{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:00:55Z","timestamp":1791295255160,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["QLG1-CT-2001-01536- IMPAD"],"award-info":[{"award-number":["QLG1-CT-2001-01536- IMPAD"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004053","name":"Masato Kawano Memorial Public Interest Foundation for Promotion of Pediatrics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005606","name":"Genome Institute of Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1016\/j.clim.2005.02.003","type":"journal-article","created":{"date-parts":[[2005,3,22]],"date-time":"2005-03-22T07:34:26Z","timestamp":1111476866000},"page":"277-285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"title":["Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant hyper-IgM syndrome type 2"],"prefix":"10.1016","volume":"115","author":[{"given":"Kohsuke","family":"Imai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Revy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Morio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuki","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Nonoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Durandy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2005.02.003_bib1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00130832-200312000-00002","article-title":"Hyper-immunoglobulin-M syndromes caused by an intrinsic B cell defect","volume":"3","author":"Durandy","year":"2003","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/361539a0","article-title":"Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM","volume":"361","author":"Korthauer","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.clim.2005.02.003_bib3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/361541a0","article-title":"CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM","volume":"361","author":"DiSanto","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.clim.2005.02.003_bib4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0092-8674(93)90668-G","article-title":"The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome","volume":"72","author":"Aruffo","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.clim.2005.02.003_bib5","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.7679801","article-title":"CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome","volume":"259","author":"Allen","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.clim.2005.02.003_bib6","doi-asserted-by":"crossref","first-page":"12614","DOI":"10.1073\/pnas.221456898","article-title":"Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM","volume":"98","author":"Ferrari","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2005.02.003_bib7","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.4049\/jimmunol.158.6.2576","article-title":"Abnormal CD40-mediated activation pathway in B lymphocytes from patients with hyper-IgM syndrome and normal CD40 ligand expression","volume":"158","author":"Durandy","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib8","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1172\/JCI117476","article-title":"Hyper IgM syndrome associated with defective CD40-mediated B cell activation","volume":"94","author":"Conley","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2005.02.003_bib9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0092-8674(00)00079-9","article-title":"Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)","volume":"102","author":"Revy","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.clim.2005.02.003_bib10","doi-asserted-by":"crossref","first-page":"18470","DOI":"10.1074\/jbc.274.26.18470","article-title":"Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells","volume":"274","author":"Muramatsu","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2005.02.003_bib11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","article-title":"Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme","volume":"102","author":"Muramatsu","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.clim.2005.02.003_bib12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature00862","article-title":"AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification","volume":"418","author":"Petersen-Mahrt","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.clim.2005.02.003_bib13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature01760","article-title":"Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation","volume":"424","author":"Pham","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.clim.2005.02.003_bib14","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1093\/nar\/gkg464","article-title":"Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations","volume":"31","author":"Sohail","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2005.02.003_bib15","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/ni920","article-title":"Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand","volume":"4","author":"Ramiro","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib16","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1084\/jem.20030481","article-title":"AID mediates hypermutation by deaminating single stranded DNA","volume":"197","author":"Dickerson","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2005.02.003_bib17","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/S0960-9822(02)01215-0","article-title":"Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice","volume":"12","author":"Rada","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.clim.2005.02.003_bib18","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/ni974","article-title":"Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination","volume":"4","author":"Imai","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib19","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/414660a","article-title":"AID is required to initiate Nbs1\/gamma-H2AX focus formation and mutations at sites of class switching","volume":"414","author":"Petersen","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.clim.2005.02.003_bib20","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.4049\/jimmunol.171.5.2504","article-title":"The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region","volume":"171","author":"Catalan","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib21","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/ni1086","article-title":"Separate domains of AID are required for somatic hypermutation and class-switch recombination","volume":"5","author":"Shinkura","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib22","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/ni964","article-title":"AID mutant analyses indicate requirement for class-switch-specific cofactors","volume":"4","author":"Ta","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.molcel.2004.10.011","article-title":"Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A\/T-focused phase of somatic mutation","volume":"16","author":"Rada","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.clim.2005.02.003_bib24","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nri858","article-title":"AID and mismatch repair in antibody diversification","volume":"2","author":"Martin","year":"2002","journal-title":"Nat. Rev., Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib25","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nri1395","article-title":"Class-switch recombination: interplay of transcription, DNA deamination and DNA repair","volume":"4","author":"Chaudhuri","year":"2004","journal-title":"Nat. Rev., Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib26","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1084\/jem.20011858","article-title":"The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process","volume":"195","author":"Papavasiliou","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2005.02.003_bib27","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/ni826","article-title":"AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line","volume":"3","author":"Faili","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib28","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S1074-7613(03)00151-1","article-title":"AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52\/Rad51 in somatic hypermutation","volume":"18","author":"Zan","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2005.02.003_bib29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/clim.2000.4956","article-title":"Mutations in activation-induced cytidine deaminase in patients with hyper IgM syndrome","volume":"97","author":"Minegishi","year":"2000","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib30","first-page":"41","article-title":"Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase","volume":"50","author":"Zhu","year":"2003","journal-title":"J. Med. Dent. Sci."},{"key":"10.1016\/j.clim.2005.02.003_bib31","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.clim.2003.10.007","article-title":"Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to activation-induced cytidine deaminase deficiency","volume":"110","author":"Quartier","year":"2004","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib32","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0091-6749(03)01860-8","article-title":"Hyper-IgM syndrome with putative dominant negative mutation in activation-induced cytidine deaminase","volume":"112","author":"Kasahara","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib33","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S1097-2765(03)00309-5","article-title":"C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion","volume":"12","author":"Barreto","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.clim.2005.02.003_bib34","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1073\/pnas.0307335101","article-title":"Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1","volume":"101","author":"Ito","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2005.02.003_bib35","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1002\/eji.1830230936","article-title":"Induction by anti-CD40 antibody or soluble CD40 ligand and cytokines of IgG, IgA and IgE production by B cells from patients with X-linked hyper IgM syndrome","volume":"23","author":"Durandy","year":"1993","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib36","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1172\/JCI18161","article-title":"Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination","volume":"112","author":"Imai","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2005.02.003_bib37","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1067\/mai.2001.117456","article-title":"Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels","volume":"108","author":"Noguchi","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib38","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.immunol.20.090501.112049","article-title":"Molecular mechanism of class switch recombination: linkage with somatic hypermutation","volume":"20","author":"Honjo","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.clim.2005.02.003_bib39","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/nature02821","article-title":"Replication protein A interacts with AID to promote deamination of somatic hypermutation targets","volume":"430","author":"Chaudhuri","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.clim.2005.02.003_bib40","doi-asserted-by":"crossref","first-page":"26395","DOI":"10.1074\/jbc.M403503200","article-title":"Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks","volume":"279","author":"Brar","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2005.02.003_bib41","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1084\/jem.20040373","article-title":"Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase","volume":"199","author":"McBride","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2005.02.003_bib42","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.immuni.2004.05.011","article-title":"AID: how does it aid antibody diversity?","volume":"20","author":"Honjo","year":"2004","journal-title":"Immunity"}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661605000410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661605000410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:54:55Z","timestamp":1761494095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661605000410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S1521661605000410"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2005.02.003","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2005,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant hyper-IgM syndrome type 2","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2005.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}