{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:22:47Z","timestamp":1779236567943,"version":"3.51.4"},"reference-count":60,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinical-genitourinary-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genitourinary Cancer"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.clgc.2018.01.014","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T02:41:47Z","timestamp":1517884907000},"page":"e751-e760","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prognostic Factors and Risk Stratification in Invasive Upper Tract Urothelial Carcinoma"],"prefix":"10.1016","volume":"16","author":[{"given":"Hamid","family":"Emamekhoo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneet","family":"Dhillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dharmesh","family":"Gopalakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Elson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Stephenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Magi-Galluzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"McKenney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly","family":"Harper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges-Pascal","family":"Haber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihad","family":"Kaouk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byron","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Fergany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Berglund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatesh","family":"Krishnamurthi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Gilligan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Ornstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Rini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petros","family":"Grivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clgc.2018.01.014_bib1","first-page":"7","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.clgc.2018.01.014_bib2","doi-asserted-by":"crossref","first-page":"8699","DOI":"10.1038\/sj.onc.1206964","article-title":"Distinct patterns of microsatellite instability are seen in tumours of the urinary tract","volume":"22","author":"Catto","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.clgc.2018.01.014_bib3","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.urology.2005.01.019","article-title":"Microsatellite instability as predictor of survival in patients with invasive upper urinary tract transitional cell carcinoma","volume":"65","author":"Roupret","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.clgc.2018.01.014_bib4","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1200\/JCO.2005.03.163","article-title":"Promoter hypermethylation is associated with tumor location, stage, and subsequent progression in transitional cell carcinoma","volume":"23","author":"Catto","year":"2005","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clgc.2018.01.014_bib5","first-page":"S1","article-title":"Prognostic significance of the genetic signature of hipoxia in the stratification of neuroblastoma patients","volume":"95","author":"Fardin","year":"2010","journal-title":"Haematol Hematol J"},{"key":"10.1016\/j.clgc.2018.01.014_bib6","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.eururo.2012.02.018","article-title":"Stage-specific impact of tumor location on oncologic outcomes in patients with upper and lower tract urothelial carcinoma following radical surgery","volume":"62","author":"Rink","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib7","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s11255-016-1214-2","article-title":"Comparison of clinicopathological features in metastatic upper tract urothelial carcinoma and urothelial bladder cancer","volume":"48","author":"Xie","year":"2016","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.clgc.2018.01.014_bib8","series-title":"NCCN Clinical Pracitice Guidelines in Oncology - Bladder Cancer","year":"2017"},{"key":"10.1016\/j.clgc.2018.01.014_bib9","series-title":"EAU Oncology Guidelines - Upper Urinary Tract Urothelial Cell Carcinoma","author":"Roupr\u00eat","year":"2017"},{"key":"10.1016\/j.clgc.2018.01.014_bib10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.eururo.2014.03.003","article-title":"A\u00a0systematic review and meta-analysis of adjuvant and neoadjuvant chemotherapy for upper tract urothelial carcinoma","volume":"66","author":"Leow","year":"2014","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib11","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1002\/cncr.25050","article-title":"Incidence of downstaging and complete remission after neoadjuvant chemotherapy for high-risk upper tract transitional cell carcinoma","volume":"116","author":"Matin","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.clgc.2018.01.014_bib12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000282755","article-title":"Neoadjuvant chemotherapy for locally advanced urothelial cancer of the upper urinary tract","volume":"55","author":"Igawa","year":"1995","journal-title":"Urol Int"},{"key":"10.1016\/j.clgc.2018.01.014_bib13","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/S0140-6736(16)00561-4","article-title":"Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial","volume":"387","author":"Rosenberg","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.clgc.2018.01.014_bib14","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S1470-2045(17)30065-7","article-title":"Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial","volume":"18","author":"Sharma","year":"2017","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clgc.2018.01.014_bib15","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1056\/NEJMoa1613683","article-title":"Pembrolizumab as second-line therapy for advanced urothelial carcinoma","volume":"376","author":"Bellmunt","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clgc.2018.01.014_bib16","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1200\/JCO.2016.67.9761","article-title":"Safety and efficacy of durvalumab (MEDI4736), an anti-programmed cell death ligand-1 immune checkpoint inhibitor, in patients with advanced urothelial bladder cancer","volume":"34","author":"Massard","year":"2016","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clgc.2018.01.014_bib17","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1200\/JCO.2016.71.6795","article-title":"Avelumab, an anti-programmed death-ligand 1 antibody, in patients with refractory metastatic urothelial carcinoma: results from a multicenter, phase Ib study","volume":"35","author":"Apolo","year":"2017","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clgc.2018.01.014_bib18","first-page":"1523","article-title":"Upper tract urothelial neoplasms: incidence and survival during the last 2 decades","volume":"164","author":"Munoz","year":"2000","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib19","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.urology.2008.07.042","article-title":"Evidence-based sex-related outcomes after radical nephroureterectomy for upper tract urothelial carcinoma: results of large multicenter study","volume":"73","author":"Fernandez","year":"2009","journal-title":"Urology"},{"key":"10.1016\/j.clgc.2018.01.014_bib20","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.urology.2009.09.048","article-title":"Gender-related differences in patients with stage I to III upper tract urothelial carcinoma: results from the Surveillance, Epidemiology, and End Results database","volume":"75","author":"Lughezzani","year":"2010","journal-title":"Urology"},{"key":"10.1016\/j.clgc.2018.01.014_bib21","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1111\/j.1464-410X.2009.09072.x","article-title":"Advanced patient age is associated with inferior cancer-specific survival after radical nephroureterectomy","volume":"105","author":"Shariat","year":"2010","journal-title":"BJU Int"},{"key":"10.1016\/j.clgc.2018.01.014_bib22","first-page":"57","article-title":"Clinicopathological prognostic factors for upper tract urothelial carcinoma","volume":"69","author":"Elenkov","year":"2016","journal-title":"Cent Eur J Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00345-010-0594-7","article-title":"Gender differences in radical nephroureterectomy for upper tract urothelial carcinoma","volume":"29","author":"Shariat","year":"2011","journal-title":"World J Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib24","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1016\/j.ejca.2009.06.016","article-title":"Nephroureterectomy and segmental ureterectomy in the treatment of invasive upper tract urothelial carcinoma: a population-based study of 2299 patients","volume":"45","author":"Lughezzani","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.clgc.2018.01.014_bib25","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/j.1464-410X.2011.10479.x","article-title":"Prognostic role of ECOG performance status in patients with urothelial carcinoma of the upper urinary tract: an international study","volume":"109","author":"Martinez-Salamanca","year":"2012","journal-title":"BJU Int"},{"key":"10.1016\/j.clgc.2018.01.014_bib26","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/jnci\/djt015","article-title":"Prognostic model for predicting survival of patients with metastatic urothelial cancer treated with cisplatin-based chemotherapy","volume":"105","author":"Apolo","year":"2013","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.clgc.2018.01.014_bib27","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1200\/JCO.2009.25.4599","article-title":"Prognostic factors in patients with advanced transitional cell carcinoma of the urothelial tract experiencing treatment failure with platinum-containing regimens","volume":"28","author":"Bellmunt","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clgc.2018.01.014_bib28","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1200\/JCO.2001.19.1.94","article-title":"Upper-tract tumors after an initial diagnosis of bladder cancer: argument for long-term surveillance","volume":"19","author":"Rabbani","year":"2001","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clgc.2018.01.014_bib29","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.urology.2004.11.001","article-title":"Prognostic value of lymphovascular invasion in transitional cell carcinoma of upper urinary tract","volume":"65","author":"Hong","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.clgc.2018.01.014_bib30","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/modpathol.3800529","article-title":"pT classification, grade, and vascular invasion as prognostic indicators in urothelial carcinoma of the upper urinary tract","volume":"19","author":"Langner","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1016\/j.clgc.2018.01.014_bib31","first-page":"48","article-title":"Prognostic significance of bladder tumor history and tumor location in upper tract transitional cell carcinoma","volume":"176","author":"Akdogan","year":"2006","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib32","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1002\/cncr.22970","article-title":"Independent predictors of cancer-specific survival in transitional cell carcinoma of the upper urinary tract: multi-institutional dataset from 3 European centers","volume":"110","author":"Novara","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.clgc.2018.01.014_bib33","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.eururo.2008.01.006","article-title":"Urothelial carcinoma of the upper urinary tract: surgical approach and prognostic factors","volume":"53","author":"Zigeuner","year":"2008","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib34","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.urology.2008.04.032","article-title":"Lymphovascular invasion and pathologic tumor stage are significant outcome predictors for patients with upper tract urothelial carcinoma","volume":"72","author":"Bolenz","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.clgc.2018.01.014_bib35","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1002\/cncr.24135","article-title":"Outcomes of radical nephroureterectomy: a series from the Upper Tract Urothelial Carcinoma Collaboration","volume":"115","author":"Margulis","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.clgc.2018.01.014_bib36","first-page":"894","article-title":"The protective role of renal parenchyma as a barrier to local tumor spread of upper tract transitional cell carcinoma and its impact on patient survival","volume":"182","author":"Park","year":"2009","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib37","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.eururo.2009.03.003","article-title":"Laparoscopic radical nephroureterectomy: a multicenter analysis in Japan","volume":"55","author":"Kamihira","year":"2009","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib38","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1097\/01.mlg.0000242118.79647.a9","article-title":"Lymphovascular invasion is associated with lateral cervical lymph node metastasis in papillary thyroid carcinoma","volume":"116","author":"Kim","year":"2006","journal-title":"Laryngoscope"},{"key":"10.1016\/j.clgc.2018.01.014_bib39","first-page":"2291","article-title":"Lymphovascular invasion is independently associated with poor prognosis in patients with localized upper urinary tract urothelial carcinoma treated surgically","volume":"178","author":"Saito","year":"2007","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib40","first-page":"879","article-title":"The role of lymphovascular invasion in predicting the prognosis of clinically localized upper tract urothelial carcinoma (pT1-3cN0M0)","volume":"180","author":"Lin","year":"2008","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib41","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1200\/JCO.2008.17.2361","article-title":"Lymphovascular invasion predicts clinical outcomes in patients with node-negative upper tract urothelial carcinoma","volume":"27","author":"Kikuchi","year":"2009","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clgc.2018.01.014_bib42","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.urology.2009.07.1350","article-title":"Lymphovascular invasion and pT stage are prognostic factors in patients treated with radical nephroureterectomy for localized upper urinary tract transitional cell carcinoma","volume":"75","author":"Kim","year":"2010","journal-title":"Urology"},{"key":"10.1016\/j.clgc.2018.01.014_bib43","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1464-410X.2009.09166.x","article-title":"Lymphovascular invasion is an independent predictor of oncological outcomes in patients with lymph node-negative urothelial bladder cancer treated by radical cystectomy: a multicentre validation trial","volume":"106","author":"Bolenz","year":"2010","journal-title":"BJU Int"},{"key":"10.1016\/j.clgc.2018.01.014_bib44","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s00120-014-3646-6","article-title":"Detection of lymphovascular invasion in urothelial carcinoma of the bladder through D2-40 immunostaining","volume":"54","author":"Martini","year":"2015","journal-title":"Urologe A"},{"key":"10.1016\/j.clgc.2018.01.014_bib45","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.eururo.2009.12.029","article-title":"Prognostic role of lymphovascular invasion in patients with urothelial carcinoma of the upper urinary tract: an international validation study","volume":"57","author":"Novara","year":"2010","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib46","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00345-016-1764-z","article-title":"Contemporary role of lymph node dissection at the time of radical nephroureterectomy for upper tract urothelial carcinoma","volume":"35","author":"Seisen","year":"2017","journal-title":"World J Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib47","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.urology.2011.11.058","article-title":"The contemporary role of lymph node dissection during nephroureterectomy in the management of upper urinary tract urothelial carcinoma: the Canadian experience","volume":"79","author":"Mason","year":"2012","journal-title":"Urology"},{"key":"10.1016\/j.clgc.2018.01.014_bib48","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00345-012-0983-1","article-title":"The impact of lymph node status and features on oncological outcomes in urothelial carcinoma of the upper urinary tract (UTUC) treated by nephroureterectomy","volume":"31","author":"Ouzzane","year":"2013","journal-title":"World J Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib49","first-page":"1662","article-title":"Prediction of cancer specific survival after radical nephroureterectomy for upper tract urothelial carcinoma: development of an optimized postoperative nomogram using decision curve analysis","volume":"189","author":"Roupret","year":"2013","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib50","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/bju.12631","article-title":"Postoperative nomogram to predict cancer-specific survival after radical nephroureterectomy in patients with localised and\/or locally advanced upper tract urothelial carcinoma without metastasis","volume":"114","author":"Seisen","year":"2014","journal-title":"BJU Int"},{"key":"10.1016\/j.clgc.2018.01.014_bib51","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1111\/j.1464-410X.2008.08134.x","article-title":"Independent prognostic value of tumour diameter and tumour necrosis in upper urinary tract urothelial carcinoma","volume":"103","author":"Simone","year":"2009","journal-title":"BJU Int"},{"key":"10.1016\/j.clgc.2018.01.014_bib52","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1111\/j.1464-410X.2010.09341.x","article-title":"Concomitant carcinoma in situ and tumour size are prognostic factors for bladder recurrence after nephroureterectomy for upper tract transitional cell carcinoma","volume":"106","author":"Pieras","year":"2010","journal-title":"BJU Int"},{"key":"10.1016\/j.clgc.2018.01.014_bib53","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.eururo.2008.04.083","article-title":"Carcinoma in situ of the upper urinary tract treated with radical nephroureterectomy\u2013results from a multicenter study","volume":"54","author":"Karam","year":"2008","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib54","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00345-011-0645-8","article-title":"Concomitant carcinoma in situ as an independent prognostic parameter for recurrence and survival in upper tract urothelial carcinoma: a multicenter analysis of 772 patients","volume":"29","author":"Otto","year":"2011","journal-title":"World J Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib55","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.urology.2010.09.032","article-title":"Prognostic effect of urinary bladder carcinoma in situ on clinical outcome of subsequent upper tract urothelial carcinoma","volume":"77","author":"Youssef","year":"2011","journal-title":"Urology"},{"key":"10.1016\/j.clgc.2018.01.014_bib56","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.urolonc.2010.01.001","article-title":"Concomitant carcinoma in situ is a feature of aggressive disease in patients with organ confined urothelial carcinoma following radical nephroureterectomy","volume":"30","author":"Wheat","year":"2012","journal-title":"Urol Oncol"},{"key":"10.1016\/j.clgc.2018.01.014_bib57","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.eururo.2010.07.003","article-title":"The effect of tumor location on prognosis in patients treated with radical nephroureterectomy at Memorial Sloan Kettering Cancer Center","volume":"58","author":"Favaretto","year":"2010","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2018.01.014_bib58","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1200\/JCO.2016.69.4141","article-title":"Effectiveness of adjuvant chemotherapy after radical nephroureterectomy for locally advanced and\/or positive regional lymph node upper tract urothelial carcinoma","volume":"35","author":"Seisen","year":"2017","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clgc.2018.01.014_bib59","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/ng.3692","article-title":"Clonal evolution of chemotherapy-resistant urothelial carcinoma","volume":"48","author":"Faltas","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.clgc.2018.01.014_bib60","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.eururo.2015.07.039","article-title":"Genomic characterization of upper tract urothelial carcinoma","volume":"68","author":"Sfakianos","year":"2015","journal-title":"Eur Urol"}],"container-title":["Clinical Genitourinary Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767318300739?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767318300739?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:30:05Z","timestamp":1761564605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1558767318300739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1558767318300739"],"URL":"https:\/\/doi.org\/10.1016\/j.clgc.2018.01.014","relation":{},"ISSN":["1558-7673"],"issn-type":[{"value":"1558-7673","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic Factors and Risk Stratification in Invasive Upper Tract Urothelial Carcinoma","name":"articletitle","label":"Article Title"},{"value":"Clinical Genitourinary Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clgc.2018.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}