{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:55:15Z","timestamp":1784357715224,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.clim.2007.08.010","type":"journal-article","created":{"date-parts":[[2007,11,21]],"date-time":"2007-11-21T10:33:32Z","timestamp":1195641212000},"page":"224-229","source":"Crossref","is-referenced-by-count":23,"title":["Increased lymphocyte Fas expression and high incidence of common variable immunodeficiency disorder in childhood Evans\u2019 syndrome"],"prefix":"10.1016","volume":"125","author":[{"given":"S\u00fcreyya","family":"Sava\u015fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indira","family":"Warrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Buck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaddanapudi","family":"Ravindranath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2007.08.010_bib1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1001\/archinte.1951.03810010058005","article-title":"Primary thrombocytopenic purpura and acquired hemolytic anemia; evidence for a common etiology","volume":"87","author":"Evans","year":"1951","journal-title":"AMA Arch. Intern. Med."},{"key":"10.1016\/j.clim.2007.08.010_bib2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0002-9343(70)80116-4","article-title":"Autoimmune hemolytic anemia. Natural history and viral\u2013immunologic interactions in childhood","volume":"49","author":"Zuelzer","year":"1970","journal-title":"Am. J. Med."},{"key":"10.1016\/j.clim.2007.08.010_bib3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1136\/adc.77.3.245","article-title":"The spectrum of Evans\u2019 syndrome","volume":"77","author":"Savasan","year":"1997","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.clim.2007.08.010_bib4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2141.2005.05809.x","article-title":"Management of Evans syndrome","volume":"132","author":"Norton","year":"2006","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.clim.2007.08.010_bib5","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/sj.bmt.1703237","article-title":"Allogeneic stem cell transplantation for Evans syndrome","volume":"28","author":"Oyama","year":"2001","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.clim.2007.08.010_bib6","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0022-3476(83)80705-7","article-title":"Autoimmune pancytopenia of childhood associated with multisystem disease manifestations","volume":"103","author":"Miller","year":"1983","journal-title":"J. Pediatr."},{"key":"10.1016\/j.clim.2007.08.010_bib7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/ajh.2830150409","article-title":"Immunoregulatory abnormalities in Evans syndrome","volume":"15","author":"Wang","year":"1983","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.clim.2007.08.010_bib8","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0092-8674(95)90013-6","article-title":"Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome","volume":"81","author":"Fisher","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.clim.2007.08.010_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2249.1995.tb06630.x","article-title":"B cells from a distinct subset of patients with common variable immunodeficiency (CVID) have increased CD95 (Apo-1\/fas), diminished CD38 expression, and undergo enhanced apoptosis","volume":"102","author":"Saxon","year":"1995","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2007.08.010_bib10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/cimm.1995.0010","article-title":"B cell lines from a subset of patients with common variable immunodeficiency undergo enhanced apoptosis associated with an increased display of CD95 (Apo-1\/fas), diminished CD38 expression, and decreased IgG and IgA production","volume":"166","author":"Guo","year":"1995","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.clim.2007.08.010_bib11","first-page":"3","article-title":"General principles of multiparameter flow cytometric analysis: applications of flow cytometry in the diagnostic pathology laboratory","volume":"6","author":"Willman","year":"1989","journal-title":"Semin. Diagn. Pathol."},{"key":"10.1016\/j.clim.2007.08.010_bib12","first-page":"585","article-title":"Multidimensional flow cytometric blood cell differentiation without erythrocyte lysis","volume":"17","author":"Terstappen","year":"1991","journal-title":"Blood Cells"},{"key":"10.1016\/j.clim.2007.08.010_bib13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0022-1759(95)00072-I","article-title":"A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V","volume":"184","author":"Vermes","year":"1995","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.clim.2007.08.010_bib14","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1080\/10428190500079951","article-title":"Evaluation of cytotoxicity by flow cytometric drug sensitivity assay in childhood T-cell acute lymphoblastic leukemia","volume":"46","author":"Savasan","year":"2005","journal-title":"Leuk. Lymphoma"},{"issue":"Suppl. 1","key":"10.1016\/j.clim.2007.08.010_bib15","first-page":"176a","article-title":"Persistent immune activation in children with Evans\u2019 syndrome: evidence for a role of \u201cFAS\u201d system","volume":"92","author":"Savasan","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.clim.2007.08.010_bib16","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.1182\/blood.V84.12.4234.bloodjournal84124234","article-title":"A defect in the early phase of T-cell receptor-mediated T-cell activation in patients with common variable immunodeficiency","volume":"84","author":"Fischer","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.clim.2007.08.010_bib17","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1023\/A:1025373601374","article-title":"Common variable immunodeficiency patient classification based on impaired B cell memory differentiation correlates with clinical aspects","volume":"23","author":"Piqueras","year":"2003","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.clim.2007.08.010_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.clim.2005.11.011","article-title":"CD8(+)HLA-DR(+) T lymphocytes are increased in common variable immunodeficiency patients with impaired memory B-cell differentiation","volume":"119","author":"Viallard","year":"2006","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2007.08.010_bib19","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1182\/blood.V87.2.674.bloodjournal872674","article-title":"Persistent activation of the tumor necrosis factor system in a subgroup of patients with common variable immunodeficiency\u2014possible immunologic and clinical consequences","volume":"87","author":"Aukrust","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.clim.2007.08.010_bib20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1046\/j.1365-2249.2001.01560.x","article-title":"Enhanced T cell apoptosis in common variable immunodeficiency: negative role of the fas\/fas ligand system and of the Bcl-2 family proteins and possible role of TNF-RS","volume":"125","author":"Di Renzo","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2007.08.010_bib21","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1182\/blood-2004-04-1325","article-title":"Common variable immunodeficiency is associated with defective functions of dendritic cells","volume":"104","author":"Bayry","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.clim.2007.08.010_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jaut.2005.04.006","article-title":"Treatment and outcome of autoimmune hematologic disease in common variable immunodeficiency (CVID)","volume":"25","author":"Wang","year":"2005","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.clim.2007.08.010_bib23","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1067\/S0022-3476(03)00445-1","article-title":"Childhood autoimmune cytopenia secondary to unsuspected common variable immunodeficiency","volume":"143","author":"Heeney","year":"2003","journal-title":"J. Pediatr."},{"key":"10.1016\/j.clim.2007.08.010_bib24","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1034\/j.1399-3038.2003.00034.x","article-title":"Development of common variable immunodeficiency in a patient with Evans syndrome treated by autologous stem cell transplantation","volume":"14","author":"Stary","year":"2003","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.clim.2007.08.010_bib25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2249.2006.02999.x","article-title":"Age dependency and mutual relations in T and B lymphocyte abnormalities in common variable immunodeficiency patients","volume":"143","author":"Vlkova","year":"2006","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2007.08.010_bib26","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1182\/blood-2004-09-3542","article-title":"Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS)","volume":"105","author":"Teachey","year":"2005","journal-title":"Blood"}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661607013174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661607013174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T09:33:51Z","timestamp":1588066431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661607013174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S1521661607013174"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2007.08.010","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}