{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:39:44Z","timestamp":1793176784644,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinical-genitourinary-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genitourinary Cancer"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.clgc.2023.10.013","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T17:53:43Z","timestamp":1698947623000},"page":"193-200.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neoadjuvant Chemoradiotherapy Followed by Radical Cystectomy for Muscle-Invasive Bladder Cancer: Analysis of Efficacy and Safety in 119 Patients"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9454-3345","authenticated-orcid":false,"given":"Motohiro","family":"Fujiwara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3632-2901","authenticated-orcid":false,"given":"Hajime","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2738-9792","authenticated-orcid":false,"given":"Masaki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4931-2489","authenticated-orcid":false,"given":"Yuki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3066-0293","authenticated-orcid":false,"given":"Bo","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-5522","authenticated-orcid":false,"given":"Yudai","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2741-8338","authenticated-orcid":false,"given":"Shohei","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuma","family":"Toda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2757-8083","authenticated-orcid":false,"given":"Soichiro","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minato","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichi","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhisa","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.clgc.2023.10.013_bib0001","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0022-5347(05)66440-3","article-title":"Cystectomy for bladder cancer: a contemporary series","volume":"165","author":"Dalbagni","year":"2001","journal-title":"J Urol"},{"issue":"3","key":"10.1016\/j.clgc.2023.10.013_bib0002","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1200\/JCO.2001.19.3.666","article-title":"Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients","volume":"19","author":"Stein","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clgc.2023.10.013_bib0003","unstructured":"Witjes JA, Bruins HM, Cathomas R, Comp\u00e9rat E, Cowan NC, Efstathiou JA. MIBC_EAU_2021_0409. EAU - Website. Published 2021. Accessed: April 9, 2021, 2021. Available at: http:\/\/uroweb.org\/guideline\/bladder-cancer-muscle-invasive-and-metastatic\/."},{"issue":"16","key":"10.1016\/j.clgc.2023.10.013_bib0004","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1200\/JCO.2010.32.3139","article-title":"International phase III trial assessing neoadjuvant cisplatin, methotrexate, and vinblastine chemotherapy for muscle-invasive bladder cancer: long-term results of the BA06 30894 trial","volume":"29","author":"Griffiths","year":"2011","journal-title":"J Clin Oncol"},{"issue":"9","key":"10.1016\/j.clgc.2023.10.013_bib0005","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1056\/NEJMoa022148","article-title":"Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer","volume":"349","author":"Grossman","year":"2003","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.clgc.2023.10.013_bib0006","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1002\/cncr.24052","article-title":"Mortality increases when radical cystectomy is delayed more than 12 weeks: results from a surveillance, epidemiology, and end results-medicare analysis","volume":"115","author":"Gore","year":"2009","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.clgc.2023.10.013_bib0007","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0022-5347(17)47119-9","article-title":"Randomized trial of cystectomy with or without preoperative radiotherapy for carcinoma of the bilharzial bladder","volume":"134","author":"Ghoneim","year":"1985","journal-title":"J Urol"},{"issue":"4","key":"10.1016\/j.clgc.2023.10.013_bib0008","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/cncr.21676","article-title":"Adjuvant chemotherapy in muscle-invasive bladder carcinoma: a pooled analysis from phase III studies","volume":"106","author":"Ruggeri","year":"2006","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.clgc.2023.10.013_bib0009","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/1097-0142(19880115)61:2<255::AID-CNCR2820610210>3.0.CO;2-X","article-title":"A comparison of preoperative radiotherapy regimens for bladder carcinoma. The university of Pennsylvania experience","volume":"61","author":"Spera","year":"1988","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.clgc.2023.10.013_bib0010","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s11912-020-0880-5","article-title":"Trimodality therapy for muscle-invasive bladder cancer: recent advances and unanswered questions","volume":"22","author":"Jiang","year":"2020","journal-title":"Curr Oncol Rep"},{"issue":"1","key":"10.1016\/j.clgc.2023.10.013_bib0011","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.eururo.2014.02.038","article-title":"Critical analysis of bladder sparing with trimodal therapy in muscle-invasive bladder cancer: a systematic review","volume":"66","author":"Ploussard","year":"2014","journal-title":"Eur Urol"},{"issue":"2","key":"10.1016\/j.clgc.2023.10.013_bib0012","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/bju.14736","article-title":"Selective tetramodal bladder-preservation therapy, incorporating induction chemoradiotherapy and consolidative partial cystectomy with pelvic lymph node dissection for muscle-invasive bladder cancer: oncological and functional outcomes of 107 patients","volume":"124","author":"Kijima","year":"2019","journal-title":"BJU Int"},{"issue":"2","key":"10.1016\/j.clgc.2023.10.013_bib0013","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1464-410X.2008.08297.x","article-title":"Favourable outcomes of patients with clinical stage T3N0M0 bladder cancer treated with induction low-dose chemo-radiotherapy plus partial or radical cystectomy vs immediate radical cystectomy: a single-institutional retrospective comparative study","volume":"104","author":"Koga","year":"2009","journal-title":"BJU Int"},{"issue":"12","key":"10.1016\/j.clgc.2023.10.013_bib0014","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1093\/jjco\/hyr150","article-title":"Perioperative complications of radical cystectomy after induction chemoradiotherapy in bladder-sparing protocol against muscle-invasive bladder cancer: a single institutional retrospective comparative study with primary radical cystectomy","volume":"41","author":"Iwai","year":"2011","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.clgc.2023.10.013_bib0015","series-title":"TNM Classification of Malignant Tumors","author":"LH","year":"2009"},{"key":"10.1016\/j.clgc.2023.10.013_bib0016","series-title":"Histological Typing of Urinary Bladder Tumours","author":"Mostofi","year":"1999"},{"issue":"6","key":"10.1016\/j.clgc.2023.10.013_bib0017","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1053\/j.ajkd.2008.12.034","article-title":"Revised equations for estimated GFR from serum creatinine in Japan","volume":"53","author":"Matsuo","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.clgc.2023.10.013_bib0018","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-4-431-54505-7_7","article-title":"Gasless single-port robosurgeon surgery in urology","author":"Kihara","year":"2015","journal-title":"Gasless Single-Port RoboSurgeon Surgery in Urology"},{"key":"10.1016\/j.clgc.2023.10.013_bib0019","unstructured":"Cancer Institute N. Common terminology criteria for adverse events (CTCAE) common terminology criteria for adverse events (CTCAE) v5.0.; 2017. Accessed: March 22, 2021, 2021. Available at: https:\/\/www.meddra.org\/."},{"issue":"2","key":"10.1016\/j.clgc.2023.10.013_bib0020","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","article-title":"The clavien-dindo classification of surgical complications: five-year experience","volume":"250","author":"Clavien","year":"2009","journal-title":"Ann Surg"},{"issue":"4","key":"10.1016\/j.clgc.2023.10.013_bib0021","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.clgc.2012.08.004","article-title":"Retrospective analysis of clinical outcomes with neoadjuvant cisplatin-based regimens for muscle-invasive bladder cancer","volume":"10","author":"Pal","year":"2012","journal-title":"Clin Genitourin Cancer"},{"issue":"18","key":"10.1016\/j.clgc.2023.10.013_bib0022","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1200\/JCO.21.02051","article-title":"Dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin or gemcitabine and cisplatin as perioperative chemotherapy for patients with nonmetastatic muscle-invasive bladder cancer: results of the GETUG-AFU V05 VESPER trial","volume":"40","author":"Pfister","year":"2022","journal-title":"J Clin Oncol"},{"issue":"11","key":"10.1016\/j.clgc.2023.10.013_bib0023","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1001\/jamaoncol.2018.3542","article-title":"Downstaging and survival outcomes associated with neoadjuvant chemotherapy regimens among patients treated with cystectomy for muscle-invasive bladder cancer","volume":"4","author":"Peyton","year":"2018","journal-title":"JAMA Oncol"},{"issue":"1","key":"10.1016\/j.clgc.2023.10.013_bib0024","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/JU.0000000000002190","article-title":"Identifying the optimal number of neoadjuvant chemotherapy cycles in patients with muscle invasive bladder cancer","volume":"207","author":"D'Andrea","year":"2022","journal-title":"J Urol"},{"key":"10.1016\/j.clgc.2023.10.013_bib0025","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.651745","article-title":"Three vs. four cycles of neoadjuvant chemotherapy for localized muscle invasive bladder cancer undergoing radical cystectomy: a retrospective multi-institutional analysis","volume":"11","author":"Ferro","year":"2021","journal-title":"Front Oncol"},{"issue":"6","key":"10.1016\/j.clgc.2023.10.013_bib0026","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.euf.2020.07.002","article-title":"Nomogram predicting bladder cancer\u2013specific mortality after neoadjuvant chemotherapy and radical cystectomy for muscle-invasive bladder cancer: results of an international consortium","volume":"7","author":"Mir","year":"2021","journal-title":"Eur Urol Focus"},{"issue":"1","key":"10.1016\/j.clgc.2023.10.013_bib0027","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/JU.0000000000002189","article-title":"Four versus 3 cycles of neoadjuvant chemotherapy for muscle-invasive bladder cancer: implications for pathological response and survival","volume":"207","author":"Patel","year":"2022","journal-title":"J Urol"},{"issue":"8","key":"10.1016\/j.clgc.2023.10.013_bib0028","doi-asserted-by":"crossref","first-page":"866","DOI":"10.6004\/jnccn.2022.0041","article-title":"Bladder cancer, version 2.2022","volume":"20","author":"Flaig","year":"2022","journal-title":"J Natl Compr Canc Netw"},{"issue":"2","key":"10.1016\/j.clgc.2023.10.013_bib0029","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ccr.2014.01.009","article-title":"Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy","volume":"25","author":"Choi","year":"2014","journal-title":"Cancer Cell"},{"issue":"5","key":"10.1016\/j.clgc.2023.10.013_bib0030","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.ijrobp.2018.06.030","article-title":"Impact of immunohistochemistry-based subtypes in muscle-invasive bladder cancer on response to chemoradiation therapy","volume":"102","author":"Tanaka","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.clgc.2023.10.013_bib0031","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/cncr.22031","article-title":"Impact of renal impairment on eligibility for adjuvant cisplatin-based chemotherapy in patients with urothelial carcinoma of the bladder","volume":"107","author":"Dash","year":"2006","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.clgc.2023.10.013_bib0032","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1002\/cncr.23848","article-title":"A role for neoadjuvant gemcitabine plus cisplatin in muscle-invasive urothelial carcinoma of the bladder: a retrospective experience","volume":"113","author":"Dash","year":"2008","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.clgc.2023.10.013_bib0033","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.eururo.2020.08.024","volume":"79","author":"Pfister","year":"2021","journal-title":"Eur Urol"},{"issue":"6","key":"10.1016\/j.clgc.2023.10.013_bib0034","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1464-410X.2009.08835.x","article-title":"Is the incidence of uretero-intestinal anastomotic stricture increased in patients undergoing radical cystectomy with previous pelvic radiation?","volume":"105","author":"Katkoori","year":"2010","journal-title":"BJU Int"},{"issue":"8","key":"10.1016\/j.clgc.2023.10.013_bib0035","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/cncr.28544","article-title":"Optimizing bladder cancer locoregional failure risk stratification after radical cystectomy using SWOG 8710","volume":"120","author":"Christodouleas","year":"2014","journal-title":"Cancer"},{"issue":"10","key":"10.1016\/j.clgc.2023.10.013_bib0036","first-page":"659","article-title":"The role of adjuvant radiotherapy after surgery for upper and lower urinary tract urothelial carcinoma: a systematic review","volume":"37","author":"Iwata","year":"2019","journal-title":"Urol Oncol Semin Orig Investig"},{"issue":"2","key":"10.1016\/j.clgc.2023.10.013_bib0037","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/bju.12952","article-title":"Pelvic recurrence after radical cystectomy: a call to arms","volume":"116","author":"Williams","year":"2015","journal-title":"BJU Int"},{"issue":"23","key":"10.1016\/j.clgc.2023.10.013_bib0038","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13236070","article-title":"Oncologic impact and safety of pre-operative radiotherapy in localized prostate and bladder cancer: a comprehensive review from the cancerology committee of the association fran\u00e7aise d'urologie","volume":"13","author":"Sargos","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.clgc.2023.10.013_bib0039","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/iju.14182","article-title":"Oncological outcomes and recurrence patterns after laparoscopic radical cystectomy for bladder cancer: a Japanese multicenter cohort","volume":"27","author":"Kanno","year":"2020","journal-title":"Int J Urol"},{"issue":"23","key":"10.1016\/j.clgc.2023.10.013_bib0040","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1158\/1078-0432.CCR-22-2158","article-title":"Neoadjuvant pembrolizumab and radical cystectomy in patients with muscle-invasive urothelial bladder cancer: 3-year median follow-up update of PURE-01 trial","volume":"28","author":"Basile","year":"2022","journal-title":"Clin Cancer Res"},{"issue":"22","key":"10.1016\/j.clgc.2023.10.013_bib0041","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1056\/NEJMoa2034442","article-title":"Adjuvant nivolumab versus placebo in muscle-invasive urothelial carcinoma","volume":"384","author":"Bajorin","year":"2021","journal-title":"N Engl J Med"},{"issue":"22","key":"10.1016\/j.clgc.2023.10.013_bib0042","doi-asserted-by":"crossref","first-page":"8355","DOI":"10.1002\/cam4.3445","article-title":"Impact of radiotherapy to the primary tumor on the efficacy of pembrolizumab for patients with advanced urothelial cancer: A preliminary study","volume":"9","author":"Fukushima","year":"2020","journal-title":"Cancer Med"},{"issue":"2","key":"10.1016\/j.clgc.2023.10.013_bib0043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22020535","article-title":"Combination of cisplatin and irradiation induces immunogenic cell death and potentiates postirradiation anti\u2013PD-1 treatment efficacy in urothelial carcinoma","volume":"22","author":"Fukushima","year":"2021","journal-title":"Int J Mol Sci"}],"container-title":["Clinical Genitourinary Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S155876732300232X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S155876732300232X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:27:09Z","timestamp":1793176029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S155876732300232X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S155876732300232X"],"URL":"https:\/\/doi.org\/10.1016\/j.clgc.2023.10.013","relation":{},"ISSN":["1558-7673"],"issn-type":[{"value":"1558-7673","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neoadjuvant Chemoradiotherapy Followed by Radical Cystectomy for Muscle-Invasive Bladder Cancer: Analysis of Efficacy and Safety in 119 Patients","name":"articletitle","label":"Article Title"},{"value":"Clinical Genitourinary Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clgc.2023.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}