{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:38:08Z","timestamp":1790804288010,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI45757"],"award-info":[{"award-number":["AI45757"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AI 45757-01"],"award-info":[{"award-number":["P01 AI 45757-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1016\/j.clim.2005.02.015","type":"journal-article","created":{"date-parts":[[2005,4,7]],"date-time":"2005-04-07T17:50:54Z","timestamp":1112896254000},"page":"313-322","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Characterization of in vivo expanded OspA-specific human T-cell clones"],"prefix":"10.1016","volume":"115","author":[{"given":"Lara J.","family":"Ausubel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Baecher-Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Trollmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hekking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Merritt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbie L.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bill","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidde","family":"Ploegh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte T.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Hafler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2005.02.015_bib1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1056\/NEJM198303313081301","article-title":"The spirochetal etiology of Lyme disease","volume":"308","author":"Steere","year":"1983","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2005.02.015_bib2","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1056\/NEJM198908313210906","article-title":"Lyme disease","volume":"321","author":"Steere","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2005.02.015_bib3","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/art.1780370616","article-title":"Treatment of Lyme arthritis","volume":"37","author":"Steere","year":"1994","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2005.02.015_bib4","series-title":"Lyme Disease","author":"Steere","year":"1998"},{"key":"10.1016\/j.clim.2005.02.015_bib5","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.274.5284.94","article-title":"Phenotypic analysis of antigen-specific T lymphocytes","volume":"274","author":"Altman","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.clim.2005.02.015_bib6","doi-asserted-by":"crossref","first-page":"R63","DOI":"10.1172\/JCI8476","article-title":"MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen","volume":"104","author":"Novak","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2005.02.015_bib7","doi-asserted-by":"crossref","first-page":"7285","DOI":"10.4049\/jimmunol.165.12.7285","article-title":"Direct detection and magnetic isolation of Chlamydia trachomatis major outer membrane protein-specific CD8+ CTLs with HLA class I tetramers","volume":"165","author":"Kim","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2005.02.015_bib8","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1182\/blood.V97.5.1232","article-title":"Direct visualization of cytomegalovirus-specific T-cell reconstitution after allogeneic stem cell transplantation","volume":"97","author":"Cwynarski","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.clim.2005.02.015_bib9","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.4049\/jimmunol.164.8.4244","article-title":"HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: direct detection of immunodominant antigen-responsive cells","volume":"164","author":"Kwok","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2005.02.015_bib10","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4049\/jimmunol.160.2.1022","article-title":"T helper 1 response is dominant and localized to the synovial fluid in patients with Lyme arthritis","volume":"160","author":"Gross","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2005.02.015_bib11","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/1529-0131(199909)42:9<1813::AID-ANR4>3.0.CO;2-0","article-title":"Association of antibiotic treatment-resistant Lyme arthritis with T cell responses to dominant epitopes of outer surface protein A of Borrelia burgdorferi","volume":"42","author":"Chen","year":"1999","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2005.02.015_bib12","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1056\/NEJM199807233390402","article-title":"A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. Recombinant outer-surface protein a Lyme disease vaccine study consortium","volume":"339","author":"Sigal","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2005.02.015_bib13","doi-asserted-by":"crossref","first-page":"11433","DOI":"10.1073\/pnas.190335897","article-title":"Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers","volume":"97","author":"Meyer","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2005.02.015_bib14","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.4049\/jimmunol.166.8.5286","article-title":"Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cells","volume":"166","author":"Trollmo","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2005.02.015_bib15","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1365-2249.1992.tb05865.x","article-title":"An altered repertoire of T cell receptor V gene expression by rheumatoid synovial fluid T lymphocytes","volume":"90","author":"Lunardi","year":"1992","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2005.02.015_bib16","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1365-3083.1992.tb03128.x","article-title":"T-cell receptor V-gene usage in synovial fluid and synovial tissue from RA patients","volume":"36","author":"Gudmundsson","year":"1992","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.clim.2005.02.015_bib17","doi-asserted-by":"crossref","first-page":"11104","DOI":"10.1073\/pnas.90.23.11104","article-title":"Dominant T-cell-receptor beta chain variable region V beta 14+ clones in juvenile rheumatoid arthritis","volume":"90","author":"Grom","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2005.02.015_bib18","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1002\/eji.1830230903","article-title":"A possible role of two hydrophobic amino acids in antigen recognition by synovial T cells in rheumatoid arthritis","volume":"23","author":"Maruyama","year":"1993","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2005.02.015_bib19","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/art.1780360908","article-title":"Biased T cell receptor V gene usage in rheumatoid arthritis. Oligoclonal expansion of T cells expressing V alpha 2 genes in synovial fluid but not in peripheral blood","volume":"36","author":"Broker","year":"1993","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2005.02.015_bib20","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1172\/JCI116886","article-title":"T cell receptor V beta gene bias in rheumatoid arthritis","volume":"92","author":"Jenkins","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2005.02.015_bib21","first-page":"1356","article-title":"Patterns of T lymphocyte clonal expansion in HLA-typed patients with juvenile rheumatoid arthritis","volume":"22","author":"Thompson","year":"1995","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.clim.2005.02.015_bib22","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/art.1780390312","article-title":"High frequencies of identical T cell clonotypes in synovial tissues of rheumatoid arthritis patients suggest the occurrence of common antigen-driven immune responses","volume":"39","author":"Ikeda","year":"1996","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2005.02.015_bib23","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1128\/IAI.66.3.1092-1099.1998","article-title":"Biased T-cell antigen receptor repertoire in Lyme arthritis","volume":"66","author":"Roessner","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.clim.2005.02.015_bib24","first-page":"590","article-title":"Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme Disease","volume":"44","year":"1995","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.clim.2005.02.015_bib25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/354082a0","article-title":"A new type of synthetic peptide library for identifying ligand-binding activity","volume":"354","author":"Lam","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.clim.2005.02.015_bib26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/bip.360370303","article-title":"One-bead-one-structure combinatorial libraries","volume":"37","author":"Lebl","year":"1995","journal-title":"Biopolymers"},{"key":"10.1016\/j.clim.2005.02.015_bib27","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1002\/bip.360341212","article-title":"Peptide libraries: determination of relative reaction rates of protected amino acids in competitive couplings","volume":"34","author":"Ostresh","year":"1994","journal-title":"Biopolymers"},{"key":"10.1016\/j.clim.2005.02.015_bib28","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.4049\/jimmunol.160.5.2365","article-title":"A peptide binding motif for HLA-DQA1*0102\/DQB1*0602, the class II MHC molecule associated with dominant protection in insulin-dependent diabetes mellitus","volume":"160","author":"Ettinger","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2005.02.015_bib29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4049\/jimmunol.163.1.301","article-title":"Invariant or highly conserved TCR alpha are expressed on double-negative (CD3+CD4\u2212CD8\u2212) and CD8+ T cells","volume":"163","author":"Han","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2005.02.015_bib30","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1034\/j.1399-0039.1999.530202.x","article-title":"Rapid screening of T-cell receptor (TCR) variable gene usage by multiplex PCR: application for assessment of clonal composition","volume":"53","author":"Akatsuka","year":"1999","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.clim.2005.02.015_bib31","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/1521-4141(200002)30:2<448::AID-IMMU448>3.0.CO;2-9","article-title":"Multiple cross-reactive self-ligands for Borrelia burgdorferi-specific HLA-DR4-restricted T cells","volume":"30","author":"Maier","year":"2000","journal-title":"Eur J. Immunol."},{"key":"10.1016\/j.clim.2005.02.015_bib32","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S1074-7613(00)80369-6","article-title":"X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II","volume":"7","author":"Dessen","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2005.02.015_bib33","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jaut.2004.06.005","article-title":"Molecular characterization of the OspA(161\u2013175) T cell epitope associated with treatment-resistant Lyme arthritis: differences among the three pathogenic species of Borrelia burgdorferi sensu lato","volume":"23","author":"Drouin","year":"2004","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2005.02.015_bib34","doi-asserted-by":"crossref","first-page":"725","DOI":"10.7326\/0003-4819-107-5-725","article-title":"The clinical evolution of Lyme arthritis","volume":"107","author":"Steere","year":"1987","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.clim.2005.02.015_bib35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0923-2508(01)01186-X","article-title":"Distinct levels of genetic diversity of Borrelia burgdorferi are associated with different aspects of pathogenicity","volume":"152","author":"Baranton","year":"2001","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.clim.2005.02.015_bib36","doi-asserted-by":"crossref","first-page":"9374","DOI":"10.1073\/pnas.142284899","article-title":"Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice","volume":"99","author":"Baker","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2005.02.015_bib37","doi-asserted-by":"crossref","first-page":"583","DOI":"10.4049\/jimmunol.165.1.583","article-title":"Clonal expansion of infiltrating T cells in the spinal cords of SJL\/J mice infected with Theiler's virus","volume":"165","author":"Kang","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2005.02.015_bib38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/brain\/awg021","article-title":"Molecular tracking of antigen-specific T cell clones in neurological immune-mediated disorders","volume":"126","author":"Muraro","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.clim.2005.02.015_bib39","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/rheumatology\/39.11.1189","article-title":"Skewed T-cell receptor variable gene usage in the synovium of early and chronic rheumatoid arthritis patients and persistence of clonally expanded T cells in a chronic patient","volume":"39","author":"VanderBorght","year":"2000","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clim.2005.02.015_bib40","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1126\/science.281.5377.703","article-title":"Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis","volume":"281","author":"Gross","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.clim.2005.02.015_bib41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3109\/08830189009056617","article-title":"Inhibition of antigen presentation in vitro and in vivo by MHC antagonist peptides","volume":"6","author":"Lamont","year":"1990","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.clim.2005.02.015_bib42","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.4049\/jimmunol.153.7.3326","article-title":"A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire","volume":"153","author":"Kuchroo","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2005.02.015_bib43","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/80516","article-title":"Encephalitogenic potential of the myelin basic protein peptide (amino acids 83\u201399) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand","volume":"6","author":"Bielekova","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.clim.2005.02.015_bib44","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1128\/iai.61.7.2774-2779.1993","article-title":"Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi","volume":"61","author":"Kalish","year":"1993","journal-title":"Infect. Immun."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661605000665?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661605000665?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:02:45Z","timestamp":1778616165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661605000665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S1521661605000665"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2005.02.015","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2005,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of in vivo expanded OspA-specific human T-cell clones","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2005.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}