{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:26:22Z","timestamp":1791307582863,"version":"4.3.1"},"reference-count":67,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","clinicalkey.com.au","clinicalkey.fr","liver.theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Liver Disease"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.cld.2016.02.012","type":"journal-article","created":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T12:16:39Z","timestamp":1463228199000},"page":"563-580","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Alcoholic Liver Disease"],"prefix":"10.1016","volume":"20","author":[{"given":"Kartik","family":"Joshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Kohli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Manch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 2","key":"10.1016\/j.cld.2016.02.012_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/ajt.13197","article-title":"OPTN\/SRTR 2013 annual data report: liver","volume":"15","author":"Kim","year":"2015","journal-title":"Am J Transplant"},{"issue":"12","key":"10.1016\/j.cld.2016.02.012_bib2","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJMra1001683","article-title":"Hepatocellular carcinoma","volume":"365","author":"El-Serag","year":"2011","journal-title":"N\u00a0Engl J Med"},{"issue":"7","key":"10.1016\/j.cld.2016.02.012_bib3","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.cgh.2011.03.027","article-title":"Factors that affect risk for hepatocellular carcinoma and effects of surveillance","volume":"9","author":"Yang","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cld.2016.02.012_bib4","series-title":"Global status report on alcohol and health 2014","author":"World Health Organization","year":"2014"},{"issue":"5 Suppl 1","key":"10.1016\/j.cld.2016.02.012_bib5","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1053\/j.gastro.2004.09.014","article-title":"Hepatocellular carcinoma in cirrhosis: incidence and risk factors","volume":"127","author":"Fattovich","year":"2004","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.cld.2016.02.012_bib6","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1111\/j.1440-1746.2009.05851.x","article-title":"Comparison of outcomes between patients with alcoholic cirrhosis and those with hepatitis C virus-related cirrhosis","volume":"24","author":"Toshikuni","year":"2009","journal-title":"J\u00a0Gastroenterol Hepatol"},{"issue":"12","key":"10.1016\/j.cld.2016.02.012_bib7","doi-asserted-by":"crossref","first-page":"841","DOI":"10.7326\/0003-4819-156-12-201206190-00004","article-title":"Risk for hepatocellular carcinoma in patients with alcoholic cirrhosis: a Danish nationwide cohort study","volume":"156","author":"Jepsen","year":"2012","journal-title":"Ann Intern Med"},{"issue":"8 Suppl","key":"10.1016\/j.cld.2016.02.012_bib8","doi-asserted-by":"crossref","first-page":"47S","DOI":"10.1097\/01.ALC.0000079449.47468.B0","article-title":"Analysis of risk factors for hepatocellular carcinoma in patients with HBs antigen- and anti-HCV antibody-negative alcoholic cirrhosis: clinical significance of prior hepatitis B virus infection","volume":"27","author":"Uetake","year":"2003","journal-title":"Alcohol Clin Exp Res"},{"issue":"8","key":"10.1016\/j.cld.2016.02.012_bib9","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cgh.2006.05.013","article-title":"Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis","volume":"4","author":"N'Kontchou","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.cld.2016.02.012_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cgh.2012.09.007","article-title":"Annual incidence of hepatocellular carcinoma among patients with alcoholic cirrhosis and identification of risk groups","volume":"11","author":"Mancebo","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"8","key":"10.1016\/j.cld.2016.02.012_bib11","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.cgh.2007.02.039","article-title":"Incidence and predictors of hepatocellular carcinoma in patients with cirrhosis","volume":"5","author":"Ioannou","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.cld.2016.02.012_bib12","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.jhep.2012.11.045","article-title":"Heavy alcohol consumption increases the incidence of hepatocellular carcinoma in hepatitis B virus-related cirrhosis","volume":"58","author":"Lin","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cld.2016.02.012_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12876-015-0307-1","article-title":"Plasma osteopontin is a biomarker for the severity of alcoholic liver cirrhosis, not for hepatocellular carcinoma screening","volume":"15","author":"Simao","year":"2015","journal-title":"BMC Gastroenterol"},{"issue":"8981","key":"10.1016\/j.cld.2016.02.012_bib14","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0140-6736(95)91685-7","article-title":"Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver","volume":"346","author":"Teli","year":"1995","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.cld.2016.02.012_bib15","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1054\/bjoc.2001.2140","article-title":"A\u00a0meta-analysis of alcohol drinking and cancer risk","volume":"85","author":"Bagnardi","year":"2001","journal-title":"Br J Cancer"},{"issue":"5","key":"10.1016\/j.cld.2016.02.012_bib16","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1111\/j.1530-0277.1993.tb05673.x","article-title":"Alcohol consumption and alcoholic liver disease: evidence of a threshold level of effects of ethanol","volume":"17","author":"Savolainen","year":"1993","journal-title":"Alcohol Clin Exp Res"},{"issue":"6","key":"10.1016\/j.cld.2016.02.012_bib17","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1136\/gut.41.6.845","article-title":"Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study Group","volume":"41","author":"Bellentani","year":"1997","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.cld.2016.02.012_bib18","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/oxfordjournals.alcalc.a008408","article-title":"Meta-analysis of alcohol intake in relation to risk of liver cirrhosis","volume":"33","author":"Corrao","year":"1998","journal-title":"Alcohol Alcohol"},{"issue":"5","key":"10.1016\/j.cld.2016.02.012_bib19","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/hep.510230513","article-title":"Prediction of risk of liver disease by alcohol intake, sex, and age: a prospective population study","volume":"23","author":"Becker","year":"1996","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.cld.2016.02.012_bib20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/aje\/155.4.323","article-title":"Alcohol and hepatocellular carcinoma: the effect of lifetime intake and hepatitis virus infections in men and women","volume":"155","author":"Donato","year":"2002","journal-title":"Am J Epidemiol"},{"issue":"4","key":"10.1016\/j.cld.2016.02.012_bib21","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1465-3362.2009.00153.x","article-title":"Alcohol as a risk factor for liver cirrhosis: a systematic review and meta-analysis","volume":"29","author":"Rehm","year":"2010","journal-title":"Drug Alcohol Rev"},{"issue":"9","key":"10.1016\/j.cld.2016.02.012_bib22","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/oxfordjournals.aje.a116397","article-title":"Selection of controls in case-control studies. II. Types of controls","volume":"135","author":"Wacholder","year":"1992","journal-title":"Am J Epidemiol"},{"issue":"16","key":"10.1016\/j.cld.2016.02.012_bib23","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.3748\/wjg.v10.i16.2423","article-title":"Risk factors for alcoholic liver disease in China","volume":"10","author":"Lu","year":"2004","journal-title":"World J Gastroenterol"},{"issue":"25","key":"10.1016\/j.cld.2016.02.012_bib24","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1056\/NEJM199306243282501","article-title":"Risk factors for hepatocellular carcinoma among patients with chronic liver disease","volume":"328","author":"Tsukuma","year":"1993","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cld.2016.02.012_bib25","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1186\/1471-2407-11-446","article-title":"How the risk of liver cancer changes after alcohol cessation: a review and meta-analysis of the current literature","volume":"11","author":"Heckley","year":"2011","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.cld.2016.02.012_bib26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0168-8278(86)80006-X","article-title":"Histological course of alcoholic hepatitis. Influence of abstinence, sex and extent of hepatic damage","volume":"2","author":"Pares","year":"1986","journal-title":"J\u00a0Hepatol"},{"issue":"3","key":"10.1016\/j.cld.2016.02.012_bib27","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0168-8278(02)00413-0","article-title":"A\u00a0comparison of fibrosis progression in chronic liver diseases","volume":"38","author":"Poynard","year":"2003","journal-title":"J\u00a0Hepatol"},{"issue":"4","key":"10.1016\/j.cld.2016.02.012_bib28","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1530-0277.2001.tb02242.x","article-title":"Gender differences in pharmacokinetics of alcohol","volume":"25","author":"Baraona","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"issue":"2","key":"10.1016\/j.cld.2016.02.012_bib29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1056\/NEJM199001113220205","article-title":"High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism","volume":"322","author":"Frezza","year":"1990","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.cld.2016.02.012_bib30","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/hep.1840030513","article-title":"Ethanol elimination in males and females: relationship to menstrual cycle and body composition","volume":"3","author":"Marshall","year":"1983","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2016.02.012_bib31","first-page":"199","article-title":"Alcohol effects on hormone levels in normal postmenopausal women and in postmenopausal women with alcohol-induced cirrhosis","volume":"12","author":"Gavaler","year":"1995","journal-title":"Recent Dev Alcohol"},{"issue":"4 Pt 1","key":"10.1016\/j.cld.2016.02.012_bib32","first-page":"G669","article-title":"Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin","volume":"274","author":"Ikejima","year":"1998","journal-title":"Am J Physiol"},{"issue":"Suppl D","key":"10.1016\/j.cld.2016.02.012_bib33","doi-asserted-by":"crossref","first-page":"129D","DOI":"10.1155\/2000\/735262","article-title":"Sex-related liver injury due to alcohol involves activation of Kupffer cells by endotoxin","volume":"14","author":"Thurman","year":"2000","journal-title":"Can J Gastroenterol"},{"issue":"1","key":"10.1016\/j.cld.2016.02.012_bib34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/hep.510310119","article-title":"Estrogen is involved in early alcohol-induced liver injury in a rat enteral feeding model","volume":"31","author":"Yin","year":"2000","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.cld.2016.02.012_bib35","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/alcalc\/agg040","article-title":"Ethnic differences in cirrhosis of the liver in a British city: alcoholic cirrhosis in South Asian men","volume":"38","author":"Douds","year":"2003","journal-title":"Alcohol Alcohol"},{"issue":"6","key":"10.1016\/j.cld.2016.02.012_bib36","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/j.1360-0443.1990.tb01688.x","article-title":"The drinking habits of Sikh, Hindu, Muslim and white men in the West Midlands: a community survey","volume":"85","author":"Cochrane","year":"1990","journal-title":"Br J Addict"},{"issue":"5","key":"10.1016\/j.cld.2016.02.012_bib37","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1053\/jhep.2002.36780","article-title":"Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus","volume":"36","author":"Hassan","year":"2002","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.cld.2016.02.012_bib38","first-page":"369","article-title":"A\u00a0comparative cross-sectional study of the development of hepatocellular carcinoma in patients with liver cirrhosis caused by hepatitis B virus, alcohol, or combination of hepatitis b virus and alcohol","volume":"49","author":"Chung","year":"2007","journal-title":"Korean J Gastroenterol"},{"issue":"3","key":"10.1016\/j.cld.2016.02.012_bib39","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1023\/A:1023636619477","article-title":"Risk of hepatocellular carcinoma and habits of alcohol drinking, betel quid chewing and cigarette smoking: a cohort of 2416 HBsAg-seropositive and 9421 HBsAg-seronegative male residents in Taiwan","volume":"14","author":"Wang","year":"2003","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.cld.2016.02.012_bib40","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.antiviral.2015.06.008","article-title":"Chronic hepatitis B: virology, natural history, current management and a glimpse at future opportunities","volume":"121","author":"Gish","year":"2015","journal-title":"Antiviral Res"},{"issue":"6","key":"10.1016\/j.cld.2016.02.012_bib41","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.alcohol.2012.03.006","article-title":"Anti-hepatitis B core positivity as a risk factor for hepatocellular carcinoma in alcoholic cirrhosis: a case-control study","volume":"46","author":"Kwon","year":"2012","journal-title":"Alcohol"},{"issue":"9055","key":"10.1016\/j.cld.2016.02.012_bib42","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0140-6736(96)07642-8","article-title":"Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups","volume":"349","author":"Poynard","year":"1997","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.cld.2016.02.012_bib43","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/hep.510280330","article-title":"Impact of alcohol on the histological and clinical progression of hepatitis C infection","volume":"28","author":"Wiley","year":"1998","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.cld.2016.02.012_bib44","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/1097-0142(20000701)89:1<53::AID-CNCR8>3.0.CO;2-6","article-title":"Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C. A long term follow-up study after histologic diagnosis","volume":"89","author":"Aizawa","year":"2000","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.cld.2016.02.012_bib45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/hep.1840180109","article-title":"A\u00a0multivariate analysis of risk factors for hepatocellular carcinogenesis: a prospective observation of 795 patients with viral and alcoholic cirrhosis","volume":"18","author":"Ikeda","year":"1993","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.cld.2016.02.012_bib46","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/(SICI)1097-0215(19990531)81:5<695::AID-IJC4>3.0.CO;2-W","article-title":"Case-control study on hepatitis C virus (HCV) as a risk factor for hepatocellular carcinoma: the role of HCV genotypes and the synergism with hepatitis B virus and alcohol. Brescia HCC Study","volume":"81","author":"Tagger","year":"1999","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.cld.2016.02.012_bib47","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1530-0277.1996.tb01683.x","article-title":"Relative risk for the development of hepatocellular carcinoma in alcoholic patients with cirrhosis: a multiple logistic-regression coefficient analysis","volume":"20","author":"Tsutsumi","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"issue":"2","key":"10.1016\/j.cld.2016.02.012_bib48","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/aje\/kwg123","article-title":"Hereditary hemochromatosis: effect of excessive alcohol consumption on disease expression in patients homozygous for the C282Y mutation","volume":"158","author":"Scotet","year":"2003","journal-title":"Am J Epidemiol"},{"issue":"2","key":"10.1016\/j.cld.2016.02.012_bib49","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1053\/gast.2002.30992","article-title":"Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis","volume":"122","author":"Fletcher","year":"2002","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.cld.2016.02.012_bib50","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/ajg.2015.137","article-title":"PNPLA3 gene polymorphism is associated with predisposition to and severity of alcoholic liver disease","volume":"110","author":"Salameh","year":"2015","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"10.1016\/j.cld.2016.02.012_bib51","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1002\/hep.26767","article-title":"Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: evidence from a meta-analysis of individual participant data","volume":"59","author":"Trepo","year":"2014","journal-title":"Hepatology"},{"issue":"Suppl 1","key":"10.1016\/j.cld.2016.02.012_bib52","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1016\/j.clinre.2015.06.001","article-title":"Proangiogenic factors in the development of HCC in alcoholic cirrhosis","volume":"39","author":"Machado","year":"2015","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"4","key":"10.1016\/j.cld.2016.02.012_bib53","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/MEG.0000000000000044","article-title":"Genetic polymorphisms of proangiogenic factors seem to favor hepatocellular carcinoma development in alcoholic cirrhosis","volume":"26","author":"Machado","year":"2014","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.cld.2016.02.012_bib54","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1470-2045(09)70019-1","article-title":"Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer","volume":"10","author":"Druesne-Pecollo","year":"2009","journal-title":"Lancet Oncol"},{"issue":"7","key":"10.1016\/j.cld.2016.02.012_bib55","first-page":"11117","article-title":"Alcohol dehydrogenase 1C (ADH1C) gene polymorphism and alcoholic liver cirrhosis risk: a meta analysis","volume":"8","author":"He","year":"2015","journal-title":"Int J Clin Exp Med"},{"issue":"2","key":"10.1016\/j.cld.2016.02.012_bib56","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/hep.21023","article-title":"Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?","volume":"43","author":"Zintzaras","year":"2006","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.cld.2016.02.012_bib57","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/hep.23187","article-title":"Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis","volume":"50","author":"Nahon","year":"2009","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.cld.2016.02.012_bib58","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/carcin\/bgh147","article-title":"The MTHFR 677C T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis","volume":"25","author":"Saffroy","year":"2004","journal-title":"Carcinogenesis"},{"issue":"3","key":"10.1016\/j.cld.2016.02.012_bib59","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cgh.2005.12.007","article-title":"The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence","volume":"4","author":"El-Serag","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"7","key":"10.1016\/j.cld.2016.02.012_bib60","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/ijc.26165","article-title":"Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: a systematic review and meta-analysis of cohort studies","volume":"130","author":"Wang","year":"2012","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1016\/j.cld.2016.02.012_bib61","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/CEJ.0000000000000038","article-title":"Effect of type 2 diabetes mellitus on the risk for hepatocellular carcinoma in chronic liver diseases: a meta-analysis of cohort studies","volume":"24","author":"Chen","year":"2015","journal-title":"Eur J Cancer Prev"},{"issue":"7","key":"10.1016\/j.cld.2016.02.012_bib62","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1872-034X.2007.00077.x","article-title":"Diabetes mellitus increases the risk of hepatocarcinogenesis in patients with alcoholic cirrhosis: a preliminary report","volume":"37","author":"Torisu","year":"2007","journal-title":"Hepatol Res"},{"issue":"5","key":"10.1016\/j.cld.2016.02.012_bib63","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/cncr.20427","article-title":"Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S","volume":"101","author":"Yuan","year":"2004","journal-title":"Cancer"},{"issue":"7","key":"10.1016\/j.cld.2016.02.012_bib64","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1111\/liv.12767","article-title":"Risk factors for hepatocellular carcinoma in Caucasian patients with non-viral cirrhosis: the importance of prior obesity","volume":"35","author":"Archambeaud","year":"2015","journal-title":"Liver Int"},{"issue":"10","key":"10.1016\/j.cld.2016.02.012_bib65","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.cgh.2010.06.027","article-title":"Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men","volume":"8","author":"Loomba","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.cld.2016.02.012_bib66","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jhep.2004.10.005","article-title":"Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma","volume":"42","author":"Marrero","year":"2005","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cld.2016.02.012_bib67","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/alcalc\/28.Supplement_1A.85","article-title":"Hepatitis C virus infection and alcoholic liver cirrhosis in Japan: its contribution to the development of hepatocellular carcinoma","volume":"1A","author":"Miyakawa","year":"1993","journal-title":"Alcohol Alcohol Suppl"}],"container-title":["Clinics in Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326116300125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326116300125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T01:27:13Z","timestamp":1536715633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089326116300125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S1089326116300125"],"URL":"https:\/\/doi.org\/10.1016\/j.cld.2016.02.012","relation":{},"ISSN":["1089-3261"],"issn-type":[{"value":"1089-3261","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alcoholic Liver Disease","name":"articletitle","label":"Article Title"},{"value":"Clinics in Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cld.2016.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}