{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:45:27Z","timestamp":1791276327526,"version":"4.1.0"},"reference-count":147,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics in Liver Disease"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.cld.2008.07.002","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T08:23:53Z","timestamp":1225441433000},"page":"861-882","source":"Crossref","is-referenced-by-count":87,"title":["Immune Interactions in Hepatic Fibrosis"],"prefix":"10.1016","volume":"12","author":[{"given":"Andrew P.","family":"Holt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cld.2008.07.002_bib1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1471-4906(01)01863-4","article-title":"Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation","volume":"22","author":"Buckley","year":"2001","journal-title":"Trends Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib2","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI1018","article-title":"Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors","volume":"102","author":"Iredale","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cld.2008.07.002_bib3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0002-9440(10)65262-5","article-title":"Expression and regulation of cell adhesion molecules by hepatic stellate cells (HSC) of rat liver: involvement of HSC in recruitment of inflammatory cells during hepatic tissue repair","volume":"154","author":"Knittel","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cld.2008.07.002_bib4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1172\/JCI200522675","article-title":"Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair","volume":"115","author":"Duffield","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.cld.2008.07.002_bib5","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1365-2249.2007.03353.x","article-title":"Lymphocyte-hepatic stellate cell proximity suggests a direct interaction","volume":"148","author":"Muhanna","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib6","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"Friedman","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cld.2008.07.002_bib7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.coph.2006.03.007","article-title":"Targeting the stromal microenvironment in chronic inflammation","volume":"6","author":"Filer","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.cld.2008.07.002_bib8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1016\/j.cld.2008.07.002_bib9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1055\/s-2001-17557","article-title":"Hepatic stellate cell behavior during resolution of liver injury","volume":"21","author":"Iredale","year":"2001","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.cld.2008.07.002_bib10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.it.2004.11.014","article-title":"A stromal address code defined by fibroblasts","volume":"26","author":"Parsonage","year":"2005","journal-title":"Trends Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib11","doi-asserted-by":"crossref","first-page":"7556","DOI":"10.4049\/jimmunol.166.12.7556","article-title":"Peripheral blood fibrocytes: differentiation pathway and migration to wound sites","volume":"166","author":"Abe","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib12","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity","volume":"5","author":"Gordon","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","article-title":"Blood monocytes consist of two principal subsets with distinct migratory properties","volume":"19","author":"Geissmann","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.cld.2008.07.002_bib14","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI200420997","article-title":"Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis","volume":"114","author":"Phillips","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cld.2008.07.002_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11926-006-0055-x","article-title":"The role of circulating fibrocytes in fibrosis","volume":"8","author":"Quan","year":"2006","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.cld.2008.07.002_bib16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jhep.2006.04.014","article-title":"Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis","volume":"45","author":"Kisseleva","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.cld.2008.07.002_bib17","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/(SICI)1097-0215(19970502)71:3<402::AID-IJC17>3.0.CO;2-H","article-title":"Discrimination of fibroblast subtypes by multivariate analysis of gene expression","volume":"71","author":"Spanakis","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cld.2008.07.002_bib18","doi-asserted-by":"crossref","first-page":"12877","DOI":"10.1073\/pnas.162488599","article-title":"Diversity, topographic differentiation, and positional memory in human fibroblasts","volume":"99","author":"Chang","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cld.2008.07.002_bib19","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/(SICI)1097-0215(19980529)76:5<767::AID-IJC24>3.0.CO;2-#","article-title":"Phenotypic diversity in human fibroblasts from myelometaplasic and non-myelometaplasic hematopoietic tissues","volume":"76","author":"Brouty-Boye","year":"1998","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cld.2008.07.002_bib20","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/hep.20427","article-title":"A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations","volume":"40","author":"Magness","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.002_bib21","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0168-8278(02)00263-5","article-title":"Beauty is in the eye of the beholder: emerging concepts and pitfalls in hepatic stellate cell research","volume":"37","author":"Cassiman","year":"2002","journal-title":"J Hepatol"},{"key":"10.1016\/j.cld.2008.07.002_bib22","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1002\/1529-0131(200009)43:9<2046::AID-ANR16>3.0.CO;2-8","article-title":"Mesenchymal cells expressing bone morphogenetic protein receptors are present in the rheumatoid arthritis joint","volume":"43","author":"Marinova-Mutafchieva","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cld.2008.07.002_bib23","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1084\/jem.20061287","article-title":"Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage","volume":"204","author":"Dunn","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.cld.2008.07.002_bib24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jhep.2005.12.025","article-title":"Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC","volume":"45","author":"Melhem","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.cld.2008.07.002_bib25","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1053\/j.gastro.2005.10.055","article-title":"Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners","volume":"130","author":"Radaeva","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2008.07.002_bib26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S1386-6346(02)00247-4","article-title":"Infiltrating neutrophils in bile duct-ligated livers do not promote hepatic fibrosis","volume":"25","author":"Saito","year":"2003","journal-title":"Hepatol Res"},{"key":"10.1016\/j.cld.2008.07.002_bib27","doi-asserted-by":"crossref","first-page":"G734","DOI":"10.1152\/ajpgi.00300.2003","article-title":"Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury","volume":"287","author":"Xu","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.cld.2008.07.002_bib28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1055\/s-2007-1007105","article-title":"Cytokines and fibrogenesis","volume":"19","author":"Friedman","year":"1999","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.cld.2008.07.002_bib29","doi-asserted-by":"crossref","first-page":"7565","DOI":"10.4049\/jimmunol.172.12.7565","article-title":"Enhancer-mediated control of macrophage-specific arginase I expression","volume":"172","author":"Pauleau","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib30","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.4049\/jimmunol.171.7.3655","article-title":"Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair","volume":"171","author":"Sandler","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib31","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/hep.22011","article-title":"Coculture of human liver macrophages and cholangiocytes leads to CD40-dependent apoptosis and cytokine secretion","volume":"47","author":"Alabraba","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.002_bib32","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1568-9972(02)00027-7","article-title":"Role of profibrogenic cytokines secreted by T cells in fibrotic processes in scleroderma","volume":"1","author":"McGaha","year":"2002","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.cld.2008.07.002_bib33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/CS20060242","article-title":"Liver fibrosis: cellular mechanisms of progression and resolution","volume":"112","author":"Henderson","year":"2007","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.cld.2008.07.002_bib34","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jcpa.2005.01.011","article-title":"Effects of gadolinium chloride (GdCl(3)) on the appearance of macrophage populations and fibrogenesis in thioacetamide-induced rat hepatic lesions","volume":"133","author":"Ide","year":"2005","journal-title":"J Comp Pathol"},{"key":"10.1016\/j.cld.2008.07.002_bib35","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1053\/j.gastro.2004.10.005","article-title":"Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats","volume":"128","author":"Imamura","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2008.07.002_bib36","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cld.2008.07.002_bib37","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/nature03491","article-title":"IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation","volume":"434","author":"Lawrence","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.cld.2008.07.002_bib38","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.4049\/jimmunol.164.7.3862","article-title":"Induction of functional IL-8 receptors by IL-4 and IL-13 in human monocytes","volume":"164","author":"Bonecchi","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1006\/cimm.2000.1687","article-title":"Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts","volume":"204","author":"Song","year":"2000","journal-title":"Cell Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib40","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1096\/fj.02-0494fje","article-title":"Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration","volume":"17","author":"Issa","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.cld.2008.07.002_bib41","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.4049\/jimmunol.178.8.5288","article-title":"Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis","volume":"178","author":"Fallowfield","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1172\/JCI200523928","article-title":"Mac the knife? Macrophages- the double-edged sword of hepatic fibrosis","volume":"115","author":"Friedman","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cld.2008.07.002_bib43","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1182\/blood-2002-01-0312","article-title":"Long-lived immature dendritic cells mediated by TRANCE-RANK interaction","volume":"100","author":"Cremer","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.cld.2008.07.002_bib44","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0002-9440(10)63141-0","article-title":"Interleukin-10 secretion differentiates dendritic cells from human liver and skin","volume":"164","author":"Goddard","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cld.2008.07.002_bib45","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1084\/jem.20011608","article-title":"The CD16(+) (FcgammaRIII(+)) subset of human monocytes preferentially becomes migratory dendritic cells in a model tissue setting","volume":"196","author":"Randolph","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.cld.2008.07.002_bib46","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1046\/j.1440-1711.1999.00851.x","article-title":"Long-term stroma-dependent cultures are a consistent source of immunostimulatory dendritic cells","volume":"77","author":"O'Neill","year":"1999","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.cld.2008.07.002_bib47","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2249.2005.02792.x","article-title":"Importance of stromal determinants in the generation of dendritic and natural killer cells in the human spleen","volume":"140","author":"Briard","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib48","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/ni1130","article-title":"Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells","volume":"5","author":"Zhang","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib49","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.4049\/jimmunol.178.8.4966","article-title":"Dermal fibroblasts induce maturation of dendritic cells","volume":"178","author":"Saalbach","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib50","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jhep.2007.03.024","article-title":"Hepatitis C is associated with perturbation of intrahepatic myeloid and plasmacytoid dendritic cell function","volume":"47","author":"Lai","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.cld.2008.07.002_bib51","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4049\/jimmunol.177.1.280","article-title":"Follicular dendritic cells are related to bone marrow stromal cell progenitors and to myofibroblasts","volume":"177","author":"Munoz-Fernandez","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib52","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.immuni.2006.11.011","article-title":"Ito cells are liver-resident antigen-presenting cells for activating T cell responses","volume":"26","author":"Winau","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.cld.2008.07.002_bib53","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1053\/jhep.2003.50097","article-title":"Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype","volume":"37","author":"Schnabl","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.002_bib54","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1172\/JCI116753","article-title":"Cultured human liver fat-storing cells produce monocyte chemotactic protein-1. Regulation by proinflammatory cytokines","volume":"92","author":"Marra","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cld.2008.07.002_bib55","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/0016-5085(94)90023-X","article-title":"Biosynthesis of platelet-activating factor and its 1O-acyl analogue by liver fat-storing cells","volume":"106","author":"Pinzani","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2008.07.002_bib56","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/S0168-8278(99)80327-4","article-title":"Hepatic stellate cells and the regulation of liver inflammation","volume":"31","author":"Marra","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.cld.2008.07.002_bib57","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1055\/s-2007-991512","article-title":"Immune-mediated liver injury","volume":"27","author":"Eksteen","year":"2007","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.cld.2008.07.002_bib58","doi-asserted-by":"crossref","first-page":"14098","DOI":"10.1073\/pnas.0511200103","article-title":"Secondary lymphoid tissue chemokine (SLC\/CCL21)\/CCR7 signaling regulates fibrocytes in renal fibrosis","volume":"103","author":"Sakai","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cld.2008.07.002_bib59","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1210\/jc.87.1.385","article-title":"Orbital fibroblast heterogeneity may determine the clinical presentation of thyroid-associated ophthalmopathy","volume":"87","author":"Smith","year":"2002","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.cld.2008.07.002_bib60","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4049\/jimmunol.171.1.380","article-title":"Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma","volume":"171","author":"Schmidt","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib61","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1160\/TH03-04-0208","article-title":"Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns","volume":"90","author":"Parsonage","year":"2003","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.cld.2008.07.002_bib62","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.4049\/jimmunol.165.6.3423","article-title":"Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium","volume":"165","author":"Buckley","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib63","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/(SICI)1521-4141(199903)29:03<1041::AID-IMMU1041>3.0.CO;2-#","article-title":"Interferon-beta mediates stromal cell rescue of T cells from apoptosis","volume":"29","author":"Pilling","year":"1999","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib64","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1002\/(SICI)1521-4141(199908)29:08<2603::AID-IMMU2603>3.0.CO;2-L","article-title":"Inhibition of T cell apoptosis by IFN-beta rapidly reverses nuclear translocation of protein kinase C-delta","volume":"29","author":"Scheel-Toellner","year":"1999","journal-title":"Eur J\u00a0Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib65","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/jcp.1041170310","article-title":"Abnormal behavior of cultured fibroblasts from nodule and nonaffected aponeurosis of Dupuytren's disease","volume":"117","author":"Azzarone","year":"1983","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.cld.2008.07.002_bib66","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/ijc.2910330608","article-title":"Abnormal properties of skin fibroblasts from patients with breast cancer","volume":"33","author":"Azzarone","year":"1984","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cld.2008.07.002_bib67","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/ar113","article-title":"Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis","volume":"2","author":"Pap","year":"2000","journal-title":"Arthritis Res"},{"key":"10.1016\/j.cld.2008.07.002_bib68","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1053\/j.gastro.2005.11.017","article-title":"From fat to inflammation","volume":"130","author":"Day","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2008.07.002_bib69","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1038\/sj.onc.1203933","article-title":"Unusual interleukin-4 and -13 signaling in human normal and tumor lung fibroblasts","volume":"19","author":"Doucet","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.cld.2008.07.002_bib70","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbrc.2004.10.020","article-title":"LPS-mediated NFkappaB activation varies between activated human hepatic stellate cells from different donors","volume":"325","author":"Muhlbauer","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cld.2008.07.002_bib71","first-page":"375","article-title":"RelB regulation of chemokine expression modulates local inflammation","volume":"151","author":"Xia","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cld.2008.07.002_bib72","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0002-9440(10)62291-2","article-title":"Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury","volume":"166","author":"Oakley","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cld.2008.07.002_bib73","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/01.RES.0000182903.16652.d7","article-title":"Endothelial\/pericyte interactions","volume":"97","author":"Armulik","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.cld.2008.07.002_bib74","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1172\/JCI32479","article-title":"Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis","volume":"117","author":"Nissen","year":"2007","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.cld.2008.07.002_bib75","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cld.2008.07.002_bib76","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.dld.2004.01.003","article-title":"Liver fibrosis: from the bench to clinical targets","volume":"36","author":"Pinzani","year":"2004","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.cld.2008.07.002_bib77","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0168-8278(01)00260-4","article-title":"Hepatic stellate cell\/myofibroblast subpopulations in fibrotic human and rat livers","volume":"36","author":"Cassiman","year":"2002","journal-title":"J Hepatol"},{"key":"10.1016\/j.cld.2008.07.002_bib78","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF00695054","article-title":"The scarring of the liver acini (cirrhosis). Tridimensional and microcirculatory considerations","volume":"402","author":"Rappaport","year":"1983","journal-title":"Virchows Arch A\u00a0Pathol Anat Histopathol"},{"key":"10.1016\/j.cld.2008.07.002_bib79","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.5858\/2000-124-1599-ROHC","article-title":"Regression of human cirrhosis. Morphologic features and the genesis of incomplete septal cirrhosis","volume":"124","author":"Wanless","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.cld.2008.07.002_bib80","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1055\/s-2001-17554","article-title":"Cytokine receptors and signaling in hepatic stellate cells","volume":"21","author":"Pinzani","year":"2001","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.cld.2008.07.002_bib81","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0676.1998.tb00120.x","article-title":"Signal transduction in hepatic stellate cells","volume":"18","author":"Pinzani","year":"1998","journal-title":"Liver"},{"key":"10.1016\/j.cld.2008.07.002_bib82","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1124\/jpet.106.114496","article-title":"Local inhibition of liver fibrosis by specific delivery of a platelet-derived growth factor kinase inhibitor to hepatic stellate cells","volume":"321","author":"Gonzalo","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.cld.2008.07.002_bib83","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1182\/blood.V100.12.3853","article-title":"Leukocyte extravasation: chemokine transport and presentation by the endothelium","volume":"100","author":"Middleton","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.cld.2008.07.002_bib84","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0168-8278(00)00058-1","article-title":"Three-dimensional observations of the human hepatic artery (arterial system in the liver)","volume":"34","author":"Takasaki","year":"2001","journal-title":"J Hepatol"},{"key":"10.1016\/j.cld.2008.07.002_bib85","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1084\/jem.185.4.777","article-title":"A novel migration pathway for rat dendritic cells from the blood: hepatic sinusoids-lymph translocation","volume":"185","author":"Kudo","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.cld.2008.07.002_bib86","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nri981","article-title":"Hepatic T cells and liver tolerance","volume":"3","author":"Crispe","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib87","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nri1784","article-title":"Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease","volume":"6","author":"Adams","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib88","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1476-5926-3-4","article-title":"Scavenger properties of cultivated pig liver endothelial cells","volume":"3","author":"Elvevold","year":"2004","journal-title":"Comp Hepatol"},{"key":"10.1016\/j.cld.2008.07.002_bib89","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1172\/JCI119468","article-title":"A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature","volume":"99","author":"Wong","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cld.2008.07.002_bib90","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/hep.510240311","article-title":"Expression of E-selectin and E-selectin ligands in human liver inflammation","volume":"24","author":"Adams","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.002_bib91","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1053\/gast.1996.v110.pm8566600","article-title":"Vascular adhesion protein 1 mediates binding of T cells to human hepatic endothelium","volume":"110","author":"McNab","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2008.07.002_bib92","doi-asserted-by":"crossref","first-page":"983","DOI":"10.4049\/jimmunol.169.2.983","article-title":"Vascular adhesion protein-1 mediates adhesion and transmigration of lymphocytes on human hepatic endothelial cells","volume":"169","author":"Lalor","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib93","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1084\/jem.191.6.1051","article-title":"An essential role for thymic mesenchyme in early T cell development","volume":"191","author":"Suniara","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.cld.2008.07.002_bib94","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/hep.510290107","article-title":"Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cells","volume":"29","author":"Marra","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.002_bib95","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/hep.510240333","article-title":"Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells","volume":"24","author":"Hellerbrand","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.002_bib96","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1046\/j.1440-1711.2002.01062.x","article-title":"Recruitment of lymphocytes to the human liver","volume":"80","author":"Lalor","year":"2002","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.cld.2008.07.002_bib97","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0002-9440(10)62060-3","article-title":"CXCR3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow","volume":"167","author":"Curbishley","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cld.2008.07.002_bib98","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.4049\/jimmunol.174.2.1055","article-title":"CXC chemokine ligand 16 promotes integrin-mediated adhesion of liver-infiltrating lymphocytes to cholangiocytes and hepatocytes within the inflamed human liver","volume":"174","author":"Heydtmann","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib99","doi-asserted-by":"crossref","first-page":"729","DOI":"10.4049\/jimmunol.177.1.729","article-title":"Detailed analysis of intrahepatic CD8 T cells in the normal and hepatitis C-infected liver reveals differences in specific populations of memory cells with distinct homing phenotypes","volume":"177","author":"Heydtmann","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib100","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0168-8278(02)00065-X","article-title":"Up-regulated expression of fractalkine and its receptor CX3CR1 during liver injury in humans","volume":"37","author":"Efsen","year":"2002","journal-title":"J Hepatol."},{"key":"10.1016\/j.cld.2008.07.002_bib101","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/hep.20582","article-title":"Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts","volume":"41","author":"Isse","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.002_bib102","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1002\/eji.1830251241","article-title":"C-C chemokines, but not the C-X-C chemokines interleukin-8 and interferon-gamma inducible protein-10, stimulate transendothelial chemotaxis of T lymphocytes","volume":"25","author":"Roth","year":"1995","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib103","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1172\/JCI117788","article-title":"Monocyte chemotactic protein-1 -2 and -3 are chemotactic for human T lymphocytes","volume":"95","author":"Taub","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cld.2008.07.002_bib104","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/jlb.55.1.120","article-title":"Monocyte chemoattractant protein-1 expression occurs in toxic rat liver injury and human liver disease","volume":"55","author":"Czaja","year":"1994","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.cld.2008.07.002_bib105","unstructured":"Holt A, et al, submitted."},{"key":"10.1016\/j.cld.2008.07.002_bib106","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1053\/j.gastro.2004.04.062","article-title":"Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes","volume":"127","author":"Safadi","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2008.07.002_bib107","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0016-5085(00)70134-X","article-title":"Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders","volume":"118","author":"Nelson","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2008.07.002_bib108","first-page":"295","article-title":"Interleukin-6 production by human liver (myo)fibroblasts in culture. Evidence for a regulatory role of LPS, IL-1 beta and TNF alpha","volume":"23","author":"Tiggelman","year":"1995","journal-title":"J Hepatol"},{"key":"10.1016\/j.cld.2008.07.002_bib109","doi-asserted-by":"crossref","first-page":"609","DOI":"10.4049\/jimmunol.147.2.609","article-title":"Transforming growth factor-beta induces human T lymphocyte migration in vitro","volume":"147","author":"Adams","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib110","first-page":"511","article-title":"Secretion of soluble chemotactic factors, including interleukin-6: a mechanism for the recruitment of CD8-positive T lymphocytes to human liver allografts during rejection","volume":"18","author":"Hathaway","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.002_bib111","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0024-3205(93)90654-L","article-title":"Hepatocyte growth factor enhances B-cell activity","volume":"53","author":"Delaney","year":"1993","journal-title":"Life Sci"},{"key":"10.1016\/j.cld.2008.07.002_bib112","doi-asserted-by":"crossref","first-page":"7144","DOI":"10.1073\/pnas.91.15.7144","article-title":"Hepatocyte growth factor and macrophage inflammatory protein 1 beta: structurally distinct cytokines that induce rapid cytoskeletal changes and subset-preferential migration in T cells","volume":"91","author":"Adams","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cld.2008.07.002_bib113","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/ni1330","article-title":"Lymphoid organ development: from ontogeny to neogenesis","volume":"7","author":"Drayton","year":"2006","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.cld.2008.07.002_bib114","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0002-9440(10)64981-4","article-title":"Lymphoid tissue homing chemokines are expressed in chronic inflammation","volume":"156","author":"Hjelmstrom","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cld.2008.07.002_bib115","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/S0016-5085(03)01194-6","article-title":"The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C","volume":"125","author":"Bonacchi","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2008.07.002_bib116","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0002-9440(10)62570-9","article-title":"Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease","volume":"160","author":"Grant","year":"2002","journal-title":"Am J\u00a0Pathol"},{"key":"10.1016\/j.cld.2008.07.002_bib117","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nri1222","article-title":"Homing and cellular traffic in lymph nodes","volume":"3","author":"von Andrian","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib118","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.immuni.2006.10.011","article-title":"Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes","volume":"25","author":"Bajenoff","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.cld.2008.07.002_bib119","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nature02238","article-title":"T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases","volume":"427","author":"Mempel","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.cld.2008.07.002_bib120","first-page":"185","article-title":"Sinusoidal intercellular adhesion molecule-1 up-regulation precedes the accumulation of leukocyte function antigen-1-positive cells and tissue necrosis in a model of carbontetrachloride-induced acute rat liver injury","volume":"78","author":"Neubauer","year":"1998","journal-title":"Lab Invest"},{"key":"10.1016\/j.cld.2008.07.002_bib121","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.bbrc.2006.11.029","article-title":"CD133+ hepatic stellate cells are progenitor cells","volume":"352","author":"Kordes","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cld.2008.07.002_bib122","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1189\/jlb.0605350","article-title":"Chemokine- and adhesion-dependent survival of neutrophils after transmigration through cytokine-stimulated endothelium","volume":"79","author":"McGettrick","year":"2006","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.cld.2008.07.002_bib123","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1182\/blood-2005-07-2692","article-title":"Interaction between integrin alpha9beta1 and vascular cell adhesion molecule-1 (VCAM-1) inhibits neutrophil apoptosis","volume":"107","author":"Ross","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cld.2008.07.002_bib124","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1002\/art.21930","article-title":"Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils","volume":"54","author":"Filer","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cld.2008.07.002_bib125","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1126\/science.272.5270.1947","article-title":"Induction of bystander T-cell proliferation by viruses and type-I Interferon in-vivo","volume":"272","author":"Tough","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.cld.2008.07.002_bib126","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1055\/s-2007-1007208","article-title":"Bystander activation by cytokines of intrahepatic T cells in chronic viral hepatitis","volume":"17","author":"Abrignani","year":"1997","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.cld.2008.07.002_bib127","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.4049\/jimmunol.162.8.4527","article-title":"Bystander virus infection prolongs activated T\u00a0cell survival","volume":"162","author":"Mitchell","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib128","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.4049\/jimmunol.163.3.1315","article-title":"Primed T cells are more resistant to Fas-mediated activation-induced cell death than naive T cells","volume":"163","author":"Inaba","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib129","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","article-title":"Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ","volume":"117","author":"Iredale","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cld.2008.07.002_bib130","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/hep.21155","article-title":"Attenuated liver fibrosis in the absence of B\u00a0cells","volume":"43","author":"Holt","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.002_bib131","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1172\/JCI24798","article-title":"Attenuated liver fibrosis in the absence of B cells","volume":"115","author":"Novobrantseva","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cld.2008.07.002_bib132","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1172\/JCI7325","article-title":"An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response","volume":"104","author":"Chiaramonte","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cld.2008.07.002_bib133","doi-asserted-by":"crossref","first-page":"920","DOI":"10.4049\/jimmunol.162.2.920","article-title":"IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs","volume":"162","author":"Chiaramonte","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib134","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1096\/fj.01-0306fje","article-title":"Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions","volume":"15","author":"Hoffmann","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.cld.2008.07.002_bib135","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.4049\/jimmunol.167.2.1081","article-title":"Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice","volume":"167","author":"Tian","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib136","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.4049\/jimmunol.170.12.5897","article-title":"B cells activated by lipopolysaccharide, but not by anti-Ig and anti-CD40 antibody, induce anergy in CD8+ T cells: role of TGF-beta 1","volume":"170","author":"Parekh","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib137","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/82707","article-title":"Complexity or coherence? Cytokine secretion by B cells","volume":"1","author":"Mosmann","year":"2000","journal-title":"Nat Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib138","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/82717","article-title":"Reciprocal regulation of polarized cytokine production by effector B and T cells","volume":"1","author":"Harris","year":"2000","journal-title":"Nat Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib139","doi-asserted-by":"crossref","first-page":"7103","DOI":"10.4049\/jimmunol.175.11.7103","article-title":"Cutting edge: the development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cells","volume":"175","author":"Harris","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib140","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nm1332","article-title":"IL-13 signaling through the IL-13alpha(2) receptor is involved in induction of TGF-beta(1) production and fibrosis","volume":"12","author":"Fichtner-Feigl","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.cld.2008.07.002_bib141","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1084\/jem.189.2.441","article-title":"CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection","volume":"189","author":"Afford","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.cld.2008.07.002_bib142","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1046\/j.1365-3083.1998.00376.x","article-title":"Infection of B-cell-deficient mice by the parasite Schistosoma mansoni: demonstration of the participation of B cells in granuloma modulation","volume":"48","author":"Ferru","year":"1998","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib143","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.4049\/jimmunol.173.2.1417","article-title":"Production of profibrotic cytokines by invariant NKT cells characterizes cirrhosis progression in chronic viral hepatitis","volume":"173","author":"de","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib144","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1093\/intimm\/dxm069","article-title":"Amelioration of hepatic fibrosis via beta-glucosylceramide-mediated immune modulation is associated with altered CD8 and NKT lymphocyte distribution","volume":"19","author":"Safadi","year":"2007","journal-title":"Int Immunol"},{"key":"10.1016\/j.cld.2008.07.002_bib145","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0002-9440(10)61211-4","article-title":"Natural killer T (NKT) cells attenuate bleomycin-induced pulmonary fibrosis by producing interferon-gamma","volume":"167","author":"Kim","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cld.2008.07.002_bib146","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/hep.22052","article-title":"Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis","volume":"47","author":"Chuang","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.002_bib147","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1084\/jem.20051759","article-title":"An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium","volume":"203","author":"Johnson","year":"2006","journal-title":"J Exp Med"}],"container-title":["Clinics in Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326108000731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326108000731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T20:59:34Z","timestamp":1684616374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089326108000731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":147,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S1089326108000731"],"URL":"https:\/\/doi.org\/10.1016\/j.cld.2008.07.002","relation":{},"ISSN":["1089-3261"],"issn-type":[{"value":"1089-3261","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}