{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:34:56Z","timestamp":1791171296333,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.clim.2010.04.001","type":"journal-article","created":{"date-parts":[[2010,5,11]],"date-time":"2010-05-11T11:53:02Z","timestamp":1273578782000},"page":"245-256","source":"Crossref","is-referenced-by-count":61,"title":["Epithelial-specific blockade of MyD88-dependent pathway causes spontaneous small intestinal inflammation"],"prefix":"10.1016","volume":"136","author":[{"given":"Jianfeng","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieshou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2010.04.001_bib1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature06005","article-title":"Unravelling the pathogenesis of inflammatory bowel disease","volume":"448","author":"Xavier","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.clim.2010.04.001_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2009.02.006","article-title":"Advances in the pathogenesis and treatment of IBD","volume":"132","author":"Braus","year":"2009","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2010.04.001_bib3","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/MOG.0b013e3282ff8b0c","article-title":"Innate immunity in inflammatory bowel disease: state of the art","volume":"24","author":"Hisamatsu","year":"2008","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.clim.2010.04.001_bib4","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/ibd.20294","article-title":"Therapeutic impact of toll-like receptors on inflammatory bowel diseases: a multiple-edged sword","volume":"14","author":"Cario","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.clim.2010.04.001_bib5","doi-asserted-by":"crossref","first-page":"966","DOI":"10.4049\/jimmunol.164.2.966","article-title":"Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors","volume":"164","author":"Cario","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2010.04.001_bib6","doi-asserted-by":"crossref","first-page":"645","DOI":"10.2119\/2008-00035.Gribar","article-title":"No longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammation","volume":"14","author":"Gribar","year":"2008","journal-title":"Mol. Med."},{"key":"10.1016\/j.clim.2010.04.001_bib7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1053\/j.gastro.2008.06.064","article-title":"Guardians of the gut: newly appreciated role of epithelial toll-like receptors in protecting the intestine","volume":"135","author":"Vijay-Kumar","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clim.2010.04.001_bib8","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1084\/jem.20061884","article-title":"Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement","volume":"203","author":"Chieppa","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2010.04.001_bib9","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.immuni.2007.04.014","article-title":"Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL","volume":"26","author":"He","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2010.04.001_bib10","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1084\/jem.20070563","article-title":"MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection","volume":"204","author":"Brandl","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2010.04.001_bib11","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nature05590","article-title":"Epithelial-cell-intrinsic IKK-\u03b2 expression regulates intestinal immune homeostasis","volume":"446","author":"Zaph","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.clim.2010.04.001_bib12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature05698","article-title":"Epithelial NEMO, links innate immunity to chronic intestinal inflammation","volume":"446","author":"Nenci","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.clim.2010.04.001_bib13","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.clim.2009.03.514","article-title":"Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome","volume":"132","author":"Cheng","year":"2009","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2010.04.001_bib14","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1126\/science.278.5343.1612","article-title":"IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling","volume":"278","author":"Muzio","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.clim.2010.04.001_bib15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1074-7613(00)80596-8","article-title":"Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function","volume":"9","author":"Adachi","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2010.04.001_bib16","doi-asserted-by":"crossref","first-page":"42984","DOI":"10.1074\/jbc.M405410200","article-title":"In vitro and ex vivo Activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain","volume":"279","author":"Bambou","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clim.2010.04.001_bib17","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1053\/gast.2001.29568","article-title":"Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1\/Yit adoptive transfer model of Crohn's disease in mice","volume":"121","author":"Burns","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clim.2010.04.001_bib18","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1084\/jem.20050407","article-title":"The primary defect in experimental ileitis originates from a nonhematopoietic source","volume":"203","author":"Olson","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2010.04.001_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/gut.2008.150888","article-title":"Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse","volume":"58","author":"Arrieta","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.clim.2010.04.001_bib20","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cyto.2008.07.005","article-title":"Increased intestinal inflammatory response and gut barrier dysfunction in Nrf2-deficient mice after traumatic brain injury","volume":"44","author":"Jin","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.clim.2010.04.001_bib21","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1128\/AEM.61.11.4131-4134.1995","article-title":"Orally administered bovine lactoferrin inhibits bacterial translocation in mice fed bovine milk","volume":"61","author":"Teraguchi","year":"1995","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.clim.2010.04.001_bib22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.clim.2007.08.017","article-title":"Interferon-gamma and tumor necrosis factor-alpha disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junction","volume":"126","author":"Li","year":"2008","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2010.04.001_bib23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1074-7613(00)80086-2","article-title":"Unresponsiveness of MyD88-deficient mice to endotoxin","volume":"11","author":"Kawai","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2010.04.001_bib24","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nature01182","article-title":"Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4","volume":"420","author":"Yamamoto","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.clim.2010.04.001_bib25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2010.04.001_bib26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/gut.43.1.71","article-title":"Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1\/Yit strain","volume":"43","author":"Matsumoto","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.clim.2010.04.001_bib27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(93)80068-P","article-title":"Interleukin-10-deficient mice develop chronic enterocolitis","volume":"75","author":"K\u00fchn","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.clim.2010.04.001_bib28","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1038\/sj.onc.1202574","article-title":"MyD genes in negative growth control","volume":"17","author":"Liebermann","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.clim.2010.04.001_bib29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","article-title":"Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis","volume":"118","author":"Rakoff-Nahoum","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.clim.2010.04.001_bib30","doi-asserted-by":"crossref","first-page":"G1282","DOI":"10.1152\/ajpgi.2000.279.6.G1282","article-title":"Transcription factor NF-kappaB participates in regulation of epithelial cell turnover in the colon","volume":"279","author":"Inan","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.clim.2010.04.001_bib31","doi-asserted-by":"crossref","first-page":"8366","DOI":"10.1073\/pnas.1432897100","article-title":"TNF-alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis","volume":"100","author":"Marini","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.clim.2010.04.001_bib32","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1136\/gut.2003.036632","article-title":"Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment","volume":"53","author":"Zeissig","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.clim.2010.04.001_bib33","doi-asserted-by":"crossref","first-page":"H985","DOI":"10.1152\/ajpheart.00720.2005","article-title":"Blockade of MyD88 attenuates cardiac hypertrophy and decreases cardiac myocyte apoptosis in pressure overload-induced cardiac hypertrophy in vivo","volume":"290","author":"Ha","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.clim.2010.04.001_bib34","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1053\/j.gastro.2007.02.056","article-title":"Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function","volume":"132","author":"Cario","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clim.2010.04.001_bib35","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1126\/science.270.5239.1203","article-title":"Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin","volume":"270","author":"Hermiston","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.clim.2010.04.001_bib36","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1084\/jem.20071416","article-title":"JAM-A regulates permeability and inflammation in the intestine in vivo","volume":"204","author":"Laukoetter","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2010.04.001_bib37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1053\/j.gastro.2008.04.002","article-title":"Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease","volume":"135","author":"Vetrano","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clim.2010.04.001_bib38","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1053\/j.gastro.2004.04.015","article-title":"Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C","volume":"127","author":"Cario","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clim.2010.04.001_bib39","doi-asserted-by":"crossref","first-page":"18129","DOI":"10.1073\/pnas.0505256102","article-title":"Reduced Paneth cell alpha-defensins in ileal Crohn's disease","volume":"102","author":"Wehkamp","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.clim.2010.04.001_bib40","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1086\/505915","article-title":"A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon","volume":"79","author":"Fellermann","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clim.2010.04.001_bib41","doi-asserted-by":"crossref","first-page":"20858","DOI":"10.1073\/pnas.0808723105","article-title":"Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface","volume":"105","author":"Vaishnava","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.clim.2010.04.001_bib42","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0002-9440(10)63304-4","article-title":"Degranulation of Paneth cells via toll-like receptor 9","volume":"165","author":"Rumio","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.clim.2010.04.001_bib43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/77783","article-title":"Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria","volume":"1","author":"Ayabe","year":"2000","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2010.04.001_bib44","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.4049\/jimmunol.173.9.5398","article-title":"Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells","volume":"173","author":"Vora","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2010.04.001_bib45","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.immuni.2006.06.010","article-title":"Role of toll-like receptors in spontaneous commensal-dependent colitis","volume":"25","author":"Rakoff-Nahoum","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2010.04.001_bib46","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.4049\/jimmunol.180.3.1886","article-title":"The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease","volume":"180","author":"Fukata","year":"2008","journal-title":"J. Immunol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661610005322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661610005322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T13:59:57Z","timestamp":1591279197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661610005322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S1521661610005322"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2010.04.001","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}