{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T03:12:26Z","timestamp":1778987546394,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinical-genitourinary-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genitourinary Cancer"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.clgc.2018.08.007","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T18:02:20Z","timestamp":1535652140000},"page":"e44-e52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of Multifocality and Multilocation of Positive Surgical Margin After Radical Prostatectomy on Predicting Oncological Outcome"],"prefix":"10.1016","volume":"17","author":[{"given":"Shulin","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharron X.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander O.","family":"Subtelny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas M.","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aria F.","family":"Olumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Lee","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clgc.2018.08.007_bib1","first-page":"2106","article-title":"Guideline for the management of clinically localized prostate cancer: 2007 update","volume":"177","author":"Thompson","year":"2007","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.08.007_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.eururo.2008.09.051","article-title":"Positive surgical margins in radical prostatectomy: outlining the problem and its long-term consequences","volume":"55","author":"Yossepowitch","year":"2009","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2018.08.007_bib3","first-page":"91","article-title":"A\u00a0close surgical margin after radical prostatectomy is an independent predictor of recurrence","volume":"188","author":"Lu","year":"2012","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.08.007_bib4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.eururo.2013.07.039","article-title":"Positive surgical margins after radical prostatectomy: a systematic review and contemporary update","volume":"65","author":"Yossepowitch","year":"2014","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2018.08.007_bib5","doi-asserted-by":"crossref","first-page":"E290","DOI":"10.1111\/j.1464-410X.2012.11640.x","article-title":"Reporting positive surgical margins after radical prostatectomy: time for standardization","volume":"111","author":"Fontenot","year":"2013","journal-title":"BJU Int"},{"key":"10.1016\/j.clgc.2018.08.007_bib6","first-page":"2292","article-title":"Variations among individual surgeons in the rate of positive surgical margins in radical prostatectomy specimens","volume":"170","author":"Eastham","year":"2003","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.08.007_bib7","doi-asserted-by":"crossref","first-page":"461.e1","DOI":"10.1016\/j.urolonc.2017.02.007","article-title":"Influence of pathologist experience on positive surgical margins following radical prostatectomy","volume":"35","author":"Tallman","year":"2017","journal-title":"Urol Oncol"},{"key":"10.1016\/j.clgc.2018.08.007_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eururo.2012.02.029","article-title":"Positive surgical margin and perioperative complication rates of primary surgical treatments for prostate cancer: a systematic review and meta-analysis comparing retropubic, laparoscopic, and robotic prostatectomy","volume":"62","author":"Tewari","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2018.08.007_bib9","first-page":"129","article-title":"Biochemical failure in men following radical retropubic prostatectomy: impact of surgical margin status and location","volume":"172","author":"Pettus","year":"2004","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.08.007_bib10","first-page":"2695","article-title":"Impact of positive apical surgical margins on likelihood of biochemical recurrence after radical prostatectomy","volume":"182","author":"Kordan","year":"2009","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.08.007_bib11","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1111\/j.1464-410X.2009.08953.x","article-title":"Defining pathological variables to predict biochemical failure in patients with positive surgical margins at radical prostatectomy: implications for adjuvant radiotherapy","volume":"105","author":"Resnick","year":"2010","journal-title":"BJU Int"},{"key":"10.1016\/j.clgc.2018.08.007_bib12","first-page":"1357","article-title":"Location, extent and number of positive surgical margins do not improve accuracy of predicting prostate cancer recurrence after radical prostatectomy","volume":"182","author":"Stephenson","year":"2009","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.08.007_bib13","first-page":"2453","article-title":"Positive surgical margins after radical retropubic prostatectomy: the influence of site and number on progression","volume":"167","author":"Sofer","year":"2002","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.08.007_bib14","first-page":"139","article-title":"Length of positive surgical margin after radical prostatectomy as a predictor of biochemical recurrence","volume":"182","author":"Shikanov","year":"2009","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.08.007_bib15","doi-asserted-by":"crossref","first-page":"109.e107","DOI":"10.1016\/j.urolonc.2014.11.005","article-title":"Surgical margin length and location affect recurrence rates after robotic prostatectomy","volume":"33","author":"Dev","year":"2015","journal-title":"Urol Oncol"},{"key":"10.1016\/j.clgc.2018.08.007_bib16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/bju.12483","article-title":"The impact of length and location of positive margins in predicting biochemical recurrence after robot-assisted radical prostatectomy with a minimum follow-up of 5 years","volume":"115","author":"Sooriakumaran","year":"2015","journal-title":"BJU Int"},{"key":"10.1016\/j.clgc.2018.08.007_bib17","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(12)61253-7","article-title":"Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911)","volume":"380","author":"Bolla","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.clgc.2018.08.007_bib18","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1200\/JCO.2008.18.9563","article-title":"Phase III postoperative adjuvant radiotherapy after radical prostatectomy compared with radical prostatectomy alone in pT3 prostate cancer with postoperative undetectable prostate-specific antigen: ARO 96-02\/AUO AP 09\/95","volume":"27","author":"Wiegel","year":"2009","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clgc.2018.08.007_bib19","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1001\/jama.296.19.2329","article-title":"Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized clinical trial","volume":"296","author":"Thompson","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.clgc.2018.08.007_bib20","first-page":"S47","article-title":"Do margins matter? The prognostic significance of positive surgical margins in radical prostatectomy specimens","volume":"179","author":"Swindle","year":"2008","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.08.007_bib21","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.urolonc.2008.07.004","article-title":"Impact of radical prostatectomy positive surgical margins on fear of cancer recurrence: results from CaPSURE","volume":"28","author":"Hong","year":"2010","journal-title":"Urol Oncol"},{"key":"10.1016\/j.clgc.2018.08.007_bib22","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1097\/00000478-198812000-00001","article-title":"Zonal distribution of prostatic adenocarcinoma. Correlation with histologic pattern and direction of spread","volume":"12","author":"McNeal","year":"1988","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.clgc.2018.08.007_bib23","first-page":"1818","article-title":"Prognostic significance of positive surgical margins in radical prostatectomy specimens","volume":"154","author":"Ohori","year":"1995","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.08.007_bib24","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/PAS.0000000000000530","article-title":"The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: definition of grading patterns and proposal for a new grading system","volume":"40","author":"Epstein","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.clgc.2018.08.007_bib25","doi-asserted-by":"crossref","first-page":"e313","DOI":"10.1016\/j.clgc.2015.12.013","article-title":"Prognostic value of focal positive surgical margins after radical prostatectomy","volume":"14","author":"Lee","year":"2016","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.clgc.2018.08.007_bib26","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.urology.2007.08.040","article-title":"Prognostic significance of location of positive margins in radical prostatectomy specimens","volume":"70","author":"Eastham","year":"2007","journal-title":"Urology"},{"key":"10.1016\/j.clgc.2018.08.007_bib27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00345-010-0641-4","article-title":"Prognostic relevance of number and bilaterality of positive surgical margins after radical prostatectomy","volume":"30","author":"Somford","year":"2012","journal-title":"World J Urol"},{"key":"10.1016\/j.clgc.2018.08.007_bib28","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/pcan.2011.36","article-title":"Clinicopathological predictors of systemic progression and prostate cancer mortality in patients with a positive surgical margin at radical prostatectomy","volume":"15","author":"Boorjian","year":"2012","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1016\/j.clgc.2018.08.007_bib29","first-page":"956","article-title":"Adjuvant radiotherapy for pathological T3N0M0 prostate cancer significantly reduces risk of metastases and improves survival: long-term followup of a randomized clinical trial","volume":"181","author":"Thompson","year":"2009","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2018.08.007_bib30","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1001\/jama.299.23.2760","article-title":"Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy","volume":"299","author":"Trock","year":"2008","journal-title":"JAMA"}],"container-title":["Clinical Genitourinary Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767318305226?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767318305226?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:29:52Z","timestamp":1761564592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1558767318305226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S1558767318305226"],"URL":"https:\/\/doi.org\/10.1016\/j.clgc.2018.08.007","relation":{},"ISSN":["1558-7673"],"issn-type":[{"value":"1558-7673","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of Multifocality and Multilocation of Positive Surgical Margin After Radical Prostatectomy on Predicting Oncological Outcome","name":"articletitle","label":"Article Title"},{"value":"Clinical Genitourinary Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clgc.2018.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}