{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:36:51Z","timestamp":1781829411836,"version":"3.54.5"},"reference-count":53,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"am","delay-in-days":352,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Liver Disease"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.cld.2022.06.010","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T20:50:35Z","timestamp":1666126235000},"page":"681-689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Noninvasive Evaluation of Fibrosis and Portal Hypertension in Primary Biliary Cholangitis"],"prefix":"10.1016","volume":"26","author":[{"given":"Christophe","family":"Corpechot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cld.2022.06.010_bib1","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0140-6736(20)31607-X","article-title":"Primary biliary cholangitis","volume":"396","author":"Lleo","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.cld.2022.06.010_bib2","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1056\/NEJM199105303242204","article-title":"A\u00a0multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis","volume":"324","author":"Poupon","year":"1991","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cld.2022.06.010_bib3","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1056\/NEJMoa1509840","article-title":"A\u00a0Placebo-controlled trial of obeticholic acid in primary biliary cholangitis","volume":"375","author":"Nevens","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cld.2022.06.010_bib4","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1056\/NEJMoa1714519","article-title":"A\u00a0Placebo-controlled trial of Bezafibrate in primary biliary cholangitis","volume":"378","author":"Corpechot","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cld.2022.06.010_bib5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jhep.2017.03.022","article-title":"The diagnosis and management of patients with primary biliary cholangitis","volume":"67","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cld.2022.06.010_bib6","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/hep.30145","article-title":"Primary biliary cholangitis: 2018 practice guidance from the American association for the study of liver diseases","volume":"69","author":"Lindor","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2022.06.010_bib7","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1136\/gutjnl-2017-315259","article-title":"The British Society of Gastroenterology\/UK-PBC primary biliary cholangitis treatment and management guidelines","volume":"67","author":"Hirschfield","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.cld.2022.06.010_bib8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0168-8278(03)00192-2","article-title":"Combined analysis of the effect of treatment with ursodeoxycholic acid on histologic progression in primary biliary cirrhosis","volume":"39","author":"Poupon","year":"2003","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cld.2022.06.010_bib9","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.4065\/72.12.1137","article-title":"Ursodeoxycholic acid delays the onset of esophageal varices in primary biliary cirrhosis","volume":"72","author":"Lindor","year":"1997","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.cld.2022.06.010_bib10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jhep.2019.04.001","article-title":"Ursodeoxycholic acid therapy and liver transplant-free survival in patients with primary biliary cholangitis","volume":"71","author":"Harms","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cld.2022.06.010_bib11","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/apt.15533","article-title":"Fibrosis stage is an independent predictor of outcome in primary biliary cholangitis despite biochemical treatment response","volume":"50","author":"Murillo Perez","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cld.2022.06.010_bib12","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/j.gastro.2005.12.029","article-title":"Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic Acid","volume":"130","author":"Pares","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2022.06.010_bib13","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/ajg.2017.440","article-title":"Major hepatic complications in ursodeoxycholic acid-treated patients with primary biliary cholangitis: risk factors and time trends in incidence and outcome","volume":"113","author":"Harms","year":"2018","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cld.2022.06.010_bib14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jhep.2021.05.025","article-title":"EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis - 2021 update","volume":"75","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cld.2022.06.010_bib15","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/hep.510290603","article-title":"Ten-year survival in ursodeoxycholic acid-treated patients with primary biliary cirrhosis","volume":"29","author":"Poupon","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2022.06.010_bib16","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1053\/j.gastro.2008.07.019","article-title":"Portal hypertension and primary biliary cirrhosis: effect of long-term ursodeoxycholic acid treatment","volume":"135","author":"Huet","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2022.06.010_bib17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jhep.2013.04.010","article-title":"A\u00a0validated clinical tool for the prediction of varices in PBC: the Newcastle Varices in PBC Score","volume":"59","author":"Patanwala","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cld.2022.06.010_bib18","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","article-title":"Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension","volume":"63","author":"de Franchis","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cld.2022.06.010_bib19","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","article-title":"Baveno VII - Renewing consensus in portal hypertension","volume":"76","author":"de Franchis","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cld.2022.06.010_bib20","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/hep.25599","article-title":"Noninvasive elastography-based assessment of liver fibrosis progression and prognosis in primary biliary cirrhosis","volume":"56","author":"Corpechot","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2022.06.010_bib21","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/hep.31810","article-title":"Accuracy of Transient Elastography in assessing fibrosis at diagnosis in naive patients with Primary Biliary Cholangitis: a dual cut-off approach","volume":"74","author":"Cristoferi","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2022.06.010_bib22","article-title":"Liver stiffness measurement by vibration-controlled transient elastography improves outcome prediction in primary biliary cholangitis","volume":"Jun 28","author":"Corpechot","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cld.2022.06.010_bib23","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41395-018-0265-7","article-title":"Non-invasive prediction of high-risk varices in patients with primary biliary cholangitis and primary sclerosing cholangitis","volume":"114","author":"Moctezuma-Velazquez","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cld.2022.06.010_bib24","doi-asserted-by":"crossref","first-page":"361","DOI":"10.14309\/ajg.0000000000000056","article-title":"Baveno-VI-guided prediction of Esogastric varices in primary biliary cholangitis","volume":"114","author":"Pariente","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cld.2022.06.010_bib25","first-page":"887","article-title":"Performance and utility of transient elastography and noninvasive markers of liver fibrosis in primary biliary cirrhosis","volume":"43","author":"Floreani","year":"2011","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.cld.2022.06.010_bib26","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/hep.22517","article-title":"Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay","volume":"48","author":"Mayo","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2022.06.010_bib27","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/MCG.0b013e3181a84b8d","article-title":"Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers","volume":"44","author":"Friedrich-Rust","year":"2010","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.cld.2022.06.010_bib28","doi-asserted-by":"crossref","first-page":"e387","DOI":"10.1016\/S0618-8278(19)30760-1","article-title":"Bezafibrate Add-on therapy in high-risk primary biliary cholangitis is associated with an Improvement of FibroMeter and FibroMeter-VCTE, two high-accuracy non-invasive fibrosis tests extensively validated in Frequent chronic liver diseases","volume":"70","author":"Corpechot","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cld.2022.06.010_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2020.10.013","article-title":"FibroMeter scores for the assessment of liver fibrosis in patients with autoimmune liver diseases","volume":"22","author":"Zachou","year":"2021","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.cld.2022.06.010_bib30","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-2796.1992.tb00964.x","article-title":"Serum hyaluronan and aminoterminal propeptide of type III procollagen in primary biliary cirrhosis: relation to clinical symptoms, liver histopathology and outcome","volume":"231","author":"Nyberg","year":"1992","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.cld.2022.06.010_bib31","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cld.2015.08.013","article-title":"Utility of noninvasive markers of fibrosis in cholestatic liver diseases","volume":"20","author":"Corpechot","year":"2016","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.cld.2022.06.010_bib32","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jhep.2014.01.029","article-title":"Optimising risk stratification in primary biliary cirrhosis: AST\/platelet ratio index predicts outcome independent of ursodeoxycholic acid response","volume":"60","author":"Trivedi","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cld.2022.06.010_bib33","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nrgastro.2016.86","article-title":"Critical comparison of elastography methods to assess chronic liver disease","volume":"13","author":"Friedrich-Rust","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.cld.2022.06.010_bib34","series-title":"Clin Use Interpretation","first-page":"737","article-title":"Liver elastography","volume":"XIX","author":"Mueller","year":"2020"},{"key":"10.1016\/j.cld.2022.06.010_bib35","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.ultrasmedbio.2003.07.001","article-title":"Transient elastography: a new noninvasive method for assessment of hepatic fibrosis","volume":"29","author":"Sandrin","year":"2003","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.cld.2022.06.010_bib36","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1053\/j.gastro.2008.01.034","article-title":"Performance of transient elastography for the staging of liver fibrosis: a meta-analysis","volume":"134","author":"Friedrich-Rust","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cld.2022.06.010_bib37","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/hep.21151","article-title":"Assessment of biliary fibrosis by transient elastography in patients with PBC and PSC","volume":"43","author":"Corpechot","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.cld.2022.06.010_bib38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1365-2036.2007.03585.x","article-title":"Transient elastography to assess hepatic fibrosis in primary biliary cirrhosis","volume":"27","author":"Gomez-Dominguez","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cld.2022.06.010_bib39","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.crad.2014.03.019","article-title":"Acoustic radiation force impulse elastography for non-invasive assessment of disease stage in patients with primary biliary cirrhosis: a preliminary study","volume":"69","author":"Zhang","year":"2014","journal-title":"Clin Radiol"},{"key":"10.1016\/j.cld.2022.06.010_bib40","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5604\/01.3001.0012.7858","article-title":"Acoustic radiation force impulse (ARFI) elastography in autoimmune and cholestatic liver diseases","volume":"18","author":"Goertz","year":"2019","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.cld.2022.06.010_bib41","article-title":"Diagnostic performance of a point shear wave elastography (pSWE) for hepatic fibrosis in patients with autoimmune liver disease","volume":"14","author":"Park","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.cld.2022.06.010_bib42","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1080\/00365521.2021.1928277","article-title":"Liver stiffness measurements by 2-dimensional shear wave elastography compared to histological and ultrasound parameters in primary biliary cholangitis","volume":"56","author":"Manesis","year":"2021","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.cld.2022.06.010_bib43","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.21037\/qims-21-657","article-title":"Shear wave elastography and shear wave dispersion imaging in primary biliary cholangitis-a pilot study","volume":"12","author":"Schulz","year":"2022","journal-title":"Quant Imaging Med Surg"},{"key":"10.1016\/j.cld.2022.06.010_bib44","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/hepr.12861","article-title":"Comparison between real-time tissue elastography and vibration-controlled transient elastography for the assessment of liver fibrosis and disease progression in patients with primary biliary cholangitis","volume":"47","author":"Koizumi","year":"2017","journal-title":"Hepatol Res"},{"key":"10.1016\/j.cld.2022.06.010_bib45","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/MCG.0000000000001433","article-title":"Liver stiffness measured by Either magnetic resonance or transient elastography is associated with liver fibrosis and is an independent predictor of outcomes Among patients with primary biliary cholangitis","volume":"55","author":"Osman","year":"2021","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.cld.2022.06.010_bib46","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jhep.2016.05.023","article-title":"Transient elastography in autoimmune hepatitis: Timing determines the impact of inflammation and fibrosis","volume":"65","author":"Hartl","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cld.2022.06.010_bib47","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3748\/wjg.v24.i6.737","article-title":"Performance of transient elastography in assessing liver fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome","volume":"24","author":"Wu","year":"2018","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.cld.2022.06.010_bib48","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/RUQ.0000000000000591","article-title":"Arrival-time Parametric imaging in Contrast-enhanced ultrasound for diagnosing fibrosis in primary biliary cholangitis","volume":"38","author":"Yoshimine","year":"2022","journal-title":"Ultrasound Q"},{"key":"10.1016\/j.cld.2022.06.010_bib49","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/s00330-011-2296-y","article-title":"Integrative role of MRI in the evaluation of primary biliary cirrhosis","volume":"22","author":"Kovac","year":"2012","journal-title":"Eur Radiol"},{"key":"10.1016\/j.cld.2022.06.010_bib50","doi-asserted-by":"crossref","first-page":"e0120110","DOI":"10.1371\/journal.pone.0120110","article-title":"The value of MRI in the diagnosis of primary biliary cirrhosis and assessment of liver fibrosis","volume":"10","author":"Meng","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.cld.2022.06.010_bib51","doi-asserted-by":"crossref","first-page":"E108","DOI":"10.1111\/hepr.12470","article-title":"Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging as a useful detection method for advanced primary biliary cirrhosis","volume":"45","author":"Takeyama","year":"2015","journal-title":"Hepatol Res"},{"key":"10.1016\/j.cld.2022.06.010_bib52","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1007\/s00330-020-06855-0","article-title":"Magnetic resonance imaging features in 283 patients with primary biliary cholangitis","volume":"30","author":"Idilman","year":"2020","journal-title":"Eur Radiol"},{"key":"10.1016\/j.cld.2022.06.010_bib53","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/jgh.14929","article-title":"Clinical utility of FibroScan as a non-invasive diagnostic test for primary biliary cholangitis","volume":"35","author":"Joshita","year":"2020","journal-title":"J\u00a0Gastroenterol Hepatol"}],"container-title":["Clinics in Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326122000484?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326122000484?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:00:11Z","timestamp":1761069611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089326122000484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S1089326122000484"],"URL":"https:\/\/doi.org\/10.1016\/j.cld.2022.06.010","relation":{},"ISSN":["1089-3261"],"issn-type":[{"value":"1089-3261","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Noninvasive Evaluation of Fibrosis and Portal Hypertension in Primary Biliary Cholangitis","name":"articletitle","label":"Article Title"},{"value":"Clinics in Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cld.2022.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}