{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:31:02Z","timestamp":1789871462848,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","clinicalkey.com.au","clinicalkey.fr","liver.theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Liver Disease"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.cld.2017.08.009","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T05:17:50Z","timestamp":1510204670000},"page":"121-132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["The Intestinal Microbiome in Nonalcoholic Fatty Liver Disease"],"prefix":"10.1016","volume":"22","author":[{"given":"Puneet","family":"Puri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun J.","family":"Sanyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cld.2017.08.009_bib1","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The human intestinal microbiome in health and disease","volume":"375","author":"Lynch","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cld.2017.08.009_bib2","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2017.08.009_bib3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1126\/science.1162986","article-title":"Real-time DNA sequencing from single polymerase molecules","volume":"323","author":"Eid","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.cld.2017.08.009_bib4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/2041-2223-2-23","article-title":"Next-generation sequencing technologies and applications for human genetic history and forensics","volume":"2","author":"Berglund","year":"2011","journal-title":"Investig Genet"},{"key":"10.1016\/j.cld.2017.08.009_bib5","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Na\u00efve bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Wang","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.cld.2017.08.009_bib6","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/cbdv.200900321","article-title":"Analysis of multitag pyrosequence data from human cervical lavage samples","volume":"7","author":"Naqvi","year":"2010","journal-title":"Chem Biodivers"},{"key":"10.1016\/j.cld.2017.08.009_bib7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat Methods"},{"key":"10.1016\/j.cld.2017.08.009_bib8","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1128\/AEM.01541-09","article-title":"Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities","volume":"75","author":"Schloss","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.cld.2017.08.009_bib9","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nbt.2676","article-title":"Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences","volume":"31","author":"Langille","year":"2013","journal-title":"Nat Biotech"},{"key":"10.1016\/j.cld.2017.08.009_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.cld.2017.08.009_bib11","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol"},{"key":"10.1016\/j.cld.2017.08.009_bib12","doi-asserted-by":"crossref","first-page":"e1000352","DOI":"10.1371\/journal.pcbi.1000352","article-title":"Statistical methods for detecting differentially abundant features in clinical metagenomic samples","volume":"5","author":"White","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.cld.2017.08.009_bib13","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/nmeth.2693","article-title":"Metagenomic species profiling using universal phylogenetic marker genes","volume":"10","author":"Sunagawa","year":"2013","journal-title":"Nat Methods"},{"key":"10.1016\/j.cld.2017.08.009_bib14","doi-asserted-by":"crossref","first-page":"14024","DOI":"10.1073\/pnas.1519288112","article-title":"Library preparation methodology can influence genomic and functional predictions in human microbiome research","volume":"112","author":"Jones","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cld.2017.08.009_bib15","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/cbdv.200900324","article-title":"Network-based modeling of the human gut microbiome","volume":"7","author":"Naqvi","year":"2010","journal-title":"Chem Biodiversity"},{"key":"10.1016\/j.cld.2017.08.009_bib16","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"10.1016\/j.cld.2017.08.009_bib17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ncpgasthep0084","article-title":"Mechanisms of disease: pathogenesis of nonalcoholic fatty liver disease","volume":"2","author":"Sanyal","year":"2005","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1016\/j.cld.2017.08.009_bib18","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1053\/gast.2001.23256","article-title":"Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities","volume":"120","author":"Sanyal","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2017.08.009_bib19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.chom.2008.02.015","article-title":"Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome","volume":"3","author":"Turnbaugh","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cld.2017.08.009_bib20","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cld.2017.08.009_bib21","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1194\/jlr.M038869","article-title":"Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens","volume":"54","author":"Ridlon","year":"2013","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.cld.2017.08.009_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2009.08.001","article-title":"TGR5-mediated bile acid sensing controls glucose homeostasis","volume":"10","author":"Thomas","year":"2009","journal-title":"Cell Metab"},{"key":"10.1016\/j.cld.2017.08.009_bib23","doi-asserted-by":"crossref","first-page":"6626","DOI":"10.1074\/jbc.M115.699504","article-title":"Activation of transmembrane bile acid receptor TGR5 modulates pancreatic islet\u00a0alpha cells to promote glucose homeostasis","volume":"291","author":"Kumar","year":"2016","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.cld.2017.08.009_bib24","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cmet.2012.04.001","article-title":"Inflammation and lipid signaling in the etiology of insulin resistance","volume":"15","author":"Glass","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.cld.2017.08.009_bib25","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.cmet.2012.03.007","article-title":"The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling","volume":"15","author":"Fu","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.cld.2017.08.009_bib26","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/JIM.0000000000000230","article-title":"Increased plasma levels of asymmetric dimethylarginine in nonalcoholic fatty liver disease: relation with insulin resistance, inflammation, and liver histology","volume":"63","author":"Boga","year":"2015","journal-title":"J\u00a0Investig Med"},{"key":"10.1016\/j.cld.2017.08.009_bib27","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/liv.12537","article-title":"Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis","volume":"34","author":"Csak","year":"2014","journal-title":"Liver Int"},{"key":"10.1016\/j.cld.2017.08.009_bib28","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.cld.2017.08.009_bib29","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3389\/fimmu.2013.00440","article-title":"An update on PYRIN domain-containing pattern recognition receptors: from immunity to pathology","volume":"4","author":"Ratsimandresy","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.cld.2017.08.009_bib30","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.3748\/wjg.v17.i43.4772","article-title":"Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver","volume":"17","author":"Ganz","year":"2011","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.cld.2017.08.009_bib31","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.cld.2017.08.009_bib32","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/hep.510290107","article-title":"Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cells","volume":"29","author":"Marra","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2017.08.009_bib33","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.cct.2016.02.012","article-title":"Efficacy and safety study of cenicriviroc for the treatment of non-alcoholic steatohepatitis in adult subjects with liver fibrosis: CENTAUR Phase 2b study design","volume":"47","author":"Friedman","year":"2016","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.cld.2017.08.009_bib34","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1111\/febs.13665","article-title":"TGF-beta signalling and liver disease","volume":"283","author":"Fabregat","year":"2016","journal-title":"FEBS J"},{"key":"10.1016\/j.cld.2017.08.009_bib35","doi-asserted-by":"crossref","first-page":"30097","DOI":"10.1074\/jbc.M109.049304","article-title":"Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling","volume":"284","author":"Yan","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.cld.2017.08.009_bib36","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Microbial ecology: human gut microbes associated with obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cld.2017.08.009_bib37","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature07540","article-title":"A\u00a0core gut microbiome in obese and lean twins","volume":"457","author":"Turnbaugh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.cld.2017.08.009_bib38","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature12506","article-title":"Richness of human gut microbiome correlates with metabolic markers","volume":"500","author":"Le Chatelier","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cld.2017.08.009_bib39","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nature09944","article-title":"Enterotypes of the human gut microbiome","volume":"473","author":"Arumugam","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cld.2017.08.009_bib40","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","author":"Human Microbiome Project Consortium","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cld.2017.08.009_bib41","doi-asserted-by":"crossref","first-page":"e84689","DOI":"10.1371\/journal.pone.0084689","article-title":"A\u00a0taxonomic signature of obesity in the microbiome? getting to the guts of the matter","volume":"9","author":"Finucane","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cld.2017.08.009_bib42","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1053\/j.gastro.2010.11.049","article-title":"Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency","volume":"140","author":"Spencer","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2017.08.009_bib43","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/hep.26093","article-title":"Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH","volume":"57","author":"Zhu","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2017.08.009_bib44","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/jgh.12510","article-title":"Endotoxemia unrequired in the pathogenesis of pediatric nonalcoholic steatohepatitis","volume":"29","author":"Yuan","year":"2014","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.cld.2017.08.009_bib45","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/hep.26319","article-title":"Intestinal microbiota in patients with nonalcoholic fatty liver disease","volume":"58","author":"Mouzaki","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2017.08.009_bib46","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.cgh.2013.02.015","article-title":"Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease","volume":"11","author":"Raman","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cld.2017.08.009_bib47","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/hep.28356","article-title":"The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota","volume":"63","author":"Boursier","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2017.08.009_bib48","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.cmet.2017.04.001","article-title":"Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease","volume":"25","author":"Loomba","year":"2017","journal-title":"Cell Metab"}],"container-title":["Clinics in Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326117300703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326117300703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,26]],"date-time":"2018-08-26T05:09:34Z","timestamp":1535260174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089326117300703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S1089326117300703"],"URL":"https:\/\/doi.org\/10.1016\/j.cld.2017.08.009","relation":{},"ISSN":["1089-3261"],"issn-type":[{"value":"1089-3261","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Intestinal Microbiome in Nonalcoholic Fatty Liver Disease","name":"articletitle","label":"Article Title"},{"value":"Clinics in Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cld.2017.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}