{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T21:09:43Z","timestamp":1784668183344,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinical-genitourinary-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genitourinary Cancer"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.clgc.2019.07.019","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T19:26:40Z","timestamp":1565033200000},"page":"e1108-e1115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Single Versus Maintenance Intravesical Chemotherapy for the Prevention of Bladder Recurrence after Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Randomized Clinical Trial"],"prefix":"10.1016","volume":"17","author":[{"given":"Ahmed M.","family":"Harraz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdy","family":"El-Shabrawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed R.","family":"El-Nahas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdy","family":"El-Kappany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clgc.2019.07.019_bib1","first-page":"7","article-title":"Cancer statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.clgc.2019.07.019_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.eururo.2017.07.036","article-title":"European Association of Urology guidelines on upper urinary tract urothelial carcinoma: 2017 update","volume":"73","author":"Roupr\u00eat","year":"2018","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2019.07.019_bib3","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.eururo.2014.08.003","article-title":"Conditional survival after radical nephroureterectomy for upper tract carcinoma","volume":"67","author":"Ploussard","year":"2015","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2019.07.019_bib4","first-page":"672","article-title":"Distinct microsatellite alterations in upper urinary tract tumors and subsequent bladder tumors","volume":"165","author":"Takahashi","year":"2001","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2019.07.019_bib5","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/jjco\/hyt129","article-title":"Intravesical seeding of upper urinary tract urothelial carcinoma cells during nephroureterectomy: an exploratory analysis from the THPMG trial","volume":"43","author":"Ito","year":"2013","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.clgc.2019.07.019_bib6","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/iju.13054","article-title":"Clinical implications of intravesical recurrence after radical nephroureterectomy for upper urinary tract urothelial carcinoma","volume":"23","author":"Yamashita","year":"2016","journal-title":"Int J Urol"},{"key":"10.1016\/j.clgc.2019.07.019_bib7","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1200\/JCO.2012.45.2128","article-title":"Prospective randomized phase II trial of a single early intravesical instillation of pirarubicin (THP) in the prevention of bladder recurrence after nephroureterectomy for upper urinary tract urothelial carcinoma: the THP Monotherapy Study Group Trial","volume":"31","author":"Ito","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clgc.2019.07.019_bib8","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.eururo.2011.05.064","article-title":"Prevention of bladder tumours after nephroureterectomy for primary upper urinary tract urothelial carcinoma: a prospective, multicentre, randomised clinical trial of a single postoperative intravesical dose of mitomycin C (the ODMIT-C Trial)","volume":"60","author":"O\u2019Brien","year":"2011","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2019.07.019_bib9","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1046\/j.1442-2042.2001.00286.x","article-title":"Prophylactic intravesical instillation of mitomycin C and cytosine arabinoside for prevention of recurrent bladder tumors following surgery for upper urinary tract tumors: a prospective randomized study","volume":"8","author":"Sakamoto","year":"2001","journal-title":"Int J Urol"},{"key":"10.1016\/j.clgc.2019.07.019_bib10","first-page":"195","article-title":"The effect of intravesical chemotherapy in the prevention of intravesical recurrence after nephroureterectomy for upper tract urothelial carcinoma: a meta-analysis","volume":"27","author":"Yuan","year":"2015","journal-title":"J\u00a0Chemother"},{"key":"10.1016\/j.clgc.2019.07.019_bib11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000350508","article-title":"Prophylactic intravesical chemotherapy to prevent bladder tumors after nephroureterectomy for primary upper urinary tract urothelial carcinomas: a systematic review and meta-analysis","volume":"91","author":"Fang","year":"2013","journal-title":"Urol Int"},{"key":"10.1016\/j.clgc.2019.07.019_bib12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.clgc.2019.07.019_bib13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav Res Methods"},{"key":"10.1016\/j.clgc.2019.07.019_bib14","first-page":"765","article-title":"Impact of intravesical chemotherapy on recurrence rate of recurrent superficial transitional cell carcinoma of the bladder: results of a meta-analysis","volume":"21","author":"Huncharek","year":"2001","journal-title":"Anticancer Res"},{"key":"10.1016\/j.clgc.2019.07.019_bib15","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/2229-3485.83221","article-title":"Intention-to-treat concept: a review","volume":"2","author":"Gupta","year":"2011","journal-title":"Perspect Clin Res"},{"key":"10.1016\/j.clgc.2019.07.019_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijc.10544","article-title":"Clonality of multifocal urothelial carcinomas: 10 years of molecular genetic studies","volume":"101","author":"Hafner","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1016\/j.clgc.2019.07.019_bib17","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1056\/NEJM199203123261108","article-title":"Bladder cancer--field versus clonal origin","volume":"326","author":"Harris","year":"1992","journal-title":"N\u00a0Eng J Med"},{"key":"10.1016\/j.clgc.2019.07.019_bib18","first-page":"56","article-title":"Should patients with primary upper urinary tract cancer receive prophylactic intravesical chemotherapy after nephroureterectomy?","volume":"183","author":"Wu","year":"2010","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.clgc.2019.07.019_bib19","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.aju.2017.03.006","article-title":"Risk factors and prognosis of intravesical recurrence after surgical management of upper tract urothelial carcinoma: a 30-year single centre experience","volume":"15","author":"Elawdy","year":"2017","journal-title":"Arab J Urol"},{"key":"10.1016\/j.clgc.2019.07.019_bib20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12894-015-0039-0","article-title":"Evaluating the safety of intraoperative instillation of intravesical chemotherapy at the time of nephroureterectomy","volume":"15","author":"Moriarty","year":"2015","journal-title":"BMC Urol"},{"key":"10.1016\/j.clgc.2019.07.019_bib21","first-page":"94","article-title":"A\u00a0phase III trial of a single early intravesical instillation of pirarubicin to prevent bladder recurrence after radical nephroureterectomy for upper tract urothelial carcinoma (JCOG1403, UTUC THP Phase III)","volume":"48","author":"Miyamoto","year":"2018","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.clgc.2019.07.019_bib22","doi-asserted-by":"crossref","first-page":"113.e111","DOI":"10.1016\/j.urolonc.2016.10.016","article-title":"Intravesical chemotherapy use after radical nephroureterectomy: a national survey of urologic oncologists","volume":"35","author":"Lu","year":"2017","journal-title":"Urol Oncol"},{"key":"10.1016\/j.clgc.2019.07.019_bib23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.suronc.2017.01.003","article-title":"Prolonged pneumoperitoneum time is an independent risk factor for intravesical recurrence after laparoscopic radical nephroureterectomy in upper tract urothelial carcinoma","volume":"26","author":"Shigeta","year":"2017","journal-title":"Surg Oncol"},{"key":"10.1016\/j.clgc.2019.07.019_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00345-008-0349-x","article-title":"Oncological risk of laparoscopic surgery in urothelial carcinomas","volume":"27","author":"Roupr\u00eat","year":"2009","journal-title":"World J Urol"},{"key":"10.1016\/j.clgc.2019.07.019_bib25","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00345-015-1712-3","article-title":"Laparoscopic radical nephroureterectomy is associated with worse survival outcomes than open radical nephroureterectomy in patients with locally advanced upper tract urothelial carcinoma","volume":"34","author":"Kim","year":"2016","journal-title":"World J Urol"},{"key":"10.1016\/j.clgc.2019.07.019_bib26","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.clgc.2015.05.011","article-title":"Oncologic results of retroperitoneoscopic versus open surgery for T2 upper tract urothelial carcinoma","volume":"13","author":"Shan","year":"2015","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.clgc.2019.07.019_bib27","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1093\/jjco\/hyx085","article-title":"Efficacy of early ureteral ligation on prevention of intravesical recurrence after radical nephroureterectomy for upper urinary tract urothelial carcinoma: a prospective single-arm multicenter clinical trial","volume":"47","author":"Yamashita","year":"2017","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.clgc.2019.07.019_bib28","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.eururo.2012.04.052","article-title":"Impact of distal ureter management on oncologic outcomes following radical nephroureterectomy for upper tract urothelial carcinoma","volume":"65","author":"Xylinas","year":"2014","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2019.07.019_bib29","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.clgc.2015.10.003","article-title":"Impact of perioperative allogenic blood transfusion on survival after radical nephroureterectomy for upper tract urothelial carcinoma","volume":"14","author":"Rink","year":"2016","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.clgc.2019.07.019_bib30","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.ejso.2014.03.018","article-title":"Association of perioperative blood transfusion with oncologic outcomes after radical nephroureterectomy for upper tract urothelial carcinoma","volume":"40","author":"Rieken","year":"2014","journal-title":"Eur J Surg Oncol"}],"container-title":["Clinical Genitourinary Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767319302472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767319302472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:31:37Z","timestamp":1761564697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1558767319302472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S1558767319302472"],"URL":"https:\/\/doi.org\/10.1016\/j.clgc.2019.07.019","relation":{},"ISSN":["1558-7673"],"issn-type":[{"value":"1558-7673","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single Versus Maintenance Intravesical Chemotherapy for the Prevention of Bladder Recurrence after Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Randomized Clinical Trial","name":"articletitle","label":"Article Title"},{"value":"Clinical Genitourinary Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clgc.2019.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}