{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:41:40Z","timestamp":1791312100104,"version":"4.3.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","clinical-genitourinary-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genitourinary Cancer"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.clgc.2024.102294","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:20:32Z","timestamp":1735604432000},"page":"102294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["CIRCULATING miR-1-3p, miR-96-5p, miR-148a-3p, and miR-375-3p Support Differentiation Between Prostate Cancer and Benign Prostate Lesions"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6565-2831","authenticated-orcid":false,"given":"Rafa\u0142","family":"Osiecki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9477-7595","authenticated-orcid":false,"given":"Piotr","family":"Pop\u0142awski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6829-5947","authenticated-orcid":false,"given":"Dorota","family":"Sys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Bogus\u0142awska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3100-3204","authenticated-orcid":false,"given":"Alex","family":"Bia\u0142as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Zawadzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5348-0760","authenticated-orcid":false,"given":"Agnieszka","family":"Piekie\u0142ko-Witkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Dobruch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clgc.2024.102294_bib0001","article-title":"Prostate Cancer Incidence and Mortality: Global Status and Temporal Trends in 89 Countries From 2000 to 2019","volume":"10","author":"Wang","year":"2022","journal-title":"Front Public Health"},{"key":"10.1016\/j.clgc.2024.102294_bib0002","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1002\/ijc.29538","article-title":"Prevalence of incidental prostate cancer: a systematic review of autopsy studies","volume":"137","author":"Bell","year":"2015","journal-title":"Int J Cancer"},{"key":"10.1016\/j.clgc.2024.102294_bib0003","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.eururo.2017.03.009","article-title":"Low-risk prostate cancer: iidentification, management, and outcomes","volume":"72","author":"Moschini","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2024.102294_bib0004","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1002\/ijc.33045","article-title":"Personalized strategies in population screening for prostate cancer","volume":"147","author":"Remmers","year":"2020","journal-title":"Int J Cancer"},{"key":"10.1016\/j.clgc.2024.102294_bib0005","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/bju.15153","article-title":"Prostate cancer screening and treatment: wwhere have we come from and where are we going?","volume":"126","author":"Albertsen","year":"2020","journal-title":"BJU Int"},{"key":"10.1016\/j.clgc.2024.102294_bib0006","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/301850","article-title":"Proliferative tumor doubling times of prostatic carcinoma","volume":"2011","author":"Werahera","year":"2011","journal-title":"Prostate Cancer"},{"key":"10.1016\/j.clgc.2024.102294_bib0007","series-title":"StatPearls","article-title":"Benign Prostatic Hyperplasia","author":"Ng","year":"2024"},{"key":"10.1016\/j.clgc.2024.102294_bib0008","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10142-022-00951-8","article-title":"Exosomal MiRNAs-a diagnostic biomarker acting as a guiding light in the diagnosis of prostate cancer","volume":"23","author":"Chowdhury","year":"2022","journal-title":"Funct Integr Genomics"},{"key":"10.1016\/j.clgc.2024.102294_bib0009","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41416-021-01677-3","article-title":"MicroRNAs as biomarkers for prostate cancer prognosis: a systematic review and a systematic reanalysis of public data","volume":"126","author":"Rana","year":"2022","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clgc.2024.102294_bib0010","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1007\/s11010-022-04431-2","article-title":"Non-invasive diagnostic potential of MicroRNA-203 in liquid biopsy of urothelial carcinoma of bladder","volume":"477","author":"Singh","year":"2022","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.clgc.2024.102294_bib0011","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.jmoldx.2022.05.005","article-title":"MiRNAs as molecular biomarkers for prostate cancer","volume":"24","author":"Coradduzza","year":"2022","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.clgc.2024.102294_bib0012","doi-asserted-by":"crossref","first-page":"e3459","DOI":"10.1002\/jgm.3459","article-title":"Circulating plasma MiR222-3P status and its potential diagnostic performance in prostate cancer","volume":"24","author":"Heydari","year":"2022","journal-title":"J Gene Med"},{"key":"10.1016\/j.clgc.2024.102294_bib0013","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1002\/pros.22495","article-title":"A panel of five circulating MicroRNAs as potential biomarkers for prostate cancer","volume":"72","author":"Chen","year":"2012","journal-title":"Prostate"},{"key":"10.1016\/j.clgc.2024.102294_bib0014","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.eururo.2024.03.027","article-title":"EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on prostate Cancer\u20142024 update. Part I: screening, diagnosis, and local treatment with curative intent","volume":"86","author":"Cornford","year":"2024","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2024.102294_bib0015","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol"},{"key":"10.1016\/j.clgc.2024.102294_bib0016","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Series B Stat Methodol"},{"key":"10.1016\/j.clgc.2024.102294_bib0017","doi-asserted-by":"crossref","first-page":"W244","DOI":"10.1093\/nar\/gkaa467","article-title":"MiRNet 2.0: nnetwork-based visual analytics for MiRNA functional analysis and Systems biology","volume":"48","author":"Chang","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.clgc.2024.102294_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.631021","article-title":"High-throughput and automated acoustic trapping of extracellular vesicles to identify MicroRNAs with diagnostic potential for prostate cancer","volume":"11","author":"Ku","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.clgc.2024.102294_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcp.2023.101901","article-title":"Identification of MiR-1-3p, MiR-143-3p and MiR-145-5p association with bone metastasis of gleason 3+4 prostate cancer and involvement of LASP1 regulation","volume":"68","author":"Guo","year":"2023","journal-title":"Mol Cell Probes"},{"key":"10.1016\/j.clgc.2024.102294_bib0020","first-page":"3499","article-title":"Silencing of MALAT1 inhibits migration and invasion by sponging MiR13p in prostate cancer cells","volume":"20","author":"Dai","year":"2019","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.clgc.2024.102294_bib0021","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s13046-018-0895-z","article-title":"The putative tumour suppressor MiR-1-3p modulates prostate cancer cell aggressiveness by repressing E2F5 and PFTK1","volume":"37","author":"Li","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.clgc.2024.102294_bib0022","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/apm.12880","article-title":"Increased levels of serum MiR-148a-3p are associated with prostate cancer","volume":"126","author":"Dybos","year":"2018","journal-title":"APMIS"},{"key":"10.1016\/j.clgc.2024.102294_bib0023","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12894-022-01143-z","article-title":"Correlations between serum levels of MicroRNA-148a-3p and MicroRNA-485-5p and the progression and recurrence of prostate cancer","volume":"22","author":"He","year":"2022","journal-title":"BMC Urol"},{"key":"10.1016\/j.clgc.2024.102294_bib0024","article-title":"Biomarker potential of plasma MicroRNA-150-5p in prostate cancer","volume":"55","author":"Paunescu","year":"2019","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.clgc.2024.102294_bib0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241813890","article-title":"Circulating MiRNAs for detection and discrimination of the main urological cancers using a DdPCR-based approach","volume":"24","author":"Sequeira","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.clgc.2024.102294_bib0026","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1038\/s41467-021-23497-y","article-title":"Single-molecule amplification-free multiplexed detection of circulating MicroRNA cancer biomarkers from serum","volume":"12","author":"Cai","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.clgc.2024.102294_bib0027","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s11255-018-1938-2","article-title":"Combination of three MiRNA (MiR-141, MiR-21, and MiR-375) as potential diagnostic tool for prostate cancer recognition","volume":"50","author":"Porzycki","year":"2018","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.clgc.2024.102294_bib0028","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41598-019-57101-7","article-title":"Circulating MiR-141 and MiR-375 are associated with treatment outcome in metastatic castration resistant prostate cancer","volume":"10","author":"Zedan","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.clgc.2024.102294_bib0029","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13092068","article-title":"MiR-182-5p and MiR-375-3p have higher performance than PSA in discriminating prostate cancer from benign prostate hyperplasia","volume":"13","author":"Abramovic","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.clgc.2024.102294_bib0030","doi-asserted-by":"crossref","first-page":"900","DOI":"10.3389\/fonc.2019.00900","article-title":"Circulating MicroRNAs as biomarkers for prostate cancer detection and metastasis development prediction","volume":"9","author":"Bidarra","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.clgc.2024.102294_bib0031","doi-asserted-by":"crossref","first-page":"686","DOI":"10.21037\/tcr-23-1313","article-title":"The value of a panel of circulating MicroRNAs in screening prostate cancer","volume":"13","author":"Sun","year":"2024","journal-title":"Transl Cancer Res"},{"key":"10.1016\/j.clgc.2024.102294_bib0032","first-page":"177","article-title":"MicroRNA dysregulation in prostate cancer","volume":"15","author":"Schitcu","year":"2022","journal-title":"Pharmgenomics Pers Med"},{"key":"10.1016\/j.clgc.2024.102294_bib0033","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE Guidelines: mminimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.clgc.2024.102294_bib0034","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1136\/gutjnl-2020-322065","article-title":"Development and validation of a serum MicroRNA biomarker panel for detecting gastric cancer in a high-risk population","volume":"70","author":"So","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.clgc.2024.102294_bib0035","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1158\/1078-0432.CCR-23-0730","article-title":"Detection of recurrence through MicroRNA-371a-3p serum levels in a follow-up of stage I testicular germ cell tumors in the DRKS-00019223 study","volume":"30","author":"Belge","year":"2024","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.clgc.2024.102294_bib0036","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.euf.2024.05.002","article-title":"Serum levels of MicroRNA-371a-3p for predicting the histology of postchemotherapy residual masses of germ cell tumours","volume":"10","author":"Dieckmann","year":"2024","journal-title":"Eur Urol Focus"},{"key":"10.1016\/j.clgc.2024.102294_bib0037","doi-asserted-by":"crossref","first-page":"19287","DOI":"10.1038\/s41598-023-45317-7","article-title":"Identification of serum MiR-1246 and MiR-150-5p as novel diagnostic biomarkers for high-grade serous ovarian cancer","volume":"13","author":"Niemira","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.clgc.2024.102294_bib0038","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s40364-023-00517-1","article-title":"Identification of exosomal MicroRNA panel as diagnostic and prognostic biomarker for small cell lung cancer","volume":"11","author":"Kim","year":"2023","journal-title":"Biomark Res"},{"key":"10.1016\/j.clgc.2024.102294_bib0039","doi-asserted-by":"crossref","first-page":"25036","DOI":"10.1073\/pnas.2006212117","article-title":"Development of a serum MiRNA panel for detection of early stage non-small cell lung cancer","volume":"117","author":"Ying","year":"2020","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.clgc.2024.102294_bib0040","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3892\/ol.2021.13053","article-title":"Four plasma MiRNAs act as biomarkers for diagnosis and prognosis of nonsmall cell lung cancer","volume":"22","author":"Jiang","year":"2021","journal-title":"Oncol Lett"},{"key":"10.1016\/j.clgc.2024.102294_bib0041","doi-asserted-by":"crossref","first-page":"6653","DOI":"10.1038\/s41598-018-24424-w","article-title":"A plasma biomarker panel of four MicroRNAs for the diagnosis of prostate cancer","volume":"8","author":"Matin","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.clgc.2024.102294_bib0042","first-page":"8","article-title":"Characterizing causality in cancer","author":"Rondeau","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.clgc.2024.102294_bib0043","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: ffrom cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.clgc.2024.102294_bib0044","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41392-024-01823-2","article-title":"Tumor biomarkers for diagnosis, prognosis and targeted therapy","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct Target Ther"}],"container-title":["Clinical Genitourinary Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767324002647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767324002647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:36:24Z","timestamp":1741696584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1558767324002647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S1558767324002647"],"URL":"https:\/\/doi.org\/10.1016\/j.clgc.2024.102294","relation":{},"ISSN":["1558-7673"],"issn-type":[{"value":"1558-7673","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CIRCULATING miR-1-3p, miR-96-5p, miR-148a-3p, and miR-375-3p Support Differentiation Between Prostate Cancer and Benign Prostate Lesions","name":"articletitle","label":"Article Title"},{"value":"Clinical Genitourinary Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clgc.2024.102294","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102294"}}