{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:24:57Z","timestamp":1791289497905,"version":"4.3.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.clim.2007.02.001","type":"journal-article","created":{"date-parts":[[2007,5,23]],"date-time":"2007-05-23T11:56:06Z","timestamp":1179921366000},"page":"41-48","source":"Crossref","is-referenced-by-count":96,"title":["Impaired in vitro regulatory T cell function associated with Wiskott\u2013Aldrich syndrome"],"prefix":"10.1016","volume":"124","author":[{"given":"Marsilio","family":"Adriani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Horai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Konno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Kirby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacie M.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Candotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela L.","family":"Schwartzberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2007.02.001_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1542\/peds.13.2.133","article-title":"Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea","volume":"13","author":"Aldrich","year":"1954","journal-title":"Pediatrics"},{"key":"10.1016\/j.clim.2007.02.001_bib2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jaci.2006.02.005","article-title":"The Wiskott\u2013Aldrich syndrome","volume":"117","author":"Ochs","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib3","first-page":"212","article-title":"Familiarer, angeborener Morbus Werlhofii?","volume":"68","author":"Wiskott","year":"1937","journal-title":"Monatsschr. Kinderheilkd."},{"key":"10.1016\/j.clim.2007.02.001_bib4","doi-asserted-by":"crossref","first-page":"e622","DOI":"10.1542\/peds.111.5.e622","article-title":"Autoimmunity in Wiskott\u2013Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients","volume":"111","author":"Dupuis-Girod","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.clim.2007.02.001_bib5","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/00002281-200307000-00012","article-title":"Autoimmunity in Wiskott\u2013Aldrich syndrome","volume":"15","author":"Schurman","year":"2003","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.clim.2007.02.001_bib6","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.4049\/jimmunol.151.8.4383","article-title":"T cells of patients with the Wiskott\u2013Aldrich syndrome have a restricted defect in proliferative responses","volume":"151","author":"Molina","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib7","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1182\/blood.V90.8.3089","article-title":"Defective actin reorganization and polymerization of Wiskott\u2013Aldrich T cells in response to CD3-mediated stimulation","volume":"90","author":"Gallego","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.clim.2007.02.001_bib8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1074-7613(00)80590-7","article-title":"Wiskott\u2013Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation","volume":"9","author":"Snapper","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2007.02.001_bib9","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1084\/jem.190.9.1329","article-title":"Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott\u2013Aldrich syndrome protein-deficient lymphocytes","volume":"190","author":"Zhang","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2007.02.001_bib10","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1182\/blood.V99.8.2694","article-title":"Autoimmunity in human primary immunodeficiency diseases","volume":"99","author":"Arkwright","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.clim.2007.02.001_bib11","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nri821","article-title":"CD4+ CD25+ suppressor T cells: more questions than answers","volume":"2","author":"Shevach","year":"2002","journal-title":"Nat. Rev., Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.autrev.2005.01.007","article-title":"Regulatory T cells: development, function and role in autoimmunity","volume":"4","author":"Lan","year":"2005","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.clim.2007.02.001_bib13","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ni1178","article-title":"Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self","volume":"6","author":"Sakaguchi","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib14","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.clim.2007.02.001_bib15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ni909","article-title":"An essential role for Scurfin in CD4+CD25+ T regulatory cells","volume":"4","author":"Khattri","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib16","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib17","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1172\/JCI11679","article-title":"JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic dysregulation syndrome","volume":"106","author":"Chatila","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2007.02.001_bib18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/83713","article-title":"The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3","volume":"27","author":"Bennett","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2007.02.001_bib19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/83707","article-title":"X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy","volume":"27","author":"Wildin","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2007.02.001_bib20","doi-asserted-by":"crossref","first-page":"8697","DOI":"10.1073\/pnas.151260498","article-title":"Somatic mosaicism in Wiskott\u2013Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism","volume":"98","author":"Wada","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2007.02.001_bib21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.188.2.287","article-title":"CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production","volume":"188","author":"Thornton","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2007.02.001_bib22","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.4049\/jimmunol.167.3.1245","article-title":"CD4+CD25high regulatory cells in human peripheral blood","volume":"167","author":"Baecher-Allan","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib23","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/eji.200324455","article-title":"Activation requirements for the induction of CD4+CD25+ T cell suppressor function","volume":"34","author":"Thornton","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.clim.2005.02.018","article-title":"Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells","volume":"115","author":"Baecher-Allan","year":"2005","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib25","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni1263","article-title":"A function for interleukin 2 in Foxp3-expressing regulatory T cells","volume":"6","author":"Fontenot","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib26","doi-asserted-by":"crossref","first-page":"6519","DOI":"10.4049\/jimmunol.172.11.6519","article-title":"Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function","volume":"172","author":"Thornton","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib27","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.1073\/pnas.0509484103","article-title":"Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development","volume":"103","author":"Gavin","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2007.02.001_bib28","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1084\/jem.20060468","article-title":"Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells","volume":"203","author":"Seddiki","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2007.02.001_bib29","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1084\/jem.20060772","article-title":"CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells","volume":"203","author":"Liu","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2007.02.001_bib30","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1084\/jem.176.3.867","article-title":"T cell lines characterize events in the pathogenesis of the Wiskott\u2013Aldrich syndrome","volume":"176","author":"Molina","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2007.02.001_bib31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1182\/blood-2005-11-4567","article-title":"TNF downmodulates the function of human CD4+CD25hi T-regulatory cells","volume":"108","author":"Valencia","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.clim.2007.02.001_bib32","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1084\/jem.20031579","article-title":"Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis","volume":"199","author":"Viglietta","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2007.02.001_bib33","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/immu.200390024","article-title":"Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis","volume":"33","author":"Cao","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib34","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4049\/jimmunol.174.1.164","article-title":"Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation","volume":"174","author":"Sugiyama","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib35","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2337\/diabetes.54.1.92","article-title":"Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes","volume":"54","author":"Lindley","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.clim.2007.02.001_bib36","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1172\/JCI29539","article-title":"Wiskott\u2013Aldrich syndrome protein is required for regulatory T cell homeostasis","author":"Humblet-Baron","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2007.02.001_bib37","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1172\/JCI19441","article-title":"Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25\u2212 T cells","volume":"112","author":"Walker","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2007.02.001_bib38","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1182\/blood.V55.2.243.243","article-title":"The Wiskott\u2013Aldrich syndrome: studies of lymphocytes, granulocytes, and platelets","volume":"55","author":"Ochs","year":"1980","journal-title":"Blood"},{"key":"10.1016\/j.clim.2007.02.001_bib39","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1182\/blood-2005-06-2336","article-title":"Analysis of T-cell repertoire diversity in Wiskott\u2013Aldrich syndrome","volume":"106","author":"Wada","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.clim.2007.02.001_bib40","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.it.2004.04.009","article-title":"Cornerstone of peripheral tolerance: naturally occurring CD4+CD25+ regulatory T cells","volume":"25","author":"Piccirillo","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib41","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1172\/JCI200423395","article-title":"CD4+ Tregs and immune control","volume":"114","author":"Fehervari","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2007.02.001_bib42","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1074-7613(02)00516-2","article-title":"The Wiskott\u2013Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse","volume":"18","author":"Badour","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2007.02.001_bib43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1074-7613(02)00360-6","article-title":"Wiskott\u2013Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation","volume":"17","author":"Dupre","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2007.02.001_bib44","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.4049\/jimmunol.174.5.2602","article-title":"The Wiskott\u2013Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-kappa B (RelA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement","volume":"174","author":"Huang","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib45","first-page":"S249","article-title":"The role of Wiskott Aldrich syndrome protein in T helper cell function","author":"Aoki","year":"2005","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2007.02.001_bib46","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1182\/blood.V90.7.2680","article-title":"Wiskott-Aldrich syndrome\/X-linked thrombocytopenia: WASP gene mutations, protein expression, and phenotype","volume":"90","author":"Zhu","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.clim.2007.02.001_bib47","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1084\/jem.20061338","article-title":"The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells","volume":"204","author":"Maillard","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2007.02.001_bib48","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1084\/jem.20061334","article-title":"WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells","volume":"204","author":"Marangoni","year":"2007","journal-title":"J. Exp. Med."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661607000356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661607000356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T23:21:28Z","timestamp":1683847288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661607000356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S1521661607000356"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2007.02.001","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}