j.clcc.2023.07.007_bib0003","unstructured":"PDQ\u00ae Adult Treatment Editorial Board. PDQ Rectal Cancer Treatment. 2022. Available from: https:\/\/www.cancer.gov\/types\/colorectal\/hp\/rectal-treatment-pdq. Accessed 13 July 2022."},{"key":"10.1016\/j.clcc.2023.07.007_bib0004","unstructured":"Zentrum f\u00fcr Krebsregisterdaten (ZfKD). Database Query: Robert Koch - Institute; 2021. Available from: https:\/\/www.krebsdaten.de\/Krebs\/DE\/Datenbankabfrage\/datenbankabfrage_stufe1_node.html;jsessionid=51C99398B0E593B69B6CEA0517607EBF.internet062. Accessed 13 July 2022."},{"issue":"3","key":"10.1016\/j.clcc.2023.07.007_bib0005","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00384-022-04105-x","article-title":"Risk of extracolonic second primary cancers following a primary colorectal cancer: a systematic review and meta-analysis","volume":"37","author":"Robertson","year":"2022","journal-title":"Int J Colorect Dis"},{"key":"10.1016\/j.clcc.2023.07.007_bib0006","series-title":"New Malignancies among Cancer Survivors: SEER Cancer Registries, 1973-2000","first-page":"111","article-title":"New malignancies following cancer of the colon, rectum, and anus","author":"Mysliwiec","year":"2006"},{"issue":"6","key":"10.1016\/j.clcc.2023.07.007_bib0007","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00432-014-1647-x","article-title":"Multiple primary tumors following stage II and III rectal cancer in patients receiving radiotherapy, 1998-2010","volume":"140","author":"Smith-Gagen","year":"2014","journal-title":"J Cancer Res Clin Oncol"},{"issue":"4","key":"10.1016\/j.clcc.2023.07.007_bib0008","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S1470-2045(11)70061-4","article-title":"Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registries","volume":"12","author":"Berrington de Gonzalez","year":"2011","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.clcc.2023.07.007_bib0009","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3390\/curroncol28010035","article-title":"The impact of radiotherapy on the incidence of secondary malignancies: a pan-cancer study in the US SEER cancer registries","volume":"28","author":"Li","year":"2021","journal-title":"Curr Oncol"},{"issue":"1","key":"10.1016\/j.clcc.2023.07.007_bib0010","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.radonc.2017.02.007","article-title":"Secondary malignancies after rectal cancer resection with and without radiation therapy: a propensity-adjusted, population-based SEER analysis","volume":"123","author":"Warschkow","year":"2017","journal-title":"Radiother Oncol"},{"issue":"25","key":"10.1016\/j.clcc.2023.07.007_bib0011","doi-asserted-by":"crossref","first-page":"6126","DOI":"10.1200\/JCO.2005.02.543","article-title":"Occurrence of second cancers in patients treated with radiotherapy for rectal cancer","volume":"23","author":"Birgisson","year":"2005","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.clcc.2023.07.007_bib0012","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/bjs.10327","article-title":"Risk of second primary cancer in patients treated with radiotherapy for rectal cancer","volume":"104","author":"Martling","year":"2017","journal-title":"BJS (British Journal of Surgery)"},{"issue":"4","key":"10.1016\/j.clcc.2023.07.007_bib0013","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3390\/medicina55040104","article-title":"A population-based study of secondary prostate cancer risk after radiotherapy in male patients with rectal cancer: a retrospective cohort study","volume":"55","author":"Chuang","year":"2019","journal-title":"Medicina (Kaunas)"},{"issue":"40","key":"10.1016\/j.clcc.2023.07.007_bib0014","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.3748\/wjg.v24.i40.4586","article-title":"Second primary malignancy risk after radiotherapy in rectal cancer survivors","volume":"24","author":"Wang","year":"2018","journal-title":"World J Gastroenterol"},{"issue":"3","key":"10.1016\/j.clcc.2023.07.007_bib0015","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/annonc\/mdw661","article-title":"Incidence of second tumors after treatment with or without radiation for rectal cancer","volume":"28","author":"Rombouts","year":"2017","journal-title":"Ann Oncol"},{"issue":"15","key":"10.1016\/j.clcc.2023.07.007_bib0016","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1200\/JCO.2014.58.6693","article-title":"No increased risk of second cancer after radiotherapy in patients treated for rectal or endometrial cancer in the randomized TME, PORTEC-1, and PORTEC-2 trials","volume":"33","author":"Wiltink","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clcc.2023.07.007_bib0017","unstructured":"Munich Cancer Registry. Catchment area of MCR 2021. Available from: https:\/\/www.tumorregister-muenchen.de\/en\/area.php. Accessed 13 July 2022."},{"key":"10.1016\/j.clcc.2023.07.007_bib0018","series-title":"The Statistical Analysis of Failure Time Data","author":"Kalbfleisch","year":"2002"},{"issue":"446","key":"10.1016\/j.clcc.2023.07.007_bib0019","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A proportional hazards model for the subdistribution of a competing risk","volume":"94","author":"Fine","year":"1999","journal-title":"J Am Stats Assoc"},{"issue":"1","key":"10.1016\/j.clcc.2023.07.007_bib0020","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/biomet\/70.1.41","article-title":"The central role of the propensity score in observational studies for causal effects","volume":"70","author":"Rosenbaum","year":"1983","journal-title":"Biometrika"},{"issue":"2","key":"10.1016\/j.clcc.2023.07.007_bib0021","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.cmpb.2014.11.009","article-title":"PSHREG: a SAS macro for proportional and nonproportional subdistribution hazards regression","volume":"118","author":"Kohl","year":"2015","journal-title":"Comput Meth Progr Biomed"},{"issue":"12","key":"10.1016\/j.clcc.2023.07.007_bib0022","doi-asserted-by":"crossref","first-page":"4744","DOI":"10.3390\/ijerph9124744","article-title":"Second malignant neoplasms following radiotherapy","volume":"9","author":"Kumar","year":"2012","journal-title":"Int J Environ Res Public Health [Internet]"},{"key":"10.1016\/j.clcc.2023.07.007_bib0023","unstructured":"Surveillance Research Program NCI. SEER*Explorer: an interactive website for SEER cancer statistics [Internet]. 2021. Available from: https:\/\/seer.cancer.gov\/statistics-network\/explorer\/. Accessed 27 September 2021."},{"issue":"11","key":"10.1016\/j.clcc.2023.07.007_bib0024","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1002\/ijc.31785","article-title":"An overview of 25 years of incidence, treatment and outcome of colorectal cancer patients","volume":"143","author":"Brouwer","year":"2018","journal-title":"Int J Cancer"},{"key":"10.1016\/j.clcc.2023.07.007_bib0025","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejca.2022.05.032","article-title":"Survival trends in patients diagnosed with colon and rectal cancer in the nordic countries 1990-2016: the NORDCAN survival studies","volume":"172","author":"Lundberg","year":"2022","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.clcc.2023.07.007_bib0026","unstructured":"Cancer Research UK. One-, five- and ten-year survival for bowel cancer 2022. Available from: https:\/\/www.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/bowel-cancer\/survival#heading-Zero. Accessed 13 July 2022."},{"issue":"34","key":"10.1016\/j.clcc.2023.07.007_bib0027","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.14694\/EdBook_AM.2014.34.e57","article-title":"The rising incidence of second cancers: patterns of occurrence and identification of risk factors for children and adults","author":"Morton","year":"2014","journal-title":"Am Soc Clin Oncol Educ Book"},{"issue":"11","key":"10.1016\/j.clcc.2023.07.007_bib0028","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1158\/1055-9965.EPI-06-0414","article-title":"The epidemiology of second primary cancers","volume":"15","author":"Travis","year":"2006","journal-title":"Cancer Epidemiol, Biomark Prev"}],"container-title":["Clinical Colorectal Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1533002823000889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1533002823000889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:09:07Z","timestamp":1761520147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1533002823000889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S1533002823000889"],"URL":"https:\/\/doi.org\/10.1016\/j.clcc.2023.07.007","relation":{},"ISSN":["1533-0028"],"issn-type":[{"value":"1533-0028","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Secondary Primary Cancer Risk After Radiation Therapy in Rectal Cancer: A Population-Based Cohort Study With Propensity Score Matching","name":"articletitle","label":"Article Title"},{"value":"Clinical Colorectal Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clcc.2023.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}