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Lipid Res."},{"key":"10.1016\/j.clim.2009.07.016_bib159","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1161\/ATVBAHA.106.139253","article-title":"Local overexpression of toll-like receptors at the vessel wall induces atherosclerotic lesion formation: synergism of TLR2 and TLR4","volume":"27","author":"Shinohara","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.clim.2009.07.016_bib160","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cardiores.2004.12.016","article-title":"Toll-like receptor 2 stimulation induces intimal hyperplasia and atherosclerotic lesion development","volume":"66","author":"Schoneveld","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.clim.2009.07.016_bib161","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1161\/01.CIR.0000109140.51366.72","article-title":"Toll-like receptor 4 is involved in outward arterial remodeling","volume":"109","author":"Hollestelle","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.clim.2009.07.016_bib162","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.atherosclerosis.2007.03.025","article-title":"Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids","volume":"196","author":"Liu","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clim.2009.07.016_bib163","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nm1008","article-title":"Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways","volume":"10","author":"Bjorkbacka","year":"2004","journal-title":"Nat. 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Med."},{"key":"10.1016\/j.clim.2009.07.016_bib167","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cca.2005.07.017","article-title":"Toll-like receptor (TLR)-9 promotor polymorphisms and atherosclerosis","volume":"364","author":"Hamann","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.clim.2009.07.016_bib168","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S1074-7613(00)80402-1","article-title":"MyD88: an adapter that recruits IRAK to the IL-1 receptor complex","volume":"7","author":"Wesche","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2009.07.016_bib169","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0968-0004(02)02145-X","article-title":"A universal role for MyD88 in TLR\/IL-1R-mediated signaling","volume":"27","author":"Janssens","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.clim.2009.07.016_bib170","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/35092578","article-title":"Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction","volume":"413","author":"Fitzgerald","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.clim.2009.07.016_bib171","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/ni0901-835","article-title":"TIRAP: an adapter molecule in the Toll signaling pathway","volume":"2","author":"Horng","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2009.07.016_bib172","doi-asserted-by":"crossref","first-page":"6668","DOI":"10.4049\/jimmunol.169.12.6668","article-title":"Cutting edge: a novel Toll\/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling","volume":"169","author":"Yamamoto","year":"2002","journal-title":"J. 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Chem."},{"key":"10.1016\/j.clim.2009.07.016_bib184","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1365-2443.2005.00852.x","article-title":"TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway","volume":"10","author":"Kishida","year":"2005","journal-title":"Genes Cells"},{"key":"10.1016\/j.clim.2009.07.016_bib185","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/35085597","article-title":"TAK1 is a ubiquitin-dependent kinase of MKK and IKK","volume":"412","author":"Wang","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.clim.2009.07.016_bib186","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.molcel.2004.08.008","article-title":"TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains","volume":"15","author":"Kanayama","year":"2004","journal-title":"Mol. 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Chem."},{"key":"10.1016\/j.clim.2009.07.016_bib190","doi-asserted-by":"crossref","first-page":"11259","DOI":"10.1073\/pnas.92.24.11259","article-title":"Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination","volume":"92","author":"Scherer","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2009.07.016_bib191","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nature01182","article-title":"Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4","volume":"420","author":"Yamamoto","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.clim.2009.07.016_bib192","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.cell.2006.03.047","article-title":"Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling","volume":"125","author":"Kagan","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.clim.2009.07.016_bib193","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1087262","article-title":"Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway","volume":"301","author":"Yamamoto","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.clim.2009.07.016_bib194","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nature04369","article-title":"Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6","volume":"439","author":"Hacker","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.clim.2009.07.016_bib195","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nature04374","article-title":"Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response","volume":"439","author":"Oganesyan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.clim.2009.07.016_bib196","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bbrc.2008.01.061","article-title":"Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling","volume":"368","author":"Tanimura","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.clim.2009.07.016_bib197","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/ni1569","article-title":"TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta","volume":"9","author":"Kagan","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2009.07.016_bib198","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1161\/01.ATV.0000064374.15232.C3","article-title":"Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice","volume":"23","author":"Kirii","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.clim.2009.07.016_bib199","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0008-6363(03)00343-2","article-title":"Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice","volume":"59","author":"Elhage","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.clim.2009.07.016_bib200","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1084\/jem.20011022","article-title":"Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis","volume":"195","author":"Gerdes","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2009.07.016_bib201","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.bbrc.2007.12.186","article-title":"Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation","volume":"367","author":"Rekhter","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.clim.2009.07.016_bib202","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1172\/JCI118598","article-title":"Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion","volume":"97","author":"Brand","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2009.07.016_bib203","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cmet.2008.08.016","article-title":"Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis","volume":"8","author":"Gareus","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.clim.2009.07.016_bib204","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1172\/JCI200318580","article-title":"Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice","volume":"112","author":"Kanters","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2009.07.016_bib205","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.1073\/pnas.0401060101","article-title":"Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis","volume":"101","author":"Monaco","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2009.07.016_bib206","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni1050","article-title":"ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance","volume":"5","author":"Brint","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2009.07.016_bib207","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1084\/jem.20071868","article-title":"IL-33 reduces the development of atherosclerosis","volume":"205","author":"Miller","year":"2008","journal-title":"J. Exp. 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A."},{"key":"10.1016\/j.clim.2009.07.016_bib211","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature03253","article-title":"CD36 is a sensor of diacylglycerides","volume":"433","author":"Hoebe","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.clim.2009.07.016_bib212","doi-asserted-by":"crossref","first-page":"31002","DOI":"10.1074\/jbc.M602794200","article-title":"Membrane sorting of toll-like receptor (TLR)-2\/6 and TLR2\/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting","volume":"281","author":"Triantafilou","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2009.07.016_bib213","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1084\/jem.20021787","article-title":"Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2","volume":"197","author":"Gantner","year":"2003","journal-title":"J. Exp. 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