{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:41:46Z","timestamp":1787312506436,"version":"build-2736575974"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinical-genitourinary-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genitourinary Cancer"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.clgc.2016.01.016","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T12:48:01Z","timestamp":1454935681000},"page":"444-449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Bladder Instillation Therapy With Hyaluronic Acid and Chondroitin Sulfate Improves Symptoms of Postradiation Cystitis: Prospective Pilot Study"],"prefix":"10.1016","volume":"14","author":[{"given":"Mauro","family":"Gacci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Giannessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Chini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Andrea","family":"Della Camera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Detti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Livi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Finazzi Agro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Li Marzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Minervini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Carini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Oelke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Gravas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Serni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clgc.2016.01.016_bib1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.eururo.2013.09.046","article-title":"EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and local treatment with curative intent-update 2013","volume":"65","author":"Heidenreich","year":"2014","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2016.01.016_bib2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijrobp.2007.06.054","article-title":"Long-term results of the M. D. Anderson randomized dose-escalation trial for prostate cancer","volume":"70","author":"Kuban","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clgc.2016.01.016_bib3","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(12)61253-7","article-title":"Postoperative radiotherapy after radical prostatectomy: a randomised controlled trial (EORTC trial, 22911)","volume":"380","author":"Bolla","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.clgc.2016.01.016_bib4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ijrobp.2012.02.061","article-title":"Acute radiation-induced nocturia in prostate cancer patients is associated with pretreatment symptoms, radical prostatectomy, and genetic markers in the TGFb1 gene","volume":"85","author":"De Langhe","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clgc.2016.01.016_bib5","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.ijrobp.2004.04.017","article-title":"Intensity-modulated radiotherapy as primary treatment for prostate cancer: acute toxicity in 114 patients","volume":"60","author":"De Meerleer","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clgc.2016.01.016_bib6","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1089\/jwh.2009.1702","article-title":"Diagnosis and treatment of interstitial cystitis\/painful bladder syndrome: a review","volume":"19","author":"Butrick","year":"2010","journal-title":"J\u00a0Womens Health (Larchmt)"},{"key":"10.1016\/j.clgc.2016.01.016_bib7","doi-asserted-by":"crossref","first-page":"470592","DOI":"10.1155\/2014\/470592","article-title":"Quality of life and sexual health in the aging of PCa survivors","volume":"2014","author":"Gacci","year":"2014","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.clgc.2016.01.016_bib8","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s00345-014-1396-0","article-title":"Nocturia: state of the art and critical analysis of current assessment and treatment strategies","volume":"32","author":"Oelke","year":"2014","journal-title":"World J Urol"},{"key":"10.1016\/j.clgc.2016.01.016_bib9","first-page":"33","article-title":"Increasing evidence of effectiveness of GAG therapy in different forms of cystitis","volume":"1","author":"Bassi","year":"2013","journal-title":"Eur Med J Urol"},{"key":"10.1016\/j.clgc.2016.01.016_bib10","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/1756287213490052","article-title":"Combined intravesical sodium hyaluronate\/chondroitin sulfate therapy for interstitial cystitis\/bladder pain syndrome: a prospective study","volume":"5","author":"Giberti","year":"2013","journal-title":"Ther Adv Urol"},{"key":"10.1016\/j.clgc.2016.01.016_bib11","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s00192-012-1742-y","article-title":"Intravesical hyaluronic acid and chondroitin sulfate for bladder pain syndrome\/interstitial cystitis: long-term treatment results","volume":"23","author":"Cervigni","year":"2012","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.clgc.2016.01.016_bib12","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s00192-011-1546-5","article-title":"Impact of intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome\/interstitial cystitis","volume":"23","author":"Porru","year":"2012","journal-title":"Int Urogynecol"},{"key":"10.1016\/j.clgc.2016.01.016_bib13","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0090-4295(99)80333-1","article-title":"The interstitial cystitis symptom index and problem index","volume":"49","author":"O'Leary","year":"1997","journal-title":"Urology"},{"key":"10.1016\/j.clgc.2016.01.016_bib14","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.eururo.2011.10.042","article-title":"patient-reported outcomes in bladder pain syndrome: qui auget dolorem, auget et scientiam (as pain increases, so increases knowledge)","volume":"61","author":"Giannantoni","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2016.01.016_bib15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/cncr.10657","article-title":"Biochemical outcome after radical prostatectomy or external beam radiation therapy for patients with clinically localized prostate carcinoma in the prostate specific antigen era","volume":"95","author":"D'Amico","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.clgc.2016.01.016_bib16","unstructured":"RTOG 2014. Available at: www.rtog.org\/researchassociates\/adverseeventreporting\/acuteradiationmorbidity scoringcriteria.aspx, 2014. Accessed: October 2014."},{"key":"10.1016\/j.clgc.2016.01.016_bib17","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.ijrobp.2013.08.019","article-title":"Health-related quality of life after stereotactic body radiation therapy for localized prostate cancer: results from a multi-institutional consortium of prospective trials","volume":"87","author":"King","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clgc.2016.01.016_bib18","first-page":"249","article-title":"Intravesical glycosaminoglycans in the management of chronic cystitis","volume":"65","author":"Iacovelli","year":"2013","journal-title":"Minerva Urol Nefrol"},{"key":"10.1016\/j.clgc.2016.01.016_bib19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/nau.22256","article-title":"GAG layer replenishment therapy for chronic forms of cystitis with intravesical glycosaminoglycans \u2013a review","volume":"32","author":"Madersbacher","year":"2013","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.clgc.2016.01.016_bib20","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.urology.2014.11.020","article-title":"Pubic symphysis osteomyelitis in the prostate cancer survivor: clinical presentation, evaluation, and management","volume":"85","author":"Gupta","year":"2015","journal-title":"Urology"},{"key":"10.1016\/j.clgc.2016.01.016_bib21","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1007\/s12094-009-0451-6","article-title":"Vesical instillations of hyaluronic acid to reduce the acute vesical toxicity caused by high-dose brachytherapy do not affect the survival: a five-year follow-up study","volume":"11","author":"Samper Ots","year":"2009","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.clgc.2016.01.016_bib22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1177\/039156031007700305","article-title":"Treatment of acute iatrogenic cystitis secondary to bladder chemo- immuno-instillation or pelvic radiotherapy","volume":"77","author":"Sommariva","year":"2010","journal-title":"Urologia"},{"key":"10.1016\/j.clgc.2016.01.016_bib23","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s00192-010-1357-0","article-title":"Prophylactic vesical instillations with 0.2% chondroitin sulfate may reduce symptoms of acute radiation cystitis in patients undergoing radiotherapy for gynecological malignancies","volume":"22","author":"Hazewinkel","year":"2011","journal-title":"Int Urogynecol J"}],"container-title":["Clinical Genitourinary Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767316300167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767316300167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:26:03Z","timestamp":1761564363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1558767316300167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1558767316300167"],"URL":"https:\/\/doi.org\/10.1016\/j.clgc.2016.01.016","relation":{},"ISSN":["1558-7673"],"issn-type":[{"value":"1558-7673","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bladder Instillation Therapy With Hyaluronic Acid and Chondroitin Sulfate Improves Symptoms of Postradiation Cystitis: Prospective Pilot Study","name":"articletitle","label":"Article Title"},{"value":"Clinical Genitourinary Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clgc.2016.01.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}