{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:10:23Z","timestamp":1792887023456,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinical-genitourinary-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genitourinary Cancer"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.clgc.2015.07.009","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T03:59:07Z","timestamp":1438919947000},"page":"323-330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["A Combination of Cisplatin and 5-Fluorouracil With a Taxane in Patients Who Underwent Lymph Node Dissection for Nodal Metastases From Squamous Cell Carcinoma of the Penis: Treatment Outcome and Survival Analyses in Neoadjuvant and Adjuvant Settings"],"prefix":"10.1016","volume":"14","author":[{"given":"Nicola","family":"Nicolai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Maria","family":"Sangalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Necchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Giannatempo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Paganoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Colecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Piva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Achille","family":"Catanzaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Biasoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Stagni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullio","family":"Torelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Raggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Far\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Pizzocaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Salvioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clgc.2015.07.009_bib1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.urolonc.2006.08.029","article-title":"Incidence trends in primary malignant penile cancer","volume":"25","author":"Barnholtz-Sloan","year":"2007","journal-title":"Urol Oncol"},{"key":"10.1016\/j.clgc.2015.07.009_bib2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/jso.20893","article-title":"Management of penile cancer","volume":"97","author":"Ornellas","year":"2008","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.clgc.2015.07.009_bib3","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.eururo.2009.02.021","article-title":"Lymphadenectomy in the surgical management of penile cancer","volume":"55","author":"Protzel","year":"2009","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2015.07.009_bib4","unstructured":"Hakenberg OW, Comp\u00e9rat E, Minhas S, Necchi A, Protzel C, Watkin N. EAU penile cancer guidelines 2014. Available at: http:\/\/uroweb.org\/wp-content\/uploads\/12-Penile-Cancer_LR.pdf. Accessed August 16,\u00a02014."},{"key":"10.1016\/j.clgc.2015.07.009_bib5","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3109\/02841868809094366","article-title":"Adjuvant and neoadjuvant vincristine, bleomycin, and methotrexate for inguinal metastases from squamous cell carcinoma of the penis","volume":"27","author":"Pizzocaro","year":"1988","journal-title":"Acta Oncol"},{"key":"10.1016\/j.clgc.2015.07.009_bib6","first-page":"630","article-title":"Cisplatin and 5-fluorouracil in advanced cancer of the penis","volume":"147","author":"Shammas","year":"1992","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2015.07.009_bib7","first-page":"1284","article-title":"Combination chemotherapy with methotrexate, bleomycin and cisplatin for advanced squamous cell carcinoma of the male genital tract","volume":"146","author":"Dexeus","year":"1991","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2015.07.009_bib8","first-page":"1823","article-title":"Cisplatin,methotrexate and bleomycin for the treatment of carcinoma of the penis: a Southwest Oncology Group study","volume":"161","author":"Haas","year":"1999","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2015.07.009_bib9","first-page":"1770","article-title":"Combination chemotherapy for metastatic or locally advanced genitourinary squamous cell carcinoma: a phase II study of methotrexate, cisplatin and bleomycin","volume":"160","author":"Corral","year":"1998","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2015.07.009_bib10","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1093\/annonc\/mdn149","article-title":"A\u00a0phase II multicentre study of irinotecan (CPT 11) in combination with cisplatin (CDDP) in metastatic or locally advanced penile carcinoma (EORTC 30992)","volume":"19","author":"Theodore","year":"2008","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clgc.2015.07.009_bib11","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.eururo.2007.02.006","article-title":"Neoadjuvant chemotherapy in advanced penile carcinoma","volume":"52","author":"Leijte","year":"2007","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2015.07.009_bib12","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1111\/j.1464-410X.2006.06496.x","article-title":"Cisplatin, methotrexate and bleomycin for treating advanced penile carcinoma","volume":"98","author":"Hakenberg","year":"2006","journal-title":"BJU Int"},{"key":"10.1016\/j.clgc.2015.07.009_bib13","doi-asserted-by":"crossref","first-page":"8636","DOI":"10.1200\/JCO.2004.00.1990","article-title":"Phase III study comparing cisplatin plus fluorouracil to paclitaxel, cisplatin, and fluorouracil induction chemotherapy followed by chemoradiotherapy in locally advanced head and neck cancer","volume":"23","author":"Hitt","year":"2005","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clgc.2015.07.009_bib14","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa071028","article-title":"Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer","volume":"357","author":"Vermorken","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clgc.2015.07.009_bib15","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1056\/NEJMoa070956","article-title":"Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer","volume":"357","author":"Posner","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clgc.2015.07.009_bib16","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.eururo.2008.07.014","article-title":"Taxanes in combination with cisplatin and fluorouracil for advanced penile cancer: preliminary results","volume":"55","author":"Pizzocaro","year":"2009","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2015.07.009_bib17","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1200\/JCO.2010.29.5477","article-title":"Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study","volume":"28","author":"Pagliaro","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clgc.2015.07.009_bib18","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1038\/bjc.2013.620","article-title":"Phase II trial of docetaxel, cisplatin and 5FU chemotherapy in locally advanced and metastatic penis cancer (CRUK\/09\/001)","volume":"109","author":"Nicholson","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clgc.2015.07.009_bib19","unstructured":"National Cancer Institute. CTEP. Common terminology criteria for adverse events, v. 4.0. Available at: http:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/ctc.htm#ctc_40. Accessed August 20,\u00a02013."},{"key":"10.1016\/j.clgc.2015.07.009_bib20","series-title":"Lymph Node Surgery in Urology","first-page":"118","article-title":"Lymphadenectomy for cancer of the penis","author":"Pizzocaro","year":"1995"},{"key":"10.1016\/j.clgc.2015.07.009_bib21","unstructured":"Response Evaluation Criteria In Solid Tumors, v. 1.1. Available at: http:\/\/www.eortc.org\/recist\/recist-1-1-2\/guidelines\/. Accessed August 20,\u00a02013."},{"key":"10.1016\/j.clgc.2015.07.009_bib22","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1200\/JCO.2009.22.4170","article-title":"TP53 mutations and pathologic complete response to neoadjuvant cisplatin and fluorouracil chemotherapy in resected oral cavity squamous cell carcinoma","volume":"28","author":"Perrone","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clgc.2015.07.009_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/1066896910380683","article-title":"Screening for human papillomavirus in basaloid squamous carcinoma: utility of p16INK4a, CISH, and PCR","volume":"19","author":"Winters","year":"2011","journal-title":"Int J Surg Pathol"},{"key":"10.1016\/j.clgc.2015.07.009_bib24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.clgc.2015.07.009_bib25","series-title":"Nonparametric Statistical Methods","author":"Hollander","year":"1999"},{"key":"10.1016\/j.clgc.2015.07.009_bib26","series-title":"Categorical Data Analysis","author":"Agresti","year":"2002"},{"key":"10.1016\/j.clgc.2015.07.009_bib27","unstructured":"R Core Team. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. Available at: http:\/\/www.R-project.org\/. Accessed April 15, 2013."},{"key":"10.1016\/j.clgc.2015.07.009_bib28","unstructured":"NCCN Clinical Practice Guidelines in Oncology: Penile Cancer. v. 1.2014. Available at: http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/penile.pdf. Accessed August 16,\u00a02014."},{"key":"10.1016\/j.clgc.2015.07.009_bib29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000480874","article-title":"Up-to-date management of carcinoma of the penis","volume":"32","author":"Pizzocaro","year":"1997","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2015.07.009_bib30","first-page":"1335","article-title":"Neoadjuvant chemotherapy followed by aggressive surgical consolidation for metastatic penile squamous cell carcinoma","volume":"177","author":"Bermejo","year":"2007","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2015.07.009_bib31","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1159\/000315432","article-title":"Feasibility and activity of sorafenib and sunitinib in advanced penile cancer: a preliminary report","volume":"85","author":"Zhu","year":"2010","journal-title":"Urol Int"},{"key":"10.1016\/j.clgc.2015.07.009_bib32","doi-asserted-by":"crossref","first-page":"e650","DOI":"10.1200\/JCO.2011.34.8367","article-title":"Proof of activity of anti-epidermal growth factor receptor-targeted therapy for relapsed squamous cell carcinoma of the penis","volume":"29","author":"Necchi","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clgc.2015.07.009_bib33","first-page":"524","article-title":"Radiotherapy for node positive penile cancer: experience of the Leeds teaching hospitals","volume":"186","author":"Franks","year":"2011","journal-title":"J\u00a0Urol"}],"container-title":["Clinical Genitourinary Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767315001822?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767315001822?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:25:38Z","timestamp":1761564338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1558767315001822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S1558767315001822"],"URL":"https:\/\/doi.org\/10.1016\/j.clgc.2015.07.009","relation":{},"ISSN":["1558-7673"],"issn-type":[{"value":"1558-7673","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Combination of Cisplatin and 5-Fluorouracil With a Taxane in Patients Who Underwent Lymph Node Dissection for Nodal Metastases From Squamous Cell Carcinoma of the Penis: Treatment Outcome and Survival Analyses in Neoadjuvant and Adjuvant Settings","name":"articletitle","label":"Article Title"},{"value":"Clinical Genitourinary Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clgc.2015.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}