{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:10:55Z","timestamp":1778112655686,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2010-0028029"],"award-info":[{"award-number":["2010-0028029"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.clim.2013.05.013","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T14:46:42Z","timestamp":1369838802000},"page":"219-226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic value of tolerance-related gene expression measured in the recipient alloantigen-reactive T cell fraction"],"prefix":"10.1016","volume":"148","author":[{"given":"Dong-Gyun","family":"Lim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youn-Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Hee","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song-Cheol","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clim.2013.05.013_bb0005","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/381434a0","article-title":"Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways","volume":"381","author":"Larsen","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.clim.2013.05.013_bb0010","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3389\/fimmu.2012.00254","article-title":"Translating tolerogenic therapies to the clinic \u2014 where do we stand?","volume":"3","author":"Issa","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2013.05.013_bb0015","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nrneph.2010.112","article-title":"A \u2018biomarker signature\u2019 for tolerance in transplantation","volume":"6","author":"Hernandez-Fuentes","year":"2010","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.clim.2013.05.013_bb0020","doi-asserted-by":"crossref","first-page":"15448","DOI":"10.1073\/pnas.0705834104","article-title":"Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance","volume":"104","author":"Brouard","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2013.05.013_bb0025","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1600-6143.2006.01621.x","article-title":"Multiparameter immune profiling of operational tolerance in liver transplantation","volume":"7","author":"Martinez-Llordella","year":"2007","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.clim.2013.05.013_bb0030","first-page":"2845","article-title":"Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients","volume":"118","author":"Martinez-Llordella","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2013.05.013_bb0035","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1172\/JCI39933","article-title":"Identification of a B cell signature associated with renal transplant tolerance in humans","volume":"120","author":"Newell","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2013.05.013_bb0040","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1172\/JCI39922","article-title":"Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans","volume":"120","author":"Sagoo","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.clim.2013.05.013_bb0045","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/lt.22480","article-title":"Identification of a novel biomarker gene set with sensitivity and specificity for distinguishing between allograft rejection and tolerance","volume":"18","author":"Xie","year":"2012","journal-title":"Liver Transpl."},{"key":"10.1016\/j.clim.2013.05.013_bb0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fimmu.2011.00009","article-title":"Biomarkers of transplantation tolerance: more hopeful than helpful?","volume":"2","author":"Cobbold","year":"2011","journal-title":"Front. Immunol."},{"key":"10.1016\/j.clim.2013.05.013_bb0055","doi-asserted-by":"crossref","first-page":"16236","DOI":"10.1073\/pnas.0807627105","article-title":"Alpha1-antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice","volume":"105","author":"Lewis","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clim.2013.05.013_bb0060","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1097\/TP.0b013e3182696a5b","article-title":"An effective immune-monitoring protocol based on gene expression profiles in the peripheral T-cell fraction reactive to graft antigens","volume":"94","author":"Lim","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.clim.2013.05.013_bb0065","doi-asserted-by":"crossref","first-page":"771","DOI":"10.4049\/jimmunol.175.2.771","article-title":"Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: the interplay of clonal anergy and immune regulation","volume":"175","author":"Quezada","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.clim.2013.05.013_bb0070","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00007890-199707270-00026","article-title":"Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand","volume":"64","author":"Markees","year":"1997","journal-title":"Transplantation"},{"key":"10.1016\/j.clim.2013.05.013_bb0075","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1111\/j.1600-6143.2007.01829.x","article-title":"CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects","volume":"7","author":"Kang","year":"2007","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.clim.2013.05.013_bb0080","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/01.tp.0000248884.71946.19","article-title":"The regulatory\/cytotoxic graft-infiltrating T cells differentiate renal allograft borderline change from acute rejection","volume":"83","author":"Grimbert","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.clim.2013.05.013_bb0085","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1097\/01.tp.0000258597.97468.88","article-title":"Intrahepatic detection of FOXP3 gene expression after liver transplantation using minimally invasive aspiration biopsy","volume":"83","author":"Demirkiran","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.clim.2013.05.013_bb0090","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.trim.2007.08.001","article-title":"FOXP3 mRNA expression analysis in the peripheral blood and allograft of heart transplant patients","volume":"18","author":"Dijke","year":"2008","journal-title":"Transpl. Immunol."},{"key":"10.1016\/j.clim.2013.05.013_bb0095","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/TP.0b013e318199fa57","article-title":"Expression of regulatory T-cell-related molecule genes and clinical outcome in kidney transplant recipients","volume":"87","author":"Alvarez","year":"2009","journal-title":"Transplantation"},{"key":"10.1016\/j.clim.2013.05.013_bb0100","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/TP.0b013e3181ffbab4","article-title":"Clinical significance of regulatory T-cell-related gene expression in peripheral blood after renal transplantation","volume":"91","author":"Iwase","year":"2011","journal-title":"Transplantation"},{"key":"10.1016\/j.clim.2013.05.013_bb0105","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1681\/ASN.2008050450","article-title":"Regulatory, effector, and cytotoxic T cell profiles in long-term kidney transplant patients","volume":"20","author":"Ashton-Chess","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.clim.2013.05.013_bb0110","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1182\/blood-2006-01-0329","article-title":"Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production","volume":"108","author":"Zeiser","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.clim.2013.05.013_bb0115","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.humimm.2004.05.016","article-title":"Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans","volume":"66","author":"Morgan","year":"2005","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.clim.2013.05.013_bb0120","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1073\/pnas.94.6.2648","article-title":"Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis","volume":"94","author":"Naeve","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"S1","key":"10.1016\/j.clim.2013.05.013_bb0125","first-page":"iii9","article-title":"The role of neuritin in regulating the immune response","volume":"22","author":"Barbi","year":"2010","journal-title":"Int. Immunol."},{"key":"10.1016\/j.clim.2013.05.013_bb0130","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1002\/1521-4141(200112)31:12<3443::AID-IMMU3443>3.0.CO;2-J","article-title":"Expression of inhibitory \u201ckiller cell lectin-like receptor G1\u201d identifies unique subpopulations of effector and memory CD8 T cells","volume":"31","author":"Beyersdorf","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2013.05.013_bb0135","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1002\/eji.200737126","article-title":"Characterization of mouse CD4 T cell subsets defined by expression of KLRG1","volume":"37","author":"Beyersdorf","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.clim.2013.05.013_bb0140","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/j.1432-2277.2007.00533.x","article-title":"Transplantation tolerance: lessons from experimental rodent models","volume":"20","author":"Kingsley","year":"2007","journal-title":"Transpl. Int."},{"key":"10.1016\/j.clim.2013.05.013_bb0145","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nri3227","article-title":"Regulatory immune cells in transplantation","volume":"12","author":"Wood","year":"2012","journal-title":"Nat. Rev. Immunol."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661613001332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661613001332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:56:40Z","timestamp":1761494200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661613001332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S1521661613001332"],"URL":"https:\/\/doi.org\/10.1016\/j.clim.2013.05.013","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic value of tolerance-related gene expression measured in the recipient alloantigen-reactive T cell fraction","name":"articletitle","label":"Article Title"},{"value":"Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clim.2013.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}