{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:50:08Z","timestamp":1788522608725,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinical-genitourinary-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genitourinary Cancer"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.clgc.2025.102447","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T06:12:17Z","timestamp":1759558337000},"page":"102447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Macrophage Cell and Diagnostic Biomarkers in BLCA: Integrating Machine Learning With Single-Cell Analysis"],"prefix":"10.1016","volume":"23","author":[{"given":"Guangliang","family":"Che","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongtuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanfeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.clgc.2025.102447_bib0001","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.eururo.2018.09.001","article-title":"Epidemiology of bladder cancer: a systematic review and contemporary update of risk factors in 2018","volume":"74","author":"Cumberbatch","year":"2018","journal-title":"Eur Urol"},{"issue":"1","key":"10.1016\/j.clgc.2025.102447_bib0002","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.eururo.2020.03.055","article-title":"European Association of Urology guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2020 guidelines","volume":"79","author":"Witjes","year":"2021","journal-title":"Eur Urol"},{"issue":"3","key":"10.1016\/j.clgc.2025.102447_bib0003","first-page":"209","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"10.1016\/j.clgc.2025.102447_bib0004","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.clgc.2025.102447_bib0005","article-title":"Identification and validation of novel biomarkers affecting bladder cancer immunotherapy via machine learning and its association with M2 macrophages","volume":"13","author":"Wang","year":"2022","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.clgc.2025.102447_bib0006","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2024.2438291","article-title":"Characterisation of the tumour microenvironment and PD-L1 granularity reveals the prognostic value of cancer-associated myofibroblasts in non-invasive bladder cancer","volume":"14","author":"Ca\u00f1izo","year":"2025","journal-title":"Oncoimmunology"},{"issue":"1","key":"10.1016\/j.clgc.2025.102447_bib0007","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1186\/s12885-023-11100-0","article-title":"Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer","volume":"23","author":"Kerzeli","year":"2023","journal-title":"BMC Cancer"},{"issue":"2","key":"10.1016\/j.clgc.2025.102447_bib0008","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41568-020-00313-1","article-title":"Advances in bladder cancer biology and therapy","volume":"21","author":"Tran","year":"2021","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"10.1016\/j.clgc.2025.102447_bib0009","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3390\/cancers13010131","article-title":"Immune checkpoint inhibitors for the treatment of bladder cancer","volume":"13","author":"Lopez-Beltran","year":"2021","journal-title":"Cancers"},{"issue":"10","key":"10.1016\/j.clgc.2025.102447_bib0010","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.6004\/jnccn.2017.7036","article-title":"Urothelial carcinoma of the bladder and the rise of immunotherapy","volume":"15","author":"Chism","year":"2017","journal-title":"J Natl Compr Canc Netw"},{"issue":"3","key":"10.1016\/j.clgc.2025.102447_bib0011","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S1470-2045(17)30065-7","article-title":"Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial","volume":"18","author":"Sharma","year":"2017","journal-title":"Lancet Oncol"},{"issue":"7693","key":"10.1016\/j.clgc.2025.102447_bib0012","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nature25501","article-title":"TGF\u03b2 attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells","volume":"554","author":"Mariathasan","year":"2018","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.clgc.2025.102447_bib0013","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/cncy.22603","article-title":"Insights on recent innovations in bladder cancer immunotherapy","volume":"130","author":"Abd El-Salam","year":"2022","journal-title":"Cancer Cytopathol"},{"issue":"2","key":"10.1016\/j.clgc.2025.102447_bib0014","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41585-019-0263-6","article-title":"Competitive glucose metabolism as a target to boost bladder cancer immunotherapy","volume":"17","author":"Afonso","year":"2020","journal-title":"Nat Rev Urol"},{"issue":"15-16","key":"10.1016\/j.clgc.2025.102447_bib0015","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.202200026","article-title":"Human peripheral blood mononuclear cells: a review of recent proteomic applications","volume":"22","author":"Alexovi\u010d","year":"2022","journal-title":"Proteomics"},{"issue":"2","key":"10.1016\/j.clgc.2025.102447_bib0016","doi-asserted-by":"crossref","DOI":"10.1002\/prca.202300072","article-title":"Human peripheral blood mononuclear cells as a valuable source of disease-related biomarkers: evidence from comparative proteomics studies","volume":"18","author":"Alexovi\u010d","year":"2024","journal-title":"Proteomics Clin Appl"},{"issue":"6","key":"10.1016\/j.clgc.2025.102447_bib0017","doi-asserted-by":"crossref","first-page":"816","DOI":"10.18632\/oncotarget.991","article-title":"Targeting HSF1 sensitizes cancer cells to HSP90 inhibition","volume":"4","author":"Chen","year":"2013","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.clgc.2025.102447_bib0018","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/sj.onc.1206099","article-title":"DEDD and DEDD2 associate with caspase-8\/10 and signal cell death","volume":"22","author":"Alcivar","year":"2003","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.clgc.2025.102447_bib0019","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s10495-014-1054-4","article-title":"Tandem DEDs and CARDs suggest novel mechanisms of signaling complex assembly","volume":"20","author":"Lo","year":"2015","journal-title":"Apoptosis"},{"issue":"6","key":"10.1016\/j.clgc.2025.102447_bib0020","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1083\/jcb.200112124","article-title":"DEDD regulates degradation of intermediate filaments during apoptosis","volume":"158","author":"Lee","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.clgc.2025.102447_bib0021","article-title":"CD8+ T cell Co-expressed genes correlate with clinical phenotype and microenvironments of urothelial cancer","volume":"10","author":"Wang","year":"2020","journal-title":"Front Oncol"},{"issue":"6","key":"10.1016\/j.clgc.2025.102447_bib0022","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004368","article-title":"Translational regulation of specific mRNAs controls feedback inhibition and survival during macrophage activation","volume":"10","author":"Schott","year":"2014","journal-title":"PLoS Genet"},{"issue":"21","key":"10.1016\/j.clgc.2025.102447_bib0023","doi-asserted-by":"crossref","first-page":"15615","DOI":"10.3390\/ijms242115615","article-title":"From fruit waste to medical insight: the comprehensive role of watermelon rind extract on renal adenocarcinoma cellular and transcriptomic dynamics","volume":"24","author":"Reddy","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"14","key":"10.1016\/j.clgc.2025.102447_bib0024","doi-asserted-by":"crossref","first-page":"7802","DOI":"10.1111\/jcmm.15411","article-title":"Tumour-derived exosomal miR-3473b promotes lung tumour cell intrapulmonary colonization by activating the nuclear factor-\u03bab of local fibroblasts","volume":"24","author":"Du","year":"2020","journal-title":"J Cell Mol Med"},{"issue":"1","key":"10.1016\/j.clgc.2025.102447_bib0025","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1186\/s12885-023-11759-5","article-title":"MYO5A overexpression promotes invasion and correlates with low lymphocyte infiltration in head and neck squamous carcinoma","volume":"23","author":"Xing","year":"2023","journal-title":"BMC Cancer"},{"issue":"6","key":"10.1016\/j.clgc.2025.102447_bib0026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008803","article-title":"MYO5B mutations in pheochromocytoma\/paraganglioma promote cancer progression","volume":"16","author":"Tomi\u0107","year":"2020","journal-title":"PLoS Genet"},{"key":"10.1016\/j.clgc.2025.102447_bib0027","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.616784","article-title":"Potassium channel protein KCNK6 promotes breast cancer cell proliferation, invasion, and migration","volume":"9","author":"Hou","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.clgc.2025.102447_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.110946","article-title":"Transcriptomic and proteomic study of cancer cell lines exposed to actinomycin D and nutlin-3a reveals numerous, novel candidates for p53-regulated genes","volume":"392","author":"\u0141asut-Szyszka","year":"2024","journal-title":"Chem Biol Interact"},{"issue":"1","key":"10.1016\/j.clgc.2025.102447_bib0029","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.immuni.2018.04.032","article-title":"The TWIK2 potassium efflux channel in macrophages mediates NLRP3 inflammasome-induced inflammation","volume":"49","author":"Di","year":"2018","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.clgc.2025.102447_bib0030","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1038\/s41467-021-24739-9","article-title":"KRAP tethers IP(3) receptors to actin and licenses them to evoke cytosolic Ca(2+) signals","volume":"12","author":"Thillaiappan","year":"2021","journal-title":"Nat Commun"},{"issue":"7","key":"10.1016\/j.clgc.2025.102447_bib0031","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.3390\/genes14071410","article-title":"Human endogenous retrovirus-H-derived miR-4454 inhibits the expression of DNAJB4 and SASH1 in non-muscle-invasive bladder cancer","volume":"14","author":"Park","year":"2023","journal-title":"Genes (Basel)"},{"issue":"43","key":"10.1016\/j.clgc.2025.102447_bib0032","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1038\/onc.2016.106","article-title":"HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms","volume":"35","author":"Chen","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.clgc.2025.102447_bib0033","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.76094","article-title":"HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12 heterodimerization in macrophages","volume":"11","author":"Luo","year":"2022","journal-title":"Elife"}],"container-title":["Clinical Genitourinary Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767325001478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767325001478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T21:09:15Z","timestamp":1770671355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1558767325001478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1558767325001478"],"URL":"https:\/\/doi.org\/10.1016\/j.clgc.2025.102447","relation":{},"ISSN":["1558-7673"],"issn-type":[{"value":"1558-7673","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macrophage Cell and Diagnostic Biomarkers in BLCA: Integrating Machine Learning With Single-Cell Analysis","name":"articletitle","label":"Article Title"},{"value":"Clinical Genitourinary Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clgc.2025.102447","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102447"}}