{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:04:07Z","timestamp":1773936247893,"version":"3.50.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.clim.2007.05.009","type":"journal-article","created":{"date-parts":[[2007,6,30]],"date-time":"2007-06-30T11:20:29Z","timestamp":1183202429000},"page":"345-352","source":"Crossref","is-referenced-by-count":33,"title":["Involvement of Toll-like receptors in the immune response of nasal polyp epithelial cells"],"prefix":"10.1016","volume":"124","author":[{"given":"Jiyun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Matsukura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harumi","family":"Suzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2007.05.009_bib1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S1081-1206(10)62101-1","article-title":"Viral respiratory infection in association with asthma and sinusitis: a review","volume":"89","author":"Osur","year":"2002","journal-title":"Ann. Allergy, Asthma, Immunol."},{"key":"10.1016\/j.clim.2007.05.009_bib2","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1165\/rcmb.2003-0388OC","article-title":"Activation of airway epithelial cells by Toll-like receptor agonists","volume":"31","author":"Sha","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.clim.2007.05.009_bib3","doi-asserted-by":"crossref","first-page":"5571","DOI":"10.1074\/jbc.M410592200","article-title":"Involvement of Toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus","volume":"280","author":"Guillot","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2007.05.009_bib4","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1177\/194589240501900303","article-title":"Expression of TLR2 and TLR4 messenger RNA in the epithelial cells of the nasal airway","volume":"19","author":"Dong","year":"2005","journal-title":"Am. J. Rhinol."},{"key":"10.1016\/j.clim.2007.05.009_bib5","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1465-9921-6-100","article-title":"Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis","volume":"6","author":"Fransson","year":"2005","journal-title":"Respir. Res."},{"key":"10.1016\/j.clim.2007.05.009_bib6","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.clim.2007.05.009_bib7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1398-9995.2004.00469.x","article-title":"Cytokine-regulated accumulation of eosinophils in inflammatory disease","volume":"59","author":"Lampinen","year":"2004","journal-title":"Allergy"},{"issue":"Suppl. 6A","key":"10.1016\/j.clim.2007.05.009_bib8","doi-asserted-by":"crossref","first-page":"19S","DOI":"10.1016\/S0002-9343(01)01060-9","article-title":"Rhinovirus respiratory infections and asthma","volume":"112","author":"Gern","year":"2002","journal-title":"Am. J. Med."},{"key":"10.1016\/j.clim.2007.05.009_bib9","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.4049\/jimmunol.171.6.3154","article-title":"Subcellular localization of Toll-like receptor 3 in human dendritic cells","volume":"171","author":"Matsumoto","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2007.05.009_bib10","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/S0006-291X(02)00380-7","article-title":"Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling","volume":"293","author":"Matsumoto","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.clim.2007.05.009_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00130832-200302000-00001","article-title":"Nasal polyposis: an update","volume":"3","author":"Pawankar","year":"2003","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2007.05.009_bib12","doi-asserted-by":"crossref","first-page":"L85","DOI":"10.1152\/ajplung.00397.2004","article-title":"Human airway epithelial cells produce IP-10(CXCL10) in vitro and in vivo upon rhinovirus infection","volume":"289","author":"Spurrell","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.clim.2007.05.009_bib13","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1164\/rccm.2107139","article-title":"Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease","volume":"165","author":"Saetta","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.clim.2007.05.009_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1476-9255-2-16","article-title":"Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response","volume":"29","author":"Ritter","year":"2005","journal-title":"J. Inflam. (Lond.)"},{"key":"10.1016\/j.clim.2007.05.009_bib15","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1365-2567.2005.02200.x","article-title":"Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria","volume":"115","author":"Furrie","year":"2005","journal-title":"Immunology"},{"key":"10.1016\/j.clim.2007.05.009_bib16","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.4049\/jimmunol.170.3.1406","article-title":"Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implication for host\u2013microbial interactions in the gut","volume":"170","author":"Melmed","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2007.05.009_bib17","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/00005176-200104000-00011","article-title":"Absence of Toll-like receptor 4 explains endotoxin hyporesponsiveness in human intestinal epithelium","volume":"32","author":"Naik","year":"2001","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.clim.2007.05.009_bib18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bbrc.2005.02.196","article-title":"Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines","volume":"331","author":"Ueta","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661607012181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661607012181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T23:51:10Z","timestamp":1556581870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661607012181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S1521661607012181"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2007.05.009","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}