{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:30:15Z","timestamp":1790735415746,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI838270"],"award-info":[{"award-number":["AI838270"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","award":["AI005285"],"award-info":[{"award-number":["AI005285"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jeffery Modell Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.clim.2013.01.011","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T16:00:53Z","timestamp":1359561653000},"page":"11-22","source":"Crossref","is-referenced-by-count":65,"title":["Signature MicroRNA expression patterns identified in humans with 22q11.2 deletion\/DiGeorge syndrome"],"prefix":"10.1016","volume":"147","author":[{"given":"M. Teresa","family":"de la Morena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Eitson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor M.","family":"Dozmorov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Belkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley R.","family":"Hoover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Anguiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Virginia","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai S.C.","family":"van Oers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2013.01.011_bb0005","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0140-6736(07)61601-8","article-title":"Velocardiofacial syndrome, DiGeorge syndrome: the chromosome 22q11.2 deletion syndromes","volume":"370","author":"Kobrynski","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.clim.2013.01.011_bb0010","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1136\/jmg.30.10.852","article-title":"DiGeorge syndrome: part of CATCH 22","volume":"30","author":"Wilson","year":"1993","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.clim.2013.01.011_bb0015","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/hmg\/9.4.489","article-title":"Chromosome 22-specific low copy repeats and the 22q11.2 deletion syndrome: genomic organization and deletion endpoint analysis","volume":"9","author":"Shaikh","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.clim.2013.01.011_bb0020","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/00125817-200101000-00003","article-title":"Evolutionarily conserved low copy repeats (LCRs) in 22q11 mediate deletions, duplications, translocations, and genomic instability: an update and literature review","volume":"3","author":"Shaikh","year":"2001","journal-title":"Genet. Med."},{"key":"10.1016\/j.clim.2013.01.011_bb0025","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1101\/gr.5986507","article-title":"Low copy repeats mediate distal chromosome 22q11.2 deletions: sequence analysis predicts breakpoint mechanisms","volume":"17","author":"Shaikh","year":"2007","journal-title":"Genome Res."},{"key":"10.1016\/j.clim.2013.01.011_bb0030","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1086\/302514","article-title":"A 22q11.2 deletion that excludes UFD1L and CDC45L in a patient with conotruncal and craniofacial defects","volume":"65","author":"Saitta","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clim.2013.01.011_bb0035","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1086\/302235","article-title":"A novel 22q11.2 microdeletion in DiGeorge syndrome","volume":"64","author":"Rauch","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clim.2013.01.011_bb0040","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nrn2841","article-title":"22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia","volume":"11","author":"Karayiorgou","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.clim.2013.01.011_bb0045","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.clim.2010.04.011","article-title":"Secondary immunologic consequences in chromosome 22q11.2 deletion syndrome (DiGeorge syndrome\/velocardiofacial syndrome)","volume":"136","author":"Zemble","year":"2010","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.clim.2013.01.011_bb0050","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1182\/blood-2002-08-2545","article-title":"Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients","volume":"102","author":"Markert","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.clim.2013.01.011_bb0055","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1182\/blood-2003-08-2824","article-title":"T-cell homeostasis in humans with thymic hypoplasia due to chromosome 22q11.2 deletion syndrome","volume":"103","author":"Piliero","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.clim.2013.01.011_bb0060","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/85845","article-title":"DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1","volume":"27","author":"Jerome","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2013.01.011_bb0065","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/35065105","article-title":"Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice","volume":"410","author":"Lindsay","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.clim.2013.01.011_bb0070","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0092-8674(01)00247-1","article-title":"TBX1 is responsible for cardiovascular defects in velo-cardio-facial\/DiGeorge syndrome","volume":"104","author":"Merscher","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.clim.2013.01.011_bb0075","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/S0140-6736(03)14632-6","article-title":"Role of TBX1 in human del22q11.2 syndrome","volume":"362","author":"Yagi","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.clim.2013.01.011_bb0080","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/jmg.2003.016352","article-title":"Non-random asynchronous replication at 22q11.2 favours unequal meiotic crossovers leading to the human 22q11.2 deletion","volume":"41","author":"Baumer","year":"2004","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.clim.2013.01.011_bb0085","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.devcel.2005.12.002","article-title":"Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome","volume":"10","author":"Guris","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.clim.2013.01.011_bb0090","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/j.cub.2004.11.001","article-title":"The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis","volume":"14","author":"Landthaler","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.clim.2013.01.011_bb0095","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","article-title":"A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?","volume":"146","author":"Salmena","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.clim.2013.01.011_bb0100","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.clim.2013.01.011_bb0105","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.cell.2012.02.005","article-title":"MicroRNAs in stress signaling and human disease","volume":"148","author":"Mendell","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.clim.2013.01.011_bb0110","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1073\/pnas.1101219108","article-title":"Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex","volume":"108","author":"Fenelon","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2013.01.011_bb0115","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/ng.138","article-title":"Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model","volume":"40","author":"Stark","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.clim.2013.01.011_bb0120","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/bioinformatics\/19.2.204","article-title":"An associative analysis of gene expression array data","volume":"19","author":"Dozmorov","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.clim.2013.01.011_bb0125","doi-asserted-by":"crossref","first-page":"6323","DOI":"10.1093\/nar\/gkp706","article-title":"Internal standard-based analysis of microarray data. Part 1: analysis of differential gene expressions","volume":"37","author":"Dozmorov","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2013.01.011_bb0130","doi-asserted-by":"crossref","first-page":"7881","DOI":"10.1093\/nar\/gkr503","article-title":"Internal standard-based analysis of microarray data2\u2014analysis of functional associations between HVE-genes","volume":"39","author":"Dozmorov","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2013.01.011_bb0135","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nbt1385","article-title":"Direct multiplexed measurement of gene expression with color-coded probe pairs","volume":"26","author":"Geiss","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.clim.2013.01.011_bb0140","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.immuni.2008.05.012","article-title":"A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus","volume":"29","author":"Chaussabel","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2013.01.011_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012657","article-title":"A comprehensive and universal method for assessing the performance of differential gene expression analyses","volume":"5","author":"Dozmorov","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.clim.2013.01.011_bb0155","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1093\/bioinformatics\/btp299","article-title":"DIANA-mirPath: integrating human and mouse microRNAs in pathways","volume":"25","author":"Papadopoulos","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.clim.2013.01.011_bb0160","doi-asserted-by":"crossref","first-page":"W498","DOI":"10.1093\/nar\/gks494","article-title":"DIANA miRPath v. 2.0: investigating the combinatorial effect of microRNAs in pathways","volume":"40","author":"Vlachos","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clim.2013.01.011_bb0165","doi-asserted-by":"crossref","first-page":"14132","DOI":"10.1523\/JNEUROSCI.1312-12.2012","article-title":"Age-dependent microRNA control of synaptic plasticity in 22q11 deletion syndrome and schizophrenia","volume":"32","author":"Earls","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.clim.2013.01.011_bb0170","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ajmg.1320550427","article-title":"Maternal diabetes causing DiGeorge anomaly and renal agenesis","volume":"55","author":"Digilio","year":"1995","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.clim.2013.01.011_bb0175","first-page":"59","article-title":"The phenotypic spectrum of the 10p deletion syndrome versus the classical DiGeorge syndrome","volume":"10","author":"Van Esch","year":"1999","journal-title":"Genet. Couns."},{"key":"10.1016\/j.clim.2013.01.011_bb0180","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1086\/378818","article-title":"Microduplication 22q11.2, an emerging syndrome: clinical, cytogenetic, and molecular analysis of thirteen patients","volume":"73","author":"Ensenauer","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.clim.2013.01.011_bb0185","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1136\/jmg.37.1.33","article-title":"An HDR (hypoparathyroidism, deafness, renal dysplasia) syndrome locus maps distal to the DiGeorge syndrome region on 10p13\/14","volume":"37","author":"Lichtner","year":"2000","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.clim.2013.01.011_bb0190","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/35019088","article-title":"GATA3 haplo-insufficiency causes human HDR syndrome","volume":"406","author":"Van Esch","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.clim.2013.01.011_bb0195","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.immuni.2010.11.010","article-title":"MicroRNAs prevent the generation of autoreactive antibodies","volume":"33","author":"Belver","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2013.01.011_bb0200","unstructured":"S. Belkaya, S. Murray, J.L. Eitson, M.T. de la Morena, J.A. Forman, N.S. van Oers, T-cell specific transgenic expression of microRNA-185 causes a severe T cell lymphopenia, submitted for publication."},{"key":"10.1016\/j.clim.2013.01.011_bb0205","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.immuni.2010.11.013","article-title":"Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells","volume":"33","author":"Flach","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.clim.2013.01.011_bb0210","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nri2708","article-title":"Physiological and pathological roles for microRNAs in the immune system","volume":"10","author":"O'Connell","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clim.2013.01.011_bb0215","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/hep.22982","article-title":"MicroRNA-23b cluster microRNAs regulate transforming growth factor-beta\/bone morphogenetic protein signaling and liver stem cell differentiation by targeting Smads","volume":"50","author":"Rogler","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.clim.2013.01.011_bb0220","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/ng.915","article-title":"Germline deletion of the miR-17[sim]92 cluster causes skeletal and growth defects in humans","volume":"43","author":"de Pontual","year":"2011","journal-title":"Nat. Genet."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661613000223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661613000223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T16:14:34Z","timestamp":1558714474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661613000223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S1521661613000223"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2013.01.011","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}