{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:56:55Z","timestamp":1788623815319,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.clim.2007.12.007","type":"journal-article","created":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T00:17:59Z","timestamp":1204849079000},"page":"34-42","source":"Crossref","is-referenced-by-count":32,"title":["Selective deficits in blood dendritic cell subsets in common variable immunodeficiency and X-linked agammaglobulinaemia but not specific polysaccharide antibody deficiency"],"prefix":"10.1016","volume":"127","author":[{"given":"Patrick F.K.","family":"Yong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarita","family":"Workman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Wahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Exley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. David B.","family":"Webster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A.A.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2007.12.007_bib1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","article-title":"Immunobiology of dendritic cells","volume":"18","author":"Banchereau","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib2","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.4049\/jimmunol.161.5.2223","article-title":"Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes","volume":"161","author":"Dubois","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib3","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/ni829","article-title":"DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL","volume":"3","author":"Litinskiy","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1074-7613(03)00208-5","article-title":"Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6","volume":"19","author":"Jego","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2007.12.007_bib5","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1182\/blood-2003-08-2972","article-title":"Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help","volume":"103","author":"Poeck","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.clim.2007.12.007_bib6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","article-title":"Common variable immunodeficiency: clinical and immunological features of 248 patients","volume":"92","author":"Cunningham-Rundles","year":"1999","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/ni902","article-title":"Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency","volume":"4","author":"Grimbacher","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib8","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/ng1600","article-title":"Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans","volume":"37","author":"Salzer","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2007.12.007_bib9","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/01.all.0000191887.89773.cc","article-title":"TACItly changing tunes: farewell to a yin and yang of BAFF receptor and TACI in humoral immunity? New genetic defects in common variable immunodeficiency","volume":"5","author":"Salzer","year":"2005","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1365-2249.1997.d01-993.x","article-title":"Lack of specific antibody response in common variable immunodeficiency (CVID) associated with failure in production of antigen-specific memory T cells","volume":"108","author":"Kondratenko","year":"1997","journal-title":"MRC Immunodeficiency Group. Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib11","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1365-2249.2004.02640.x","article-title":"Monocyte derived dendritic cell responses in common variable immunodeficiency","volume":"138","author":"Scott-Taylor","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib12","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1182\/blood-2004-04-1325","article-title":"Common variable immunodeficiency is associated with defective functions of dendritic cells","volume":"104","author":"Bayry","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.clim.2007.12.007_bib13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.clim.2004.12.007","article-title":"Deficient IL-12 and dendritic cell function in common variable immune deficiency","volume":"115","author":"Cunningham-Rundles","year":"2005","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib14","doi-asserted-by":"crossref","first-page":"R1052","DOI":"10.1186\/ar1774","article-title":"Altered dendritic cell distribution in patients with common variable immunodeficiency","volume":"7","author":"Viallard","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.clim.2007.12.007_bib15","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.4049\/jimmunol.176.3.1978","article-title":"TLR9 activation is defective in common variable immune deficiency","volume":"176","author":"Cunningham-Rundles","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/00005792-199611000-00001","article-title":"X-linked agammaglobulinemia. A clinical and molecular analysis","volume":"75","author":"Ochs","year":"1996","journal-title":"Medicine (Baltimore)"},{"issue":"Suppl 1","key":"10.1016\/j.clim.2007.12.007_bib17","first-page":"1","article-title":"Primary immunodeficiency diseases. Report of an IUIS Scientific Committee.","volume":"118","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib18","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1182\/blood.V99.5.1544","article-title":"Severe deficiency of switched memory B cells (CD27(+)IgM(\u2212)IgD(\u2212)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease","volume":"99","author":"Warnatz","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.clim.2007.12.007_bib19","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.4049\/jimmunol.165.11.6037","article-title":"BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood","volume":"165","author":"Dzionek","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jim.2003.10.006","article-title":"Monitoring dendritic cells in clinical practice using a new whole blood single-platform TruCOUNT assay","volume":"284","author":"Vuckovic","year":"2004","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.clim.2007.12.007_bib21","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-2249.2005.02793.x","article-title":"Measurement of peripheral B cell subpopulations in common variable immunodeficiency (CVID) using a whole blood method","volume":"140","author":"Ferry","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib22","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1365-2249.2005.02951.x","article-title":"Common variable immunodeficiency and the complement system; low mannose-binding lectin levels are associated with bronchiectasis","volume":"142","author":"Fevang","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib23","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1182\/blood-2006-08-038422","article-title":"Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets","volume":"109","author":"Piccioli","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.clim.2007.12.007_bib24","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1165\/rcmb.2005-0382OC","article-title":"Different roles for human lung dendritic cell subsets in pulmonary immune defense mechanisms","volume":"35","author":"Demedts","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.clim.2007.12.007_bib25","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.4049\/jimmunol.165.7.3584","article-title":"Monocyte-derived CD1a+ and CD1a\u2212 dendritic cell subsets differ in their cytokine production profiles, susceptibilities to transfection, and capacities to direct Th cell differentiation","volume":"165","author":"Chang","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib26","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.autrev.2005.10.002","article-title":"Inflammatory and autoimmune complications of common variable immune deficiency","volume":"5","author":"Knight","year":"2006","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.clim.2007.12.007_bib27","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.4049\/jimmunol.176.6.3635","article-title":"Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production","volume":"176","author":"Horwood","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib28","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1182\/blood-2006-07-037960","article-title":"Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia","volume":"109","author":"Sochorova","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.clim.2007.12.007_bib29","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.jaci.2006.01.037","article-title":"Bruton's tyrosine kinase is not essential for LPS-induced activation of human monocytes","volume":"117","author":"Perez de","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1046\/j.1365-2249.2003.t01-1-02178.x","article-title":"Bruton's tyrosine kinase defect in dendritic cells from X-linked agammaglobulinaemia patients does not influence their differentiation, maturation and antigen-presenting cell function","volume":"133","author":"Gagliardi","year":"2003","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib31","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.clim.2005.10.007","article-title":"Genotype\/phenotype correlations in X-linked agammaglobulinemia","volume":"118","author":"Broides","year":"2006","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib32","series-title":"Blood First Edition Paper","article-title":"The EUROclass trial: defining subgroups in common variable immunodeficiency","author":"Wehr","year":"2007"},{"key":"10.1016\/j.clim.2007.12.007_bib33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1365-2249.2006.03063.x","article-title":"Elevated serum interleukin (IL)-12p40 levels in common variable immunodeficiency disease and decreased peripheral blood dendritic cells: analysis of IL-12p40 and interferon-gamma gene","volume":"144","author":"Martinez-Pomar","year":"2006","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2007.12.007_bib34","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.cell.2006.02.019","article-title":"Translating innate immunity into immunological memory: implications for vaccine development","volume":"124","author":"Pulendran","year":"2006","journal-title":"Cell"}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152166160701443X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152166160701443X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T21:52:27Z","timestamp":1684273947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152166160701443X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S152166160701443X"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2007.12.007","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}