{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:39:27Z","timestamp":1792643967958,"version":"4.5.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinical-genitourinary-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genitourinary Cancer"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.clgc.2022.12.008","type":"journal-article","created":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T02:03:48Z","timestamp":1672452228000},"page":"238-247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Epidemiology and Economic Burden of von Hippel-Lindau Disease-Associated Renal Cell Carcinoma in the United States"],"prefix":"10.1016","volume":"21","author":[{"given":"Eric","family":"Jonasch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-2813","authenticated-orcid":false,"given":"Yan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Freimark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5329-4688","authenticated-orcid":false,"given":"Richard","family":"Berman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Signorovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murali","family":"Sundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clgc.2022.12.008_bib0001","doi-asserted-by":"crossref","first-page":"5669","DOI":"10.2147\/OTT.S190753","article-title":"Von Hippel-Lindau Disease: current challenges and future prospects","volume":"13","author":"Glasker","year":"2020","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.clgc.2022.12.008_bib0002","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/jmg.28.7.443","article-title":"Von Hippel-Lindau disease: a genetic study","volume":"28","author":"Maher","year":"1991","journal-title":"J Med Genetics"},{"key":"10.1016\/j.clgc.2022.12.008_bib0003","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1093\/neuonc\/nov313","article-title":"Von Hippel-Lindau disease: an evaluation of natural history and functional disability","volume":"18","author":"Feletti","year":"2016","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.clgc.2022.12.008_bib0004","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/0140-6736(91)91705-Y","article-title":"Clustering of features of von Hippel-Lindau syndrome: evidence for a complex genetic locus","volume":"337","author":"Neumann","year":"1991","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.clgc.2022.12.008_bib0005","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/ajmg.a.33139","article-title":"Birth incidence and prevalence of tumor-prone syndromes: estimates from a UK family genetic register service","volume":"152a","author":"Evans","year":"2010","journal-title":"Am J Med Genetics Part A"},{"key":"10.1016\/j.clgc.2022.12.008_bib0006","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ejhg.2016.173","article-title":"Prevalence, birth incidence, and penetrance of von Hippel\u2013Lindau disease (vHL) in Denmark","volume":"25","author":"Binderup","year":"2017","journal-title":"Eur J Hum Genetics"},{"key":"10.1016\/j.clgc.2022.12.008_bib0007","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1148\/rg.2018184005","article-title":"Tumors in von Hippel-Lindau Syndrome: from head to toe-comprehensive state-of-the-art review","volume":"38","author":"Ganeshan","year":"2018","journal-title":"Radiographics"},{"key":"10.1016\/j.clgc.2022.12.008_bib0008","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1056\/NEJMoa2103425","article-title":"Belzutifan for renal cell carcinoma in von Hippel-Lindau Disease","volume":"385","author":"Jonasch","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clgc.2022.12.008_bib0009","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fped.2018.00016","article-title":"Renal cell carcinoma in von Hippel-Lindau disease-from tumor genetics to novel therapeutic strategies","volume":"6","author":"Kim","year":"2018","journal-title":"Front Pediatr"},{"key":"10.1016\/j.clgc.2022.12.008_bib0010","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000441462","article-title":"Health-related quality of life in end-stage renal disease patients: how often should we ask and what do we do with the answer?","volume":"41","author":"Chen","year":"2016","journal-title":"Blood Purif"},{"key":"10.1016\/j.clgc.2022.12.008_bib0011","series-title":"FDA approves belzutifan for cancers associated with von Hippel-Lindau disease","year":"2021"},{"key":"10.1016\/j.clgc.2022.12.008_bib0012","series-title":"Annual Social and Economic supplement","article-title":"Current Population Survey","year":"2019"},{"issue":"4S","key":"10.1016\/j.clgc.2022.12.008_bib0013","first-page":"e634","article-title":"Demographics and management costs of VHL patients with a pheochromocytoma: a national inpatient service analysis","volume":"203","author":"King","year":"2020","journal-title":"J Urol"},{"key":"10.1016\/j.clgc.2022.12.008_bib0014","doi-asserted-by":"crossref","first-page":"356.e319","DOI":"10.1016\/j.urolonc.2019.01.016","article-title":"Economic burden of renal cell carcinoma among older adults in the targeted therapy era","volume":"37","author":"Kale","year":"2019","journal-title":"Urol Oncol"},{"key":"10.1016\/j.clgc.2022.12.008_bib0015","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.urolonc.2007.02.014","article-title":"The burden of illness associated with renal cell carcinoma in the United States","volume":"25","author":"Lang","year":"2007","journal-title":"Urol Oncol"},{"key":"10.1016\/j.clgc.2022.12.008_bib0016","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s00345-017-2040-6","article-title":"Minimally invasive vs open nephrectomy in the modern era: does approach matter?","volume":"35","author":"Golombos","year":"2017","journal-title":"World J Urol"},{"key":"10.1016\/j.clgc.2022.12.008_bib0017","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.ejso.2016.08.023","article-title":"Mortality, morbidity and healthcare expenditures after local tumour ablation or partial nephrectomy for T1A kidney cancer","volume":"43","author":"Larcher","year":"2017","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.clgc.2022.12.008_bib0018","first-page":"9401","article-title":"Societal costs of localized renal cancer surgery","volume":"25","author":"Chang","year":"2018","journal-title":"Can J Urol"}],"container-title":["Clinical Genitourinary Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S155876732200266X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S155876732200266X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:37:02Z","timestamp":1761565022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S155876732200266X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S155876732200266X"],"URL":"https:\/\/doi.org\/10.1016\/j.clgc.2022.12.008","relation":{},"ISSN":["1558-7673"],"issn-type":[{"value":"1558-7673","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epidemiology and Economic Burden of von Hippel-Lindau Disease-Associated Renal Cell Carcinoma in the United States","name":"articletitle","label":"Article Title"},{"value":"Clinical Genitourinary Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clgc.2022.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}