{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:40:56Z","timestamp":1760856056018,"version":"build-2065373602"},"reference-count":20,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Liver Disease"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.cld.2025.06.007","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T03:59:27Z","timestamp":1753156767000},"page":"771-780","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pediatric Liver Diseases"],"prefix":"10.1016","volume":"29","author":[{"given":"Jeff","family":"Teckman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashlesha","family":"Bagwe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.cld.2025.06.007_bib1","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/apt.17967","article-title":"Review article: new developments in biomarkers and clinical drug development in alpha-1 antitrypsin deficiency-related liver disease","volume":"59","author":"Loomba","year":"2024","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.cld.2025.06.007_bib2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cld.2022.03.004","article-title":"Alpha-1 antitrypsin deficiency liver disease","volume":"26","author":"Suri","year":"2022","journal-title":"Clin Liver Dis"},{"issue":"11","key":"10.1016\/j.cld.2025.06.007_bib3","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1080\/17474124.2019.1686975","article-title":"Updates in the management of hepatitis B in children","volume":"13","author":"Lai","year":"2019","journal-title":"Expet Rev Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.cld.2025.06.007_bib4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/hep.28156","article-title":"AASLD guidelines for treatment of chronic hepatitis B","volume":"63","author":"Terrault","year":"2016","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.cld.2025.06.007_bib5","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.jhep.2018.01.037","article-title":"Antiviral therapy in hepatitis B virus-infected children with immune-tolerant characteristics: a pilot open-label randomized study","volume":"68","author":"Zhu","year":"2018","journal-title":"J Hepatol"},{"issue":"11","key":"10.1016\/j.cld.2025.06.007_bib6","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1097\/INF.0000000000004057","article-title":"Efficacy and safety of antiviral therapy for immune-tolerant hepatitis b viral infection in children: a systematic review and meta-analysis","volume":"42","author":"Zheng","year":"2023","journal-title":"Pediatr Infect Dis J"},{"issue":"12","key":"10.1016\/j.cld.2025.06.007_bib7","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/INF.0000000000002876","article-title":"Efficacy and safety of pegylated interferon for the treatment of chronic hepatitis B in children and adolescents: a systematic review and meta-analysis","volume":"39","author":"He","year":"2020","journal-title":"Pediatr Infect Dis J"},{"issue":"4","key":"10.1016\/j.cld.2025.06.007_bib8","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.jhep.2023.05.023","article-title":"Evaluation of RNAi therapeutics VIR-2218 and ALN-HBV for chronic hepatitis B: results from randomized clinical trials","volume":"79","author":"Gane","year":"2023","journal-title":"J Hepatol"},{"issue":"11","key":"10.1016\/j.cld.2025.06.007_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/v16111710","article-title":"Evaluation of interfering RNA efficacy in treating hepatitis B: is it promising?","volume":"16","author":"Angelice","year":"2024","journal-title":"Viruses"},{"issue":"4","key":"10.1016\/j.cld.2025.06.007_bib10","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/liv.15544","article-title":"Increase of liver stiffness and altered bile acid metabolism after triple CFTR modulator initiation in children and young adults with cystic fibrosis","volume":"43","author":"Schnell","year":"2023","journal-title":"Liver Int"},{"key":"10.1016\/j.cld.2025.06.007_bib11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jpeds.2018.11.021","article-title":"Prevalence of nonalcoholic fatty liver disease in children with obesity","volume":"207","author":"Yu","year":"2019","journal-title":"J Pediatr"},{"issue":"3","key":"10.1016\/j.cld.2025.06.007_bib12","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/jpn3.12312","article-title":"Effect of N-acetyl cysteine in children with metabolic dysfunction-associated steatotic liver disease-A pilot study","volume":"79","author":"Babu Balagopal","year":"2024","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"3","key":"10.1016\/j.cld.2025.06.007_bib13","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1124\/pharmrev.123.001087","article-title":"Steatotic liver disease: pathophysiology and emerging pharmacotherapies","volume":"76","author":"Kokkorakis","year":"2024","journal-title":"Pharmacol Rev"},{"issue":"22","key":"10.1016\/j.cld.2025.06.007_bib14","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1097\/CM9.0000000000003355","article-title":"Drug treatment for metabolic dysfunction-associated steatotic liver disease: progress and direction","volume":"137","author":"Zhou","year":"2024","journal-title":"Chin Med J (Engl Ed)"},{"issue":"3","key":"10.1016\/j.cld.2025.06.007_bib15","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/hep.510290331","article-title":"Features of alagille syndrome in 92 patients: frequency and relation to prognosis","volume":"29","author":"Emerick","year":"1999","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.cld.2025.06.007_bib16","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1053\/jhep.2002.33332","article-title":"Partial external biliary diversion for intractable pruritus and xanthomas in alagille syndrome","volume":"35","author":"Emerick","year":"2002","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.cld.2025.06.007_bib17","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S2468-1253(24)00074-8","article-title":"Efficacy and safety of odevixibat in patients with alagille syndrome (ASSERT): a phase 3, double-blind, randomised, placebo-controlled trial","volume":"9","author":"Ovchinsky","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.cld.2025.06.007_bib18","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cld.2018.06.003","article-title":"Progressive familial intrahepatic cholestasis","volume":"22","author":"Bull","year":"2018","journal-title":"Clin Liver Dis"},{"issue":"1","key":"10.1016\/j.cld.2025.06.007_bib19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.clinre.2018.07.010","article-title":"Systematic review of progressive familial intrahepatic cholestasis","volume":"43","author":"Baker","year":"2019","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"1","key":"10.1016\/j.cld.2025.06.007_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010273","article-title":"Gene therapy for progressive familial intrahepatic cholestasis: current progress and future prospects","volume":"22","author":"Bosma","year":"2020","journal-title":"Int J Mol Sci"}],"container-title":["Clinics in Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326125000479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089326125000479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:27:29Z","timestamp":1760855249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089326125000479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1089326125000479"],"URL":"https:\/\/doi.org\/10.1016\/j.cld.2025.06.007","relation":{},"ISSN":["1089-3261"],"issn-type":[{"type":"print","value":"1089-3261"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pediatric Liver Diseases","name":"articletitle","label":"Article Title"},{"value":"Clinics in Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cld.2025.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}