{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:08:10Z","timestamp":1769162890262,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.clim.2004.02.001","type":"journal-article","created":{"date-parts":[[2004,5,13]],"date-time":"2004-05-13T11:02:56Z","timestamp":1084446176000},"page":"24-29","source":"Crossref","is-referenced-by-count":60,"title":["Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency"],"prefix":"10.1016","volume":"112","author":[{"given":"A","family":"Aslam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.A","family":"Misbah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Talbot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Chapel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2004.02.001_BIB1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev.nu.08.070188.002031","article-title":"Vitamin E deficiency and neurologic disease","volume":"8","author":"Sokol","year":"1988","journal-title":"Annu. Rev. Nutr."},{"issue":"7","key":"10.1016\/j.clim.2004.02.001_BIB2","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1212\/WNL.36.7.917","article-title":"The spectrum of neurologic disorder from vitamin E deficiency","volume":"36","author":"Satya-Murti","year":"1986","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.clim.2004.02.001_BIB3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1136\/adc.60.2.162-a","article-title":"Symptomatic vitamin E deficiency in cystic fibrosis","volume":"60","author":"Bye","year":"1985","journal-title":"Arch. Dis. Child."},{"issue":"9","key":"10.1016\/j.clim.2004.02.001_BIB4","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1136\/gut.35.9.1244","article-title":"Studies on the enteropathy associated with primary hypogammaglobulinaemia","volume":"35","author":"Teahon","year":"1994","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.clim.2004.02.001_BIB5","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1046\/j.1365-2362.2000.00619.x","article-title":"Decreased vitamin A levels in common variable immunodeficiency: vitamin A supplementation in vivo enhances immunoglobulin production and downregulates inflammatory responses","volume":"30","author":"Aukrust","year":"2000","journal-title":"Eur. J. Clin. Invest."},{"issue":"Pt 1","key":"10.1016\/j.clim.2004.02.001_BIB6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/brain\/119.1.1","article-title":"Encephalomyelitis in primary hypogammaglobulinaemia","volume":"119","author":"Rudge","year":"1996","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.clim.2004.02.001_BIB7","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/00005176-200108000-00022","article-title":"Ataxia with isolated vitamin E deficiency: case report and review of the literature","volume":"33","author":"Aparicio","year":"2001","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"issue":"3","key":"10.1016\/j.clim.2004.02.001_BIB8","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/ana.410350309","article-title":"Nigrostriatal function in vitamin E deficiency: clinical, experimental, and positron emission tomographic studies","volume":"35","author":"Dexter","year":"1994","journal-title":"Ann. Neurol."},{"issue":"9","key":"10.1016\/j.clim.2004.02.001_BIB9","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1002\/(SICI)1097-4598(199609)19:9<1161::AID-MUS12>3.0.CO;2-Y","article-title":"Isolated vitamin E deficiency","volume":"19","author":"Jackson","year":"1996","journal-title":"Muscle Nerve"},{"issue":"Suppl. 4","key":"10.1016\/j.clim.2004.02.001_BIB10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1017\/S0317167100035046","article-title":"A progressive neurological syndrome associated with an isolated vitamin E deficiency","volume":"11","author":"Laplante","year":"1984","journal-title":"Can. J. Neurol. Sci."},{"issue":"2","key":"10.1016\/j.clim.2004.02.001_BIB11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0022-510X(98)00038-0","article-title":"Supplemental therapy in isolated vitamin E deficiency improves the peripheral neuropathy and prevents the progression of ataxia","volume":"156","author":"Martinello","year":"1998","journal-title":"J. Neurol. Sci."},{"issue":"5","key":"10.1016\/j.clim.2004.02.001_BIB12","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1046\/j.1440-1754.2000.00534.x","article-title":"Ataxia with isolated vitamin E deficiency: a clinical, biochemical and genetic diagnosis","volume":"36","author":"Alex","year":"2000","journal-title":"J. Paediatr. Child Health"},{"issue":"1","key":"10.1016\/j.clim.2004.02.001_BIB13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1212\/WNL.37.1.68","article-title":"Friedreich's disease: v. variant form with vitamin E deficiency and normal fat absorption","volume":"37","author":"Stumpf","year":"1987","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.clim.2004.02.001_BIB14","first-page":"548","article-title":"Isolated vitamin E deficiency in the absence of fat malabsorption\u2014Familial and sporadic cases: characterization and investigation of causes","volume":"111","author":"Sokol","year":"1988","journal-title":"J. Lab. Clin. Med."},{"issue":"5","key":"10.1016\/j.clim.2004.02.001_BIB15","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1136\/adc.69.5.602","article-title":"Isolated vitamin E deficiency and progressive ataxia","volume":"69","author":"Rayner","year":"1993","journal-title":"Arch. Dis. Child."},{"issue":"1","key":"10.1016\/j.clim.2004.02.001_BIB16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/ana.410220119","article-title":"Adult-onset spinocerebellar syndrome with idiopathic vitamin E deficiency","volume":"22","author":"Yokota","year":"1987","journal-title":"Ann. Neurol."},{"issue":"10","key":"10.1016\/j.clim.2004.02.001_BIB17","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1007\/s004150050499","article-title":"Familial ataxia with isolated vitamin E deficiency not due to mutation of alpha-TTP","volume":"246","author":"Shiojiri","year":"1999","journal-title":"J. Neurol."},{"issue":"3","key":"10.1016\/j.clim.2004.02.001_BIB18","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1136\/jnnp.64.3.368","article-title":"Ataxia with isolated vitamin E deficiency presenting as mutation negative Friedreich's ataxia","volume":"64","author":"Hammans","year":"1998","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"6","key":"10.1016\/j.clim.2004.02.001_BIB19","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/1531-8249(199906)45:6<809::AID-ANA19>3.0.CO;2-9","article-title":"Ataxia with isolated vitamin E deficiency: a Japanese family carrying a novel mutation in the alpha-tocopherol transfer protein gene","volume":"45","author":"Hoshino","year":"1999","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.clim.2004.02.001_BIB20","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/mds.10026","article-title":"Myoclonic dystonia as unique presentation of isolated vitamin E deficiency in a young patient","volume":"17","author":"Angelini","year":"2002","journal-title":"Mov. Disord."},{"issue":"10","key":"10.1016\/j.clim.2004.02.001_BIB21","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1212\/WNL.55.10.1584","article-title":"Ataxia with vitamin E deficiency: biochemical effects of malcompliance with vitamin E therapy","volume":"55","author":"Schuelke","year":"2000","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.clim.2004.02.001_BIB22","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1136\/jnnp.69.2.254","article-title":"Ataxia caused by mutations in the alpha-tocopherol transfer protein gene","volume":"69","author":"Usuki","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"3","key":"10.1016\/j.clim.2004.02.001_BIB23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1055\/s-2008-1059615","article-title":"Progressive neurological disorder associated with obstructive jaundice and vitamin E deficiency","volume":"13","author":"Lloyd","year":"1982","journal-title":"Neuropediatrics"},{"issue":"8","key":"10.1016\/j.clim.2004.02.001_BIB24","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1212\/WNL.29.8.1182","article-title":"Reversibility of human myopathy caused by vitamin E deficiency","volume":"29","author":"Tomasi","year":"1979","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.clim.2004.02.001_BIB25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0022-3476(82)80234-5","article-title":"Progressive neuromuscular disease in children with chronic cholestasis and vitamin E deficiency: diagnosis and treatment with alpha tocopherol","volume":"100","author":"Guggenheim","year":"1982","journal-title":"J. Pediatr."},{"issue":"6","key":"10.1016\/j.clim.2004.02.001_BIB26","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/ana.410180618","article-title":"Vitamin E deficiency associated with vision loss and bulbar weakness","volume":"18","author":"Larsen","year":"1985","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.clim.2004.02.001_BIB27","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/ana.410130311","article-title":"Neuromuscular dysfunction and ultrastructural pathology in children with chronic cholestasis and vitamin E deficiency","volume":"13","author":"Werlin","year":"1983","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.clim.2004.02.001_BIB28","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0002-9394(14)76791-1","article-title":"Retinopathy in human vitamin E deficiency","volume":"111","author":"Berger","year":"1991","journal-title":"Am. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.clim.2004.02.001_BIB29","first-page":"339","article-title":"Disappearance of skin lipofuscin storage and marked clinical improvement in adult onset coeliac disease and severe vitamin E deficiency after chronic vitamin E megatherapy","volume":"28","author":"Battisti","year":"1996","journal-title":"J. Submicrosc. Cytol. Pathol."},{"issue":"2","key":"10.1016\/j.clim.2004.02.001_BIB30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1600-0404.1991.tb04927.x","article-title":"Cerebellar syndrome in adult celiac disease with vitamin E deficiency","volume":"84","author":"Mauro","year":"1991","journal-title":"Acta Neurol. Scand."},{"issue":"6","key":"10.1016\/j.clim.2004.02.001_BIB31","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1093\/ajcn\/36.6.1243","article-title":"Reversible neurological symptoms caused by vitamin E deficiency in a patient with short bowel syndrome","volume":"36","author":"Howard","year":"1982","journal-title":"Am. J. Clin. Nutr."},{"issue":"4","key":"10.1016\/j.clim.2004.02.001_BIB32","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0168-5597(88)90026-3","article-title":"Visual and somatosensory evoked potentials in vitamin E deficiency with cystic fibrosis","volume":"71","author":"Kaplan","year":"1988","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"issue":"12","key":"10.1016\/j.clim.2004.02.001_BIB33","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1212\/WNL.34.12.1561","article-title":"Neurologic disorder of vitamin E deficiency in acquired intestinal malabsorption","volume":"34","author":"Weder","year":"1984","journal-title":"Neurology"},{"issue":"8974","key":"10.1016\/j.clim.2004.02.001_BIB34","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0140-6736(95)91384-X","article-title":"Symptomatic vitamin E deficiency diagnosed after histological recognition of myometrial lipofuscinosis","volume":"346","author":"Evans","year":"1995","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.clim.2004.02.001_BIB35","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1212\/WNL.34.8.1046","article-title":"Small bowel resection with vitamin E deficiency and progressive spinocerebellar syndrome","volume":"34","author":"Bertoni","year":"1984","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.clim.2004.02.001_BIB36","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/ana.410120503","article-title":"Spinocerebellar degeneration secondary to chronic intestinal malabsorption: a vitamin E deficiency syndrome","volume":"12","author":"Harding","year":"1982","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.clim.2004.02.001_BIB37","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1016\/0016-5085(92)90344-X","article-title":"Vitamin E deficiency and impaired cellular immunity related to intestinal fat malabsorption","volume":"102","author":"Kowdley","year":"1992","journal-title":"Gastroenterology"},{"issue":"Suppl. 1","key":"10.1016\/j.clim.2004.02.001_BIB38","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1007\/BF02278134","article-title":"Spinal MRI in progressive myeloneuropathy associated with vitamin E deficiency","volume":"38","author":"Vorgerd","year":"1996","journal-title":"Neuroradiology"},{"issue":"1","key":"10.1016\/j.clim.2004.02.001_BIB39","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/ajcn\/41.1.66","article-title":"Vitamin E deficiency in adults with chronic liver disease","volume":"41","author":"Sokol","year":"1985","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.clim.2004.02.001_BIB40","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1006\/clim.2001.5140","article-title":"Progressive neurodegeneration in patients with primary immunodeficiency disease on IVIG treatment","volume":"102","author":"Ziegner","year":"2002","journal-title":"Clin. Immunol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661604000348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661604000348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,9]],"date-time":"2019-02-09T13:25:00Z","timestamp":1549718700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661604000348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S1521661604000348"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2004.02.001","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}