{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:03:50Z","timestamp":1784966630438,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinical-genitourinary-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genitourinary Cancer"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.clgc.2025.102405","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T15:15:16Z","timestamp":1753283716000},"page":"102405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and Pathological Predictors for Occult Lymph Node Involvement in Patients With Clinical Node-Negative Bladder Cancer Undergoing Radical Cystectomy"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4334-1300","authenticated-orcid":false,"given":"Salvador","family":"Jaime-Casas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2181-8405","authenticated-orcid":false,"given":"Miguel","family":"Zugman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Barragan-Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedyeh","family":"Ebrahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4868-8276","authenticated-orcid":false,"given":"Koral","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2389-3046","authenticated-orcid":false,"given":"Wesley","family":"Yip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory M.","family":"Hugen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-1344","authenticated-orcid":false,"given":"Kevin G.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clayton S.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertram E.","family":"Yuh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Salgia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5423-9821","authenticated-orcid":false,"given":"Daniela V.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnn","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1898-5501","authenticated-orcid":false,"given":"Charles B.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5205-4527","authenticated-orcid":false,"given":"Alexander","family":"Chehrazi-Raffle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumanta K","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clgc.2025.102405_bib0001","series-title":"Key statistics for bladder cancer","author":"American Cancer","year":"2024"},{"issue":"4","key":"10.1016\/j.clgc.2025.102405_bib0002","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.eururo.2020.12.033","article-title":"European Association of Urology (EAU) prognostic factor risk groups for non\u2013muscle-invasive bladder cancer (NMIBC) incorporating the WHO 2004\/2016 and WHO 1973 classification systems for grade: an update from the EAU NMIBC guidelines panel","volume":"79","author":"Sylvester","year":"2021","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2025.102405_bib0003","unstructured":"Flaig, T.W., Spiess, P.E., Abern M., et al. National Comprehensive Cancer Network. NCCN clinical practice Guidelines in Oncology (NCCN Guidelines\u00ae) bladder cancer; 2024."},{"issue":"10061","key":"10.1016\/j.clgc.2025.102405_bib0004","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1016\/S0140-6736(16)30512-8","article-title":"Bladder cancer","volume":"388","author":"Kamat","year":"2016","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.clgc.2025.102405_bib0005","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1056\/NEJMoa022148","article-title":"Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer","volume":"349","author":"Grossman","year":"2003","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.clgc.2025.102405_bib0006","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.hoc.2014.11.002","article-title":"Perioperative therapy for muscle invasive bladder cancer","volume":"29","author":"Leow","year":"2015","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.clgc.2025.102405_bib0007","series-title":"N Engl J Med","article-title":"Perioperative Durvalumab with Neoadjuvant Chemotherapy in Operable Bladder Cancer","author":"Powles","year":"2024"},{"issue":"3","key":"10.1016\/j.clgc.2025.102405_bib0008","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.hoc.2021.02.006","article-title":"Contemporary and emerging approaches to bladder-preserving trimodality therapy for muscle-invasive bladder cancer","volume":"35","author":"Konieczkowski","year":"2021","journal-title":"Hematol Oncol Clin North Am"},{"issue":"6","key":"10.1016\/j.clgc.2025.102405_bib0009","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S1470-2045(23)00170-5","article-title":"Radical cystectomy versus trimodality therapy for muscle-invasive bladder cancer: a multi-institutional propensity score matched and weighted analysis","volume":"24","author":"Zlotta","year":"2023","journal-title":"Lancet Oncol"},{"issue":"4","key":"10.1016\/j.clgc.2025.102405_bib0010","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1464-410X.2010.09912.x","article-title":"Contemporary outcomes of 2287 patients with bladder cancer who were treated with radical cystectomy: a Canadian multicentre experience","volume":"108","author":"Yafi","year":"2011","journal-title":"BJU Int"},{"issue":"1","key":"10.1016\/j.clgc.2025.102405_bib0011","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/1748-717X-9-213","article-title":"Trimodality bladder-sparing approach without neoadjuvant chemotherapy for node-negative localized muscle-invasive urinary bladder cancer resulted in comparable cystectomy-free survival","volume":"9","author":"Lee","year":"2014","journal-title":"Radiat Oncol"},{"issue":"2","key":"10.1016\/j.clgc.2025.102405_bib0012","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.clgc.2023.12.009","article-title":"Prognostic significance of lymph node density in pathological node positive urothelial carcinoma of the bladder -upfront surgery and post neoadjuvant chemotherapy cohorts","volume":"22","author":"Jaganmurugan","year":"2024","journal-title":"Clin Genitourin Cancer"},{"issue":"6","key":"10.1016\/j.clgc.2025.102405_bib0013","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1586\/14737140.4.6.1007","article-title":"The importance of an extended lymphadenectomy in the management of high-grade invasive bladder cancer","volume":"4","author":"Quek","year":"2004","journal-title":"Expert Rev Antican Ther"},{"key":"10.1016\/j.clgc.2025.102405_bib0014","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-076743","article-title":"Advances in diagnosis and treatment of bladder cancer","author":"Lopez-Beltran","year":"2024","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.clgc.2025.102405_bib0015","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00345-018-2439-8","article-title":"Comparative sensitivity and specificity of imaging modalities in staging bladder cancer prior to radical cystectomy: a systematic review and meta-analysis","volume":"37","author":"Crozier","year":"2019","journal-title":"World J Urol"},{"issue":"3","key":"10.1016\/j.clgc.2025.102405_bib0016","doi-asserted-by":"crossref","first-page":"W95","DOI":"10.2214\/AJR.17.18481","article-title":"The diagnostic performance of MRI for detection of lymph node metastasis in bladder and prostate cancer: an updated systematic review and diagnostic meta-analysis","volume":"210","author":"Woo","year":"2018","journal-title":"Am J Roentgenol"},{"issue":"8","key":"10.1016\/j.clgc.2025.102405_bib0017","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.urolonc.2014.05.008","article-title":"Presence of lymphovascular invasion in urothelial bladder cancer specimens after transurethral resections correlates with risk of upstaging and survival: a systematic review and meta-analysis","volume":"32","author":"Kim","year":"2014","journal-title":"Urol Oncol: Sem Orig Investigat"},{"issue":"2","key":"10.1016\/j.clgc.2025.102405_bib0018","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3390\/diagnostics11020244","article-title":"Impact of lymphovascular invasion on prognosis in the patients with bladder cancer\u2014Comparison of transurethral resection and radical cystectomy","volume":"11","author":"Yoneda","year":"2021","journal-title":"Diagnostics"},{"key":"10.1016\/j.clgc.2025.102405_bib0019","article-title":"Urothelial carcinoma: perioperative considerations from top to bottom","author":"Yip","year":"2025","journal-title":"CA Cancer J Clin."},{"issue":"5","key":"10.1016\/j.clgc.2025.102405_bib0020","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.juro.2010.01.025","article-title":"Characteristics and outcomes of patients with clinical carcinoma In situ only treated with radical cystectomy: an international study of 243 patients","volume":"183","author":"Tilki","year":"2010","journal-title":"J Urol"},{"issue":"1","key":"10.1016\/j.clgc.2025.102405_bib0021","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0022-5347(17)34865-6","article-title":"Radical cystectomy for stages TA, TIS and T1 transitional cell carcinoma of the bladder","volume":"151","author":"Amling","year":"1994","journal-title":"J Urol"},{"issue":"3","key":"10.1016\/j.clgc.2025.102405_bib0022","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1097\/01.ju.0000052721.61645.a3","article-title":"Extent of pelvic lymphadenectomy and its impact on outcome in patients diagnosed with bladder cancer: analysis of data from the surveillance, epidemiology and end results program data base","volume":"169","author":"KONETY","year":"2003","journal-title":"J Urol"},{"issue":"10","key":"10.1016\/j.clgc.2025.102405_bib0023","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1056\/NEJMoa2312117","article-title":"Enfortumab Vedotin and Pembrolizumab in untreated advanced urothelial cancer","volume":"390","author":"Powles","year":"2024","journal-title":"N Engl J Med"},{"issue":"19","key":"10.1016\/j.clgc.2025.102405_bib0024","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1056\/NEJMoa2309863","article-title":"Nivolumab plus Gemcitabine\u2013Cisplatin in advanced urothelial carcinoma","volume":"389","author":"van der Heijden","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clgc.2025.102405_bib0025","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2019.00158","article-title":"Association between preoperative hydronephrosis and prognosis after radical cystectomy among patients with bladder cancer: a systemic review and meta-analysis","volume":"9","author":"Oh","year":"2019","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.clgc.2025.102405_bib0026","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/jso.2930520109","article-title":"The significance of ureteral obstruction in lnvasive transitional cell carcinoma of the urinary bladder","volume":"52","author":"Leibovitch","year":"1993","journal-title":"J Surg Oncol"},{"issue":"12","key":"10.1016\/j.clgc.2025.102405_bib0027","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1007\/s00259-005-1886-9","article-title":"FDG-PET for preoperative staging of bladder cancer","volume":"32","author":"Drieskens","year":"2005","journal-title":"Eur J Nucl Med Mol Imag"},{"issue":"5S","key":"10.1016\/j.clgc.2025.102405_bib0028","doi-asserted-by":"crossref","DOI":"10.1097\/01.JU.0001008836.73392.92.07","article-title":"PD02-07\u2003Positive ctdna status before radical cystectomy predicts lymph node status and pathological upstaging","volume":"211","author":"Ben-David","year":"2024","journal-title":"J Urol"},{"issue":"1","key":"10.1016\/j.clgc.2025.102405_bib0029","first-page":"21","article-title":"Preoperative CT-based deep learning radiomics model to predict lymph node metastasis and patient prognosis in bladder cancer: a two-center study","volume":"15","author":"Sun","year":"2024","journal-title":"Ins Imag"},{"issue":"13","key":"10.1016\/j.clgc.2025.102405_bib0030","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1056\/NEJMoa2401497","article-title":"Standard or extended lymphadenectomy for muscle-invasive bladder cancer","volume":"391","author":"Lerner","year":"2024","journal-title":"N Engl J Med"}],"container-title":["Clinical Genitourinary Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767325001053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767325001053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T15:26:07Z","timestamp":1757517967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1558767325001053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S1558767325001053"],"URL":"https:\/\/doi.org\/10.1016\/j.clgc.2025.102405","relation":{},"ISSN":["1558-7673"],"issn-type":[{"value":"1558-7673","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and Pathological Predictors for Occult Lymph Node Involvement in Patients With Clinical Node-Negative Bladder Cancer Undergoing Radical Cystectomy","name":"articletitle","label":"Article Title"},{"value":"Clinical Genitourinary Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clgc.2025.102405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102405"}}