{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:37:03Z","timestamp":1792816623630,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100018925","name":"Health Commission of Henan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinical-genitourinary-cancer.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genitourinary Cancer"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.clgc.2026.102686","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:53:59Z","timestamp":1790783639000},"page":"102686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Preoperative Fibrinogen in Metastatic Clear Cell Renal Cell Carcinoma Patients Undergoing Cytoreductive Nephrectomy"],"prefix":"10.1016","author":[{"given":"Honglei","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youyan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingang","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhe","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Shou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clgc.2026.102686_bib0001","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ccell.2022.12.001","article-title":"Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness","volume":"41","author":"Li","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.clgc.2026.102686_bib0002","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41585-022-00666-2","article-title":"Adjuvant therapy options in renal cell carcinoma - targeting the metastatic cascade","volume":"20","author":"Fitzgerald","year":"2023","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.clgc.2026.102686_bib0003","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.eururo.2025.02.020","article-title":"European Association of Urology Guidelines on renal cell Carcinoma: the 2025 update","volume":"87","author":"Bex","year":"2025","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2026.102686_bib0004","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.euo.2023.10.002","article-title":"Characterization of patients with metastatic renal cell carcinoma undergoing deferred, upfront, or No cytoreductive nephrectomy in the era of Combination Immunotherapy: results from the International Metastatic Renal Cell Carcinoma Database Consortium","volume":"7","author":"Takemura","year":"2024","journal-title":"Eur Urol Oncol"},{"key":"10.1016\/j.clgc.2026.102686_bib0005","doi-asserted-by":"crossref","first-page":"5794","DOI":"10.1200\/JCO.2008.21.4809","article-title":"Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study","volume":"27","author":"Heng","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clgc.2026.102686_bib0006","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.eururo.2022.10.004","article-title":"Upfront cytoreductive nephrectomy for metastatic renal cell carcinoma treated with immune checkpoint inhibitors or targeted therapy: an observational study from the International Metastatic Renal Cell Carcinoma Database Consortium","volume":"83","author":"Bakouny","year":"2023","journal-title":"Eur Urol"},{"key":"10.1016\/j.clgc.2026.102686_bib0007","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1001\/jamaoncol.2018.5543","article-title":"Comparison of immediate vs deferred cytoreductive nephrectomy in patients with synchronous metastatic renal cell carcinoma receiving Sunitinib: the SURTIME randomized clinical trial","volume":"5","author":"Bex","year":"2019","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.clgc.2026.102686_bib0008","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3389\/fonc.2019.00504","article-title":"Cooperation between the inflammation and coagulation systems promotes the survival of circulating tumor cells in renal cell carcinoma patients","volume":"9","author":"Wen","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.clgc.2026.102686_bib0009","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.ejso.2018.07.052","article-title":"Clinical significance of plasma D-dimer and fibrinogen in digestive cancer: a systematic review and meta-analysis","volume":"44","author":"Lin","year":"2018","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.clgc.2026.102686_bib0010","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.ctrv.2015.10.002","article-title":"Prognostic role of pretreatment plasma fibrinogen in patients with solid tumors: a systematic review and meta-analysis","volume":"41","author":"Perisanidis","year":"2015","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.clgc.2026.102686_bib0011","doi-asserted-by":"crossref","DOI":"10.3802\/jgo.2017.28.e36","article-title":"Elevated plasma fibrinogen levels and prognosis of epithelial ovarian cancer: a cohort study and meta-analysis","volume":"28","author":"Luo","year":"2017","journal-title":"J Gynecol Oncol"},{"key":"10.1016\/j.clgc.2026.102686_bib0012","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clgc.2019.10.025","article-title":"Preoperative plasma fibrinogen and d-dimer as prognostic biomarkers for non-muscle-invasive bladder cancer","volume":"18","author":"Li","year":"2020","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.clgc.2026.102686_bib0013","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1590\/s1677-5538.ibju.2021.0859","article-title":"A novel nomogram can predict pathological T3a upstaged from clinical T1a in localized renal cell carcinoma","volume":"48","author":"Cao","year":"2022","journal-title":"Int Braz J Urol"},{"key":"10.1016\/j.clgc.2026.102686_bib0014","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMoa1803675","article-title":"Sunitinib alone or after nephrectomy in metastatic renal-cell carcinoma","volume":"379","author":"M\u00e9jean","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clgc.2026.102686_bib0015","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1111\/iju.70207","article-title":"Role of cytoreductive nephrectomy in the Immune checkpoint inhibitor era: a multicenter collaborative study","volume":"32","author":"Nukaya","year":"2025","journal-title":"Int J Urol"},{"key":"10.1016\/j.clgc.2026.102686_bib0016","doi-asserted-by":"crossref","DOI":"10.1111\/iju.70356","article-title":"Deferred cytoreductive nephrectomy in unresectable\/metastatic renal cell carcinoma: a real-world multicenter retrospective study","volume":"33","author":"Tanaka","year":"2026","journal-title":"Int J Urol"},{"key":"10.1016\/j.clgc.2026.102686_bib0017","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.urolonc.2024.12.272","article-title":"Deferred cytoreductive nephrectomy in patients with metastatic renal cell carcinoma: a systematic review and patient-level meta-analysis","volume":"43","author":"Fong","year":"2025","journal-title":"Urol Oncol"},{"key":"10.1016\/j.clgc.2026.102686_bib0018","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.euf.2024.08.002","article-title":"Upfront versus deferred cytoreductive nephrectomy in metastatic renal cell carcinoma: a systematic review and individual patient data meta-analysis","volume":"11","author":"Esagian","year":"2025","journal-title":"Eur Urol Focus"},{"key":"10.1016\/j.clgc.2026.102686_bib0019","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.euo.2025.02.011","article-title":"A nationwide real-world evaluation of upfront cytoreductive nephrectomy in patients with synchronous metastatic renal cell carcinoma in the immunotherapy era","volume":"8","author":"Yildirim","year":"2025","journal-title":"Eur Urol Oncol"},{"key":"10.1016\/j.clgc.2026.102686_bib0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.eururo.2023.09.016","article-title":"Impact of prior cytoreductive nephrectomy on efficacy in patients with synchronous metastatic renal cell carcinoma treated with Avelumab plus Axitinib or Sunitinib: post hoc analysis from the JAVELIN Renal 101 Phase 3 trial","volume":"85","author":"Grimm","year":"2024","journal-title":"Eur Urol"},{"issue":"suppl 1","key":"10.1016\/j.clgc.2026.102686_bib0021","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.thromres.2021.12.013","article-title":"Crosstalk between hemostasis and immunity in cancer pathogenesis","volume":"213","author":"Palumbo","year":"2022","journal-title":"Thromb Res"},{"key":"10.1016\/j.clgc.2026.102686_bib0022","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202202984","article-title":"Impact of fibrinogen, fibrin thrombi, and thrombin on cancer cell extravasation using in vitro microvascular networks","volume":"12","author":"Angelidakis","year":"2023","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.clgc.2026.102686_bib0023","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/bjc.2013.443","article-title":"High plasma fibrinogen level represents an independent negative prognostic factor regarding cancer-specific, metastasis-free, as well as overall survival in a European cohort of non-metastatic renal cell carcinoma patients","volume":"109","author":"Pichler","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clgc.2026.102686_bib0024","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.urolonc.2014.03.013","article-title":"Increased preoperative levels of plasma fibrinogen and D dimer in patients with renal cell carcinoma is associated with poor survival and adverse tumor characteristics","volume":"32","author":"Erdem","year":"2014","journal-title":"Urol Oncol"},{"key":"10.1016\/j.clgc.2026.102686_bib0025","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/bju.13414","article-title":"Plasma fibrinogen level: an independent prognostic factor for disease-free survival and cancer-specific survival in patients with localised renal cell carcinoma","volume":"118","author":"Obata","year":"2016","journal-title":"BJU Int"},{"key":"10.1016\/j.clgc.2026.102686_bib0026","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.7150\/jca.40961","article-title":"High preoperative plasma fibrinogen independently predicts a poor prognosis in patients with nonmetastatic RCC","volume":"11","author":"Wang","year":"2020","journal-title":"J Cancer"},{"key":"10.1016\/j.clgc.2026.102686_bib0027","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/j.1349-7006.2009.01115.x","article-title":"Platelets and fibrinogen facilitate each other in protecting tumor cells from natural killer cytotoxicity","volume":"100","author":"Zheng","year":"2009","journal-title":"Cancer Sci"},{"key":"10.1016\/j.clgc.2026.102686_bib0028","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/ijc.24340","article-title":"The VE-cadherin binding domain of fibrinogen induces endothelial barrier permeability and enhances transendothelial migration of malignant breast epithelial cells","volume":"125","author":"Sahni","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1016\/j.clgc.2026.102686_bib0029","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1158\/1541-7786.MCR-19-1033","article-title":"Fibrinogen alpha chain knockout promotes tumor growth and metastasis through integrin-AKT signaling pathway in lung cancer","volume":"18","author":"Wang","year":"2020","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.clgc.2026.102686_bib0030","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1007\/s00432-017-2493-4","article-title":"Fibrinogen promotes malignant biological tumor behavior involving epithelial-mesenchymal transition via the p-AKT\/p-mTOR pathway in esophageal squamous cell carcinoma","volume":"143","author":"Zhang","year":"2017","journal-title":"J Cancer Res Clin Oncol"}],"container-title":["Clinical Genitourinary Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767326001862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1558767326001862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:47:53Z","timestamp":1792813673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1558767326001862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"alternative-id":["S1558767326001862"],"URL":"https:\/\/doi.org\/10.1016\/j.clgc.2026.102686","relation":{},"ISSN":["1558-7673"],"issn-type":[{"value":"1558-7673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic Value of Preoperative Fibrinogen in Metastatic Clear Cell Renal Cell Carcinoma Patients Undergoing Cytoreductive Nephrectomy","name":"articletitle","label":"Article Title"},{"value":"Clinical Genitourinary Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clgc.2026.102686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102686"}}