{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T13:31:34Z","timestamp":1702906294306},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.clim.2012.12.003","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T07:40:00Z","timestamp":1355989200000},"page":"140-152","source":"Crossref","is-referenced-by-count":13,"title":["Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans"],"prefix":"10.1016","volume":"146","author":[{"given":"Monica A.","family":"McArthur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo B.","family":"Sztein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2012.12.003_bb0005","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S1473-3099(09)70066-0","article-title":"Gram-positive toxic shock syndromes","volume":"9","author":"Lappin","year":"2009","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.clim.2012.12.003_bb0010","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.immunol.17.1.435","article-title":"The structural basis of T cell activation by superantigens","volume":"17","author":"Li","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.clim.2012.12.003_bb0015","doi-asserted-by":"crossref","first-page":"e1001149","DOI":"10.1371\/journal.pbio.1001149","article-title":"Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock","volume":"9","author":"Arad","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.clim.2012.12.003_bb0020","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/infdis\/167.5.997","article-title":"Role of superantigens in human disease","volume":"167","author":"Schlievert","year":"1993","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.clim.2012.12.003_bb0025","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.4049\/jimmunol.158.4.1862","article-title":"Induction of acute inflammatory lung injury by staphylococcal enterotoxin B","volume":"158","author":"Neumann","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2012.12.003_bb0030","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1365-2249.2003.02203.x","article-title":"Bacterial superantigens","volume":"133","author":"Proft","year":"2003","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.clim.2012.12.003_bb0035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev.micro.55.1.77","article-title":"Toxic shock syndrome and bacterial superantigens: an update","volume":"55","author":"McCormick","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.clim.2012.12.003_bb0040","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1128\/JCM.23.6.1138-1139.1986","article-title":"Involvement of staphylococcal enterotoxins in nonmenstrual toxic shock syndrome","volume":"23","author":"Crass","year":"1986","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.clim.2012.12.003_bb0045","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/infdis\/166.4.911","article-title":"Detection of staphylococcal enterotoxin B among toxic shock syndrome (TSS)- and non-TSS-associated Staphylococcus aureus isolates","volume":"166","author":"Lee","year":"1992","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.clim.2012.12.003_bb0050","doi-asserted-by":"crossref","first-page":"e8473","DOI":"10.1371\/journal.pone.0008473","article-title":"IL-2 regulates SEB induced toxic shock syndrome in BALB\/c mice","volume":"4","author":"Khan","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2012.12.003_bb0055","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"Kolls","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2012.12.003_bb0060","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.immuni.2005.01.011","article-title":"Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17","volume":"22","author":"Stark","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2012.12.003_bb0065","doi-asserted-by":"crossref","first-page":"e16764","DOI":"10.1371\/journal.pone.0016764","article-title":"Interferon gamma-dependent intestinal pathology contributes to the lethality in bacterial superantigen-induced toxic shock syndrome","volume":"6","author":"Tilahun","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2012.12.003_bb0070","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.clim.2012.12.003_bb0075","doi-asserted-by":"crossref","first-page":"423","DOI":"10.4161\/viru.1.5.12862","article-title":"IL-17 in protective immunity to intracellular pathogens","volume":"1","author":"Khader","year":"2010","journal-title":"Virulence"},{"key":"10.1016\/j.clim.2012.12.003_bb0080","doi-asserted-by":"crossref","first-page":"745","DOI":"10.4049\/jimmunol.1002807","article-title":"Loss of IL-17-producing CD8 T cells during late chronic stage of pathogenic simian immunodeficiency virus infection","volume":"186","author":"Nigam","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2012.12.003_bb0085","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.4049\/jimmunol.0801347","article-title":"Cutting edge: phenotypic characterization and differentiation of human CD8+ T cells producing IL-17","volume":"182","author":"Kondo","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2012.12.003_bb0090","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.yexcr.2010.12.018","article-title":"CCR6 as a mediator of immunity in the lung and gut","volume":"317","author":"Ito","year":"2011","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.clim.2012.12.003_bb0095","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1093\/infdis\/170.6.1508","article-title":"Cytokine production patterns and lymphoproliferative responses in volunteers orally immunized with attenuated vaccine strains of Salmonella typhi","volume":"170","author":"Sztein","year":"1994","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.clim.2012.12.003_bb0100","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.4049\/jimmunol.155.8.3987","article-title":"Cytotoxic T lymphocytes after oral immunization with attenuated vaccine strains of Salmonella typhi in humans","volume":"155","author":"Sztein","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2012.12.003_bb0105","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1128\/CVI.00234-10","article-title":"Ex Vivo kinetics of early and long-term multifunctional human leukocyte antigen E-specific CD8+ cells in volunteers immunized with the Ty21a typhoid vaccine","volume":"17","author":"Salerno-Goncalves","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.clim.2012.12.003_bb0110","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-1759(03)00265-5","article-title":"Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation","volume":"281","author":"Betts","year":"2003","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.clim.2012.12.003_bb0115","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cyto.a.21015","article-title":"SPICE: exploration and analysis of post-cytometric complex multivariate datasets","volume":"79","author":"Roederer","year":"2011","journal-title":"Cytometry A"},{"issue":"Suppl. 1","key":"10.1016\/j.clim.2012.12.003_bb0120","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1002\/cyto.b.20554","article-title":"Elucidation of seventeen human peripheral blood B-cell subsets and quantification of the tetanus response using a density-based method for the automated identification of cell populations in multidimensional flow cytometry data","volume":"78","author":"Qian","year":"2010","journal-title":"Cytometry B Clin. Cytom."},{"key":"10.1016\/j.clim.2012.12.003_bb0125","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1073\/pnas.0914839107","article-title":"Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties","volume":"107","author":"Billerbeck","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2012.12.003_bb0130","doi-asserted-by":"crossref","first-page":"e38408","DOI":"10.1371\/journal.pone.0038408","article-title":"Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization","volume":"7","author":"McArthur","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2012.12.003_bb0135","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nm1592","article-title":"Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major","volume":"13","author":"Darrah","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.clim.2012.12.003_bb0140","doi-asserted-by":"crossref","first-page":"8468","DOI":"10.1128\/JVI.00228-07","article-title":"Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells","volume":"81","author":"Kannanganat","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2012.12.003_bb0145","doi-asserted-by":"crossref","first-page":"12071","DOI":"10.1128\/JVI.01261-07","article-title":"Human immunodeficiency virus type 1 controllers but not noncontrollers maintain CD4 T cells coexpressing three cytokines","volume":"81","author":"Kannanganat","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.clim.2012.12.003_bb0150","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.4049\/jimmunol.165.11.6107","article-title":"Microbial lipopeptides induce the production of IL-17 in Th cells","volume":"165","author":"Infante-Duarte","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2012.12.003_bb0155","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1084\/jem.20070663","article-title":"Phenotypic and functional features of human Th17 cells","volume":"204","author":"Annunziato","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2012.12.003_bb0160","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri2274","article-title":"T-cell quality in memory and protection: implications for vaccine design","volume":"8","author":"Seder","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2012.12.003_bb0165","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/jlb.66.1.158","article-title":"Induction of CC chemokines in human peripheral blood mononuclear cells by staphylococcal exotoxins and its prevention by pentoxifylline","volume":"66","author":"Krakauer","year":"1999","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.clim.2012.12.003_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-3083.2011.02536.x","article-title":"Th17 cell, the new player of neuroinflammatory process in multiple sclerosis","volume":"74","author":"Jadidi-Niaragh","year":"2011","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.clim.2012.12.003_bb0175","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/intimm\/dxr001","article-title":"Recent advances in IL-22 biology","volume":"23","author":"Zenewicz","year":"2011","journal-title":"Int. Immunol."},{"key":"10.1016\/j.clim.2012.12.003_bb0180","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.it.2011.02.005","article-title":"Mucosal-associated invariant T cells: unconventional development and function","volume":"32","author":"Le Bourhis","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.clim.2012.12.003_bb0185","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1084\/jem.20081712","article-title":"Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation","volume":"206","author":"Kleinschek","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.clim.2012.12.003_bb0190","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature10228","article-title":"Control of TH17 cells occurs in the small intestine","volume":"475","author":"Esplugues","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.clim.2012.12.003_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3858\/emm.2011.43.1.007","article-title":"Genetic controls of Th17 cell differentiation and plasticity","volume":"43","author":"Dong","year":"2011","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.clim.2012.12.003_bb0200","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1016\/j.lfs.2007.01.012","article-title":"Roles played by lymphocyte function-associated antigen-1 in the regulation of lymphocytic cholinergic activity","volume":"80","author":"Fujii","year":"2007","journal-title":"Life Sci."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661612002938?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661612002938?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T23:38:45Z","timestamp":1687909125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661612002938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S1521661612002938"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2012.12.003","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}