{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:14:03Z","timestamp":1790957643309,"version":"4.1.0"},"reference-count":105,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Liver Disease"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.cld.2023.01.004","type":"journal-article","created":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T15:15:49Z","timestamp":1677424549000},"page":"251-273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Extrahepatic Outcomes of Nonalcoholic Fatty Liver Disease"],"prefix":"10.1016","volume":"27","author":[{"given":"Maryam K.","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey G.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Rinella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cld.2023.01.004_bib1","doi-asserted-by":"crossref","unstructured":"Younossi ZM, Golabi P, Paik JM, et\u00a0al. The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review [published online ahead of print, 2023 Jan 3], Hepatology, 2023, https:\/\/doi.org\/10.1097\/HEP.0000000000000004.","DOI":"10.1097\/HEP.0000000000000004"},{"issue":"5","key":"10.1016\/j.cld.2023.01.004_bib2","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/hep.28785","article-title":"The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.cld.2023.01.004_bib3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3350\/cmh.2020.0239","article-title":"Evaluation and management of extrahepatic manifestations of nonalcoholic fatty liver disease","volume":"27","author":"Wijarnpreecha","year":"2021","journal-title":"Clin Mol Hepatol"},{"issue":"7","key":"10.1016\/j.cld.2023.01.004_bib4","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1136\/gutjnl-2020-322786","article-title":"Mortality in biopsy-confirmed nonalcoholic fatty liver disease","volume":"70","author":"Simon","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.cld.2023.01.004_bib5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.canep.2017.04.007","article-title":"Nonalcoholic fatty liver disease and mortality among cancer survivors","volume":"48","author":"Brown","year":"2017","journal-title":"Cancer Epidemiol"},{"key":"10.1016\/j.cld.2023.01.004_bib6","doi-asserted-by":"crossref","first-page":"j477","DOI":"10.1136\/bmj.j477","article-title":"Adiposity and cancer at major anatomical sites: umbrella review of the literature","volume":"356","author":"Kyrgiou","year":"2017","journal-title":"BMJ"},{"issue":"9","key":"10.1016\/j.cld.2023.01.004_bib7","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.2337\/dc20-0204","article-title":"Association of type 2 diabetes with cancer: a meta-analysis with bias analysis for unmeasured confounding in 151 cohorts comprising 32 million people","volume":"43","author":"Ling","year":"2020","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib8","doi-asserted-by":"crossref","first-page":"17376","DOI":"10.1038\/s41598-020-73668-y","article-title":"A\u00a0national observation study of cancer incidence and mortality risks in type 2 diabetes compared to the background population over time","volume":"10","author":"Bjornsdottir","year":"2020","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.cld.2023.01.004_bib9","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.jhep.2019.08.018","article-title":"The risk of incident extrahepatic cancers is higher in non-alcoholic fatty liver disease than obesity - a longitudinal cohort study","volume":"71","author":"Allen","year":"2019","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib10","doi-asserted-by":"crossref","first-page":"12795","DOI":"10.1038\/s41598-017-13209-2","article-title":"Clinical implication of ectopic liver lipid accumulation in renal cell carcinoma patients without visceral obesity","volume":"7","author":"Watanabe","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.cld.2023.01.004_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fendo.2013.00071","article-title":"Adipokines mediate inflammation and insulin resistance","volume":"4","author":"Kwon","year":"2013","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.cld.2023.01.004_bib12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cca.2014.07.043","article-title":"Insulin resistance to malignancy","volume":"438","author":"Codo\u00f1er-Franch","year":"2015","journal-title":"Clin Chim Acta Int J Clin Chem"},{"key":"10.1016\/j.cld.2023.01.004_bib13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1749-6632.2012.06737.x","article-title":"Obesity, metabolic dysregulation, and cancer: a growing concern and an inflammatory (and microenvironmental) issue","volume":"1271","author":"Hursting","year":"2012","journal-title":"Ann N Y Acad Sci"},{"issue":"12","key":"10.1016\/j.cld.2023.01.004_bib14","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1158\/1541-7786.MCR-11-0271","article-title":"IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway","volume":"9","author":"Yadav","year":"2011","journal-title":"Mol Cancer Res MCR"},{"issue":"5","key":"10.1016\/j.cld.2023.01.004_bib15","doi-asserted-by":"crossref","first-page":"E717","DOI":"10.3390\/ijms17050717","article-title":"Non-alcoholic fatty liver disease and extra-hepatic cancers","volume":"17","author":"Sanna","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.cld.2023.01.004_bib16","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1158\/0008-5472.CAN-11-2771","article-title":"Adipokines linking obesity with colorectal cancer risk in postmenopausal women","volume":"72","author":"Ho","year":"2012","journal-title":"Cancer Res"},{"issue":"11","key":"10.1016\/j.cld.2023.01.004_bib17","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1002\/ijc.23821","article-title":"Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways","volume":"123","author":"Jaffe","year":"2008","journal-title":"Int J Cancer"},{"issue":"13","key":"10.1016\/j.cld.2023.01.004_bib18","first-page":"2241","article-title":"Association of serum levels of adipokines and insulin with risk of Barrett\u2019s esophagus: a systematic review and meta-analysis","volume":"13","author":"Chandar","year":"2015","journal-title":"Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/gut.2007.131672","article-title":"The association of gastric leptin with oesophageal inflammation and metaplasia","volume":"57","author":"Francois","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.cld.2023.01.004_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.lfs.2015.04.012","article-title":"Leptin, adipocytes and breast cancer: focus on inflammation and anti-tumor immunity","volume":"140","author":"Delort","year":"2015","journal-title":"Life Sci"},{"key":"10.1016\/j.cld.2023.01.004_bib21","first-page":"65","article-title":"Mechanisms linking excess adiposity and carcinogenesis promotion","volume":"5","author":"P\u00e9rez-Hern\u00e1ndez","year":"2014","journal-title":"Front Endocrinol"},{"issue":"2","key":"10.1016\/j.cld.2023.01.004_bib22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.chom.2020.07.007","article-title":"Microbiota and fatty liver disease\u2014the known, the unknown, and the future","volume":"28","author":"Lang","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cld.1006","article-title":"Molecular mechanisms linking nonalcoholic steatohepatitis to cancer","volume":"17","author":"Wegermann","year":"2021","journal-title":"Clin Liver Dis"},{"issue":"3","key":"10.1016\/j.cld.2023.01.004_bib24","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1055\/s-0035-1562944","article-title":"Systemic complications of nonalcoholic fatty liver disease: when the liver is not an innocent bystander","volume":"35","author":"Vanni","year":"2015","journal-title":"Semin Liver Dis"},{"issue":"3","key":"10.1016\/j.cld.2023.01.004_bib25","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3390\/biomedicines10030524","article-title":"The role of gut\u2013liver axis in gut microbiome dysbiosis associated NAFLD and NAFLD-HCC","volume":"10","author":"Song","year":"2022","journal-title":"Biomedicines"},{"issue":"5","key":"10.1016\/j.cld.2023.01.004_bib26","doi-asserted-by":"crossref","first-page":"947","DOI":"10.4251\/wjgo.v14.i5.947","article-title":"Gut microbiome in non-alcoholic fatty liver disease associated hepatocellular carcinoma: current knowledge and potential for therapeutics","volume":"14","author":"Said","year":"2022","journal-title":"World J Gastrointest Oncol"},{"key":"10.1016\/j.cld.2023.01.004_bib27","doi-asserted-by":"crossref","first-page":"615056","DOI":"10.3389\/fimmu.2020.615056","article-title":"The intestinal microbiota and colorectal cancer","volume":"11","author":"Cheng","year":"2020","journal-title":"Front Immunol"},{"issue":"11","key":"10.1016\/j.cld.2023.01.004_bib28","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/s41575-019-0209-8","article-title":"Gut microbiota in colorectal cancer: mechanisms of action and clinical applications","volume":"16","author":"Wong","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12876-017-0696-4","article-title":"Non-alcoholic fatty liver disease as a risk factor for cholangiocarcinoma: a systematic review and meta-analysis","volume":"17","author":"Wongjarupong","year":"2017","journal-title":"BMC Gastroenterol"},{"issue":"10","key":"10.1016\/j.cld.2023.01.004_bib30","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.cgh.2007.05.020","article-title":"Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based case-control study","volume":"5","author":"Welzel","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cld.2023.01.004_bib31","doi-asserted-by":"crossref","first-page":"880298","DOI":"10.3389\/fimmu.2022.880298","article-title":"Association of inflammatory cytokines with non-alcoholic fatty liver disease","volume":"13","author":"Duan","year":"2022","journal-title":"Front Immunol"},{"issue":"21","key":"10.1016\/j.cld.2023.01.004_bib32","doi-asserted-by":"crossref","first-page":"10517","DOI":"10.1158\/0008-5472.CAN-06-2130","article-title":"Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression","volume":"66","author":"Wehbe","year":"2006","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib33","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1053\/gast.2001.20875","article-title":"Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes","volume":"120","author":"Jaiswal","year":"2001","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib34","doi-asserted-by":"crossref","first-page":"G88","DOI":"10.1152\/ajpgi.00539.2003","article-title":"Inducible nitric oxide synthase upregulates cyclooxygenase-2 in mouse cholangiocytes promoting cell growth","volume":"287","author":"Ishimura","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib35","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/MEG.0000000000001684","article-title":"Nonalcoholic fatty liver disease is associated with intrahepatic cholangiocarcinoma and not with extrahepatic form: definitive evidence from meta-analysis and trial sequential analysis","volume":"33","author":"Corrao","year":"2021","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.cld.2023.01.004_bib36","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2353\/ajpath.2006.050464","article-title":"Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma","volume":"169","author":"Alvaro","year":"2006","journal-title":"Am J Pathol"},{"issue":"10","key":"10.1016\/j.cld.2023.01.004_bib37","doi-asserted-by":"crossref","first-page":"e0186643","DOI":"10.1371\/journal.pone.0186643","article-title":"Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based study in SEER-Medicare","volume":"12","author":"Petrick","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib38","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12944-020-01288-6","article-title":"Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis","volume":"19","author":"Liu","year":"2020","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.cld.2023.01.004_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.metabol.2018.06.004","article-title":"Association between nonalcoholic fatty liver disease and colorectal tumours in asymptomatic adults undergoing screening colonoscopy: a systematic review and meta-analysis","volume":"87","author":"Mantovani","year":"2018","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.cld.2023.01.004_bib40","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/apt.13866","article-title":"Non-alcoholic fatty liver diseases and risk of colorectal neoplasia","volume":"45","author":"Ahn","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"10.1016\/j.cld.2023.01.004_bib41","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/17474124.2019.1580143","article-title":"The association between nonalcoholic fatty liver disease and risk of colorectal adenoma and cancer incident and recurrence: a meta-analysis of observational studies","volume":"13","author":"Chen","year":"2019","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.cld.2023.01.004_bib42","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1440-1746.2009.06117.x","article-title":"Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps","volume":"25","author":"Hwang","year":"2010","journal-title":"J\u00a0Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1365-2796.2011.02377.x","article-title":"Nonalcoholic fatty liver disease: an independent risk factor for colorectal neoplasia","volume":"270","author":"Stadlmayr","year":"2011","journal-title":"J\u00a0Intern Med"},{"issue":"6","key":"10.1016\/j.cld.2023.01.004_bib44","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1136\/gut.2011.237974","article-title":"High prevalence of colorectal neoplasm in patients with non-alcoholic steatohepatitis","volume":"60","author":"Wong","year":"2011","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib45","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1440-1746.2011.06816.x","article-title":"Colorectal neoplasms in relation to non-alcoholic fatty liver disease in Korean women: a retrospective cohort study","volume":"27","author":"Lee","year":"2012","journal-title":"J\u00a0Gastroenterol Hepatol"},{"issue":"7","key":"10.1016\/j.cld.2023.01.004_bib46","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/codi.12172","article-title":"Patients with nonalcoholic fatty liver disease have higher risk of colorectal adenoma after negative baseline colonoscopy","volume":"15","author":"Huang","year":"2013","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.cld.2023.01.004_bib47","doi-asserted-by":"crossref","first-page":"607909","DOI":"10.3389\/fonc.2020.607909","article-title":"Sexual dimorphism in colon cancer","volume":"10","author":"Abancens","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.cld.2023.01.004_bib48","doi-asserted-by":"crossref","DOI":"10.1002\/hep4.2073","article-title":"Risk of nonalcoholic fatty liver disease and associations with gastrointestinal cancers","author":"McHenry","year":"2022","journal-title":"Hepatol Commun"},{"issue":"5","key":"10.1016\/j.cld.2023.01.004_bib49","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1002\/hep.31845","article-title":"Cancer risk in patients with biopsy-confirmed nonalcoholic fatty liver disease: a population-based cohort study","volume":"74","author":"Simon","year":"2021","journal-title":"Hepatol Baltim Md"},{"key":"10.1016\/j.cld.2023.01.004_bib50","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-230X-13-66","article-title":"Liver disease and 30-day mortality after colorectal cancer surgery: a Danish population-based cohort study","volume":"13","author":"Montomoli","year":"2013","journal-title":"BMC Gastroenterol"},{"issue":"8","key":"10.1016\/j.cld.2023.01.004_bib51","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1007\/DCR.0b013e3181a80dca","article-title":"The impact of cirrhosis and portal hypertension on mortality following colorectal surgery: a nationwide, population-based study","volume":"52","author":"Nguyen","year":"2009","journal-title":"Dis Colon Rectum"},{"issue":"8","key":"10.1016\/j.cld.2023.01.004_bib52","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s10350-008-9336-y","article-title":"Colorectal surgery in cirrhotic patients: assessment of operative morbidity and mortality","volume":"51","author":"Meunier","year":"2008","journal-title":"Dis Colon Rectum"},{"issue":"7","key":"10.1016\/j.cld.2023.01.004_bib53","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/BF02554783","article-title":"The surgical risk of colectomy in patients with cirrhosis","volume":"30","author":"Metcalf","year":"1987","journal-title":"Dis Colon Rectum"},{"issue":"6","key":"10.1016\/j.cld.2023.01.004_bib54","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S1072-7515(03)00117-0","article-title":"Colorectal adenocarcinoma in cirrhotic patients","volume":"196","author":"Gervaz","year":"2003","journal-title":"J\u00a0Am Coll Surg"},{"issue":"7","key":"10.1016\/j.cld.2023.01.004_bib55","doi-asserted-by":"crossref","first-page":"e020511","DOI":"10.1136\/bmjopen-2017-020511","article-title":"Short-term postoperative outcomes of colorectal cancer among patients with chronic liver disease: a national population-based study","volume":"8","author":"Lee","year":"2018","journal-title":"BMJ Open"},{"issue":"5","key":"10.1016\/j.cld.2023.01.004_bib56","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ncpgasthep0794","article-title":"Preoperative evaluation of patients with liver disease","volume":"4","author":"Hanje","year":"2007","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1016\/j.cld.2023.01.004_bib57","first-page":"192","article-title":"Surgery in the patient with liver disease","volume":"121","author":"Friedman","year":"2010","journal-title":"Trans Am Clin Climatol Assoc"},{"issue":"2","key":"10.1016\/j.cld.2023.01.004_bib58","first-page":"165","article-title":"Non-alcoholic fatty liver disease and colorectal cancer survival","volume":"30","author":"Wu","year":"2019","journal-title":"Cancer Causes Control CCC"},{"key":"10.1016\/j.cld.2023.01.004_bib59","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12957-018-1461-z","article-title":"The combined effect of non-alcoholic fatty liver disease and metabolic syndrome on colorectal carcinoma mortality: a retrospective in Chinese females","volume":"16","author":"Chen","year":"2018","journal-title":"World J Surg Oncol"},{"issue":"5","key":"10.1016\/j.cld.2023.01.004_bib60","doi-asserted-by":"crossref","first-page":"e479","DOI":"10.1097\/MD.0000000000000479","article-title":"Nonalcoholic fatty liver disease: a negative risk factor for colorectal cancer prognosis","volume":"94","author":"You","year":"2015","journal-title":"Medicine (Baltim)"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib61","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.clinre.2011.10.006","article-title":"Influence of non-alcoholic fatty liver disease on the prognosis in patients with colorectal cancer","volume":"36","author":"Min","year":"2012","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"8","key":"10.1016\/j.cld.2023.01.004_bib62","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s00384-013-1656-2","article-title":"Hepatic steatosis is associated with lower incidence of liver metastasis from colorectal cancer","volume":"28","author":"Murono","year":"2013","journal-title":"Int J Colorectal Dis"},{"issue":"16","key":"10.1016\/j.cld.2023.01.004_bib63","first-page":"1069","article-title":"Liver metastasis rare in colorectal cancer patients with fatty liver","volume":"44","author":"Hayashi","year":"1997","journal-title":"Hepato-Gastroenterology"},{"issue":"9","key":"10.1016\/j.cld.2023.01.004_bib64","doi-asserted-by":"crossref","first-page":"e108618","DOI":"10.1371\/journal.pone.0108618","article-title":"Patients with chronically diseased livers have lower incidence of colorectal liver metastases: a meta-analysis","volume":"9","author":"Cai","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib65","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/bjc.2016.155","article-title":"The impact of hepatic fibrosis on the incidence of liver metastasis from colorectal cancer","volume":"115","author":"Kondo","year":"2016","journal-title":"Br J Cancer"},{"issue":"6","key":"10.1016\/j.cld.2023.01.004_bib66","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/bjs.9057","article-title":"Fatty liver disease as a predictor of local recurrence following resection of colorectal liver metastases","volume":"100","author":"Hamady","year":"2013","journal-title":"Br J Surg"},{"issue":"5","key":"10.1016\/j.cld.2023.01.004_bib67","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nrgastro.2013.53","article-title":"Metastatic colorectal cancer outcome and fatty liver disease","volume":"10","author":"Brouquet","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.cld.2023.01.004_bib68","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3389\/fonc.2020.00251","article-title":"Effect of non-alcoholic fatty liver disease on the risk of synchronous liver metastasis: analysis of 451 consecutive patients of newly diagnosed colorectal cancer","volume":"10","author":"Lv","year":"2020","journal-title":"Front Oncol"},{"issue":"7","key":"10.1016\/j.cld.2023.01.004_bib69","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1872-034X.2011.00813.x","article-title":"Systematic review with meta-analyses of studies on the association between cirrhosis and liver metastases","volume":"41","author":"Dahl","year":"2011","journal-title":"Hepatol Res Off J Jpn Soc Hepatol"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib70","doi-asserted-by":"crossref","first-page":"e000295","DOI":"10.1136\/bmjgast-2019-000295","article-title":"Non-alcoholic fatty liver disease with obesity as an independent predictor for incident gastric and colorectal cancer: a population-based longitudinal study","volume":"6","author":"Hamaguchi","year":"2019","journal-title":"BMJ Open Gastroenterol"},{"issue":"8","key":"10.1016\/j.cld.2023.01.004_bib71","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1111\/cas.13292","article-title":"Body mass index and risk of gastric cancer: a 30-year follow-up study in the Linxian general population trial cohort","volume":"108","author":"Fan","year":"2017","journal-title":"Cancer Sci"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib72","doi-asserted-by":"crossref","first-page":"e0226351","DOI":"10.1371\/journal.pone.0226351","article-title":"The association between nonalcoholic fatty liver disease and esophageal, stomach, or colorectal cancer: national population-based cohort study","volume":"15","author":"Lee","year":"2020","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.cld.2023.01.004_bib73","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11901-019-00499-5","article-title":"Extrahepatic malignancies in nonalcoholic fatty liver disease","volume":"18","author":"Ahmed","year":"2019","journal-title":"Curr Hepatol Rep"},{"issue":"3","key":"10.1016\/j.cld.2023.01.004_bib74","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1038\/ctg.2014.5","article-title":"Association of pancreatic fatty infiltration with pancreatic ductal adenocarcinoma","volume":"5","author":"Hori","year":"2014","journal-title":"Clin Transl Gastroenterol"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib75","doi-asserted-by":"crossref","first-page":"10681","DOI":"10.1038\/s41598-022-14856-w","article-title":"Increased risk of pancreatic cancer in individuals with non-alcoholic fatty liver disease","volume":"12","author":"Park","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.cld.2023.01.004_bib76","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-3-0348-0837-8_6","article-title":"The role of inflammation in pancreatic cancer","volume":"816","author":"Hausmann","year":"2014","journal-title":"Adv Exp Med Biol"},{"issue":"8","key":"10.1016\/j.cld.2023.01.004_bib77","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1097\/MPA.0000000000001386","article-title":"Inflammation promotes progression of pancreatic cancer through WNT\/\u03b2-catenin pathway-dependent manner","volume":"48","author":"Ren","year":"2019","journal-title":"Pancreas"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib78","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12943-019-1008-0","article-title":"The microbiota and microbiome in pancreatic cancer: more influential than expected","volume":"18","author":"Wei","year":"2019","journal-title":"Mol Cancer"},{"issue":"2","key":"10.1016\/j.cld.2023.01.004_bib79","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11739-017-1774-x","article-title":"Exploring the relationship between nonalcoholic fatty liver disease and pancreatic cancer by computed tomographic survey","volume":"13","author":"Chang","year":"2018","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.cld.2023.01.004_bib80","article-title":"Association between non-alcoholic fatty liver disease and cancer incidence rate","volume":"2","author":"Kim","year":"2017","journal-title":"J\u00a0Hepatol. Published online November"},{"issue":"2","key":"10.1016\/j.cld.2023.01.004_bib81","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ki.2014.285","article-title":"TNF receptors: signaling pathways and contribution to renal dysfunction","volume":"87","author":"Al-Lamki","year":"2015","journal-title":"Kidney Int"},{"issue":"4","key":"10.1016\/j.cld.2023.01.004_bib82","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.eururo.2008.02.044","article-title":"Lower plasma adiponectin levels are associated with larger tumor size and metastasis in clear-cell carcinoma of the kidney","volume":"54","author":"Pinthus","year":"2008","journal-title":"Eur Urol"},{"issue":"4 Pt 1","key":"10.1016\/j.cld.2023.01.004_bib83","first-page":"1631","article-title":"Increased serum leptin levels and over expression of leptin receptors are associated with the invasion and progression of renal cell carcinoma","volume":"176","author":"Horiguchi","year":"2006","journal-title":"J\u00a0Urol"},{"issue":"5","key":"10.1016\/j.cld.2023.01.004_bib84","doi-asserted-by":"crossref","first-page":"R253","DOI":"10.1530\/ERC-15-0135","article-title":"Insulin and IGFs in renal cancer risk and progression","volume":"22","author":"Solarek","year":"2015","journal-title":"Endocr Relat Cancer"},{"issue":"4","key":"10.1016\/j.cld.2023.01.004_bib85","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/00004836-200304000-00015","article-title":"Risk of cancer in patients hospitalized with fatty liver: a Danish cohort study","volume":"36","author":"S\u00f8rensen","year":"2003","journal-title":"J\u00a0Clin Gastroenterol"},{"issue":"49","key":"10.1016\/j.cld.2023.01.004_bib86","doi-asserted-by":"crossref","first-page":"e2080","DOI":"10.1097\/MD.0000000000002080","article-title":"Nonalcoholic cirrhosis increased risk of digestive tract malignancies: a population-based cohort study","volume":"94","author":"Sun","year":"2015","journal-title":"Medicine (Baltim)"},{"issue":"9","key":"10.1016\/j.cld.2023.01.004_bib87","doi-asserted-by":"crossref","first-page":"e0201308","DOI":"10.1371\/journal.pone.0201308","article-title":"Is nonalcoholic fatty liver disease associated with the development of prostate cancer? A nationwide study with 10,516,985 Korean men","volume":"13","author":"Choi","year":"2018","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.cld.2023.01.004_bib88","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1530\/ERC-14-0036","article-title":"Nonalcoholic fatty liver disease is a negative risk factor for prostate cancer recurrence","volume":"21","author":"Choi","year":"2014","journal-title":"Endocr Relat Cancer"},{"issue":"7","key":"10.1016\/j.cld.2023.01.004_bib89","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.dld.2018.12.024","article-title":"Nonalcoholic fatty liver disease is associated with breast cancer in nonobese women","volume":"51","author":"Kwak","year":"2019","journal-title":"Dig Liver Dis"},{"issue":"7","key":"10.1016\/j.cld.2023.01.004_bib90","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3748\/wjg.v9.i7.1618","article-title":"Fatty metamorphosis of the liver in patients with breast cancer: possible associated factors","volume":"9","author":"Chu","year":"2003","journal-title":"World J Gastroenterol WJG"},{"issue":"40","key":"10.1016\/j.cld.2023.01.004_bib91","doi-asserted-by":"crossref","first-page":"e1718","DOI":"10.1097\/MD.0000000000001718","article-title":"Selective estrogen receptor modulator-associated nonalcoholic fatty liver disease improved survival in patients with breast cancer: a retrospective cohort analysis","volume":"94","author":"Zheng","year":"2015","journal-title":"Medicine (Baltim)"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib92","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10549-017-4411-5","article-title":"Fatty liver decreases the risk of liver metastasis in patients with breast cancer: a two-center cohort study","volume":"166","author":"Wu","year":"2017","journal-title":"Breast Cancer Res Treat"},{"issue":"8","key":"10.1016\/j.cld.2023.01.004_bib93","doi-asserted-by":"crossref","first-page":"e653","DOI":"10.1634\/theoncologist.2018-0370","article-title":"Aromatase inhibitors and newly developed nonalcoholic fatty liver disease in postmenopausal patients with early breast cancer: a propensity score-matched cohort study","volume":"24","author":"Lee","year":"2019","journal-title":"Oncol"},{"issue":"3","key":"10.1016\/j.cld.2023.01.004_bib94","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.clbc.2016.12.004","article-title":"The relationship between tamoxifen-associated nonalcoholic fatty liver disease and the prognosis of patients with early-stage breast cancer","volume":"17","author":"Yan","year":"2017","journal-title":"Clin Breast Cancer"},{"issue":"39","key":"10.1016\/j.cld.2023.01.004_bib95","doi-asserted-by":"crossref","first-page":"e17277","DOI":"10.1097\/MD.0000000000017277","article-title":"Underlying nonalcoholic fatty liver disease is a significant factor for breast cancer recurrence after curative surgery","volume":"98","author":"Lee","year":"2019","journal-title":"Medicine (Baltim)"},{"issue":"15","key":"10.1016\/j.cld.2023.01.004_bib96","first-page":"4597","article-title":"The impact of pre-existed and SERM-induced non-alcoholic fatty liver disease on breast cancer survival: a meta-analysis","volume":"11","author":"Wang","year":"2020","journal-title":"J\u00a0Cancer"},{"issue":"5","key":"10.1016\/j.cld.2023.01.004_bib97","doi-asserted-by":"crossref","first-page":"417","DOI":"10.4048\/jbc.2021.24.e41","article-title":"Fatty liver in hormone receptor-positive breast cancer and its impact on patient\u2019s survival","volume":"24","author":"Taroeno-Hariadi","year":"2021","journal-title":"J\u00a0Breast Cancer"},{"issue":"2","key":"10.1016\/j.cld.2023.01.004_bib98","doi-asserted-by":"crossref","first-page":"e000042","DOI":"10.1136\/esmoopen-2016-000042","article-title":"Cancer and liver cirrhosis: implications on prognosis and management","volume":"1","author":"Pinter","year":"2016","journal-title":"ESMO Open"},{"issue":"2","key":"10.1016\/j.cld.2023.01.004_bib99","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1665-2681(19)31651-5","article-title":"Effects of systemic chemotherapy on the liver","volume":"9","author":"Ramadori","year":"2010","journal-title":"Ann Hepatol"},{"issue":"4","key":"10.1016\/j.cld.2023.01.004_bib100","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.3390\/curroncol28040265","article-title":"Evaluation of adjuvant chemotherapy-associated steatosis (CAS) in colorectal cancer","volume":"28","author":"Lee","year":"2021","journal-title":"Curr Oncol Tor Ont"},{"issue":"2","key":"10.1016\/j.cld.2023.01.004_bib101","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.suc.2015.11.005","article-title":"Chemotherapy-associated hepatotoxicities","volume":"96","author":"White","year":"2016","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.cld.2023.01.004_bib102","first-page":"S366","article-title":"An unintended consequence: chemotherapy associated steatohepatitis: 844","volume":"110","author":"West","year":"2015","journal-title":"J\u00a0Am Coll Gastroenterol ACG"},{"issue":"6","key":"10.1016\/j.cld.2023.01.004_bib103","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.aohep.2019.11.012","article-title":"Chemotherapy-associated steatohepatitis","volume":"19","author":"Meunier","year":"2020","journal-title":"Ann Hepatol"},{"issue":"2","key":"10.1016\/j.cld.2023.01.004_bib104","doi-asserted-by":"crossref","DOI":"10.21037\/tlcr.2020.04.15","article-title":"Non-alcoholic fatty liver disease is associated with immune checkpoint inhibitor-based treatment response in patients with non-small cell lung cancer with liver metastases","volume":"9","author":"Zhou","year":"2020","journal-title":"Transl Lung Cancer Res"},{"issue":"1","key":"10.1016\/j.cld.2023.01.004_bib105","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1053\/j.gastro.2021.03.021","article-title":"Bariatric surgery reduces cancer risk in adults with nonalcoholic fatty liver disease and severe obesity","volume":"161","author":"Rustgi","year":"2021","journal-title":"Gastroenterology"}],"container-title":["Clinics in Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326123000041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326123000041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:01:05Z","timestamp":1761069665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089326123000041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":105,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S1089326123000041"],"URL":"https:\/\/doi.org\/10.1016\/j.cld.2023.01.004","relation":{},"ISSN":["1089-3261"],"issn-type":[{"value":"1089-3261","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extrahepatic Outcomes of Nonalcoholic Fatty Liver Disease","name":"articletitle","label":"Article Title"},{"value":"Clinics in Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cld.2023.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}