{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:09:42Z","timestamp":1765357782645,"version":"3.41.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Liver Disease"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.cld.2024.12.010","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T12:39:55Z","timestamp":1738845595000},"page":"337-346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Innovations to Expand the Liver Donor Pool"],"prefix":"10.1016","volume":"29","author":[{"given":"Tsukasa","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alban","family":"Longchamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Markmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2S1","key":"10.1016\/j.cld.2024.12.010_bib1","doi-asserted-by":"crossref","first-page":"S457","DOI":"10.1016\/j.ajt.2024.01.018","article-title":"OPTN\/SRTR 2022 annual data report: deceased organ donation","volume":"24","author":"Israni","year":"2024","journal-title":"Am J Transplant"},{"issue":"1","key":"10.1016\/j.cld.2024.12.010_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.suc.2023.07.001","article-title":"Role of machine perfusion in liver transplantation","volume":"104","author":"Longchamp","year":"2024","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.cld.2024.12.010_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.900594","article-title":"Xenotransplantation: a new era","volume":"13","author":"Carrier","year":"2022","journal-title":"Front Immunol"},{"issue":"7553","key":"10.1016\/j.cld.2024.12.010_bib4","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/S0140-6736(68)91869-2","article-title":"Pig-to-baboon liver xenografts","volume":"1","author":"Calne","year":"1968","journal-title":"Lancet"},{"issue":"7638","key":"10.1016\/j.cld.2024.12.010_bib5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0140-6736(70)90462-9","article-title":"Hepatic allografts and xenografts in primates","volume":"1","author":"Calne","year":"1970","journal-title":"Lancet"},{"issue":"8837","key":"10.1016\/j.cld.2024.12.010_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0140-6736(93)92553-6","article-title":"Baboon-to-human liver transplantation","volume":"341","author":"Starzl","year":"1993","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.cld.2024.12.010_bib7","first-page":"1082","article-title":"Prospects of clinical xenotransplantation","volume":"26","author":"Starzl","year":"1994","journal-title":"Transplant Proc"},{"issue":"12","key":"10.1016\/j.cld.2024.12.010_bib8","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1097\/00007890-199506270-00002","article-title":"The use of a pig liver xenograft for temporary support of a patient with fulminant hepatic failure","volume":"59","author":"Makowa","year":"1995","journal-title":"Transplantation"},{"issue":"9","key":"10.1016\/j.cld.2024.12.010_bib9","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1128\/jb.171.9.4617-4622.1989","article-title":"New method for generating deletions and gene replacements in Escherichia coli","volume":"171","author":"Hamilton","year":"1989","journal-title":"J\u00a0Bacteriol"},{"issue":"6569","key":"10.1016\/j.cld.2024.12.010_bib10","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/380064a0","article-title":"Sheep cloned by nuclear transfer from a cultured cell line","volume":"380","author":"Campbell","year":"1996","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.cld.2024.12.010_bib11","first-page":"1395","article-title":"Comparison of newborn versus adult natural heterophile anti-pig red blood cell IgM xenoantibodies as correlates of xenograft survival","volume":"26","author":"Fukushima","year":"1994","journal-title":"Transplant Proc"},{"issue":"3","key":"10.1016\/j.cld.2024.12.010_bib12","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/xen.12161","article-title":"Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1\/CMAH\/beta4GalNT2 genes","volume":"22","author":"Estrada","year":"2015","journal-title":"Xenotransplantation"},{"issue":"7829","key":"10.1016\/j.cld.2024.12.010_bib13","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/d41586-020-02765-9","article-title":"Pioneers of revolutionary CRISPR gene editing win chemistry Nobel","volume":"586","author":"Ledford","year":"2020","journal-title":"Nature"},{"issue":"6357","key":"10.1016\/j.cld.2024.12.010_bib14","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.aan4187","article-title":"Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9","volume":"357","author":"Niu","year":"2017","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.cld.2024.12.010_bib15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s11248-016-9934-8","article-title":"The production of multi-transgenic pigs: update and perspectives for xenotransplantation","volume":"25","author":"Niemann","year":"2016","journal-title":"Transgenic Res"},{"issue":"5","key":"10.1016\/j.cld.2024.12.010_bib16","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/xen.12111","article-title":"Increased transfusion-free survival following auxiliary pig liver xenotransplantation","volume":"21","author":"Yeh","year":"2014","journal-title":"Xenotransplantation"},{"issue":"8","key":"10.1016\/j.cld.2024.12.010_bib17","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1111\/ajt.14341","article-title":"Prolonged survival following pig-to-primate liver xenotransplantation utilizing exogenous coagulation factors and costimulation blockade","volume":"17","author":"Shah","year":"2017","journal-title":"Am J Transplant"},{"issue":"5","key":"10.1016\/j.cld.2024.12.010_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/xen.12814","article-title":"Auxiliary liver xenotransplantation technique in a transgenic pig-to-non-human primate model: a surgical approach to prolong survival","volume":"30","author":"Lee","year":"2023","journal-title":"Xenotransplantation"},{"issue":"4","key":"10.1016\/j.cld.2024.12.010_bib19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S2468-1253(24)00047-5","article-title":"Can genetically engineered pig livers offer patients precious time?","volume":"9","author":"Furlow","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"8005","key":"10.1016\/j.cld.2024.12.010_bib20","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/d41586-024-00853-8","article-title":"First pig liver transplanted into a person lasts for 10\u00a0days","volume":"627","author":"Mallapaty","year":"2024","journal-title":"Nature"},{"issue":"8015","key":"10.1016\/j.cld.2024.12.010_bib21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/d41586-024-01613-4","article-title":"First pig-to-human liver transplant recipient 'doing very well'","volume":"630","author":"Mallapaty","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cld.2024.12.010_bib22","series-title":"Normothermic machine perfusion of discarded human livers alleviates ischemia-reperfusion injury and promotes regenerative pathways","first-page":"S26","author":"Ohman","year":"2020"},{"issue":"4","key":"10.1016\/j.cld.2024.12.010_bib23","first-page":"196","article-title":"A\u00a0novel model for ex situ reperfusion of the human liver following subnormothermic machine perfusion","volume":"5","author":"Avruch","year":"2017","journal-title":"Technology (Singap World Sci)"},{"issue":"4","key":"10.1016\/j.cld.2024.12.010_bib24","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/lt.25005","article-title":"Normothermic machine perfusion of donor livers without the need for human blood products","volume":"24","author":"Matton","year":"2018","journal-title":"Liver Transplant"},{"issue":"6","key":"10.1016\/j.cld.2024.12.010_bib25","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1111\/ajt.13708","article-title":"Liver transplantation after ex\u00a0vivo normothermic machine preservation: a phase 1 (First-in-Man) clinical trial","volume":"16","author":"Ravikumar","year":"2016","journal-title":"Am J Transplant"},{"issue":"7703","key":"10.1016\/j.cld.2024.12.010_bib26","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41586-018-0047-9","article-title":"A\u00a0randomized trial of normothermic preservation in liver transplantation","volume":"557","author":"Nasralla","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cld.2024.12.010_bib27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/lt.20287","article-title":"Non-heart-beating donor porcine livers: the adverse effect of cooling","volume":"11","author":"Reddy","year":"2005","journal-title":"Liver Transplant"},{"issue":"1","key":"10.1016\/j.cld.2024.12.010_bib28","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/lt.24369","article-title":"First human liver transplantation using a marginal allograft resuscitated by normothermic machine perfusion","volume":"22","author":"Perera","year":"2016","journal-title":"Liver Transplant"},{"issue":"11","key":"10.1016\/j.cld.2024.12.010_bib29","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1111\/ajt.13875","article-title":"Transplantation of declined liver allografts following normothermic ex-situ evaluation","volume":"16","author":"Mergental","year":"2016","journal-title":"Am J Transplant"},{"issue":"10","key":"10.1016\/j.cld.2024.12.010_bib30","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/lt.25584","article-title":"Transient cold storage prior to normothermic liver perfusion may facilitate adoption of a novel technology","volume":"25","author":"Ceresa","year":"2019","journal-title":"Liver Transplant"},{"issue":"6","key":"10.1016\/j.cld.2024.12.010_bib31","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/lt.25464","article-title":"A\u00a0back-to-base experience of human normothermic ex situ liver perfusion: does the chill kill?","volume":"25","author":"Bral","year":"2019","journal-title":"Liver Transplant"},{"issue":"3","key":"10.1016\/j.cld.2024.12.010_bib32","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1001\/jamasurg.2021.6781","article-title":"Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant: the OCS liver PROTECT randomized clinical trial","volume":"157","author":"Markmann","year":"2022","journal-title":"JAMA Surg"},{"issue":"5","key":"10.1016\/j.cld.2024.12.010_bib33","doi-asserted-by":"crossref","first-page":"e912","DOI":"10.1097\/SLA.0000000000005934","article-title":"Normothermic machine perfusion of donor livers for transplantation in the United States: a randomized controlled trial","volume":"278","author":"Chapman","year":"2023","journal-title":"Ann Surg"},{"issue":"2","key":"10.1016\/j.cld.2024.12.010_bib34","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jhep.2023.04.010","article-title":"A\u00a0randomized-controlled trial of ischemia-free liver transplantation for end-stage liver disease","volume":"79","author":"Guo","year":"2023","journal-title":"J\u00a0Hepatol"},{"issue":"2","key":"10.1016\/j.cld.2024.12.010_bib35","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1600-6143.2009.02932.x","article-title":"Hypothermic machine preservation in human liver transplantation: the first clinical series","volume":"10","author":"Guarrera","year":"2010","journal-title":"Am J Transplant"},{"issue":"1","key":"10.1016\/j.cld.2024.12.010_bib36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/ajt.12958","article-title":"Hypothermic machine preservation facilitates successful transplantation of \u201corphan\u201d extended criteria donor livers","volume":"15","author":"Guarrera","year":"2015","journal-title":"Am J Transplant"},{"issue":"5","key":"10.1016\/j.cld.2024.12.010_bib37","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1097\/HEP.0000000000000715","article-title":"Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation: a randomized, open-label, clinical trial","volume":"79","author":"Panayotova","year":"2024","journal-title":"Hepatology"},{"issue":"15","key":"10.1016\/j.cld.2024.12.010_bib38","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1056\/NEJMoa2031532","article-title":"Hypothermic machine perfusion in liver transplantation - a randomized trial","volume":"384","author":"van Rijn","year":"2021","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.cld.2024.12.010_bib39","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/SLA.0000000000005110","volume":"274","author":"Czigany","year":"2021","journal-title":"Ann Surg"},{"issue":"10","key":"10.1016\/j.cld.2024.12.010_bib40","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1111\/ajt.17115","article-title":"Hypothermic oxygenated perfusion in extended criteria donor liver transplantation-A randomized clinical trial","volume":"22","author":"Ravaioli","year":"2022","journal-title":"Am J Transplant"},{"issue":"4","key":"10.1016\/j.cld.2024.12.010_bib41","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jhep.2013.11.023","article-title":"HOPE for human liver grafts obtained from donors after cardiac death","volume":"60","author":"Dutkowski","year":"2014","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"10.1016\/j.cld.2024.12.010_bib42","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jhep.2018.10.005","article-title":"Outcomes of DCD liver transplantation using organs treated by hypothermic oxygenated perfusion before implantation","volume":"70","author":"Schlegel","year":"2019","journal-title":"J\u00a0Hepatol"},{"issue":"4","key":"10.1016\/j.cld.2024.12.010_bib43","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jhep.2022.12.030","article-title":"A\u00a0multicenter randomized-controlled trial of hypothermic oxygenated perfusion (HOPE) for human liver grafts before transplantation","volume":"78","author":"Schlegel","year":"2023","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cld.2024.12.010_bib44","article-title":"Long-term outcomes after hypothermic oxygenated machine perfusion and transplantation of 1,202 donor livers in a real-world setting (HOPE-REAL study)","author":"Eden","year":"2024","journal-title":"J\u00a0Hepatol"},{"issue":"2","key":"10.1016\/j.cld.2024.12.010_bib45","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jhep.2012.10.004","article-title":"Protective mechanisms of end-ischemic cold machine perfusion in DCD liver grafts","volume":"58","author":"Schlegel","year":"2013","journal-title":"J\u00a0Hepatol"},{"issue":"8","key":"10.1016\/j.cld.2024.12.010_bib46","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1111\/ajt.15800","article-title":"Brief O(2) uploading during continuous hypothermic machine perfusion is simple yet effective oxygenation method to improve initial kidney function in a porcine autotransplant model","volume":"20","author":"Darius","year":"2020","journal-title":"Am J Transplant"},{"issue":"2","key":"10.1016\/j.cld.2024.12.010_bib47","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cmet.2015.12.009","article-title":"A\u00a0unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury","volume":"23","author":"Chouchani","year":"2016","journal-title":"Cell Metab"},{"issue":"7527","key":"10.1016\/j.cld.2024.12.010_bib48","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cld.2024.12.010_bib49","article-title":"Assessment of liver graft quality during hypothermic oxygenated perfusion: the first international validation study","author":"Eden","year":"2024","journal-title":"J\u00a0Hepatol"}],"container-title":["Clinics in Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108932612400117X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108932612400117X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T23:24:52Z","timestamp":1750375492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S108932612400117X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S108932612400117X"],"URL":"https:\/\/doi.org\/10.1016\/j.cld.2024.12.010","relation":{},"ISSN":["1089-3261"],"issn-type":[{"type":"print","value":"1089-3261"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Innovations to Expand the Liver Donor Pool","name":"articletitle","label":"Article Title"},{"value":"Clinics in Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cld.2024.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}