{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:39:26Z","timestamp":1793176766886,"version":"4.5.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020QH186"],"award-info":[{"award-number":["ZR2020QH186"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073131"],"award-info":[{"award-number":["82073131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870525"],"award-info":[{"award-number":["81870525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018583","name":"Wuhan Science and Technology Project","doi-asserted-by":"publisher","award":["2021MSGY047"],"award-info":[{"award-number":["2021MSGY047"]}],"id":[{"id":"10.13039\/501100018583","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinical-genitourinary-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genitourinary Cancer"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.clgc.2024.01.012","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T11:50:24Z","timestamp":1705924224000},"page":"569-579.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Urinary Exosomal miR-17-5p Accelerates Bladder Cancer Invasion by Repressing its Target Gene ARID4B and Regulating the Immune Microenvironment"],"prefix":"10.1016","volume":"22","author":[{"given":"Hejia","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhunan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanshan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7924-3923","authenticated-orcid":false,"given":"Jitao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clgc.2024.01.012_bib0001","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.clgc.2024.01.012_bib0002","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1001\/jama.2020.17598","article-title":"Bladder cancer: a review","volume":"324","author":"Lenis","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.clgc.2024.01.012_bib0003","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.eururo.2020.03.055","article-title":"European Association of Urology guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2020 guidelines","volume":"79","author":"Witjes","year":"2021","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2024.01.012_bib0004","first-page":"404","article-title":"Treatment of muscle-invasive and advanced bladder cancer in 2020","volume":"70","author":"Patel","year":"2020","journal-title":"CA Cancer J Clin."},{"key":"10.1016\/j.clgc.2024.01.012_bib0005","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.eururo.2021.09.026","article-title":"The 2021 updated European Association of Urology guidelines on metastatic urothelial carcinoma","volume":"81","author":"Cathomas","year":"2022","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2024.01.012_bib0006","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev-biochem-013118-111902","article-title":"Exosomes","volume":"88","author":"Pegtel","year":"2019","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.clgc.2024.01.012_bib0007","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.annonc.2021.01.074","article-title":"Exosome-based liquid biopsies in cancer: opportunities and challenges","volume":"32","author":"Yu","year":"2021","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clgc.2024.01.012_bib0008","doi-asserted-by":"crossref","first-page":"7872","DOI":"10.7150\/thno.44634","article-title":"Urine biopsy technologies: cancer and beyond","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.clgc.2024.01.012_bib0009","doi-asserted-by":"crossref","first-page":"eaau6977","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.clgc.2024.01.012_bib0010","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12943-018-0831-z","article-title":"Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment","volume":"17","author":"Sun","year":"2018","journal-title":"Mol Cancer"},{"key":"10.1016\/j.clgc.2024.01.012_bib0011","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.canlet.2020.04.023","article-title":"Non-coding RNA in bladder cancer","volume":"485","author":"Li","year":"2020","journal-title":"Cancer Lett"},{"key":"10.1016\/j.clgc.2024.01.012_bib0012","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41592-020-01034-x","article-title":"Exosome detection via the ultrafast-isolation system: EXODUS","volume":"18","author":"Chen","year":"2021","journal-title":"Nat Methods"},{"key":"10.1016\/j.clgc.2024.01.012_bib0013","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.semcancer.2022.06.001","article-title":"Extracellular vesicles in cancer therapy","volume":"86","author":"Wang","year":"2022","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.clgc.2024.01.012_bib0014","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1158\/2159-8290.CD-20-0655","article-title":"Tumor-infiltrating natural killer cells","volume":"11","author":"C\u00f3zar","year":"2021","journal-title":"Cancer Discov"},{"key":"10.1016\/j.clgc.2024.01.012_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2020.101407","article-title":"NK cells in the tumor microenvironment: prognostic and theranostic impact. Recent advances and trends","volume":"48","author":"Russick","year":"2020","journal-title":"Semin Immunol"},{"key":"10.1016\/j.clgc.2024.01.012_bib0016","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41568-020-00313-1","article-title":"Advances in bladder cancer biology and therapy","volume":"21","author":"Tran","year":"2021","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.clgc.2024.01.012_bib0017","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s40291-017-0314-8","article-title":"miRNAs as potential treatment targets and treatment options in cancer","volume":"22","author":"Petrovic","year":"2018","journal-title":"Mol Diagn Ther"},{"key":"10.1016\/j.clgc.2024.01.012_bib0018","doi-asserted-by":"crossref","first-page":"7753","DOI":"10.1093\/nar\/gkz638","article-title":"Systems biology-based investigation of cooperating microRNAs as monotherapy or adjuvant therapy in cancer","volume":"47","author":"Lai","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.clgc.2024.01.012_bib0019","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12943-018-0897-7","article-title":"Effect of exosomal miRNA on cancer biology and clinical applications","volume":"17","author":"Sun","year":"2018","journal-title":"Mol Cancer"},{"key":"10.1016\/j.clgc.2024.01.012_bib0020","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1172\/JCI81136","article-title":"Exosomes and tumor-mediated immune suppression","volume":"126","author":"Whiteside","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.clgc.2024.01.012_bib0021","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1038\/s41467-019-12184-8","article-title":"Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer","volume":"10","author":"Wu","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.clgc.2024.01.012_bib0022","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/jnci\/djn253","article-title":"Identification of chromatin remodeling genes Arid4a and Arid4b as leukemia suppressor genes","volume":"100","author":"Wu","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.clgc.2024.01.012_bib0023","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.dld.2020.07.019","article-title":"Circ-SMARCA5 suppresses colorectal cancer progression via downregulating miR-39-3p and upregulating ARID4B","volume":"52","author":"Miao","year":"2020","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.clgc.2024.01.012_bib0024","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2108876118","article-title":"The genetic source tracking of human urinary exosomes","volume":"118","author":"Zhu","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.clgc.2024.01.012_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2022.188776","article-title":"Role of exosomes in lung cancer: a comprehensive insight from immunomodulation to theragnostic applications","volume":"1877","author":"Khan","year":"2022","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10.1016\/j.clgc.2024.01.012_bib0026","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.ymthe.2022.01.022","article-title":"Exosome-derived circTRPS1 promotes malignant phenotype and CD8+ T cell exhaustion in bladder cancer microenvironments","volume":"30","author":"Yang","year":"2022","journal-title":"Mol Ther"},{"key":"10.1016\/j.clgc.2024.01.012_bib0027","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ni1581","article-title":"Up on the tightrope: natural killer cell activation and inhibition","volume":"9","author":"Lanier","year":"2008","journal-title":"Nat Immunol"}],"updated-by":[{"DOI":"10.1016\/j.clgc.2026.102584","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000}},{"DOI":"10.1016\/j.clgc.2026.102584","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000}}],"container-title":["Clinical Genitourinary Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767324000120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767324000120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:26:35Z","timestamp":1793175995000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1558767324000120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S1558767324000120"],"URL":"https:\/\/doi.org\/10.1016\/j.clgc.2024.01.012","relation":{},"ISSN":["1558-7673"],"issn-type":[{"value":"1558-7673","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urinary Exosomal miR-17-5p Accelerates Bladder Cancer Invasion by Repressing its Target Gene ARID4B and Regulating the Immune Microenvironment","name":"articletitle","label":"Article Title"},{"value":"Clinical Genitourinary Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clgc.2024.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}