{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:51:21Z","timestamp":1762458681527},"reference-count":53,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics in Liver Disease"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.cld.2008.07.012","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T08:23:53Z","timestamp":1225441433000},"page":"747-757","source":"Crossref","is-referenced-by-count":30,"title":["Genetic Determinants in Hepatic Fibrosis: From Experimental Models to Fibrogenic Gene Signatures in Humans"],"prefix":"10.1016","volume":"12","author":[{"given":"Susanne","family":"Weber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olav A.","family":"Gressner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabea","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Gr\u00fcnhage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Lammert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cld.2008.07.012_bib1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s004410051073","article-title":"The cell biology of liver fibrogenesis\u2014an imbalance of proliferation,\u00a0growth arrest and apoptosis of myofibroblasts","volume":"292","author":"Gressner","year":"1998","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.cld.2008.07.012_bib2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ncpgasthep0055","article-title":"Mechanisms of disease: mechanisms of hepatic fibrosis and therapeutic implications","volume":"1","author":"Friedman","year":"2004","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1016\/j.cld.2008.07.012_bib3","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1582-4934.2006.tb00292.x","article-title":"Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets","volume":"10","author":"Gressner","year":"2006","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.cld.2008.07.012_bib4","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0140-6736(08)60383-9","article-title":"Liver cirrhosis","volume":"371","author":"Schupan","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.cld.2008.07.012_bib5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cld.2008.07.012_bib6","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0140-6736(96)07642-8","article-title":"Natural history of liver fibrosis progression in patients with chronic hepatitis C","volume":"349","author":"Poynard","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.cld.2008.07.012_bib7","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1053\/gast.2002.37069","article-title":"Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15","volume":"123","author":"Hillebrandt","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2008.07.012_bib8","series-title":"Textbook of hepatology: from basic science to clinical practice","first-page":"371","article-title":"Genetic determinants of complex liver diseases: mouse models and quantitative trait locus analysis","author":"Lammert","year":"2007"},{"key":"10.1016\/j.cld.2008.07.012_bib9","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1572-0241.2004.04059.x","article-title":"Ethnic differences in the prevalence of cryptogenic cirrhosis","volume":"99","author":"Browning","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cld.2008.07.012_bib10","series-title":"Methodology for genetic studies of twins and families Dordrecht","author":"Neale","year":"1992"},{"key":"10.1016\/j.cld.2008.07.012_bib11","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.1371\/journal.pgen.0030097","article-title":"Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci","volume":"3","author":"Perola","year":"2007","journal-title":"PLoS Genet"},{"key":"10.1016\/j.cld.2008.07.012_bib12","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1111\/j.1530-0277.1996.tb01695.x","article-title":"Genetic predisposition to organ-specific endpoints of alcoholism","volume":"20","author":"Reed","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.cld.2008.07.012_bib13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/ng0702-235","article-title":"From QTL to gene: the harvest begins","volume":"31","author":"Korstanje","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.cld.2008.07.012_bib14","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1136\/jmg.2005.032557","article-title":"A combination of genetic polymorphisms increases the risk of progressive disease in chronic hepatitis C","volume":"42","author":"Richardson","year":"2005","journal-title":"J Med Genet"},{"key":"10.1016\/j.cld.2008.07.012_bib15","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hep.21695","article-title":"A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C","volume":"46","author":"Huang","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.012_bib16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nm0395-215","article-title":"A miracle enough: the power of mice","volume":"1","author":"Paigen","year":"1995","journal-title":"Nat Med"},{"key":"10.1016\/j.cld.2008.07.012_bib17","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature01262","article-title":"Initial sequencing and comparative analysis of the mouse genome","volume":"420","author":"Mouse Genome Sequencing Consortium","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.cld.2008.07.012_bib18","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1152\/japplphysiol.00562.2003","article-title":"Mouse phenome project: understanding human biology through mouse genetics and genomics","volume":"95","author":"Bogue","year":"2003","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.cld.2008.07.012_bib19","doi-asserted-by":"crossref","first-page":"10663","DOI":"10.1073\/pnas.94.20.10663","article-title":"Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses","volume":"94","author":"Shi","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cld.2008.07.012_bib20","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/ng1599","article-title":"Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans","volume":"37","author":"Hillebrandt","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.cld.2008.07.012_bib21","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","article-title":"Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ","volume":"117","author":"Iredale","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cld.2008.07.012_bib22","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/hep.20130","article-title":"Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers","volume":"39","author":"Roskams","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.012_bib23","first-page":"706","article-title":"The effect of complete biliary obstruction on bile flow and bile acid excretion: postcholestatic choleresis in the rat","volume":"93","author":"Accatino","year":"1979","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.cld.2008.07.012_bib24","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.3748\/wjg.v11.i27.4167","article-title":"Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation","volume":"11","author":"Chang","year":"2005","journal-title":"World J\u00a0Gastroenterol"},{"key":"10.1016\/j.cld.2008.07.012_bib25","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jhep.2006.03.017","article-title":"Combination of systemic thioacetamide (TAA) injections and ethanol feeding accelerates hepatic fibrosis in C3H\/He mice and is associated with intrahepatic up regulation of MMP-2, VEGF and ICAM-1","volume":"45","author":"Kornek","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.cld.2008.07.012_bib26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1055\/s-2006-927387","article-title":"Mouse models of liver fibrosis","volume":"45","author":"Weiler-Normann","year":"2007","journal-title":"Z Gastroenterol"},{"key":"10.1016\/j.cld.2008.07.012_bib27","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/jat.892","article-title":"Kupffer cells are responsible for liver cirrhosis induced by carbon tetrachloride","volume":"23","author":"Muriel","year":"2003","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.cld.2008.07.012_bib28","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/carcin\/bgh037","article-title":"Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human cholangiocarcinoma","volume":"25","author":"Yeh","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cld.2008.07.012_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ng0198-19","article-title":"Experimental strategies for the genetic dissection of complex traits in animal models","volume":"18","author":"Darvasi","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.cld.2008.07.012_bib30","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrg1576","article-title":"Strategies for mapping and cloning quantitative trait genes in rodents","volume":"6","author":"Flint","year":"2005","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.cld.2008.07.012_bib31","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nrg2025","article-title":"The mouse as a model for human biology: a resource guide for complex trait analysis","volume":"8","author":"Peters","year":"2007","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.cld.2008.07.012_bib32","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nrg1206","article-title":"The nature and identification of quantitative trait loci: a community's view","volume":"4","author":"The Complex Trait Consortium","year":"2003","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.cld.2008.07.012_bib33","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1046\/j.1365-2362.2003.01089.x","article-title":"Mouse models for genetic dissection of polygenic gastrointestinal diseases","volume":"33","author":"Hillebrandt","year":"2003","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.cld.2008.07.012_bib34","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1007\/s00335-001-1016-3","article-title":"Map Manager QTX, cross-platform software for genetic mapping","volume":"12","author":"Manly","year":"2001","journal-title":"Mamm Genome"},{"key":"10.1016\/j.cld.2008.07.012_bib35","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/ng0305-209","article-title":"Mapping expression in randomized rodent genomes","volume":"37","author":"Broman","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.cld.2008.07.012_bib36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/genetics\/121.1.185","article-title":"Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps","volume":"121","author":"Lander","year":"1989","journal-title":"Genetics"},{"key":"10.1016\/j.cld.2008.07.012_bib37","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ng1195-241","article-title":"Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results","volume":"11","author":"Lander","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.cld.2008.07.012_bib38","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/genetics\/138.3.963","article-title":"Empirical threshold values for quantitative trait mapping","volume":"138","author":"Churchill","year":"1994","journal-title":"Genetics"},{"key":"10.1016\/j.cld.2008.07.012_bib39","first-page":"A427","article-title":"Identification of multiple interacting quantitative trait loci (QTL) for hepatic fibrosis in mice","volume":"130","author":"Hillebrandt","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2008.07.012_bib40","first-page":"568A","article-title":"The chemokine CXCL9 (MIG) is a genetic modifier of liver fibrogenesis in chronic hepatitis C","volume":"44","author":"Wasmuth","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.012_bib41","first-page":"46","article-title":"The CC chemokine RANTES (CCL5) mediates liver fibrosis in mice and humans","author":"Berres","year":"2008","journal-title":"Z Gastroenterol"},{"key":"10.1016\/j.cld.2008.07.012_bib42","doi-asserted-by":"crossref","first-page":"e393","DOI":"10.1371\/journal.pbio.0020393","article-title":"Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse","volume":"2","author":"Pletcher","year":"2004","journal-title":"PLoS Biol"},{"key":"10.1016\/j.cld.2008.07.012_bib43","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1534\/genetics.106.065359","article-title":"An integrated in silico gene mapping strategy in inbred mice","volume":"175","author":"Cervino","year":"2007","journal-title":"Genetics"},{"key":"10.1016\/j.cld.2008.07.012_bib44","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1058889","article-title":"In silico mapping of complex disease-related traits in mice","volume":"292","author":"Grupe","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cld.2008.07.012_bib45","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/hep.20150","article-title":"From genotypes to haplotypes in hepatobiliary diseases: one plus one equals (sometimes) more than two","volume":"39","author":"Wasmuth","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.012_bib46","first-page":"315","article-title":"Genetic studies to identify hepatic fibrosis genes and SNPs in human populations","volume":"117","author":"Day","year":"2005","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.cld.2008.07.012_bib47","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nature02168","article-title":"The International HapMap Project","volume":"426","author":"The International HapMap Consortium","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.cld.2008.07.012_bib48","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1007\/s00063-003-1324-3","article-title":"Genetische Risikofaktoren der Fibrogenese bei chronischen Lebererkrankungen","volume":"98","author":"Wasmuth","year":"2003","journal-title":"Med Klin"},{"key":"10.1016\/j.cld.2008.07.012_bib49","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1055\/s-2006-960169","article-title":"Genomics of liver fibrosis and cirrhosis","volume":"27","author":"\u00d6sterreicher","year":"2007","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.cld.2008.07.012_bib50","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/j.1582-4934.2007.00092.x","article-title":"Biomarkers of hepatic fibrosis, fibrogenesis and genetic pre-disposition pending between fiction and reality","volume":"11","author":"Gressner","year":"2007","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.cld.2008.07.012_bib51","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/hep.21885","article-title":"Hemochromatosis genotypes and risk of 31 disease endpoints: meta-analyses including 66,000 cases and 226,000 controls","volume":"46","author":"Ellervik","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.012_bib52","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1002\/hep.22054","article-title":"Genomewide genetic association studies in hepatology: the end of searching for the needle in the haystack?","volume":"46","author":"Hellerbrand","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2008.07.012_bib53","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nrg2316","article-title":"The road to genome-wide association studies","volume":"9","author":"Kruglyak","year":"2008","journal-title":"Nat Rev Genet"}],"container-title":["Clinics in Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326108000809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326108000809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T20:16:42Z","timestamp":1632082602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089326108000809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S1089326108000809"],"URL":"https:\/\/doi.org\/10.1016\/j.cld.2008.07.012","relation":{},"ISSN":["1089-3261"],"issn-type":[{"value":"1089-3261","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}