{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:04:43Z","timestamp":1760267083716},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.clim.2011.02.005","type":"journal-article","created":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T09:40:03Z","timestamp":1297417203000},"page":"215-227","source":"Crossref","is-referenced-by-count":17,"title":["Abrogation of pathogenic IgG autoantibody production in CD40L gene-deleted lupus-prone New Zealand Black mice"],"prefix":"10.1016","volume":"139","author":[{"given":"Evelyn","family":"Pau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan-Hua","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Loh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginette","family":"Lajoie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan E.","family":"Wither","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2011.02.005_bb0005","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0092-8674(00)81108-3","article-title":"Systemic lupus erythematosus","volume":"85","author":"Kotzin","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.clim.2011.02.005_bb0010","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1056\/NEJM199805073381906","article-title":"Antibodies to DNA","volume":"338","author":"Hahn","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clim.2011.02.005_bb0015","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1084\/jem.184.3.853","article-title":"Intrinsic B cell defects in NZB and NZW mice contribute to systemic lupus erythematosus in (NZB\u00d7NZW)F1 mice","volume":"184","author":"Reininger","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2011.02.005_bb0020","doi-asserted-by":"crossref","first-page":"5357","DOI":"10.4049\/jimmunol.178.8.5357","article-title":"Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodies","volume":"178","author":"Hsu","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0025","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1365-2567.2008.02882.x","article-title":"Activation-induced deaminase heterozygous MRL\/lpr mice are delayed in the production of high-affinity pathogenic antibodies and in the development of lupus nephritis","volume":"126","author":"Jiang","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.clim.2011.02.005_bb0030","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1359-6101(03)00024-8","article-title":"The CD40\u2013CD154 interaction in B cell\u2013T cell liaisons","volume":"14","author":"Bishop","year":"2003","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.clim.2011.02.005_bb0035","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.4049\/jimmunol.157.7.3159","article-title":"Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand Black\u00d7New Zealand White mice. Response correlates with the absence of an anti-antibody response","volume":"157","author":"Early","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0040","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/art.10273","article-title":"The effect of anti-CD40 ligand antibody on B cells in human systemic lupus erythematosus","volume":"46","author":"Huang","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2011.02.005_bb0045","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/art.10856","article-title":"A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis","volume":"48","author":"Boumpas","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2011.02.005_bb0050","doi-asserted-by":"crossref","first-page":"417","DOI":"10.4049\/jimmunol.157.1.417","article-title":"Autoimmune lpr\/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses","volume":"157","author":"Ma","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0055","doi-asserted-by":"crossref","first-page":"729","DOI":"10.4049\/jimmunol.161.2.729","article-title":"Anti-CD40L accelerates renal disease and adenopathy in MRL-lpr mice in parallel with decreased thymocyte apoptosis","volume":"161","author":"Russell","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0060","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1084\/jem.20052438","article-title":"TLR9\/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE","volume":"203","author":"Ehlers","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2011.02.005_bb0065","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1084\/jem.20062567","article-title":"BAFF and MyD88 signals promote a lupuslike disease independent of T cells","volume":"204","author":"Groom","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2011.02.005_bb0070","doi-asserted-by":"crossref","first-page":"7770","DOI":"10.4049\/jimmunol.181.11.7770","article-title":"T cell-independent spontaneous loss of tolerance by anti-double-stranded DNA B cells in C57BL\/6 mice","volume":"181","author":"Tsao","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0075","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.4049\/jimmunol.157.6.2676","article-title":"The natural history of disease expression in CD4 and CD8 gene-deleted New Zealand Black (NZB) mice","volume":"157","author":"Chen","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0080","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1002\/art.22571","article-title":"Protection against autoimmune nephritis in MyD88-deficient MRL\/lpr mice","volume":"56","author":"Sadanaga","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2011.02.005_bb0085","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1084\/jem.20050630","article-title":"RNA-associated autoantigens activate B cells by combined B cell antigen receptor\/Toll-like receptor 7 engagement","volume":"202","author":"Lau","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2011.02.005_bb0090","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/416603a","article-title":"Chromatin\u2013IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors","volume":"416","author":"Leadbetter","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.clim.2011.02.005_bb0095","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nri1957","article-title":"Toll-like receptors in systemic autoimmune disease","volume":"6","author":"Marshak-Rothstein","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0100","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1084\/jem.20031942","article-title":"Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin\u2013immunoglobulin G complexes","volume":"199","author":"Boule","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2011.02.005_bb0105","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.coi.2007.04.008","article-title":"B cells and the BAFF\/APRIL axis: fast-forward on autoimmunity and signaling","volume":"19","author":"Mackay","year":"2007","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0110","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1002\/art.20254","article-title":"Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG","volume":"50","author":"Lovgren","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2011.02.005_bb0115","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1177\/0961203308090020","article-title":"The innate immune system in SLE: type I interferons and dendritic cells","volume":"17","author":"Ronnblom","year":"2008","journal-title":"Lupus"},{"key":"10.1016\/j.clim.2011.02.005_bb0120","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0065-2776(08)60342-9","article-title":"Murine models of systemic lupus erythematosus","volume":"37","author":"Theofilopoulos","year":"1985","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0125","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.4049\/jimmunol.121.6.2213","article-title":"Increased spontaneous polyclonal activation of B lymphocytes in mice with spontaneous autoimmune disease","volume":"121","author":"Izui","year":"1978","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0130","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.4049\/jimmunol.119.4.1534","article-title":"Abnormal polyclonal B cell activation in NZB\/NZW F1 mice","volume":"119","author":"Cohen","year":"1977","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0135","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/clim.1999.4806","article-title":"Activated B cells express increased levels of costimulatory molecules in young autoimmune NZB and (NZB\u00d7NZW)F(1) mice","volume":"94","author":"Wither","year":"2000","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0140","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.4049\/jimmunol.129.3.1219","article-title":"Cell cycle analysis of lymphocyte activation in normal and autoimmune strains of mice","volume":"129","author":"Raveche","year":"1982","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0145","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/eji.200737334","article-title":"Immune mechanisms leading to abnormal B cell selection and activation in New Zealand Black mice","volume":"37","author":"Roy","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0150","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1084\/jem.180.5.1889","article-title":"Humoral immune responses in CD40 ligand-deficient mice","volume":"180","author":"Renshaw","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2011.02.005_bb0155","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1021\/bi00431a045","article-title":"Salt-induced release of DNA from nucleosome core particles","volume":"28","author":"Yager","year":"1989","journal-title":"Biochemistry"},{"key":"10.1016\/j.clim.2011.02.005_bb0160","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.4049\/jimmunol.175.7.4309","article-title":"Colocalization of expansion of the splenic marginal zone population with abnormal B cell activation and autoantibody production in B6 mice with an introgressed New Zealand Black chromosome 13 interval","volume":"175","author":"Wither","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0165","doi-asserted-by":"crossref","first-page":"5283","DOI":"10.4049\/jimmunol.173.8.5283","article-title":"Expansion of bone marrow IFN-alpha-producing dendritic cells in New Zealand Black (NZB) mice: high level expression of TLR9 and secretion of IFN-alpha in NZB bone marrow","volume":"173","author":"Lian","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0170","doi-asserted-by":"crossref","first-page":"5345","DOI":"10.4049\/jimmunol.165.9.5345","article-title":"Anti-SSA\/Ro and anti-SSB\/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of TNF-alpha by macrophages","volume":"165","author":"Miranda-Carus","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0175","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/ar1015","article-title":"Microarray analysis of gene expression in lupus","volume":"5","author":"Crow","year":"2003","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.clim.2011.02.005_bb0180","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev.biochem.67.1.227","article-title":"How cells respond to interferons","volume":"67","author":"Stark","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.clim.2011.02.005_bb0185","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/(SICI)1521-4141(199802)28:02<548::AID-IMMU548>3.0.CO;2-2","article-title":"Regulation of cytoplasmic, surface and soluble forms of CD40 ligand in mouse B cells","volume":"28","author":"Wykes","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0190","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.4049\/jimmunol.159.9.4580","article-title":"CD40 ligand expressed on B cells in the BXSB mouse model of systemic lupus erythematosus","volume":"159","author":"Blossom","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0195","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.smim.2006.12.005","article-title":"Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors","volume":"19","author":"Christensen","year":"2007","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0200","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.immuni.2008.06.009","article-title":"T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells","volume":"29","author":"Herlands","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2011.02.005_bb0205","doi-asserted-by":"crossref","first-page":"8154","DOI":"10.4049\/jimmunol.175.12.8154","article-title":"Functional interplay between intrinsic B and T cell defects leads to amplification of autoimmune disease in New Zealand Black chromosome 1 congenic mice","volume":"175","author":"Cheung","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0210","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S1074-7613(02)00290-X","article-title":"CD40L blockade prevents autoimmune diabetes by induction of bitypic NK\/DC regulatory cells","volume":"16","author":"Homann","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2011.02.005_bb0215","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1182\/blood-2007-02-076364","article-title":"Natural killer cells trigger differentiation of monocytes into dendritic cells","volume":"110","author":"Zhang","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.clim.2011.02.005_bb0220","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1002\/art.24686","article-title":"Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells","volume":"60","author":"Eloranta","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.clim.2011.02.005_bb0225","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1084\/jem.20040168","article-title":"Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB\/W mice","volume":"199","author":"Hoyer","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2011.02.005_bb0230","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1084\/jem.20080840","article-title":"ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity","volume":"205","author":"Odegard","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2011.02.005_bb0235","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.4049\/jimmunol.182.3.1421","article-title":"B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells","volume":"182","author":"Hu","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0240","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.coi.2005.04.005","article-title":"The role of APRIL and BAFF in lymphocyte activation","volume":"17","author":"Schneider","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0245","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.4049\/jimmunol.163.11.6306","article-title":"Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus","volume":"163","author":"Vallin","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0250","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.4049\/jimmunol.165.6.3519","article-title":"The combination of apoptotic U937 cells and lupus IgG is a potent IFN-alpha inducer","volume":"165","author":"Bave","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0255","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.smim.2009.05.010","article-title":"The role of CD40 and CD154\/CD40L in dendritic cells","volume":"21","author":"Ma","year":"2009","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0260","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1084\/jem.20021996","article-title":"Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice","volume":"197","author":"Santiago-Raber","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2011.02.005_bb0265","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/intimm\/11.2.279","article-title":"Type I IFN sets the stringency of B cell repertoire selection in the bone marrow","volume":"11","author":"Vasconcellos","year":"1999","journal-title":"Int. Immunol."},{"key":"10.1016\/j.clim.2011.02.005_bb0270","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1073\/pnas.0408506102","article-title":"Cross-regulation of TNF and IFN-alpha in autoimmune diseases","volume":"102","author":"Palucka","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661611000544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661611000544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T05:58:55Z","timestamp":1685944735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661611000544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S1521661611000544"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2011.02.005","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}