{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:39:26Z","timestamp":1790141966462,"version":"4.0.1"},"reference-count":84,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics in Liver Disease"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.cld.2012.08.011","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T21:26:36Z","timestamp":1351113996000},"page":"839-850","source":"Crossref","is-referenced-by-count":97,"title":["Liver Cancer and Alcohol"],"prefix":"10.1016","volume":"16","author":[{"given":"Priya","family":"Grewal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay Anand","family":"Viswanathen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cld.2012.08.011_bib1","series-title":"GLOBOCAN 2000: cancer incidence, mortality and prevalence worldwide, version 1.0","author":"Ferlay","year":"2001"},{"key":"10.1016\/j.cld.2012.08.011_bib2","series-title":"Surveillance, epidemiology, and End results (SEER) Program. SEER*Stat database: incidence \u2014 SEER 9 Regs research data, Nov 2009 Sub (1973-2007)","year":"2010"},{"key":"10.1016\/j.cld.2012.08.011_bib3","unstructured":"World Health Organization, International Agency for Research on Cancer. GLOBOCAN 2008. Available at: http:\/\/globocan.iarc.fr."},{"key":"10.1016\/j.cld.2012.08.011_bib4","first-page":"243","article-title":"Prevalence of DSM-IV alcohol abuse and dependence United States, 1992","volume":"18","author":"Grant","year":"1994","journal-title":"Alcohol Health Res World"},{"key":"10.1016\/j.cld.2012.08.011_bib5","unstructured":"Alcoholic beverage consumption and ethyl caramate (urethane). IARC monographs on the evaluation of carcinogenic risks to humans 96. Lyon: International Agency for Research on Cancer."},{"key":"10.1016\/j.cld.2012.08.011_bib6","unstructured":"IARC. Preamble to the IARC monographs on the evaluation of carcinogenic risks\u00a0to humans. Available at: http:\/\/monographs.iarc.fr\/ENG\/Preamble\/CurrentPreamble.pdf."},{"issue":"4","key":"10.1016\/j.cld.2012.08.011_bib7","first-page":"277","article-title":"Alcohol, oxidative stress, and free radical damage","volume":"27","author":"Wu","year":"2003","journal-title":"Alcohol Res Health"},{"key":"10.1016\/j.cld.2012.08.011_bib8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/aje\/155.4.323","article-title":"Alcohol and hepatocellular carcinoma the effect of lifetime intake and hepatitis virus infections in men and women","volume":"155","author":"Donato","year":"2002","journal-title":"Am J Epidemiol"},{"issue":"11","key":"10.1016\/j.cld.2012.08.011_bib9","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1054\/bjoc.2001.2140","article-title":"A\u00a0meta-analysis of alcohol drinking and cancer risk","volume":"85","author":"Bagnardi","year":"2001","journal-title":"Br J Cancer"},{"issue":"6","key":"10.1016\/j.cld.2012.08.011_bib10","doi-asserted-by":"crossref","first-page":"892","DOI":"10.15288\/jsad.2011.72.892","article-title":"Heavy alcohol use and premature death from hepatocellular carcinoma in the United States, 1999\u20132006","volume":"72","author":"Dong","year":"2011","journal-title":"J\u00a0Stud Alcohol Drugs"},{"issue":"22","key":"10.1016\/j.cld.2012.08.011_bib11","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1093\/jnci\/djr395","article-title":"Hepatocellular carcinoma risk factors and disease burden in a European cohort: a nested case\u2013control study","volume":"103","author":"Trichopoulos","year":"2011","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.cld.2012.08.011_bib12","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.cgh.2011.03.027","article-title":"Factors that affect risk for hepatocellular carcinoma and effects of surveillance","volume":"9","author":"Yang","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cld.2012.08.011_bib13","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jhep.2004.10.005","article-title":"Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma","volume":"42","author":"Marrero","year":"2005","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cld.2012.08.011_bib14","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.ypmed.2003.11.027","article-title":"A\u00a0meta-analysis of alcohol consumption and the risk of 15 diseases","volume":"38","author":"Corrao","year":"2004","journal-title":"Prev Med"},{"issue":"11","key":"10.1016\/j.cld.2012.08.011_bib15","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/ijc.26255","article-title":"Alcohol drinking and primary liver cancer: a pooled analysis of four Japanese cohort studies","volume":"130","author":"Shimazu","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cld.2012.08.011_bib16","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1186\/1471-2407-11-446","article-title":"How the risk of liver cancer changes after alcohol cessation: a review and meta-analysis of the current literature","volume":"11","author":"Heckley","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cld.2012.08.011_bib17","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/hep.1840190303","article-title":"Clinical significance of concomitant hepatitis\u00a0C infection in patients with alcoholic liver disease","volume":"19","author":"Fong","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2012.08.011_bib18","first-page":"367","article-title":"Hepatitis C virus antibodies in alcoholic patients","volume":"195","author":"Gonzalez-Quintela","year":"1995","journal-title":"Rev Clin Esp"},{"key":"10.1016\/j.cld.2012.08.011_bib19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/hep.1840190306","article-title":"\u201cInapparent\u201d hepatitis B virus infection and hepatitis C virus replication in alcoholic subjects with and without liver disease","volume":"19","author":"Zignego","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2012.08.011_bib20","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/hep.1840200503","article-title":"Increased serum hepatitis C virus RNA levels among alcoholic patients with chronic hepatitis","volume":"20","author":"Oshita","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2012.08.011_bib21","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3109\/00365529509101616","article-title":"Chronic hepatitis C in alcoholic patients: prevalence, genotypes, and correlation to liver disease","volume":"30","author":"Befrits","year":"1995","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.cld.2012.08.011_bib22","first-page":"1022","article-title":"Epidemiology of hepatitis C among veterans with alcoholic liver disease","volume":"88","author":"Mendenhall","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cld.2012.08.011_bib23","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0140-6736(96)07642-8","article-title":"Natural history of liver fibrosis progression in patients with chronic hepatitis C; for the OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC group","volume":"349","author":"Poynard","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.cld.2012.08.011_bib24","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/ajg.2010.477","article-title":"Hepatic and extrahepatic cancer in cirrhosis: a longitudinal cohort study","volume":"106","author":"Berman","year":"2011","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.cld.2012.08.011_bib25","first-page":"75","article-title":"A\u00a0prospective study on hepatocellular carcinoma in liver cirrhosis respective roles of alcohol and hepatitis C virus infection","volume":"29","author":"Miyakawa","year":"1994","journal-title":"Alcohol Alcohol Suppl"},{"key":"10.1016\/j.cld.2012.08.011_bib26","doi-asserted-by":"crossref","first-page":"64S","DOI":"10.1111\/j.1530-0277.2000.tb00015.x","article-title":"Clinical characteristics of patients in their 40s with HCV antibody-positive hepatocellular carcinoma","volume":"24","author":"Shimauchi","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.cld.2012.08.011_bib27","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1349-7006.1996.tb02113.x","article-title":"Effect of heavy alcohol intake on long-term results after curative resection of hepatitis C virus-related hepatocellular carcinoma","volume":"87","author":"Okada","year":"1996","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/j.cld.2012.08.011_bib28","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0039-6060(97)90313-5","article-title":"High malignancy of hepatocellular carcinoma in alcoholic patients with hepatitis C virus","volume":"121","author":"Kubo","year":"1997","journal-title":"Surgery"},{"issue":"5","key":"10.1016\/j.cld.2012.08.011_bib29","first-page":"328","volume":"25","author":"Zhu","year":"2011","journal-title":"Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi"},{"key":"10.1016\/j.cld.2012.08.011_bib30","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3350\/kjhep.2010.16.3.308","article-title":"Effect of alcohol on the development of hepatocellular carcinoma in patients with hepatitis B virus-related cirrhosis: a cross-sectional case-control study","volume":"16","author":"Kwon","year":"2010","journal-title":"Korean J Hepatol"},{"key":"10.1016\/j.cld.2012.08.011_bib31","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/(SICI)1097-0215(20000215)85:4<498::AID-IJC9>3.0.CO;2-F","article-title":"Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma","volume":"85","author":"Kuper","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cld.2012.08.011_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.27508","article-title":"Influences of tobacco and alcohol use on hepatocellular carcinoma survival","author":"Shih","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cld.2012.08.011_bib33","first-page":"154","article-title":"Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes","volume":"25","author":"Staretz","year":"1997","journal-title":"Drug Metab Dispos"},{"issue":"5","key":"10.1016\/j.cld.2012.08.011_bib34","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/cncr.20427","article-title":"Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S","volume":"101","author":"Yuan","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.cld.2012.08.011_bib35","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3390\/ijerph7041366","article-title":"Alcohol and HCV chronic infection are risk cofactors of type 2 diabetes mellitus for hepatocellular carcinoma in Italy","volume":"7","author":"Balbi","year":"2010","journal-title":"Int J Environ Res Public Health"},{"issue":"10","key":"10.1016\/j.cld.2012.08.011_bib36","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.cgh.2010.06.027","article-title":"Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men","volume":"8","author":"Loomba","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cld.2012.08.011_bib37","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cgh.2006.05.013","article-title":"Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis","volume":"4","author":"N'Kontchou","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cld.2012.08.011_bib38","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/gut.46.2.277","article-title":"Liver iron is predictive of death in alcoholic cirrhosis: a multivariate study of 229 consecutive patients with alcoholic and\/or hepatitis C virus cirrhosis: a prospective follow up study","volume":"46","author":"Ganne-Carrie","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.cld.2012.08.011_bib39","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1053\/j.gastro.2007.10.038","article-title":"Liver iron, HFE gene mutations, and hepatocellular carcinoma occurrence in patients with cirrhosis","volume":"134","author":"Nahon","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2012.08.011_bib40","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1572-0241.2002.05553.x","article-title":"HFE gene mutations in alcoholic and virus-related cirrhotic patients with hepatocellular carcinoma","volume":"97","author":"Lauret","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cld.2012.08.011_bib41","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/aje\/kwg123","article-title":"Hereditary hemochromatosis: effect of excessive alcohol consumption on disease expression in patients homozygous for the C282Y mutation","volume":"158","author":"Scotet","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.cld.2012.08.011_bib42","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1572-0241.2003.07222.x","article-title":"Mutations of the HFE gene in patients with hepatocellular carcinoma","volume":"98","author":"Cauza","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cld.2012.08.011_bib43","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1136\/gut.52.8.1178","article-title":"Lack of association between HFE gene mutations and hepatocellular carcinoma in patients with cirrhosis","volume":"52","author":"Boige","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.cld.2012.08.011_bib44","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/ije\/11.2.112","article-title":"A\u00a0case\u2013control dietary study of\u00a0primary liver cancer risk from aflatoxin exposure","volume":"11","author":"Bulatao-Jayme","year":"1982","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.cld.2012.08.011_bib45","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0300-5089(21)00820-8","article-title":"Primary hepatic cancer in alcoholics","volume":"10","author":"Tamburro","year":"1981","journal-title":"Clin Gastroenterol"},{"issue":"1","key":"10.1016\/j.cld.2012.08.011_bib46","first-page":"8","article-title":"Individual susceptibility and alcohol effects: biochemical and genetic aspects","volume":"42","author":"Gemma","year":"2006","journal-title":"Ann Ist Super Sanita"},{"issue":"1","key":"10.1016\/j.cld.2012.08.011_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00003088-200342010-00001","article-title":"Role of variability in explaining ethanol pharmacokinetics: research and forensic applications","volume":"42","author":"Norberg","year":"2003","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.cld.2012.08.011_bib48","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/9780470511848.ch2","article-title":"Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes","volume":"285","author":"Crabb","year":"2007","journal-title":"Novartis Found Symp"},{"issue":"Suppl","key":"10.1016\/j.cld.2012.08.011_bib49","doi-asserted-by":"crossref","first-page":"15S","DOI":"10.1111\/j.1530-0277.2001.tb02369.x","article-title":"The role of acetaldehyde in the actions of alcohol (update 2000)","volume":"25","author":"Eriksson","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"issue":"1","key":"10.1016\/j.cld.2012.08.011_bib50","first-page":"38","article-title":"Alcohol metabolism and cancer risk","volume":"30","author":"Seitz","year":"2007","journal-title":"Alcohol Res Health"},{"issue":"4","key":"10.1016\/j.cld.2012.08.011_bib51","first-page":"285","article-title":"Dangerous byproducts of alcohol breakdown\u2013focus on adducts","volume":"27","author":"Tuma","year":"2003","journal-title":"Alcohol Res Health"},{"issue":"4","key":"10.1016\/j.cld.2012.08.011_bib52","first-page":"245","article-title":"Overview: how is alcohol metabolized by the body?","volume":"29","author":"Zakhari","year":"2006","journal-title":"Alcohol Res Health"},{"key":"10.1016\/j.cld.2012.08.011_bib53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/9780470511848.ch3","article-title":"Removal of acetaldehyde from the body","volume":"285","author":"Deitrich","year":"2007","journal-title":"Novartis Found Symp"},{"issue":"8","key":"10.1016\/j.cld.2012.08.011_bib54","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/ijc.21583","article-title":"Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers","volume":"118","author":"Homann","year":"2006","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.cld.2012.08.011_bib55","first-page":"657","article-title":"CYP2E1\u2013biochemical and toxicological aspects and role in alcohol-induced liver injury","volume":"73","author":"Cederbaum","year":"2006","journal-title":"Mt Sinai J Med"},{"issue":"3","key":"10.1016\/j.cld.2012.08.011_bib56","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.lfs.2007.05.005","article-title":"Alcohol-induced oxidative stress","volume":"81","author":"Das","year":"2007","journal-title":"Life Sci"},{"issue":"Suppl 1","key":"10.1016\/j.cld.2012.08.011_bib57","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1111\/j.1440-1746.2006.04638.x","article-title":"Role of microsomal enzymes in development of alcoholic liver diseases","volume":"22","author":"Konishi","year":"2007","journal-title":"J\u00a0Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.cld.2012.08.011_bib58","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.freeradbiomed.2007.11.004","article-title":"CYP2E1 and oxidative liver injury by alcohol","volume":"44","author":"Lu","year":"2008","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"10.1016\/j.cld.2012.08.011_bib59","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0022-3565(25)29204-7","article-title":"The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in\u00a0vivo","volume":"181","author":"Lieber","year":"1972","journal-title":"J\u00a0Pharmacol Exp Ther"},{"issue":"2","key":"10.1016\/j.cld.2012.08.011_bib60","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/01.ALC.0000052583.87673.37","article-title":"Alcohol metabolism: role in toxicity and carcinogenesis","volume":"27","author":"Badger","year":"2003","journal-title":"Alcohol Clin Exp Res"},{"issue":"2","key":"10.1016\/j.cld.2012.08.011_bib61","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1096\/fasebj.6.2.1537462","article-title":"Oxidative and reductive metabolism by cytochrome P450 2E1","volume":"6","author":"Koop","year":"1992","journal-title":"FASEB J"},{"issue":"Suppl 11","key":"10.1016\/j.cld.2012.08.011_bib62","doi-asserted-by":"crossref","first-page":"110S","DOI":"10.1097\/01.alc.0000189288.30358.4b","article-title":"Oxidative stress and signal transduction pathways in alcoholic liver disease","volume":"29","author":"Zima","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"issue":"4","key":"10.1016\/j.cld.2012.08.011_bib63","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1470-2045(07)70099-2","article-title":"Carcinogenicity of alcoholic beverages","volume":"8","author":"Baan","year":"2007","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.cld.2012.08.011_bib64","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.alcohol.2005.03.009","article-title":"DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis","volume":"35","author":"Brooks","year":"2005","journal-title":"Alcohol"},{"issue":"3\u20135","key":"10.1016\/j.cld.2012.08.011_bib65","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/15216540152845957","article-title":"The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology","volume":"52","author":"Lenaz","year":"2001","journal-title":"IUBMB Life"},{"issue":"3","key":"10.1016\/j.cld.2012.08.011_bib66","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1365-2710.2000.00282.x","article-title":"Cytochrome P450 2E1: its clinical and toxicological role","volume":"25","author":"Tanaka","year":"2000","journal-title":"J\u00a0Clin Pharm Ther"},{"issue":"1","key":"10.1016\/j.cld.2012.08.011_bib67","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0009-2797(95)03632-V","article-title":"Studies of the reaction of acetaldehyde with deoxynucleosides","volume":"98","author":"Vaca","year":"1995","journal-title":"Chem Biol Interact"},{"issue":"2","key":"10.1016\/j.cld.2012.08.011_bib68","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1152\/physrev.1997.77.2.517","article-title":"Cytochrome P-4502E1: its physiological and pathological role","volume":"77","author":"Lieber","year":"1997","journal-title":"Physiol Rev"},{"key":"10.1016\/j.cld.2012.08.011_bib69","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.nutr.20.1.395","article-title":"ALCOHOL: its metabolism and interaction with nutrients","volume":"20","author":"Lieber","year":"2000","journal-title":"Annu Rev Nutr"},{"issue":"Suppl 9","key":"10.1016\/j.cld.2012.08.011_bib70","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1289\/ehp.94102s949","article-title":"Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes","volume":"102","author":"Guengerich","year":"1994","journal-title":"Environ Health Perspect"},{"issue":"2\u20133","key":"10.1016\/j.cld.2012.08.011_bib71","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/03602539009041082","article-title":"Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation","volume":"22","author":"Yang","year":"1990","journal-title":"Drug Metab Rev"},{"issue":"5","key":"10.1016\/j.cld.2012.08.011_bib72","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2131\/jts.32.453","article-title":"Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis","volume":"32","author":"Nagata","year":"2007","journal-title":"J\u00a0Toxicol Sci"},{"issue":"4 Pt 1","key":"10.1016\/j.cld.2012.08.011_bib73","first-page":"G605","article-title":"Alcoholic liver injury involves activation of Kupffer cells by endotoxin","volume":"275","author":"Thurman","year":"1998","journal-title":"Am J Physiol"},{"issue":"Suppl","key":"10.1016\/j.cld.2012.08.011_bib74","doi-asserted-by":"crossref","first-page":"166S","DOI":"10.1097\/01.alc.0000189280.19073.28","article-title":"Activation of the innate immune system and alcoholic liver disease: effects of ethanol per se or enhanced intestinal translocation of bacterial toxins induced by ethanol","volume":"29","author":"Bode","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"issue":"1","key":"10.1016\/j.cld.2012.08.011_bib75","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0741-8329(02)00215-X","article-title":"Ethanol, oxidative stress, and cytokine-induced liver cell injury","volume":"27","author":"Hoek","year":"2002","journal-title":"Alcohol"},{"issue":"3","key":"10.1016\/j.cld.2012.08.011_bib76","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1055\/s-2004-832939","article-title":"Cellular signaling mechanisms in alcohol-induced liver damage","volume":"24","author":"Hoek","year":"2004","journal-title":"Semin Liver Dis"},{"issue":"1","key":"10.1016\/j.cld.2012.08.011_bib77","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/toxsci\/kfl173","article-title":"Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis","volume":"96","author":"Roberts","year":"2007","journal-title":"Toxicol Sci"},{"issue":"Suppl 1","key":"10.1016\/j.cld.2012.08.011_bib78","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1111\/j.1440-1746.2006.04650.x","article-title":"Regulation of macrophage activation in alcoholic liver disease","volume":"22","author":"Thakur","year":"2007","journal-title":"J\u00a0Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.cld.2012.08.011_bib79","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0168-8278(96)80302-3","article-title":"In\u00a0vivo assessment of hepatic alterations following gadolinium chloride-induced Kupffer cell blockade","volume":"25","author":"Ruttinger","year":"1996","journal-title":"J\u00a0Hepatol"},{"issue":"6","key":"10.1016\/j.cld.2012.08.011_bib80","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/00024382-199612000-00008","article-title":"Modulation of Kupffer cell activity by gadolinium chloride in endotoxemic rats","volume":"6","author":"Vollmar","year":"1996","journal-title":"Shock"},{"issue":"1\u20132","key":"10.1016\/j.cld.2012.08.011_bib81","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mam.2007.09.004","article-title":"Oxidative mechanisms in the pathogenesis of alcoholic liver disease","volume":"29","author":"Albano","year":"2008","journal-title":"Mol Aspects Med"},{"issue":"1","key":"10.1016\/j.cld.2012.08.011_bib82","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004996.pub3","article-title":"Antioxidant supplements for non-alcoholic\u00a0fatty liver disease and\/or steatohepatitis","author":"Lirussi","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.cld.2012.08.011_bib83","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ijc.21371","article-title":"Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages and neovascularization","volume":"118","author":"Yang","year":"2006","journal-title":"Int J Cancer"},{"issue":"3","key":"10.1016\/j.cld.2012.08.011_bib84","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/hep.24199","article-title":"AASLD practice guideline for management of HCC","volume":"53","author":"Bruix","year":"2011","journal-title":"Hepatology"}],"container-title":["Clinics in Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326112000943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326112000943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T16:35:09Z","timestamp":1745080509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089326112000943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":84,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S1089326112000943"],"URL":"https:\/\/doi.org\/10.1016\/j.cld.2012.08.011","relation":{},"ISSN":["1089-3261"],"issn-type":[{"value":"1089-3261","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}